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The map label for this gene is mdh [H]

Identifier: 148359794

GI number: 148359794

Start: 2668182

End: 2669342

Strand: Reverse

Name: mdh [H]

Synonym: LPC_1719

Alternate gene names: 148359794

Gene position: 2669342-2668182 (Counterclockwise)

Preceding gene: 148359795

Following gene: 148359793

Centisome position: 74.64

GC content: 43.84

Gene sequence:

>1161_bases
ATGAAAAACCAATCATTAATTGTCAATTGGAATTACCCGACACGAATCCTGGTTGGGGCTGGGCGAATCAATGAACTAGC
GAAAGCATGTCGTGAGTTAGGCATGAATGCTCCTCTGTTAGTCACAGACCCGGGATTGGCTTCGTCGTTAATGGTGAGTA
AAGTCATACAACAGGCTCAGGCATCCGGTTTGCGAACGGGGTTATTTTGCCAAATTAAAACAAATCCTACCGGCGACAAT
GTGATGAATGGAGTCTGTGCTTTTAAAGCTGGCCAGCATGATGGCGTGATTGCTTTCGGAGGTGGCTCGGCTTTGGATGC
CGGCAAAGCCATCGCTTTAATGGTTGGCCAGGATCGACCTTTATGGGATTTCGAGGATGTGGGTGATAACTGGACTCGAG
TGAATGTTTCAGCCATGGCCCCAGTTCTTGCCATTCCAACAACAGCAGGAACTGGTTCAGAGGTCGGGCGAGCTTCTGTA
ATTACCGATGCTGAAAAGCAGGTTAAAAAAATTATTTTTCATCCTAAAATGTTGCCTGCCATGGTTATTCTGGATCCAGA
GTTAACAGTCGGGCTTCCCAAATTACTCACTGCAGCCACAGGTATGGATGCTCTTTCCCATTGTCTTGAAGCTTATTGTT
CCAATTATTATCATCCTATGGCAGAAGGTATTGCGTTAGAAGGAATAAGATTAATCAAGGAGAATTTAATTCAAGCTTAC
AAGGATGGTAGTGACCTGGAGGCAAGAACCCATATGCTAGTTGCTTCAGCAATGGGAGCTACTGCCTTTCAGCGTGGTCT
TGGAGCGATGCATGCCTTGGCTCATCCATTAGGTGCAATTTATGATATCCATCACGGGCGGCTTAATGCGGTTTTGATGC
CCTATGTTTTATTGGCTAATCGTAGTGAAATTGAAAACAAGATAGAGCGTCTGGCAAATTATTTGTCAATAGCAAATGGA
TTTGATGGTTTTTTGGATTGGATAGAGCAGATGAGATTAGAGTTAGGAATCGAAAATACACTAAGTCAGTTAGGTATTGA
TCATTCGCAGATAGACAGACTGGCAAAAATGGCCACTGAGGATGCGGCAGCAGCTTCCAATCCTGTTCTTTTTACATTCG
AGCAATACAAAGAACTATTGAGCAAAGCTATTGGTGAATAA

Upstream 100 bases:

>100_bases
AAAACTCAAAATAAAATTATAAAAAAGACCTAATCTTTCCTGCGGAAAGGTACTTGCTATCAGTTACAATGGTCTTTTTC
GAATCAAAGGAAGATCATAC

Downstream 100 bases:

>100_bases
TCGTTGTAAAGGAAAAGATGCAGAAACGGGTTGTTTGCCAGGTATAAATTAGATGGAAAGGACTTGTATATTGAAATTAA
GTCTAATCCAGACAATAAAA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKNQSLIVNWNYPTRILVGAGRINELAKACRELGMNAPLLVTDPGLASSLMVSKVIQQAQASGLRTGLFCQIKTNPTGDN
VMNGVCAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRPLWDFEDVGDNWTRVNVSAMAPVLAIPTTAGTGSEVGRASV
ITDAEKQVKKIIFHPKMLPAMVILDPELTVGLPKLLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKENLIQAY
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDIHHGRLNAVLMPYVLLANRSEIENKIERLANYLSIANG
FDGFLDWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATEDAAAASNPVLFTFEQYKELLSKAIGE

