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The map label for this gene is nhaA

Identifier: 148360168

GI number: 148360168

Start: 2867668

End: 2868822

Strand: Direct

Name: nhaA

Synonym: LPC_2099

Alternate gene names: 148360168

Gene position: 2867668-2868822 (Clockwise)

Preceding gene: 148360169

Following gene: 148360167

Centisome position: 80.18

GC content: 38.96

Gene sequence:

>1155_bases
ATGAATAAATCGGATTCTTTCTACAATCTGGAAACCATAGGGGGTATCCTCTTATTTATTGCTGCCGTGCTTGCGATAAT
CACAGCCAACTCGCCTTACCGGGTTGGCTATGAATATTTTTTAAGCATCAATGGCAGTGTTTCTGTGGGAAATATGTCTA
TAACAAAACCTCTGCTTTTATGGATCAATGATGGATTAATGGCCATTTATTTCCTGTTGATTGGTCTGGAAATAAAACGG
GAAGTTAATCGAGGCATTTTAAGTGACAAAACAAATCTTTTGGTGCCTGCCCTTACAGCGTTAGCGGGATTGCTATTCCC
CGCATTAATATTTATTTTCTTTAATGCTCACCATCCTGTGTATCTGAAAGGTTGGGCAATTCCTACCGCTACTGATATTG
CCTTTACTCTTGGAATTGTCTCTCTTTTAGGCTCACGCGTACCATTCTCACTCAAGATTTTGCTGACTGCCATTGCCATT
TTTGATGATATTGCAGCCATTGTCATTATTGCATTATTTTATACCGAACAATTATCGTTGCTCTCTCTTTCACTTGCTTT
GGTATTTACTCTGATTTTGATTGGTTTAAATTATTTTAAATGTCGTCGTATTTCAGTCTTCATGCTGTTTGGGGTAGCTC
TATGGATTGCCGTTTTAAAATCAGGTGTTCATGCCACCCTTGCAGGGATTGTGATTGCCATGACGATTCCTGATGAGGGT
AAGGAGTCCATGCTGACCCGTTTGGAAGACGGTTTACATCACTGGGTTGTGTTTTTGATTCTCCCCTTGTTTGCTTTTGC
CAATGCAGGGGTTAGCTTTGTCGGACTTGATGCGTCCATGTTGACTCATCCTGTTGTTTTAGGAATTGGGTTAGGATTAT
TTCTTGGCAAGCAGTTGGGTATTTTCTTGTCTTTGGGTTATTTTGTTCAATTTAAAAAATTTCTTAAAGCCGATAAAGTG
AATCTTGCTCAGGTTTATGGCATTGCGCTCATTTGTGGAGTAGGCTTTACCATGAGTTTGTTTATTGGTTCTTTGGCTTA
CCAAAATTATGATTTAAGTTTAATGCCAATGGTTAAAATTGGCGTAGTATTTGGTTCTTTTATAGCGGGGTTAACCGGAT
TTTTAGTGTTAAAAATGACTTCACTCAAGCGTTAG

Upstream 100 bases:

>100_bases
CTTGTTTTTTATTTTTAGAAGTATTAATCAAGAATAAAAAGTTGTATGAAGCTATAACACAAAGTACACTTAATTTTTAG
CCACTCGTGAACTAAAATCC

Downstream 100 bases:

>100_bases
TTGATAAGGTGCTTTTATAAAGAAAAACCGATTTAATTAAGGAGGATGCTCATGGAAAGGAAAATAGCCATTGTAACAGG
AGGTACGGGCGGCATTGGGA

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MNKSDSFYNLETIGGILLFIAAVLAIITANSPYRVGYEYFLSINGSVSVGNMSITKPLLLWINDGLMAIYFLLIGLEIKR
EVNRGILSDKTNLLVPALTALAGLLFPALIFIFFNAHHPVYLKGWAIPTATDIAFTLGIVSLLGSRVPFSLKILLTAIAI
FDDIAAIVIIALFYTEQLSLLSLSLALVFTLILIGLNYFKCRRISVFMLFGVALWIAVLKSGVHATLAGIVIAMTIPDEG
KESMLTRLEDGLHHWVVFLILPLFAFANAGVSFVGLDASMLTHPVVLGIGLGLFLGKQLGIFLSLGYFVQFKKFLKADKV
NLAQVYGIALICGVGFTMSLFIGSLAYQNYDLSLMPMVKIGVVFGSFIAGLTGFLVLKMTSLKR

Sequences:

