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The map label for this gene is hpt [C]

Identifier: 148359097

GI number: 148359097

Start: 1796219

End: 1796830

Strand: Direct

Name: hpt [C]

Synonym: LPC_0985

Alternate gene names: 148359097

Gene position: 1796219-1796830 (Clockwise)

Preceding gene: 148359096

Following gene: 148359100

Centisome position: 50.22

GC content: 34.64

Gene sequence:

>612_bases
ATGAAACAAGATTTTTCCGCAAAAATAATAACACTGCGAGAAGTTTATGACATCAGTTATAAACTGGCAAAAATTATTAC
CCAATCAGCTTATCAATTTGATGTAGTTGTCGCTATTGCAAGAGGAGGTTTTCCAGCAGCACGTTTTATCTGTGATTTTT
TGAATATCAGACAGTTAGGCTCAATGCAGATTAGTCATTATTCTGGTGGAGCCCAAAAATATGCCGACACTCAAGTGGTG
TCTCCTGCCAATATTAATATTTCTGGAAAAAGCGTATTGGTTGTTGATGATGTGAATGATACAGGTGAAACACTCAAATC
GGCTTCTGACTATATTCAATCACTAAATCCTGCTTTGTACAAAATAGCCGTACTTTATGAAAAATCATCGACGGTATTCA
AAGCTGATTTTGTAAGTAAGCACCAAAAAAAATGGAAATGGCTAATGTATCAGTGGGCGGTAACAAAGGATATCCTCACT
TTTCTTAAACAGGATAATATGCTAGAAAGCAATGAGGATGAGGTTTGCAAGCATTTACATAGAAAATATAATTTGAGTAT
AAGTAAGAAACTTTTGCAACAAATACGTAGCATGAAGGGAAACTATTATTAA

Upstream 100 bases:

>100_bases
AATTGGATAAGTAGATTTTTAATCAACTATATGTTTTTTATGTATTATATATACTAATAAAACTCTATAATGATATTAAT
CTATCAACCAGATTATTACG

Downstream 100 bases:

>100_bases
ATATATGTTTTTTTGATGGAAAGAAAAATACACACTATTTAACTTAATCTTAAACGATGTTTGACTTCTTTTTCATCAGA
TAAAATTTCAATAACATGGG

Product: hypothetical protein

Products: IMP; Diphosphate [C]

Alternate protein names: Purine Phosphoribosyltransferase; Xanthine-Guanine Phosphoribosyltransferase; Hypoxanthine/Guanine Phosphoribosyltransferase; Phosphoribosyl Transferase Domain Protein; Phosphoribosyl Transferase Domain-Containing Protein; Phosphoribosyl Transferase; Xanthine-Guanine Phosphoribosyltransferase Conjectural; Phosphoribosyltransferase-Like Protein; Purine Phosphoribosyltransferase Related Protein

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MKQDFSAKIITLREVYDISYKLAKIITQSAYQFDVVVAIARGGFPAARFICDFLNIRQLGSMQISHYSGGAQKYADTQVV
SPANINISGKSVLVVDDVNDTGETLKSASDYIQSLNPALYKIAVLYEKSSTVFKADFVSKHQKKWKWLMYQWAVTKDILT
FLKQDNMLESNEDEVCKHLHRKYNLSISKKLLQQIRSMKGNYY

Sequences:

>Translated_203_residues
MKQDFSAKIITLREVYDISYKLAKIITQSAYQFDVVVAIARGGFPAARFICDFLNIRQLGSMQISHYSGGAQKYADTQVV
SPANINISGKSVLVVDDVNDTGETLKSASDYIQSLNPALYKIAVLYEKSSTVFKADFVSKHQKKWKWLMYQWAVTKDILT
FLKQDNMLESNEDEVCKHLHRKYNLSISKKLLQQIRSMKGNYY
>Mature_203_residues
MKQDFSAKIITLREVYDISYKLAKIITQSAYQFDVVVAIARGGFPAARFICDFLNIRQLGSMQISHYSGGAQKYADTQVV
SPANINISGKSVLVVDDVNDTGETLKSASDYIQSLNPALYKIAVLYEKSSTVFKADFVSKHQKKWKWLMYQWAVTKDILT
FLKQDNMLESNEDEVCKHLHRKYNLSISKKLLQQIRSMKGNYY

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG2236

COG function: function code R; Predicted phosphoribosyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.4.2.8 [C]

Molecular weight: Translated: 23214; Mature: 23214

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQDFSAKIITLREVYDISYKLAKIITQSAYQFDVVVAIARGGFPAARFICDFLNIRQLG
CCCCCCHHEEEHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHC
SMQISHYSGGAQKYADTQVVSPANINISGKSVLVVDDVNDTGETLKSASDYIQSLNPALY
CEEEEECCCCCHHHCCCEEECCCCEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHE
KIAVLYEKSSTVFKADFVSKHQKKWKWLMYQWAVTKDILTFLKQDNMLESNEDEVCKHLH
EEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
RKYNLSISKKLLQQIRSMKGNYY
HHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKQDFSAKIITLREVYDISYKLAKIITQSAYQFDVVVAIARGGFPAARFICDFLNIRQLG
CCCCCCHHEEEHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHC
SMQISHYSGGAQKYADTQVVSPANINISGKSVLVVDDVNDTGETLKSASDYIQSLNPALY
CEEEEECCCCCHHHCCCEEECCCCEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHE
KIAVLYEKSSTVFKADFVSKHQKKWKWLMYQWAVTKDILTFLKQDNMLESNEDEVCKHLH
EEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
RKYNLSISKKLLQQIRSMKGNYY
HHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Mg [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.0038 {hypoxanthine}} 0.0024 {guanine}} 0.36 {8-azahypoxanthine}} 0.0076 {6-thioguanine}} 0.0062 {6-mercaptopurine}} [C]

Substrates: Hypoxanthine; 5-Phospho-alpha-D-ribose 1-diphosphate [C]

Specific reaction: Hypoxanthine + 5-Phospho-alpha-D-ribose 1-diphosphate --> IMP + Diphosphate [C]

General reaction: Pentosyl group transfer [C]

Inhibitor: 6-Chloropurine; 6-Thioinosine; 9-beta-Arabin of uranosyl hypoxanthine; Azaguanine; Xanthine [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA