Click here to switch to the map view.

The map label for this gene is dapA

Identifier: 148359852

GI number: 148359852

Start: 2729919

End: 2730791

Strand: Reverse

Name: dapA

Synonym: LPC_1780

Alternate gene names: 148359852

Gene position: 2730791-2729919 (Counterclockwise)

Preceding gene: 148359854

Following gene: 148359851

Centisome position: 76.35

GC content: 42.61

Gene sequence:

>873_bases
ATGTTCAGTGGAAGTATAGTAGCCTTGGTAACCCCCATGCGAAATGATAGTGTCGATGTTCATCATTTGCGAGAACTGGT
TGAGTTTCACATAGCCAAGGGAACTCATGCCTTGGTTGCGGCTGGCACAACTGGTGAGGCTGGTACTTTATCACATAGCG
AAAAACTTCTGGTCATCAAAACAGTCATCGAACAAGCAAAAGAAAGAGTGCCTGTGATTGCAGGTACTGCTATGAATGCG
ACCAAGGATTGTATTGAGCTAACCCAGCAAGCTATGGAATATGGGGCGCATGCTGCTTTTATCATGACACCAGCCTATAT
CAAGCCTACTCAAGAAGGATTGTATTTGCACTATAGTCATATTGCCCAATCCGTAGCGATTCCGATTATTTTATATAACG
TTCCGGGAAGAACAGCCTGTGATATGTTACCCGAAACGGTAGCAAGACTGGCTAAAATTTCGAATATAATAGGAATAAAG
GAAGCAACCGGACAGATGACTCGTTTACAGCAGATTTTGCGGTTATGCGAAGGGAGCATTGATGTTTACAGTGGCGATGA
TTTGACAGCTGCCCAATGGTTGTTGTCCGGGGCTAAAGGTGTTATTTCAGTCACGGCTAATGTGGCTGCTAAATTGATGG
CAAAAATGTGTGATTTGGCAATGGATGATGATCAAGCAGGATGTTTGCGTATTCAAGAGCAATTAATGCCTTTACATGAA
CTTTTGTTCGTGGAGTCGAATCCAATTCCAGTGAAATGGGCCATGAAGAAAATGGGATTGATTGGTGGAGAATTAAGATT
ACCGATGACGGAGTTGTCTGAGAAACATCATCAGGCTTTGGAAAAGGTGTTGAAGAATTTAGAGTTGATATAA

Upstream 100 bases:

>100_bases
TGATAGAGATTCCGGTTGACTAAAGTGTTATATAAAAATTTACTCGGATGTCTGTTTTCCAGTAATATACGATTATGGAC
CATTAATTTTTGAGGGCAAC

Downstream 100 bases:

>100_bases
CTGAGGGTTTTGTTGTGAAAAAATTGAGTTTTATAGTTTTGGCAGCATTGGCATTAACAGCATGTAATTCTCGTTATGCC
AGTAATGGAGAAAATTTATA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MFSGSIVALVTPMRNDSVDVHHLRELVEFHIAKGTHALVAAGTTGEAGTLSHSEKLLVIKTVIEQAKERVPVIAGTAMNA
TKDCIELTQQAMEYGAHAAFIMTPAYIKPTQEGLYLHYSHIAQSVAIPIILYNVPGRTACDMLPETVARLAKISNIIGIK
EATGQMTRLQQILRLCEGSIDVYSGDDLTAAQWLLSGAKGVISVTANVAAKLMAKMCDLAMDDDQAGCLRIQEQLMPLHE
LLFVESNPIPVKWAMKKMGLIGGELRLPMTELSEKHHQALEKVLKNLELI

Sequences:

>Translated_290_residues
MFSGSIVALVTPMRNDSVDVHHLRELVEFHIAKGTHALVAAGTTGEAGTLSHSEKLLVIKTVIEQAKERVPVIAGTAMNA
TKDCIELTQQAMEYGAHAAFIMTPAYIKPTQEGLYLHYSHIAQSVAIPIILYNVPGRTACDMLPETVARLAKISNIIGIK
EATGQMTRLQQILRLCEGSIDVYSGDDLTAAQWLLSGAKGVISVTANVAAKLMAKMCDLAMDDDQAGCLRIQEQLMPLHE
LLFVESNPIPVKWAMKKMGLIGGELRLPMTELSEKHHQALEKVLKNLELI
>Mature_290_residues
MFSGSIVALVTPMRNDSVDVHHLRELVEFHIAKGTHALVAAGTTGEAGTLSHSEKLLVIKTVIEQAKERVPVIAGTAMNA
TKDCIELTQQAMEYGAHAAFIMTPAYIKPTQEGLYLHYSHIAQSVAIPIILYNVPGRTACDMLPETVARLAKISNIIGIK
EATGQMTRLQQILRLCEGSIDVYSGDDLTAAQWLLSGAKGVISVTANVAAKLMAKMCDLAMDDDQAGCLRIQEQLMPLHE
LLFVESNPIPVKWAMKKMGLIGGELRLPMTELSEKHHQALEKVLKNLELI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=258, Percent_Identity=30.2325581395349, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI13540533, Length=299, Percent_Identity=24.0802675585284, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=50.3424657534247, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI87082415, Length=288, Percent_Identity=29.8611111111111, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786463, Length=246, Percent_Identity=28.8617886178862, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1789620, Length=207, Percent_Identity=31.4009661835749, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_LEGPC (A5IEB3)

Other databases:

- EMBL:   CP000675
- RefSeq:   YP_001251059.1
- ProteinModelPortal:   A5IEB3
- SMR:   A5IEB3
- STRING:   A5IEB3
- GeneID:   5181588
- GenomeReviews:   CP000675_GR
- KEGG:   lpc:LPC_1780
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   AQGNFVE
- ProtClustDB:   PRK03170
- BioCyc:   LPNE400673:LPC_1780-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31616; Mature: 31616

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 160-160

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSGSIVALVTPMRNDSVDVHHLRELVEFHIAKGTHALVAAGTTGEAGTLSHSEKLLVIK
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHH
TVIEQAKERVPVIAGTAMNATKDCIELTQQAMEYGAHAAFIMTPAYIKPTQEGLYLHYSH
HHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEECCCCCCCEEEHHH
IAQSVAIPIILYNVPGRTACDMLPETVARLAKISNIIGIKEATGQMTRLQQILRLCEGSI
HHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
DVYSGDDLTAAQWLLSGAKGVISVTANVAAKLMAKMCDLAMDDDQAGCLRIQEQLMPLHE
EEECCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LLFVESNPIPVKWAMKKMGLIGGELRLPMTELSEKHHQALEKVLKNLELI
HHEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFSGSIVALVTPMRNDSVDVHHLRELVEFHIAKGTHALVAAGTTGEAGTLSHSEKLLVIK
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHH
TVIEQAKERVPVIAGTAMNATKDCIELTQQAMEYGAHAAFIMTPAYIKPTQEGLYLHYSH
HHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEECCCCCCCEEEHHH
IAQSVAIPIILYNVPGRTACDMLPETVARLAKISNIIGIKEATGQMTRLQQILRLCEGSI
HHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
DVYSGDDLTAAQWLLSGAKGVISVTANVAAKLMAKMCDLAMDDDQAGCLRIQEQLMPLHE
EEECCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LLFVESNPIPVKWAMKKMGLIGGELRLPMTELSEKHHQALEKVLKNLELI
HHEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA