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The map label for this gene is dctA [H]

Identifier: 148359789

GI number: 148359789

Start: 2661658

End: 2662950

Strand: Reverse

Name: dctA [H]

Synonym: LPC_1714

Alternate gene names: 148359789

Gene position: 2662950-2661658 (Counterclockwise)

Preceding gene: 148359790

Following gene: 148359783

Centisome position: 74.46

GC content: 39.06

Gene sequence:

>1293_bases
ATGAATTTTCTTAAAAAATTATATGTACAAGTTCTTCTGGGTGTTTTCATTGGTATTTTGCTTGGATATTTTTTGCCTGA
TGTAGGGGTTCAATTAAAAGCTATAGCTGATGTTTTTATCAAAATCATTAAGATGCTAATTTCTCCTATTATATTTCTCA
CTCTGGTCTCTGGAATTGCAGCAATGAATGATATGAGGCAAGTTGGACGCTTGGCGGGTGGGGCATTACTTTTTTTTACG
TTCATCACAACCCTGGCTTTGCTGCTAGGTCTTCTGGCGACAGATTATTTTAAGCCTGGTGTTGGTTTGAATGTGAATCC
CAATTCTCTGGATGTCAAAGAAGCGAGTTCTTACCTTGAGGGTGCGCATAAGGTAACTAATGTGACTGATCTGCTAATTA
ATATTATCCCCAAAACGTTTATTAGCGCCTTTGTCGATGGTGAACTGCTGCAAGTTATTTTTATTTCAATATTGTTTGCG
ATCGGTCTGATTCTTACAGGCAATGCAGGAAAATCATTGGTTACTGGAATGCAAACCCTGTCTAATGTTTTTTTTAAAAT
CATTCATTTTGTAATGTATATGGCGCCTGTAGCTGCCTTTGCTGCCATGGCATTCAGTGTCGGGAAATTTGGAGTTGGCC
CTTTGTTTAATTTAATTGGATTATTGGCTTGTTATTATCTAACTTCCATTTTCTTTATCTTGATTATCTTGGGAAGTCTT
TTGCAATGGTACTGCAAAATTAATATTTGGCATTTGTTAAGGTATTTAAAGGATGAGCTTTTAATCGTGTGGAGCACCGC
TTCCTCCGAAACCGTACTGCCAAGTTTGATGCAGAAACTGGAGCGACTGGGGTGTGAGCAATCTGTAGTCGGTTTGATCC
TGCCATTAGGATATTCTTTTAATTTGGCAGGAACTGCAATCTATTTAACAATGGCTGCCATGTTTATTGCACAGGCTACT
AATACTGATCTAACAGTTTGGCAGGAGTTATCGCTTCTGGGAGTTATGATCATTAGTTCCAAGGGTGCCGCTGGGGTGTC
CGGAAGCGGATTTATTGTGCTGGCGAGTTCATTAGCAACGATAGGACACATTCCTGCTGCAGGCGTCGTTCTTGTTTTGG
GTATCGATAAATTCATGAATGAAGCCAGGTCAATTATTAATATGATGGCTAATGCAATCGCCACGATTATTATTTCCAGG
TGGCAACAATCTTTGGATTACCAGAAAACTCAATTTGAATTGCAAGAAAAAGGACCAGCAGAAACCAAAAATGTTTATGC
TAGTGGGATGTAA

Upstream 100 bases:

>100_bases
AACTATTCATGTAATAATGACTTGTCTAGGGAAAGAATTTTTAGTGCTTCATGCTTTGCTTTTGAATAGTTGTTTATAGT
AAACGACCTGGAGAATAAAA

Downstream 100 bases:

