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The map label for this gene is mrpD [H]

Identifier: 148360037

GI number: 148360037

Start: 2997530

End: 2998750

Strand: Direct

Name: mrpD [H]

Synonym: LPC_1968

Alternate gene names: 148360037

Gene position: 2997530-2998750 (Clockwise)

Preceding gene: 148360038

Following gene: 148360036

Centisome position: 83.81

GC content: 40.21

Gene sequence:

>1221_bases
ATGCCTAAATCACATAATTCCATTATATTTCTTGGTTTGCTTTCTGCGTTTTCTTTGCTTACATTTGATCTTTATCAACC
ATCACTGCCTTTCATAACGAATTATTTTAATATTACCCCAAGTATGGGGCAATTAACCCTAAGTATTTATTTGCTAGTTT
ATGGTATCACTCATCTTCTATGGGGACCACTTATAGACCATTTTGGGCGCCGGCGCCTACTTCCTGGAAACCTTTTATTA
GCCTTAATTGGCAGTTTAATGTGTGCTTTTGCGCCGAATATCACCATGCTTATTTGCGGTCGTGCCCTACAAGGATTCGC
CTTATGCTGCGCAAATCTCATTGCCTATTCCGCAGCACGTGATTTTGAAGACACGATTGTTCGCGCCAAAGTGCTGTCCT
ATATTTCCATGACCGTTTCAGTTTCACCGATTATAGCCCCGGTAATTGGTGCTCTTATCTTTCATCATTTTGGCTGGCAA
GCCAATTTTATAGTCATGGCAATCGTTGCCTGTATTCTATTGATACAAACCAAACTCTCCTTGTTAGAGTCCCCTTTCTG
GACGCCTCCCCAGGAAAGGTTCTCGGTCAAAAAAATACTCCGGGAATATAAGTCCATACTCAATATACCCTCTCTATGGT
GTGCATCATTTATTTTAATGTTTGGCATTTCTGCTGTCATGCTCACTGTAATTAATTCCTCTTACCTTATTATCGAGGTA
CTGAATTACTCTCCACTTGCCTATGGACTTATTTTTATTCTGAATGGTTTAAATATTATTTTTGGAAACTATCTGGGCAT
TTGGCTTCGTGATCGATTACCCATTATAACCACCATCTATTTGGGGAACTGGTTCATTGTCCTTGGTGGTACAGCGATGT
TGCTTACTTCCAAATTGTTTGGGTTTAGTCTGTTAGCATTATCATTTTCATTAATTGCCAACTTGGGAATTAGTGTCAGT
GCCGCTCCGACTATCTCCATCGCCCTAACGGATTTTAAGCAAAATGCAGGAATAGTTATGGCTTTTATGAATACCATACG
TTTAATCGGCCCCTCTCTTTTAACTATTCTAACCGGCTATTTATTGACAAGGAATCTTGACGCTCTTCCACTAGGATTAA
TAGGTTCAGGAATTGGAGCCCTTTTTTTCTCATGGCATTTTAGCCGATTGACTACTGAATCGAGGAGCTCGGATATGGAT
AGCAAAGAAGCGGTGACCTAA

Upstream 100 bases:

>100_bases
GTAAAGCAAGTTGGCAATTGCCAACTTGCTTTAATATTTCCTTTCAAATGCAAGCTGAATTTGGTTACAATCGCATAATT
TTTGGTGAATGATTTTTTAT

Downstream 100 bases:

>100_bases
CAACCTGTTCCCCCCATATGCTTAATTACTTTTGATGGATCTAACCTCATATTAATACTCTGAATTATGAATAATGGCTT
TTTTCAAGTTCTATTTATGC

Product: multidrug resistance protein D

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MPKSHNSIIFLGLLSAFSLLTFDLYQPSLPFITNYFNITPSMGQLTLSIYLLVYGITHLLWGPLIDHFGRRRLLPGNLLL
ALIGSLMCAFAPNITMLICGRALQGFALCCANLIAYSAARDFEDTIVRAKVLSYISMTVSVSPIIAPVIGALIFHHFGWQ
ANFIVMAIVACILLIQTKLSLLESPFWTPPQERFSVKKILREYKSILNIPSLWCASFILMFGISAVMLTVINSSYLIIEV
LNYSPLAYGLIFILNGLNIIFGNYLGIWLRDRLPIITTIYLGNWFIVLGGTAMLLTSKLFGFSLLALSFSLIANLGISVS
AAPTISIALTDFKQNAGIVMAFMNTIRLIGPSLLTILTGYLLTRNLDALPLGLIGSGIGALFFSWHFSRLTTESRSSDMD
SKEAVT

Sequences:

>Translated_406_residues
MPKSHNSIIFLGLLSAFSLLTFDLYQPSLPFITNYFNITPSMGQLTLSIYLLVYGITHLLWGPLIDHFGRRRLLPGNLLL
ALIGSLMCAFAPNITMLICGRALQGFALCCANLIAYSAARDFEDTIVRAKVLSYISMTVSVSPIIAPVIGALIFHHFGWQ
ANFIVMAIVACILLIQTKLSLLESPFWTPPQERFSVKKILREYKSILNIPSLWCASFILMFGISAVMLTVINSSYLIIEV
LNYSPLAYGLIFILNGLNIIFGNYLGIWLRDRLPIITTIYLGNWFIVLGGTAMLLTSKLFGFSLLALSFSLIANLGISVS
AAPTISIALTDFKQNAGIVMAFMNTIRLIGPSLLTILTGYLLTRNLDALPLGLIGSGIGALFFSWHFSRLTTESRSSDMD
SKEAVT
>Mature_405_residues
PKSHNSIIFLGLLSAFSLLTFDLYQPSLPFITNYFNITPSMGQLTLSIYLLVYGITHLLWGPLIDHFGRRRLLPGNLLLA
LIGSLMCAFAPNITMLICGRALQGFALCCANLIAYSAARDFEDTIVRAKVLSYISMTVSVSPIIAPVIGALIFHHFGWQA
NFIVMAIVACILLIQTKLSLLESPFWTPPQERFSVKKILREYKSILNIPSLWCASFILMFGISAVMLTVINSSYLIIEVL
NYSPLAYGLIFILNGLNIIFGNYLGIWLRDRLPIITTIYLGNWFIVLGGTAMLLTSKLFGFSLLALSFSLIANLGISVSA
APTISIALTDFKQNAGIVMAFMNTIRLIGPSLLTILTGYLLTRNLDALPLGLIGSGIGALFFSWHFSRLTTESRSSDMDS
KEAVT

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790146, Length=341, Percent_Identity=28.7390029325513, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788509, Length=356, Percent_Identity=25, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI48994889, Length=360, Percent_Identity=23.8888888888889, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1787065, Length=331, Percent_Identity=23.8670694864048, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790794, Length=190, Percent_Identity=28.9473684210526, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87082312, Length=250, Percent_Identity=24.8, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI87081738, Length=164, Percent_Identity=30.4878048780488, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788068, Length=153, Percent_Identity=28.1045751633987, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1789207, Length=175, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319657, Length=160, Percent_Identity=28.75, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44703; Mature: 44572

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKSHNSIIFLGLLSAFSLLTFDLYQPSLPFITNYFNITPSMGQLTLSIYLLVYGITHLL
CCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHEECCCCHHHHHHHHHHHHHHHHHHH
WGPLIDHFGRRRLLPGNLLLALIGSLMCAFAPNITMLICGRALQGFALCCANLIAYSAAR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHC
DFEDTIVRAKVLSYISMTVSVSPIIAPVIGALIFHHFGWQANFIVMAIVACILLIQTKLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LLESPFWTPPQERFSVKKILREYKSILNIPSLWCASFILMFGISAVMLTVINSSYLIIEV
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
LNYSPLAYGLIFILNGLNIIFGNYLGIWLRDRLPIITTIYLGNWFIVLGGTAMLLTSKLF
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCHHHHHHHHHH
GFSLLALSFSLIANLGISVSAAPTISIALTDFKQNAGIVMAFMNTIRLIGPSLLTILTGY
HHHHHHHHHHHHHHCCCCEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLTRNLDALPLGLIGSGIGALFFSWHFSRLTTESRSSDMDSKEAVT
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PKSHNSIIFLGLLSAFSLLTFDLYQPSLPFITNYFNITPSMGQLTLSIYLLVYGITHLL
CCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHEECCCCHHHHHHHHHHHHHHHHHHH
WGPLIDHFGRRRLLPGNLLLALIGSLMCAFAPNITMLICGRALQGFALCCANLIAYSAAR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHC
DFEDTIVRAKVLSYISMTVSVSPIIAPVIGALIFHHFGWQANFIVMAIVACILLIQTKLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LLESPFWTPPQERFSVKKILREYKSILNIPSLWCASFILMFGISAVMLTVINSSYLIIEV
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
LNYSPLAYGLIFILNGLNIIFGNYLGIWLRDRLPIITTIYLGNWFIVLGGTAMLLTSKLF
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCHHHHHHHHHH
GFSLLALSFSLIANLGISVSAAPTISIALTDFKQNAGIVMAFMNTIRLIGPSLLTILTGY
HHHHHHHHHHHHHHCCCCEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLTRNLDALPLGLIGSGIGALFFSWHFSRLTTESRSSDMDSKEAVT
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]