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The map label for this gene is hemE [H]

Identifier: 148359600

GI number: 148359600

Start: 2385452

End: 2386510

Strand: Reverse

Name: hemE [H]

Synonym: LPC_1512

Alternate gene names: 148359600

Gene position: 2386510-2385452 (Counterclockwise)

Preceding gene: 148359602

Following gene: 148359598

Centisome position: 66.73

GC content: 41.17

Gene sequence:

>1059_bases
ATGTTTGATTTGAACCAATCCCTTTTTCTACGAGCTTTGAGACGACAACCTGTGGAGAGAACTCCAATCTGGATTATGCG
CCAGGCTGGGCGTTATTTGCCTGAATATAGAAAAGTAAGAGAGCATGCTGGTGATTTTTTAAATCTTTGCAAGAATCCGG
AACTCGCCTGTGAAGTAACCTTGCAACCGTTGCGTCGCTATGCTTTGGATGCAGCTATTTTATTTTCCGATATTTTAACA
ATACCTGATGCTATGGGGCTAGGACTCTATTTTGCCGAAGGAGAAGGACCTTGTTTCACAAATCCTTTACAAGATACCAA
GGCAATTCATACCCTGAAAATTCCTTCCATTCCTGAATCTTTATCCTATGTCTTTGATGCTGCGCGCTTAATCCGCCAGG
AAATGCCTAAAGAATTACCTTTGATCGGATTTTCTGGTAGTCCATGGACTTTAGCTTGTTACATGGTTGAGGGCGGGAGC
AGTAGAGATTTTAAGCGAATTTTAAATTTAATATACACTGAAAAAGAAGCAGCGCACCTGTTATTGAATAAATTGGCTGT
CTCTGTGACTGCCTATTTAATTGAGCAAATAAAGGCGGGGGTTAATGCGGTTATGATCTTTGATACGTGGGGGGGAGTTT
TAACTCCACAAAATTATAAGGATTTTTCTTTGGCATATATGCATCAAATTGTTCAGCAATTGAAAAAAGAATACCCCGAT
ATCCCCGTAATTTTATTTACCAAGAATGGTGGGCAATGGTTAGAATGGATGGCAGAAACTGGTTGTGATGCATTAGGAGT
TGACTGGACGTGTGATTTGGCTTCCGCGCGCAAGAGAGTAGGCGGAAAGGTTGCTTTACAAGGAAATCTGGATCCTGCTG
TTTTACTAACTACAAAAAATTGCATACGAAGAGAGGTTGGGAGTGTACTGGCATCTTATGGTTATGGAACAGGGCATATC
TTTAATTTGGGCCATGGCATTACTCCGGATGTACCCCCTGAGAATGTTGCAATAATGATTGAGGCGGTGCATGAAATAAG
TCCTCAATATCATTTGTAG

Upstream 100 bases:

>100_bases
TCCTGTTTAAATTGTTAAGTATCGATTGCTATTTATACCACTGTATTGATTACCTTAACATGATACTATAAACACTTTTT
ATTGTGATAGTGATTAAATG

Downstream 100 bases:

>100_bases
CCTGTGCGAGGCAAATTATTGTTTCAAAATAGTGAAATGCCTCAAGAATAAGACAATCGTAACTGTACACGGGGTATGCA
AGTTTTTCTGTTTATAAGCC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MFDLNQSLFLRALRRQPVERTPIWIMRQAGRYLPEYRKVREHAGDFLNLCKNPELACEVTLQPLRRYALDAAILFSDILT
IPDAMGLGLYFAEGEGPCFTNPLQDTKAIHTLKIPSIPESLSYVFDAARLIRQEMPKELPLIGFSGSPWTLACYMVEGGS
SRDFKRILNLIYTEKEAAHLLLNKLAVSVTAYLIEQIKAGVNAVMIFDTWGGVLTPQNYKDFSLAYMHQIVQQLKKEYPD
IPVILFTKNGGQWLEWMAETGCDALGVDWTCDLASARKRVGGKVALQGNLDPAVLLTTKNCIRREVGSVLASYGYGTGHI
FNLGHGITPDVPPENVAIMIEAVHEISPQYHL

Sequences:

>Translated_352_residues
MFDLNQSLFLRALRRQPVERTPIWIMRQAGRYLPEYRKVREHAGDFLNLCKNPELACEVTLQPLRRYALDAAILFSDILT
IPDAMGLGLYFAEGEGPCFTNPLQDTKAIHTLKIPSIPESLSYVFDAARLIRQEMPKELPLIGFSGSPWTLACYMVEGGS
SRDFKRILNLIYTEKEAAHLLLNKLAVSVTAYLIEQIKAGVNAVMIFDTWGGVLTPQNYKDFSLAYMHQIVQQLKKEYPD
IPVILFTKNGGQWLEWMAETGCDALGVDWTCDLASARKRVGGKVALQGNLDPAVLLTTKNCIRREVGSVLASYGYGTGHI
FNLGHGITPDVPPENVAIMIEAVHEISPQYHL
>Mature_352_residues
MFDLNQSLFLRALRRQPVERTPIWIMRQAGRYLPEYRKVREHAGDFLNLCKNPELACEVTLQPLRRYALDAAILFSDILT
IPDAMGLGLYFAEGEGPCFTNPLQDTKAIHTLKIPSIPESLSYVFDAARLIRQEMPKELPLIGFSGSPWTLACYMVEGGS
SRDFKRILNLIYTEKEAAHLLLNKLAVSVTAYLIEQIKAGVNAVMIFDTWGGVLTPQNYKDFSLAYMHQIVQQLKKEYPD
IPVILFTKNGGQWLEWMAETGCDALGVDWTCDLASARKRVGGKVALQGNLDPAVLLTTKNCIRREVGSVLASYGYGTGHI
FNLGHGITPDVPPENVAIMIEAVHEISPQYHL

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=351, Percent_Identity=42.4501424501425, Blast_Score=290, Evalue=1e-78,
Organism=Escherichia coli, GI2367337, Length=353, Percent_Identity=63.4560906515581, Blast_Score=467, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6320252, Length=357, Percent_Identity=38.9355742296919, Blast_Score=262, Evalue=6e-71,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=40.0576368876081, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=40.0576368876081, Blast_Score=273, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39399; Mature: 39399

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDLNQSLFLRALRRQPVERTPIWIMRQAGRYLPEYRKVREHAGDFLNLCKNPELACEVT
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
LQPLRRYALDAAILFSDILTIPDAMGLGLYFAEGEGPCFTNPLQDTKAIHTLKIPSIPES
HHHHHHHHHHHHHHHHHHHHCCCHHCCCEEEECCCCCCCCCCCCHHHCEEEEECCCCCHH
LSYVFDAARLIRQEMPKELPLIGFSGSPWTLACYMVEGGSSRDFKRILNLIYTEKEAAHL
HHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLNKLAVSVTAYLIEQIKAGVNAVMIFDTWGGVLTPQNYKDFSLAYMHQIVQQLKKEYPD
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
IPVILFTKNGGQWLEWMAETGCDALGVDWTCDLASARKRVGGKVALQGNLDPAVLLTTKN
CCEEEEECCCCHHHHHHHHCCCCCCCCCCEECHHHHHHHCCCEEEEECCCCCEEEEECHH
CIRREVGSVLASYGYGTGHIFNLGHGITPDVPPENVAIMIEAVHEISPQYHL
HHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCEEHEEEHHHCCCCCCC
>Mature Secondary Structure
MFDLNQSLFLRALRRQPVERTPIWIMRQAGRYLPEYRKVREHAGDFLNLCKNPELACEVT
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
LQPLRRYALDAAILFSDILTIPDAMGLGLYFAEGEGPCFTNPLQDTKAIHTLKIPSIPES
HHHHHHHHHHHHHHHHHHHHCCCHHCCCEEEECCCCCCCCCCCCHHHCEEEEECCCCCHH
LSYVFDAARLIRQEMPKELPLIGFSGSPWTLACYMVEGGSSRDFKRILNLIYTEKEAAHL
HHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLNKLAVSVTAYLIEQIKAGVNAVMIFDTWGGVLTPQNYKDFSLAYMHQIVQQLKKEYPD
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
IPVILFTKNGGQWLEWMAETGCDALGVDWTCDLASARKRVGGKVALQGNLDPAVLLTTKN
CCEEEEECCCCHHHHHHHHCCCCCCCCCCEECHHHHHHHCCCEEEEECCCCCEEEEECHH
CIRREVGSVLASYGYGTGHIFNLGHGITPDVPPENVAIMIEAVHEISPQYHL
HHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCEEHEEEHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA