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The map label for this gene is helC [H]

Identifier: 148359920

GI number: 148359920

Start: 2797765

End: 2799009

Strand: Reverse

Name: helC [H]

Synonym: LPC_1849

Alternate gene names: 148359920

Gene position: 2799009-2797765 (Counterclockwise)

Preceding gene: 148359921

Following gene: 148359919

Centisome position: 78.26

GC content: 39.92

Gene sequence:

>1245_bases
ATGCGTATTTATTTTTATTTAGTTATTGCATGGATGAACCTCATGACTCATGAAGCTATGGCATCATCCTCATTTACTTT
CAAAGATGCTTTGGCAATTGCATATCGGAATAATCCGGAATTACAAGCTGAAATAGATAAAGCGCAGGCCATGCGTGGGT
ATTTTGTACAAAGCGGGCTTTACCCTAATCCACAACTTACCTTAACTGCCGAGAATTTTGGCGGATCTGGCAGTTATTCC
AGTTACGAATCTGCAGAAACTACCGCATCAGTGACACAGCCTATTCCTTTAGGTAATCGTTTATCTTATTTGAAAAAAGC
CAGCTATGCAGATTATTTAGCCTCATTAGCACAAATTCAAGTCCAAAAAGCAGCGATTTATATGGCTGTTGGTGGCGCAT
ATGTCGATGCATTGTATGCCGGACAATGGCACCAGGTAACTAAAAAGCTTATTTCACTCAATGAGAGTATCGTTAAAGCA
ATTGAGCGGCGTGTTAAAGCGGGTGCGGGAGCTGAATTGGATTTACGTTTAGCTCAAATTCGATTGGGTGAATCGCACAT
TCAAGAAAAAAAAGCGGCACGTGATGCACTGTCACAACGTGCTAAATTGGCTCGTTTATTAGGTATCGGATTAAGGGTGG
ATCAACCATTAGTAGATAAAGGGCTACCTGATGTTACATTAAATTGGTCAGTGCTTTTAAAAACATTACCTCAAAGCCCG
CAATTGATACAAATGCAACAACAACTAAAAGCCAAACGAGCAACCATTACAGCAGTTAAAAAATCCGTTTGGCCGGATTT
AAACATTCAATTAGGCGCTCGCCATTTTTCTGATGATGGAAGCAATGCTGCAGTGATGTCGGCTTATGCACAAGTTCCTG
TTTTTGATCGCAATCAAGGAAAAATAATGACAGCGGAAGCGCAATTCACGCAAACTGCGCATGAATACCAGGGAACAAAG
CTCGATATACGTCAAACAGCATATACTGTATTTTTACAAGCCCAACAAAGTCATTATGAAGCAGAATTAGTAACCAGTAC
TTTGTTACCACTTGCTCGTAAATCAATAAAACTCGCTCAAGATGGCTATCAAATGGGACGCTATACCTACATTGAATTAT
CTACAGCCTTAAATGCTTTGTATGAAGAGGAACGACACTATCAACAGGCACATGCAGATTATCATAAAACATTAATTCAA
CTTACAGGGCTTTTAGGTCTTCATCCTACCAAGGAGAGTAAATGA

Upstream 100 bases:

>100_bases
TGAAGATTTATCAATAAGTTATCACAATATAAACGTGTAAAAACACTCAAATACAATTAAACTAAAAAAGTATATTTGCA
AGTTAAGGGTAAGTTAAGGG

Downstream 100 bases:

>100_bases
ATCTATTAAAACCAATCGGTTTATCCCTAAAACTTGCTGTGTTCCTGTTAGGAATGAGCTCTTTTTCGCTTTGGGCGGAA
GAAACAACTCATGCTACAGA

Product: cobalt/zinc/cadmium efflux RND transporter outer membrane protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MRIYFYLVIAWMNLMTHEAMASSSFTFKDALAIAYRNNPELQAEIDKAQAMRGYFVQSGLYPNPQLTLTAENFGGSGSYS
SYESAETTASVTQPIPLGNRLSYLKKASYADYLASLAQIQVQKAAIYMAVGGAYVDALYAGQWHQVTKKLISLNESIVKA
IERRVKAGAGAELDLRLAQIRLGESHIQEKKAARDALSQRAKLARLLGIGLRVDQPLVDKGLPDVTLNWSVLLKTLPQSP
QLIQMQQQLKAKRATITAVKKSVWPDLNIQLGARHFSDDGSNAAVMSAYAQVPVFDRNQGKIMTAEAQFTQTAHEYQGTK
LDIRQTAYTVFLQAQQSHYEAELVTSTLLPLARKSIKLAQDGYQMGRYTYIELSTALNALYEEERHYQQAHADYHKTLIQ
LTGLLGLHPTKESK

Sequences:

>Translated_414_residues
MRIYFYLVIAWMNLMTHEAMASSSFTFKDALAIAYRNNPELQAEIDKAQAMRGYFVQSGLYPNPQLTLTAENFGGSGSYS
SYESAETTASVTQPIPLGNRLSYLKKASYADYLASLAQIQVQKAAIYMAVGGAYVDALYAGQWHQVTKKLISLNESIVKA
IERRVKAGAGAELDLRLAQIRLGESHIQEKKAARDALSQRAKLARLLGIGLRVDQPLVDKGLPDVTLNWSVLLKTLPQSP
QLIQMQQQLKAKRATITAVKKSVWPDLNIQLGARHFSDDGSNAAVMSAYAQVPVFDRNQGKIMTAEAQFTQTAHEYQGTK
LDIRQTAYTVFLQAQQSHYEAELVTSTLLPLARKSIKLAQDGYQMGRYTYIELSTALNALYEEERHYQQAHADYHKTLIQ
LTGLLGLHPTKESK
>Mature_414_residues
MRIYFYLVIAWMNLMTHEAMASSSFTFKDALAIAYRNNPELQAEIDKAQAMRGYFVQSGLYPNPQLTLTAENFGGSGSYS
SYESAETTASVTQPIPLGNRLSYLKKASYADYLASLAQIQVQKAAIYMAVGGAYVDALYAGQWHQVTKKLISLNESIVKA
IERRVKAGAGAELDLRLAQIRLGESHIQEKKAARDALSQRAKLARLLGIGLRVDQPLVDKGLPDVTLNWSVLLKTLPQSP
QLIQMQQQLKAKRATITAVKKSVWPDLNIQLGARHFSDDGSNAAVMSAYAQVPVFDRNQGKIMTAEAQFTQTAHEYQGTK
LDIRQTAYTVFLQAQQSHYEAELVTSTLLPLARKSIKLAQDGYQMGRYTYIELSTALNALYEEERHYQQAHADYHKTLIQ
LTGLLGLHPTKESK

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 46114; Mature: 46114

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIYFYLVIAWMNLMTHEAMASSSFTFKDALAIAYRNNPELQAEIDKAQAMRGYFVQSGL
CEEEEHHHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCC
YPNPQLTLTAENFGGSGSYSSYESAETTASVTQPIPLGNRLSYLKKASYADYLASLAQIQ
CCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VQKAAIYMAVGGAYVDALYAGQWHQVTKKLISLNESIVKAIERRVKAGAGAELDLRLAQI
HHHHEEEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHH
RLGESHIQEKKAARDALSQRAKLARLLGIGLRVDQPLVDKGLPDVTLNWSVLLKTLPQSP
HHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCEEHHHHHHHHCCCCC
QLIQMQQQLKAKRATITAVKKSVWPDLNIQLGARHFSDDGSNAAVMSAYAQVPVFDRNQG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEECCCCCCCHHHHHHHHHCCEEECCCC
KIMTAEAQFTQTAHEYQGTKLDIRQTAYTVFLQAQQSHYEAELVTSTLLPLARKSIKLAQ
CEEEEHHHHHHHHHHHCCCEEEHHHHEEHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGYQMGRYTYIELSTALNALYEEERHYQQAHADYHKTLIQLTGLLGLHPTKESK
CCHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRIYFYLVIAWMNLMTHEAMASSSFTFKDALAIAYRNNPELQAEIDKAQAMRGYFVQSGL
CEEEEHHHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCC
YPNPQLTLTAENFGGSGSYSSYESAETTASVTQPIPLGNRLSYLKKASYADYLASLAQIQ
CCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VQKAAIYMAVGGAYVDALYAGQWHQVTKKLISLNESIVKAIERRVKAGAGAELDLRLAQI
HHHHEEEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHH
RLGESHIQEKKAARDALSQRAKLARLLGIGLRVDQPLVDKGLPDVTLNWSVLLKTLPQSP
HHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCEEHHHHHHHHCCCCC
QLIQMQQQLKAKRATITAVKKSVWPDLNIQLGARHFSDDGSNAAVMSAYAQVPVFDRNQG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEECCCCCCCHHHHHHHHHCCEEECCCC
KIMTAEAQFTQTAHEYQGTKLDIRQTAYTVFLQAQQSHYEAELVTSTLLPLARKSIKLAQ
CEEEEHHHHHHHHHHHCCCEEEHHHHEEHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGYQMGRYTYIELSTALNALYEEERHYQQAHADYHKTLIQLTGLLGLHPTKESK
CCHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]