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The map label for this gene is bcr [H]

Identifier: 148359777

GI number: 148359777

Start: 2641996

End: 2643219

Strand: Reverse

Name: bcr [H]

Synonym: LPC_1702

Alternate gene names: 148359777

Gene position: 2643219-2641996 (Counterclockwise)

Preceding gene: 148359780

Following gene: 148359776

Centisome position: 73.91

GC content: 39.38

Gene sequence:

>1224_bases
ATGCATCAGGAACATCCAGGCCAAACAGATACCCCAAAAATAGATCCGTGGTTAATATTTGTCATATTAATGTTGATGGC
TTTGATGCAAACTACAACCGATCAATACATTCCTTCTCTTCCAGCGATTACCACAGCATTGAACAGCACTGAAGCGTCTA
TTCAGTTAACCATTTCTATGTTTATGCTGGGTTTAAGCCTATCTCATATCTTTTATGGTCCCTTGTCAGATAAAATAGGA
CGAAAACCTCCGTTAATGTTCGGTGTTGGGCTAAGTGTATTGGGTAGTTTGGTTTGTTTTTTTGCGCCCAACGTCAGTGT
GTTAATCTTGGGTCGATTTCTTCAGGGGTTTGGAATCGGGTGTTGCAATTCAGTGGGGCGATCTTTGGTGAGAGATTTAT
TCACCGATCGTTTGCTGGCTAAAATTGGTTCTTATGTCGGTGTTGTCAGTATTTTTATTATGGCAGCCTCACCCACTTTA
GGAGGGTTTATTCAAGAGATGGCTGGGTGGAAAGCCAATTTTATGTTTTTATTTGTTTTTGGAATCCTTGTTTGGCTTTT
AGCATTTTGTATTCTTCCTGAAACGAATAAACACTTAAATCCTGAAGCTACAAAAATCAAAGTGATGGCGAAGAATTATT
TTACCTTATTACGTAGCAAGGTCTTTGTGGGATATACACTGTGTGCTTGCTTTGCTTTTGCGGGAATGGTTTCTTATCTT
ACGATTGCGCCATTTTTATTTCAAAATACCATGGGATTGAGCCCCTTGGAATTTGGACGTTTAACTTTTTTTATTGCGGG
CGCCATCTGTTTTAGCGGGATTGTCAACAGTCAGCTGGTCATGCGTAAAGGAATATCCTTTATGGTTTGTACTGGTGTTC
TTTTTATGATTGTCGGCGGTTTAAGCCTGTTATTAATTACGATGCTGGGTTGGTCACAAATCTATTTTATTATGATTTCA
ATGACATTATTTAGTGCTGGTGCCGGATTTACATTTATTAATGCCTTTGCAGGTGCGTTTCATCCTTTTCCGCAAATGGC
TGGAACGGCTGGGGCTTTATATGCCAGCATGCAGGATTTAAGTGCAGCGCTGACCAGCGGTTTTATTGCGGGAATTAAGG
GGTATGGTCAATATTCTTTAGCTATGATATTACTGATTTTAGGTTTAAGTTCTTTAGTGGCATGGTATTATCTTGGATTG
CAAGATGACGCTATTTCAAATTAA

Upstream 100 bases:

>100_bases
AGACGTTGAGGCCTATGCCTTATTTTCTAATACTTTTGTTTTGCTTGTAAATAATGATATTGTTATCAGCCATGTTAGAA
ATCATTCTAAAGGATATTTG

Downstream 100 bases:

>100_bases
GGGGTATTAATGAAAATTACCGATGAAGAATTGAAAAAAATTATCAGCAAATTATCTGGCTCTAAAGCCGATGACATTCA
AGATGATACGGCCCTAATAG

Product: multidrug resistance protein D

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MHQEHPGQTDTPKIDPWLIFVILMLMALMQTTTDQYIPSLPAITTALNSTEASIQLTISMFMLGLSLSHIFYGPLSDKIG
RKPPLMFGVGLSVLGSLVCFFAPNVSVLILGRFLQGFGIGCCNSVGRSLVRDLFTDRLLAKIGSYVGVVSIFIMAASPTL
GGFIQEMAGWKANFMFLFVFGILVWLLAFCILPETNKHLNPEATKIKVMAKNYFTLLRSKVFVGYTLCACFAFAGMVSYL
TIAPFLFQNTMGLSPLEFGRLTFFIAGAICFSGIVNSQLVMRKGISFMVCTGVLFMIVGGLSLLLITMLGWSQIYFIMIS
MTLFSAGAGFTFINAFAGAFHPFPQMAGTAGALYASMQDLSAALTSGFIAGIKGYGQYSLAMILLILGLSSLVAWYYLGL
QDDAISN

Sequences:

>Translated_407_residues
MHQEHPGQTDTPKIDPWLIFVILMLMALMQTTTDQYIPSLPAITTALNSTEASIQLTISMFMLGLSLSHIFYGPLSDKIG
RKPPLMFGVGLSVLGSLVCFFAPNVSVLILGRFLQGFGIGCCNSVGRSLVRDLFTDRLLAKIGSYVGVVSIFIMAASPTL
GGFIQEMAGWKANFMFLFVFGILVWLLAFCILPETNKHLNPEATKIKVMAKNYFTLLRSKVFVGYTLCACFAFAGMVSYL
TIAPFLFQNTMGLSPLEFGRLTFFIAGAICFSGIVNSQLVMRKGISFMVCTGVLFMIVGGLSLLLITMLGWSQIYFIMIS
MTLFSAGAGFTFINAFAGAFHPFPQMAGTAGALYASMQDLSAALTSGFIAGIKGYGQYSLAMILLILGLSSLVAWYYLGL
QDDAISN
>Mature_407_residues
MHQEHPGQTDTPKIDPWLIFVILMLMALMQTTTDQYIPSLPAITTALNSTEASIQLTISMFMLGLSLSHIFYGPLSDKIG
RKPPLMFGVGLSVLGSLVCFFAPNVSVLILGRFLQGFGIGCCNSVGRSLVRDLFTDRLLAKIGSYVGVVSIFIMAASPTL
GGFIQEMAGWKANFMFLFVFGILVWLLAFCILPETNKHLNPEATKIKVMAKNYFTLLRSKVFVGYTLCACFAFAGMVSYL
TIAPFLFQNTMGLSPLEFGRLTFFIAGAICFSGIVNSQLVMRKGISFMVCTGVLFMIVGGLSLLLITMLGWSQIYFIMIS
MTLFSAGAGFTFINAFAGAFHPFPQMAGTAGALYASMQDLSAALTSGFIAGIKGYGQYSLAMILLILGLSSLVAWYYLGL
QDDAISN

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=347, Percent_Identity=27.9538904899135, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790146, Length=354, Percent_Identity=27.4011299435028, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87082312, Length=357, Percent_Identity=28.0112044817927, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI48994889, Length=336, Percent_Identity=27.6785714285714, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787065, Length=260, Percent_Identity=21.9230769230769, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081983, Length=180, Percent_Identity=28.8888888888889, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790794, Length=310, Percent_Identity=21.6129032258065, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324264, Length=165, Percent_Identity=29.6969696969697, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44180; Mature: 44180

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQEHPGQTDTPKIDPWLIFVILMLMALMQTTTDQYIPSLPAITTALNSTEASIQLTISM
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHH
FMLGLSLSHIFYGPLSDKIGRKPPLMFGVGLSVLGSLVCFFAPNVSVLILGRFLQGFGIG
HHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCH
CCNSVGRSLVRDLFTDRLLAKIGSYVGVVSIFIMAASPTLGGFIQEMAGWKANFMFLFVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHH
GILVWLLAFCILPETNKHLNPEATKIKVMAKNYFTLLRSKVFVGYTLCACFAFAGMVSYL
HHHHHHHHHHHCCCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIAPFLFQNTMGLSPLEFGRLTFFIAGAICFSGIVNSQLVMRKGISFMVCTGVLFMIVGG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LSLLLITMLGWSQIYFIMISMTLFSAGAGFTFINAFAGAFHPFPQMAGTAGALYASMQDL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHH
SAALTSGFIAGIKGYGQYSLAMILLILGLSSLVAWYYLGLQDDAISN
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]