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The map label for this gene is capD [H]

Identifier: 148360382

GI number: 148360382

Start: 1165816

End: 1167693

Strand: Direct

Name: capD [H]

Synonym: LPC_2321

Alternate gene names: 148360382

Gene position: 1165816-1167693 (Clockwise)

Preceding gene: 148360383

Following gene: 148360379

Centisome position: 32.6

GC content: 41.91

Gene sequence:

>1878_bases
GTGGTTTTTATAATGCAAAAAATAATCATATTGACAAAAAAAATCATTGCAAAACTCCCAGTAATTTTGTTTGATGTGGC
CGCAATACCAGTTGCCTGGTATGCCGCTTACTGGTTGCGCTATAACATGCAGCCATATCCCAGCAGCCTGACATCCACCC
ATTCTTTTATTGCTTTAGCTTTATTATCAATTGTTCAGATTAGTTGTTACTATTATTTTAAAATTTACAGAGGATTATGG
CGTTTCTCTTCTCTGAATGATGTCATCAGGATACTGAAGGCTACTATCACAGCAATGGTTTTAGTAATCCCTGTTTTTTA
CTTGACTTCAATTCTTCAGCACCTGCCCAGATCAGTTTTTCCTTTGTATTGCATTATCCTGGCTACCATCCTTTGCGGGG
GAAGGTTGGTGATCCGTCTGCATTGGGATAAGCCTGGCAGAGGAAACAGGGAATTGGAAACGAAAAGAGTTTTGGTGGTT
GGTGCCGGGCAGGCTGGTGAAGGCTTGGTGCGTGATTTGAAAAGAAGCAGTTATTATCGGCCAATAGGCTTTGTAGATGA
CAATAAAAGCAAGAGAGGATTAGAAGTTCATGGAGTGCGGGTTCTGGGAACGACTAACCAAATTACCGAATTAGTCAATC
AGTACGACGTGGATTTGATTTTCATTGCCATACCTTCTGCCAAATCGGCAACCATGCGAAGAATTGTAACGCTTTGTGAA
CAAAGCCATGTGCCTTTTAGTACTTTACCCAGTATTTCAGCCCTGGCTGCGGGCCGGGTTGAAGTGAATGCGCTGAGGCC
TGTGAATATTGAGGATTTATTGGGTCGGGATCAAGTGACGCTCGAATGGGAAAAAATTGCTCGTTCAATAGCAGGAAGAC
GCATATTGATTACAGGCGGTGGTGGCTCAATCGGTTCGGAATTGTGCCGTCAGGTTATGGCTTTAGAGCCTGCGAGCATA
GCCATTGTTGAGAATAGTGAGTTTAACCTGTATCGCATTGAACAGGAGTTGTTAAAGAGTTTTCCAGGTATCCCCGTTGA
ATTGAGTTTAATCAGTGTGACAGACGAAATTGCGATTAATCACTTATTTCGTCGGTTTCAACCTGAAATTGTATTTCATG
CGGCTGCTTACAAACATGTTCCCATGCTTCAGCATCAAGTACGGGTTGCTGTGTTTAATAATGTCATAGGTACTCAGGTT
GTTGCCAAAGCCAGTGTAACATTCGGAGCTGAGAAATTCATTTTAATTTCCACTGATAAAGCAGTGAATCCAACGAATAT
AATGGGAACTACCAAGAGAGTCGCTGAAATTTATTGTCAGAATTTAAATACACGAGTTAAAACCCAGTTTATTACGGTTC
GTTTTGGAAATGTTCTGGGTTCAGCTGGAAGTGTGGTGCCTTTGTTCCAAAAGCAGTTGCAGGAAGGTGGTCCACTGACT
GTGACCCATCCTGATATGCAAAGATATTTTATGACTATACCGGAAGCATGCCAGTTGATTTTGCAAGCGATGGTGAATGG
GGAGGGTGGTGAAATTTTTGTCCTGGATATGGGAGAGCCGGTTAAAATCAGCTATCTTGCAGAGCAAATGATTCGCTTGG
CAGGCAAAGAACCAGGAAGAGACATCATGATTGAATATACAGGTTTGCGTCCTGGCGAAAAAATGTATGAAGAGTTGTTT
CATGAGACTGAACAGTTAACTTCAACAAAACATGAAAAATTATTCAAAGCAAGGTTTCGTGAACTGGATTGGAATGATTT
GACACAAACCATGCGAATGTTACAGGCAGCTTGTATTGAGCATCAGGATGAGGAGTTGCTTGTTCTGTTAAAAAGTCTGG
TGCCGGAGTTTCAATTGGAACCTATGGTTGAAGCTTAA

Upstream 100 bases:

>100_bases
CAGTGCTGAGTCACAATATAGGTATGAATTGTTTGCTAATTTTTGATGCGGGAAACTGTAACATAGTGTACCATCTTTCC
TTTATAAAGGATTACAGACT

Downstream 100 bases:

>100_bases
TCAATATCCCTAATCTGGTAAATCAAGATTGTGTTATGGCAATTACTTATGTTGATTTTGAAACTCTATTTTCTCATCAT
TTGATGGTAAAATGAAAAAC

Product: nucleoside-diphosphate sugar epimerase

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MVFIMQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPSSLTSTHSFIALALLSIVQISCYYYFKIYRGLW
RFSSLNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVFPLYCIILATILCGGRLVIRLHWDKPGRGNRELETKRVLVV
GAGQAGEGLVRDLKRSSYYRPIGFVDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCE
QSHVPFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGGGGSIGSELCRQVMALEPASI
AIVENSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAINHLFRRFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQV
VAKASVTFGAEKFILISTDKAVNPTNIMGTTKRVAEIYCQNLNTRVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLT
VTHPDMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGRDIMIEYTGLRPGEKMYEELF
HETEQLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIEHQDEELLVLLKSLVPEFQLEPMVEA

Sequences:

>Translated_625_residues
MVFIMQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPSSLTSTHSFIALALLSIVQISCYYYFKIYRGLW
RFSSLNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVFPLYCIILATILCGGRLVIRLHWDKPGRGNRELETKRVLVV
GAGQAGEGLVRDLKRSSYYRPIGFVDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCE
QSHVPFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGGGGSIGSELCRQVMALEPASI
AIVENSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAINHLFRRFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQV
VAKASVTFGAEKFILISTDKAVNPTNIMGTTKRVAEIYCQNLNTRVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLT
VTHPDMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGRDIMIEYTGLRPGEKMYEELF
HETEQLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIEHQDEELLVLLKSLVPEFQLEPMVEA
>Mature_625_residues
MVFIMQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPSSLTSTHSFIALALLSIVQISCYYYFKIYRGLW
RFSSLNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVFPLYCIILATILCGGRLVIRLHWDKPGRGNRELETKRVLVV
GAGQAGEGLVRDLKRSSYYRPIGFVDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCE
QSHVPFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGGGGSIGSELCRQVMALEPASI
AIVENSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAINHLFRRFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQV
VAKASVTFGAEKFILISTDKAVNPTNIMGTTKRVAEIYCQNLNTRVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLT
VTHPDMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGRDIMIEYTGLRPGEKMYEELF
HETEQLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIEHQDEELLVLLKSLVPEFQLEPMVEA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=290, Percent_Identity=25.1724137931034, Blast_Score=76, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 70372; Mature: 70372

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFIMQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPSSLTSTHSFIALA
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LLSIVQISCYYYFKIYRGLWRFSSLNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVF
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
PLYCIILATILCGGRLVIRLHWDKPGRGNRELETKRVLVVGAGQAGEGLVRDLKRSSYYR
HHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCC
PIGFVDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCE
CCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHH
QSHVPFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGG
CCCCCHHHCCCHHHHHCCCEEEEEECCCCHHHHCCCCCEEEEHHHHHHHHCCCEEEEECC
GGSIGSELCRQVMALEPASIAIVENSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAIN
CCCHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHCCCCCEEEEEEEHHHHHHHH
HLFRRFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQVVAKASVTFGAEKFILISTDK
HHHHHCCCHHEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEECCC
AVNPTNIMGTTKRVAEIYCQNLNTRVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLT
CCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEECHHHCCCCCCHHHHHHHHHCCCCEE
VTHPDMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGR
EECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
DIMIEYTGLRPGEKMYEELFHETEQLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIE
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
HQDEELLVLLKSLVPEFQLEPMVEA
CCCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MVFIMQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPSSLTSTHSFIALA
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LLSIVQISCYYYFKIYRGLWRFSSLNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVF
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
PLYCIILATILCGGRLVIRLHWDKPGRGNRELETKRVLVVGAGQAGEGLVRDLKRSSYYR
HHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCC
PIGFVDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCE
CCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHH
QSHVPFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGG
CCCCCHHHCCCHHHHHCCCEEEEEECCCCHHHHCCCCCEEEEHHHHHHHHCCCEEEEECC
GGSIGSELCRQVMALEPASIAIVENSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAIN
CCCHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHCCCCCEEEEEEEHHHHHHHH
HLFRRFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQVVAKASVTFGAEKFILISTDK
HHHHHCCCHHEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEECCC
AVNPTNIMGTTKRVAEIYCQNLNTRVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLT
CCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEECHHHCCCCCCHHHHHHHHHCCCCEE
VTHPDMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGR
EECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
DIMIEYTGLRPGEKMYEELFHETEQLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIE
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
HQDEELLVLLKSLVPEFQLEPMVEA
CCCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.093 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: p-Chloromercuribenzoate; TMP [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]