>100_bases
GATTTCTACGGGGCTTTTCATAAGCCCTGTTCTGTTGTGAAAGGAGTATTTAACCTGTCAAAAAAACAGGCTTGCAGTAA
AAGTCTTGATGTCCTTTTGT

Product: C4-dicarboxylate transport protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MNFLKKLYVQVLLGVFIGILLGYFLPDVGVQLKAIADVFIKIIKMLISPIIFLTLVSGIAAMNDMRQVGRLAGGALLFFT
FITTLALLLGLLATDYFKPGVGLNVNPNSLDVKEASSYLEGAHKVTNVTDLLINIIPKTFISAFVDGELLQVIFISILFA
IGLILTGNAGKSLVTGMQTLSNVFFKIIHFVMYMAPVAAFAAMAFSVGKFGVGPLFNLIGLLACYYLTSIFFILIILGSL
LQWYCKINIWHLLRYLKDELLIVWSTASSETVLPSLMQKLERLGCEQSVVGLILPLGYSFNLAGTAIYLTMAAMFIAQAT
NTDLTVWQELSLLGVMIISSKGAAGVSGSGFIVLASSLATIGHIPAAGVVLVLGIDKFMNEARSIINMMANAIATIIISR
WQQSLDYQKTQFELQEKGPAETKNVYASGM

Sequences:

>Translated_430_residues
MNFLKKLYVQVLLGVFIGILLGYFLPDVGVQLKAIADVFIKIIKMLISPIIFLTLVSGIAAMNDMRQVGRLAGGALLFFT
FITTLALLLGLLATDYFKPGVGLNVNPNSLDVKEASSYLEGAHKVTNVTDLLINIIPKTFISAFVDGELLQVIFISILFA
IGLILTGNAGKSLVTGMQTLSNVFFKIIHFVMYMAPVAAFAAMAFSVGKFGVGPLFNLIGLLACYYLTSIFFILIILGSL
LQWYCKINIWHLLRYLKDELLIVWSTASSETVLPSLMQKLERLGCEQSVVGLILPLGYSFNLAGTAIYLTMAAMFIAQAT
NTDLTVWQELSLLGVMIISSKGAAGVSGSGFIVLASSLATIGHIPAAGVVLVLGIDKFMNEARSIINMMANAIATIIISR
WQQSLDYQKTQFELQEKGPAETKNVYASGM
>Mature_430_residues
MNFLKKLYVQVLLGVFIGILLGYFLPDVGVQLKAIADVFIKIIKMLISPIIFLTLVSGIAAMNDMRQVGRLAGGALLFFT
FITTLALLLGLLATDYFKPGVGLNVNPNSLDVKEASSYLEGAHKVTNVTDLLINIIPKTFISAFVDGELLQVIFISILFA
IGLILTGNAGKSLVTGMQTLSNVFFKIIHFVMYMAPVAAFAAMAFSVGKFGVGPLFNLIGLLACYYLTSIFFILIILGSL
LQWYCKINIWHLLRYLKDELLIVWSTASSETVLPSLMQKLERLGCEQSVVGLILPLGYSFNLAGTAIYLTMAAMFIAQAT
NTDLTVWQELSLLGVMIISSKGAAGVSGSGFIVLASSLATIGHIPAAGVVLVLGIDKFMNEARSIINMMANAIATIIISR
WQQSLDYQKTQFELQEKGPAETKNVYASGM

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=419, Percent_Identity=25.0596658711217, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4827012, Length=462, Percent_Identity=22.5108225108225, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI169790839, Length=449, Percent_Identity=22.9398663697105, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI66773030, Length=435, Percent_Identity=22.0689655172414, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI5032093, Length=395, Percent_Identity=24.3037974683544, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI194239697, Length=287, Percent_Identity=27.5261324041812, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI223468566, Length=281, Percent_Identity=24.5551601423488, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI223468564, Length=269, Percent_Identity=24.5353159851301, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI40254478, Length=484, Percent_Identity=21.4876033057851, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI301601644, Length=158, Percent_Identity=32.2784810126582, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI262359914, Length=374, Percent_Identity=23.5294117647059, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789947, Length=418, Percent_Identity=46.6507177033493, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI1790514, Length=411, Percent_Identity=36.7396593673966, Blast_Score=288, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17537407, Length=430, Percent_Identity=22.7906976744186, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71996953, Length=465, Percent_Identity=24.9462365591398, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71983106, Length=466, Percent_Identity=24.8927038626609, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71983099, Length=466, Percent_Identity=24.8927038626609, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI193206505, Length=466, Percent_Identity=23.3905579399142, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI193206654, Length=455, Percent_Identity=22.6373626373626, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24583025, Length=464, Percent_Identity=23.4913793103448, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137668, Length=464, Percent_Identity=23.4913793103448, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24583023, Length=464, Percent_Identity=23.4913793103448, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46643; Mature: 46643

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCC
>Mature Secondary Structure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HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA