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The map label for this gene is merA1 [H]

Identifier: 148359096

GI number: 148359096

Start: 1793984

End: 1796128

Strand: Direct

Name: merA1 [H]

Synonym: LPC_0984

Alternate gene names: 148359096

Gene position: 1793984-1796128 (Clockwise)

Preceding gene: 148359095

Following gene: 148359097

Centisome position: 50.16

GC content: 39.58

Gene sequence:

>2145_bases
ATGATTAAAAAAATACATCGTTGGTTGCCTTTGCTTGTATTAATCGGGCTATTGGTGCTTTTCTTCAGCCTACACCTTGA
TAAATACTTAAGTTTTAATGCATTAAGAGAAAATCATGCTTTACTCATTGCGTGGACCCAAACTCATTATTTTATTGCGC
CACTGATTTTTATTGTTTTTTATACCACTGCTGTAGCCATCTCTATTCCAGGAGCAGTTCTTCTTACTTTAACTGGAGGA
TTTTTATTCGGAGTATTCTGGGGCGTGTTATTTGTAGTCATCAGTGCTACGCTTGGGGCCACCATACTGTTTTTTGCGGT
TCGCACTGCTTTGGGCGACTGGTTTGCCCAAAAGGCGTCTGGATGGATAGAGCGTATGCGTCAGGGATTTCAGCATAATG
CTTTTTCTTATTTAGTTACACTGCGATTAATTCCATTATTTCCCTTTTGGGCAGTTAATATTGTACCGGCTTTTTTAAAT
ATTCGAGCAAAAACATTCATTACAGCGACTTTTATTGGCATCATTCCGGGAACAACAGTATATGTAATGGTTGGAAATGG
TCTAAGCCAAATATTTGCAGCCAATCAGACGCCTAATCTTGGGATCATATTTGAACTGCAAATATTAGGTCCACTGCTCG
CGTTGGCTGTTCTGTCTCTAATGCCAGTTCTTTATCAATTCTTAACTCGCAAGCATCAGAATCATCATAGTTTCTCAGAT
ATTAGTCGAGTAATAAATTGTGATTTAGCCATTATAGGCGGTGGAGCTGGAGGTTTGAGTTTAGCTTCCGGTTGTTCACA
ATTAGGACTCAAAGTTGTTTTGGTTGAGTCAGGGAAAATGGGAGGAGACTGTTTAAATTACGGTTGCATCCCATCCAAAT
CCTTACTTGCTGCAGCCAAGACGTTTTATTATGCAAAACATGCAACACATTTTGGAGTACATACTGAAGCAATAAAAGTT
AATTTTCAACAAGTAATGCAACATGTGCATCAAATCATAGACAACATTTCTGAACACGATTCTGTCCAACGTTTTGAGTC
GCTAGGAGTACAGGTTATTAAACAAGTTGGGAAATTTTTAACTCCCGATACATTACAAGCTGGCGATAGTATTATTAAAG
CGAAGCGTTTCGTGATTGCGACAGGCTCATCACCATTTATCCCACCCATTCCCGGATTGGATACAGTCTCTTACTTCACC
AATGAAACGATTTTTGATTTAAAGGAACAACCTGAGCACTTGATTGTCATAGGTGGTGGCCCTATTGGTTGTGAACTTGC
TCAAGCGTTCGCCATGCTCGGTTCTAAAGTTACTCTGCTTGAAGGATTGAATCTTCTTCCCAAGGACGATCCTGATTGTG
TTGCTGTCCTACGCACACAGATGAAATCGATGAATATCCTCATTTATGAACAAATCGAGATTACCCAAATAAACTCTCAC
CCTGATGCGGGTATTTCCGTATGTTTTGAATTTCAAAACACACAATTTACAATTACAGCCAGTCATCTGCTCATTGCAAC
TGGACGTCGGGCGAATGTAACTCCTCTTGATTTGGAAAAAGCAGGGGTTAAATTCACCAGTAAAGGTGTCGAAGTAAATA
AATACTTACAAACCAGTAATAAAAAAATCTATGCTCTGGGTGATGTAACAGGGCTTTATCAGTTTACTCATATGGCGAGT
TATCATGCCGGTATAGTGCTTCGTAATATTGTTTTTAAACTACCGTCTAAAGTGGATTATAGAGCGATTCCATGGGTCAC
TTATACTGATCCCGAATTAGCTCATGTTGGACTAGGAGCCAGTGATGCCTTGAAGCATCCTGATTCCCAAATAATCGAGT
GGCCATTTGTCGATAATGATCGAGCACAAACTGAGCATACATTAAATGGAAAAATAAAAATCATCACGGACAACAAAGCA
AGGATCCTTGGAGTCACCATAGTTGGCCCACATGCCGGAGAACTCATTTTACCTTGGGTTATGGCGATTCGTGAGAAAAA
AAACCTCCGAAGTTTTACTGATGTAATCGTTCCTTACCCTACTCTGAGTGAAATCAGCAAACGCGTTGCCGGTAATTTTT
ATGCACCTAAATTATTTTCCAATAAAACACGAACATTAGTTCGCTGGTTGCAAAAAATTGGATAA

Upstream 100 bases:

>100_bases
ATTAAACCCTATCGATAATTAAGGTATGACCTCAAAGTAAATTCCTGTTAGGATCTTCATATAATTTATATCAGTTTATC
GGGTTAAAGGAATAACATGA

Downstream 100 bases:

>100_bases
GTAGATTTTTAATCAACTATATGTTTTTTATGTATTATATATACTAATAAAACTCTATAATGATATTAATCTATCAACCA
GATTATTACGATGAAACAAG

Product: mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 714; Mature: 714

Protein sequence:

>714_residues
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVFYTTAVAISIPGAVLLTLTGG
FLFGVFWGVLFVVISATLGATILFFAVRTALGDWFAQKASGWIERMRQGFQHNAFSYLVTLRLIPLFPFWAVNIVPAFLN
IRAKTFITATFIGIIPGTTVYVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFLTRKHQNHHSFSD
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAKTFYYAKHATHFGVHTEAIKV
NFQQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFLTPDTLQAGDSIIKAKRFVIATGSSPFIPPIPGLDTVSYFT
NETIFDLKEQPEHLIVIGGGPIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMNILIYEQIEITQINSH
PDAGISVCFEFQNTQFTITASHLLIATGRRANVTPLDLEKAGVKFTSKGVEVNKYLQTSNKKIYALGDVTGLYQFTHMAS
YHAGIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGLGASDALKHPDSQIIEWPFVDNDRAQTEHTLNGKIKIITDNKA
RILGVTIVGPHAGELILPWVMAIREKKNLRSFTDVIVPYPTLSEISKRVAGNFYAPKLFSNKTRTLVRWLQKIG

Sequences:

>Translated_714_residues
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVFYTTAVAISIPGAVLLTLTGG
FLFGVFWGVLFVVISATLGATILFFAVRTALGDWFAQKASGWIERMRQGFQHNAFSYLVTLRLIPLFPFWAVNIVPAFLN
IRAKTFITATFIGIIPGTTVYVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFLTRKHQNHHSFSD
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAKTFYYAKHATHFGVHTEAIKV
NFQQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFLTPDTLQAGDSIIKAKRFVIATGSSPFIPPIPGLDTVSYFT
NETIFDLKEQPEHLIVIGGGPIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMNILIYEQIEITQINSH
PDAGISVCFEFQNTQFTITASHLLIATGRRANVTPLDLEKAGVKFTSKGVEVNKYLQTSNKKIYALGDVTGLYQFTHMAS
YHAGIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGLGASDALKHPDSQIIEWPFVDNDRAQTEHTLNGKIKIITDNKA
RILGVTIVGPHAGELILPWVMAIREKKNLRSFTDVIVPYPTLSEISKRVAGNFYAPKLFSNKTRTLVRWLQKIG
>Mature_714_residues
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVFYTTAVAISIPGAVLLTLTGG
FLFGVFWGVLFVVISATLGATILFFAVRTALGDWFAQKASGWIERMRQGFQHNAFSYLVTLRLIPLFPFWAVNIVPAFLN
IRAKTFITATFIGIIPGTTVYVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFLTRKHQNHHSFSD
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAKTFYYAKHATHFGVHTEAIKV
NFQQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFLTPDTLQAGDSIIKAKRFVIATGSSPFIPPIPGLDTVSYFT
NETIFDLKEQPEHLIVIGGGPIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMNILIYEQIEITQINSH
PDAGISVCFEFQNTQFTITASHLLIATGRRANVTPLDLEKAGVKFTSKGVEVNKYLQTSNKKIYALGDVTGLYQFTHMAS
YHAGIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGLGASDALKHPDSQIIEWPFVDNDRAQTEHTLNGKIKIITDNKA
RILGVTIVGPHAGELILPWVMAIREKKNLRSFTDVIVPYPTLSEISKRVAGNFYAPKLFSNKTRTLVRWLQKIG

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=464, Percent_Identity=30.1724137931034, Blast_Score=178, Evalue=2e-44,
Organism=Homo sapiens, GI33519430, Length=449, Percent_Identity=24.7216035634744, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI33519428, Length=449, Percent_Identity=24.7216035634744, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI33519426, Length=449, Percent_Identity=24.7216035634744, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI148277065, Length=449, Percent_Identity=24.7216035634744, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=25.7019438444924, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI148277071, Length=449, Percent_Identity=24.7216035634744, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI22035672, Length=467, Percent_Identity=24.6252676659529, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI291045266, Length=447, Percent_Identity=23.7136465324385, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI66392190, Length=190, Percent_Identity=26.8421052631579, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI291045268, Length=440, Percent_Identity=22.5, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786307, Length=456, Percent_Identity=31.140350877193, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI87081717, Length=446, Percent_Identity=29.5964125560538, Blast_Score=159, Evalue=6e-40,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=27.1551724137931, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=28.7703016241299, Blast_Score=131, Evalue=2e-31,
Organism=Escherichia coli, GI1789065, Length=182, Percent_Identity=31.3186813186813, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32565766, Length=499, Percent_Identity=30.4609218436874, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17557007, Length=468, Percent_Identity=25.2136752136752, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71983419, Length=436, Percent_Identity=25, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71983429, Length=438, Percent_Identity=24.8858447488584, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71982272, Length=474, Percent_Identity=27.2151898734177, Blast_Score=96, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17532687, Length=238, Percent_Identity=22.6890756302521, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=500, Percent_Identity=31.4, Blast_Score=155, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=25.7510729613734, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6325240, Length=475, Percent_Identity=24.4210526315789, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21358499, Length=473, Percent_Identity=29.5983086680761, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=26.6949152542373, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=26.6949152542373, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24640551, Length=472, Percent_Identity=26.6949152542373, Blast_Score=130, Evalue=5e-30,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=23.4672304439746, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18859941, Length=186, Percent_Identity=23.1182795698925, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 78856; Mature: 78856

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHH
YTTAVAISIPGAVLLTLTGGFLFGVFWGVLFVVISATLGATILFFAVRTALGDWFAQKAS
HHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GWIERMRQGFQHNAFSYLVTLRLIPLFPFWAVNIVPAFLNIRAKTFITATFIGIIPGTTV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
YVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFLTRKHQNHHSFSD
EEEECCCHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAK
HHHHHCCCEEEEECCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
TFYYAKHATHFGVHTEAIKVNFQQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFL
HHHHHHHCCCCCCCHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPDTLQAGDSIIKAKRFVIATGSSPFIPPIPGLDTVSYFTNETIFDLKEQPEHLIVIGGG
CCCHHHCCHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHCCCCEEECCCCCCEEEEECCC
PIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMNILIYEQIEITQINSH
CCHHHHHHHHHHHCCCEEHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEEEEEECCC
PDAGISVCFEFQNTQFTITASHLLIATGRRANVTPLDLEKAGVKFTSKGVEVNKYLQTSN
CCCCEEEEEEECCCEEEEEEEEEEEEECCCCCCCCCCHHHCCCEEECCCCCHHHHHHCCC
KKIYALGDVTGLYQFTHMASYHAGIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGLGA
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEECCCCHHEECCCC
SDALKHPDSQIIEWPFVDNDRAQTEHTLNGKIKIITDNKARILGVTIVGPHAGELILPWV
HHHHCCCCCCEEECCCCCCCCCCCCEECCCEEEEEECCCCEEEEEEEECCCCCCHHHHHH
MAIREKKNLRSFTDVIVPYPTLSEISKRVAGNFYAPKLFSNKTRTLVRWLQKIG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MIKKIHRWLPLLVLIGLLVLFFSLHLDKYLSFNALRENHALLIAWTQTHYFIAPLIFIVF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHH
YTTAVAISIPGAVLLTLTGGFLFGVFWGVLFVVISATLGATILFFAVRTALGDWFAQKAS
HHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GWIERMRQGFQHNAFSYLVTLRLIPLFPFWAVNIVPAFLNIRAKTFITATFIGIIPGTTV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
YVMVGNGLSQIFAANQTPNLGIIFELQILGPLLALAVLSLMPVLYQFLTRKHQNHHSFSD
EEEECCCHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
ISRVINCDLAIIGGGAGGLSLASGCSQLGLKVVLVESGKMGGDCLNYGCIPSKSLLAAAK
HHHHHCCCEEEEECCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
TFYYAKHATHFGVHTEAIKVNFQQVMQHVHQIIDNISEHDSVQRFESLGVQVIKQVGKFL
HHHHHHHCCCCCCCHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPDTLQAGDSIIKAKRFVIATGSSPFIPPIPGLDTVSYFTNETIFDLKEQPEHLIVIGGG
CCCHHHCCHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHCCCCEEECCCCCCEEEEECCC
PIGCELAQAFAMLGSKVTLLEGLNLLPKDDPDCVAVLRTQMKSMNILIYEQIEITQINSH
CCHHHHHHHHHHHCCCEEHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEEEEEECCC
PDAGISVCFEFQNTQFTITASHLLIATGRRANVTPLDLEKAGVKFTSKGVEVNKYLQTSN
CCCCEEEEEEECCCEEEEEEEEEEEEECCCCCCCCCCHHHCCCEEECCCCCHHHHHHCCC
KKIYALGDVTGLYQFTHMASYHAGIVLRNIVFKLPSKVDYRAIPWVTYTDPELAHVGLGA
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEECCCCHHEECCCC
SDALKHPDSQIIEWPFVDNDRAQTEHTLNGKIKIITDNKARILGVTIVGPHAGELILPWV
HHHHCCCCCCEEECCCCCCCCCCCCEECCCEEEEEECCCCEEEEEEEECCCCCCHHHHHH
MAIREKKNLRSFTDVIVPYPTLSEISKRVAGNFYAPKLFSNKTRTLVRWLQKIG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]