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The map label for this gene is fadD [C]

Identifier: 148360395

GI number: 148360395

Start: 1142795

End: 1144462

Strand: Direct

Name: fadD [C]

Synonym: LPC_2334

Alternate gene names: 148360395

Gene position: 1142795-1144462 (Clockwise)

Preceding gene: 148360396

Following gene: 148360390

Centisome position: 31.95

GC content: 38.31

Gene sequence:

>1668_bases
ATGCAAAAAGAATCCAATTCCAATTCATTATTTGACTTACTGTTGAAAAATGAAAAAAATTCGGCAGACCGTGTGTATTT
AAGACAGCCAAAAAATGGAGTTTGGCATGAATACACCTGGTCGTCTGTGATGCTGCAGGCCAGAAAAGTAGCTGGTTTTT
TACACCATCTGGGGTTAAAAAAAGGCGATCATGTTTCCATTATCTCCAAGAATTGCGCGGAATGGTTTATCGCTGATTTT
GGAATTCATATTGCTGGAATGGTCAATGTTCCGCTATTTGCTAATCAAAATGAAGAAAGTGCGCATTATGTTTTAGAGCA
TGGGGATGTGAAACTGGTTTTTGTTGGAAAATTAGATGATCATCAGCGAGTCAGACAATTTATCCCTAAGAGTTATCCTA
CAATTGGTTTTGATTACCATAAAGATTTGCAAGTTGATTACGAATGGTCTGATGTTTTGAAAAGTGACCCTATGATTAAC
CTGGTGGAACCAGAGCCAGATGCGTTGTATACCATTATTTATTCATCCGGGACTTCGGGGGCACCCAAAGGGGCTATGTA
TACCAATCGGTCCATAGCCAATTACTTGACAGTTTTCCCCAAGGACTTGCTCAGAATCAGAGAGTTGGAACATTATAAAT
TAATATCTTATCTTCCCCTGGCTCATGTCTATGAACGCTCTGCCATCCAATTAGGCAGTGTTGCTATTAATGCATCGGTA
TCTTTTGTTGAAAGTCTGGAGAAGTTTGCAGAGAACTTAAGGGAAGTGAGTCCTACCTTTTTCACTGCAGTTCCACGCAT
TTGGGGAGTATTTAAGCAGAAAATTGAACAAAAACTGCCACCAGCCAAATTGAATTTTTTATTAAAAATTCCTCTTATAT
CCAGTCTGATAAAAAGAAAGATCATTCACAGTTTAGGATTAAGCGAGTGTACTAATTGTTTTAGCGGGGCATCTCATCTG
CCAATATCCATTATTGATTTTTTTGAAAAATTGGGAATTTATATTCAGGAAGGATATGGTCAATCTGAGAATTTGGCTTA
TGCTACCTTATCGATGTTAAATGAGAGAAAACGTGGTTACGTTGGTACTCCGAGGCTGGAGGTTGAGATAAAAGTAGGCG
AAGAGAATGAATTGCTAATGAAGTGCCCTTGTCTAATGTCAGGTTATTATAAAAATGAACAAGCGACTAAAAATGCCTTT
ACAGAAGAGGGTTGGTTGCGAACAGGAGATGTTGTTGATGTTGATAATGAAGACAGAGTTAAAATATTAGGAAGACTTTC
TGAGAACTTTAAAAATCAGACAGGAGAGTTCATTGCCCCTTCACCGATAGAAAAACTGTTTTCAGTGAACCCTATGCTAG
AACAACTGTGCCTGGTAGGTAGAGAGTTACCTAGTAACGTTTTGTTAGTTACCTTGAATGAAGGAGTGCGTTTGGGTATG
CCAAAAGAAGAGATCACTCACGCATTGCAAGAAACCTTAAAGCAAGTCAATTCCAAATTGGTTAAATACGAAAAAGTCAG
TCACATCCTTGTGCTGAAAGATGCCTGGACAACTGAAAATGATAAATTAACACCTACACTGAAAGTAAAGAGAAGGGTAG
TTGAAAAAGATTATGCCGAGTTAATCCAAAAGGCACTGCAGAAATCTCAGTCAATCGTTTGGGAATGA

Upstream 100 bases:

>100_bases
AGGCGATTCATGAAGGTGAAAATTGTGTTTTGCGAGAAAAAAATAATATTTTACAACTAGTTGGTCTAGAATAGTAATTA
AACAAGCTTAAGGAAGAGCC

Downstream 100 bases:

>100_bases
GGAGACAGTTTATTTAATAAAGAACTGATTTCAAATATTCGTTCCTCTGCTGACGTGCTGTCTAAAGTAAAACGCAGACG
TTGTGGTCCTTCCATTTGAT

Product: AMP-binding protein

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MQKESNSNSLFDLLLKNEKNSADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLKKGDHVSIISKNCAEWFIADF
GIHIAGMVNVPLFANQNEESAHYVLEHGDVKLVFVGKLDDHQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMIN
LVEPEPDALYTIIYSSGTSGAPKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRKIIHSLGLSECTNCFSGASHL
PISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGYVGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAF
TEEGWLRTGDVVDVDNEDRVKILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPSNVLLVTLNEGVRLGM
PKEEITHALQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAELIQKALQKSQSIVWE

Sequences:

>Translated_555_residues
MQKESNSNSLFDLLLKNEKNSADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLKKGDHVSIISKNCAEWFIADF
GIHIAGMVNVPLFANQNEESAHYVLEHGDVKLVFVGKLDDHQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMIN
LVEPEPDALYTIIYSSGTSGAPKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRKIIHSLGLSECTNCFSGASHL
PISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGYVGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAF
TEEGWLRTGDVVDVDNEDRVKILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPSNVLLVTLNEGVRLGM
PKEEITHALQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAELIQKALQKSQSIVWE
>Mature_555_residues
MQKESNSNSLFDLLLKNEKNSADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLKKGDHVSIISKNCAEWFIADF
GIHIAGMVNVPLFANQNEESAHYVLEHGDVKLVFVGKLDDHQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMIN
LVEPEPDALYTIIYSSGTSGAPKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRKIIHSLGLSECTNCFSGASHL
PISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGYVGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAF
TEEGWLRTGDVVDVDNEDRVKILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPSNVLLVTLNEGVRLGM
PKEEITHALQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAELIQKALQKSQSIVWE

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42794756, Length=578, Percent_Identity=27.3356401384083, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI42794760, Length=578, Percent_Identity=27.3356401384083, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI42794758, Length=578, Percent_Identity=27.3356401384083, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI83745141, Length=594, Percent_Identity=25.7575757575758, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI40807491, Length=531, Percent_Identity=25.6120527306968, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI57165412, Length=576, Percent_Identity=26.9097222222222, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI57165410, Length=580, Percent_Identity=26.551724137931, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI27477105, Length=610, Percent_Identity=22.7868852459016, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI42794754, Length=597, Percent_Identity=23.6180904522613, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI42794752, Length=597, Percent_Identity=23.6180904522613, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI12669909, Length=610, Percent_Identity=22.7868852459016, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4758332, Length=610, Percent_Identity=22.7868852459016, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI156151445, Length=507, Percent_Identity=22.4852071005917, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI1788107, Length=524, Percent_Identity=22.9007633587786, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17556552, Length=615, Percent_Identity=25.8536585365854, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17510401, Length=589, Percent_Identity=26.6553480475382, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17541856, Length=592, Percent_Identity=25.3378378378378, Blast_Score=159, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI193204819, Length=621, Percent_Identity=27.0531400966184, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17564090, Length=571, Percent_Identity=22.5919439579685, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI25147511, Length=601, Percent_Identity=22.4625623960067, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17553312, Length=610, Percent_Identity=23.6065573770492, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI133901848, Length=244, Percent_Identity=28.6885245901639, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=397, Percent_Identity=27.455919395466, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17531443, Length=520, Percent_Identity=22.8846153846154, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI32563687, Length=370, Percent_Identity=25.6756756756757, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71994690, Length=564, Percent_Identity=23.0496453900709, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71994694, Length=564, Percent_Identity=23.0496453900709, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71994703, Length=564, Percent_Identity=23.0496453900709, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17559526, Length=488, Percent_Identity=24.7950819672131, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320852, Length=571, Percent_Identity=24.8686514886165, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323903, Length=433, Percent_Identity=26.3279445727483, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322182, Length=433, Percent_Identity=25.8660508083141, Blast_Score=111, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324893, Length=451, Percent_Identity=24.390243902439, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI17933690, Length=620, Percent_Identity=23.8709677419355, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI281366413, Length=569, Percent_Identity=25.3075571177504, Blast_Score=145, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24666501, Length=569, Percent_Identity=25.3075571177504, Blast_Score=145, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24666497, Length=569, Percent_Identity=25.3075571177504, Blast_Score=145, Evalue=1e-34,
Organism=Drosophila melanogaster, GI19921316, Length=623, Percent_Identity=22.6324237560193, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI62471679, Length=596, Percent_Identity=23.489932885906, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI62471683, Length=596, Percent_Identity=23.489932885906, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI62471685, Length=596, Percent_Identity=23.489932885906, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24586636, Length=596, Percent_Identity=23.489932885906, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI62471681, Length=596, Percent_Identity=23.489932885906, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI62471687, Length=596, Percent_Identity=23.489932885906, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24586634, Length=596, Percent_Identity=23.489932885906, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI22026970, Length=596, Percent_Identity=23.489932885906, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI62471689, Length=596, Percent_Identity=23.489932885906, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI21355181, Length=572, Percent_Identity=24.1258741258741, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 63185; Mature: 63185

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKESNSNSLFDLLLKNEKNSADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLK
CCCCCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHCCC
KGDHVSIISKNCAEWFIADFGIHIAGMVNVPLFANQNEESAHYVLEHGDVKLVFVGKLDD
CCCEEEEHHHHHHHHHHHHCCEEEEEEEECCEEECCCCCCCEEEEECCCEEEEEEECCCC
HQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMINLVEPEPDALYTIIYSSGTSG
HHHHHHHCCCCCCCCCCCCCCCCEEECCHHHHHCCCCCEEEECCCCCEEEEEEEECCCCC
APKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEECHH
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECHHHHHHHHHH
IIHSLGLSECTNCFSGASHLPISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGY
HHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCC
VGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAFTEEGWLRTGDVVDVDNEDRV
CCCCEEEEEEEECCCCCEEEECCHHHCCCCCCCHHHHHHCCCCCCEECCCEEECCCCCHH
KILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPSNVLLVTLNEGVRLGM
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
PKEEITHALQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAE
CHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LIQKALQKSQSIVWE
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MQKESNSNSLFDLLLKNEKNSADRVYLRQPKNGVWHEYTWSSVMLQARKVAGFLHHLGLK
CCCCCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHCCC
KGDHVSIISKNCAEWFIADFGIHIAGMVNVPLFANQNEESAHYVLEHGDVKLVFVGKLDD
CCCEEEEHHHHHHHHHHHHCCEEEEEEEECCEEECCCCCCCEEEEECCCEEEEEEECCCC
HQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMINLVEPEPDALYTIIYSSGTSG
HHHHHHHCCCCCCCCCCCCCCCCEEECCHHHHHCCCCCEEEECCCCCEEEEEEEECCCCC
APKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEECHH
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECHHHHHHHHHH
IIHSLGLSECTNCFSGASHLPISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGY
HHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCC
VGTPRLEVEIKVGEENELLMKCPCLMSGYYKNEQATKNAFTEEGWLRTGDVVDVDNEDRV
CCCCEEEEEEEECCCCCEEEECCHHHCCCCCCCHHHHHHCCCCCCEECCCEEECCCCCHH
KILGRLSENFKNQTGEFIAPSPIEKLFSVNPMLEQLCLVGRELPSNVLLVTLNEGVRLGM
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
PKEEITHALQETLKQVNSKLVKYEKVSHILVLKDAWTTENDKLTPTLKVKRRVVEKDYAE
CHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LIQKALQKSQSIVWE
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]