Sequences:

>Translated_386_residues
MKNQSLIVNWNYPTRILVGAGRINELAKACRELGMNAPLLVTDPGLASSLMVSKVIQQAQASGLRTGLFCQIKTNPTGDN
VMNGVCAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRPLWDFEDVGDNWTRVNVSAMAPVLAIPTTAGTGSEVGRASV
ITDAEKQVKKIIFHPKMLPAMVILDPELTVGLPKLLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKENLIQAY
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDIHHGRLNAVLMPYVLLANRSEIENKIERLANYLSIANG
FDGFLDWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATEDAAAASNPVLFTFEQYKELLSKAIGE
>Mature_386_residues
MKNQSLIVNWNYPTRILVGAGRINELAKACRELGMNAPLLVTDPGLASSLMVSKVIQQAQASGLRTGLFCQIKTNPTGDN
VMNGVCAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRPLWDFEDVGDNWTRVNVSAMAPVLAIPTTAGTGSEVGRASV
ITDAEKQVKKIIFHPKMLPAMVILDPELTVGLPKLLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKENLIQAY
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDIHHGRLNAVLMPYVLLANRSEIENKIERLANYLSIANG
FDGFLDWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATEDAAAASNPVLFTFEQYKELLSKAIGE

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=308, Percent_Identity=26.6233766233766, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI48994951, Length=371, Percent_Identity=32.8840970350404, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI87082107, Length=388, Percent_Identity=32.9896907216495, Blast_Score=187, Evalue=7e-49,
Organism=Escherichia coli, GI1789163, Length=375, Percent_Identity=31.2, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1787493, Length=383, Percent_Identity=28.9817232375979, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1789386, Length=369, Percent_Identity=26.2872628726287, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17537053, Length=284, Percent_Identity=27.8169014084507, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321181, Length=391, Percent_Identity=36.3171355498721, Blast_Score=224, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24657991, Length=384, Percent_Identity=23.4375, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 41570; Mature: 41570

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNQSLIVNWNYPTRILVGAGRINELAKACRELGMNAPLLVTDPGLASSLMVSKVIQQAQ
CCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHH
ASGLRTGLFCQIKTNPTGDNVMNGVCAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRP
HCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCCEEEECCCCCCCCCCEEEEEECCCCC
LWDFEDVGDNWTRVNVSAMAPVLAIPTTAGTGSEVGRASVITDAEKQVKKIIFHPKMLPA
CCCHHHCCCCCEEEEHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCE
MVILDPELTVGLPKLLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKENLIQAY
EEEECCCHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHH
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDIHHGRLNAVLMPYVLLAN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
RSEIENKIERLANYLSIANGFDGFLDWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHH
DAAAASNPVLFTFEQYKELLSKAIGE
HHHHCCCCEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNQSLIVNWNYPTRILVGAGRINELAKACRELGMNAPLLVTDPGLASSLMVSKVIQQAQ
CCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHH
ASGLRTGLFCQIKTNPTGDNVMNGVCAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRP
HCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCCEEEECCCCCCCCCCEEEEEECCCCC
LWDFEDVGDNWTRVNVSAMAPVLAIPTTAGTGSEVGRASVITDAEKQVKKIIFHPKMLPA
CCCHHHCCCCCEEEEHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCE
MVILDPELTVGLPKLLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKENLIQAY
EEEECCCHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHH
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDIHHGRLNAVLMPYVLLAN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
RSEIENKIERLANYLSIANGFDGFLDWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHH
DAAAASNPVLFTFEQYKELLSKAIGE
HHHHCCCCEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]