>Translated_384_residues
MNKSDSFYNLETIGGILLFIAAVLAIITANSPYRVGYEYFLSINGSVSVGNMSITKPLLLWINDGLMAIYFLLIGLEIKR
EVNRGILSDKTNLLVPALTALAGLLFPALIFIFFNAHHPVYLKGWAIPTATDIAFTLGIVSLLGSRVPFSLKILLTAIAI
FDDIAAIVIIALFYTEQLSLLSLSLALVFTLILIGLNYFKCRRISVFMLFGVALWIAVLKSGVHATLAGIVIAMTIPDEG
KESMLTRLEDGLHHWVVFLILPLFAFANAGVSFVGLDASMLTHPVVLGIGLGLFLGKQLGIFLSLGYFVQFKKFLKADKV
NLAQVYGIALICGVGFTMSLFIGSLAYQNYDLSLMPMVKIGVVFGSFIAGLTGFLVLKMTSLKR
>Mature_384_residues
MNKSDSFYNLETIGGILLFIAAVLAIITANSPYRVGYEYFLSINGSVSVGNMSITKPLLLWINDGLMAIYFLLIGLEIKR
EVNRGILSDKTNLLVPALTALAGLLFPALIFIFFNAHHPVYLKGWAIPTATDIAFTLGIVSLLGSRVPFSLKILLTAIAI
FDDIAAIVIIALFYTEQLSLLSLSLALVFTLILIGLNYFKCRRISVFMLFGVALWIAVLKSGVHATLAGIVIAMTIPDEG
KESMLTRLEDGLHHWVVFLILPLFAFANAGVSFVGLDASMLTHPVVLGIGLGLFLGKQLGIFLSLGYFVQFKKFLKADKV
NLAQVYGIALICGVGFTMSLFIGSLAYQNYDLSLMPMVKIGVVFGSFIAGLTGFLVLKMTSLKR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=382, Percent_Identity=47.3821989528796, Blast_Score=295, Evalue=3e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_LEGPC (A5IF79)

Other databases:

- EMBL:   CP000675
- RefSeq:   YP_001251375.1
- ProteinModelPortal:   A5IF79
- SMR:   A5IF79
- STRING:   A5IF79
- GeneID:   5179937
- GenomeReviews:   CP000675_GR
- KEGG:   lpc:LPC_2099
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   IYLKFFA
- ProtClustDB:   PRK14854
- BioCyc:   LPNE400673:LPC_2099-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 41780; Mature: 41780

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x125f6b78)-; HASH(0x13bdb028)-; HASH(0x1372badc)-; HASH(0x13b58694)-; HASH(0x1313091c)-; HASH(0x1190ff3c)-; HASH(0x13ac46f8)-; HASH(0x1241e6a4)-; HASH(0x1383e760)-; HASH(0x13a7ec6c)-; HASH(0x139326e4)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSDSFYNLETIGGILLFIAAVLAIITANSPYRVGYEYFLSINGSVSVGNMSITKPLLL
CCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCEECEEEEEEECCEEEECCCCCCCCEEE
WINDGLMAIYFLLIGLEIKREVNRGILSDKTNLLVPALTALAGLLFPALIFIFFNAHHPV
EECCCHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
YLKGWAIPTATDIAFTLGIVSLLGSRVPFSLKILLTAIAIFDDIAAIVIIALFYTEQLSL
EEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLSLALVFTLILIGLNYFKCRRISVFMLFGVALWIAVLKSGVHATLAGIVIAMTIPDEG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCCCC
KESMLTRLEDGLHHWVVFLILPLFAFANAGVSFVGLDASMLTHPVVLGIGLGLFLGKQLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH
IFLSLGYFVQFKKFLKADKVNLAQVYGIALICGVGFTMSLFIGSLAYQNYDLSLMPMVKI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHH
GVVFGSFIAGLTGFLVLKMTSLKR
HHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MNKSDSFYNLETIGGILLFIAAVLAIITANSPYRVGYEYFLSINGSVSVGNMSITKPLLL
CCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCEECEEEEEEECCEEEECCCCCCCCEEE
WINDGLMAIYFLLIGLEIKREVNRGILSDKTNLLVPALTALAGLLFPALIFIFFNAHHPV
EECCCHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
YLKGWAIPTATDIAFTLGIVSLLGSRVPFSLKILLTAIAIFDDIAAIVIIALFYTEQLSL
EEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLSLALVFTLILIGLNYFKCRRISVFMLFGVALWIAVLKSGVHATLAGIVIAMTIPDEG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCCCC
KESMLTRLEDGLHHWVVFLILPLFAFANAGVSFVGLDASMLTHPVVLGIGLGLFLGKQLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH
IFLSLGYFVQFKKFLKADKVNLAQVYGIALICGVGFTMSLFIGSLAYQNYDLSLMPMVKI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHH
GVVFGSFIAGLTGFLVLKMTSLKR
HHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA