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The map label for this gene is hisS [H]

Identifier: 148359078

GI number: 148359078

Start: 1775174

End: 1776451

Strand: Reverse

Name: hisS [H]

Synonym: LPC_0965

Alternate gene names: 148359078

Gene position: 1776451-1775174 (Counterclockwise)

Preceding gene: 148359079

Following gene: 148359077

Centisome position: 49.67

GC content: 38.42

Gene sequence:

>1278_bases
GTGGTTGATAAAATTCAAGCTATCCGAGGAATGAATGATGTACTGCCTGATAGTACCTCGGTATGGCGCTTTATAGAACA
GACTTTTATAAATTGCCTCGTACGATATGGTTACAAGGAAATTCGTTTTCCAATTGTTGAGAATACACAGCTATTTAAAC
GTACAATTGGTGAAATAACAGATATTGTTGAAAAAGAAATGTACACTTTCAACGATTTGAATGGTGATAGCATAACCCTC
AGGCCAGAAGGAACAGCCGGCTGTGTTCGTGCCTGTATAGAACATGGTTTATTGCATAATCAACAACAAAAATTATGGTA
CTTAGGACCTATGTTTCGTCATGAACGTCCTCAGAAGGGTAGATACCGCCAATTTAACCAATTTGGGGTTGAGGCGCTAG
GAATTACCGGTACTGCCATTGAGCTTGAGTTGATATCAATTTGCCGTAGATTATGGGCTGATCTGGGCTTTTCTCAGTCA
GTTCAATTACAAGTTAATTCACTAGGTGAAATAAATGAGCGTCAGAAATATCGCTCTATCCTGGTAGAGTATCTACGCGA
TCATTTTCATATACTTGATGAAGACAGTAAGAGGCGATTGGATAAAAACCCTTTGAGAGTTCTTGATAGTAAAAACCCTG
ATCTTCAACAGCTCATTCAAAATGCCCCTAAGTTAATTGATGTTCTTGGTGATGATAGCAAAGAACACTTTCAATCGTTC
TGCAACGGATTGGAAACACTTGGTATTCCTTATTCCATCAACCCTGTATTGGTAAGAGGATTAGATTATTATGGCCAAAC
GGTGTTTGAATGGGTAACAGACCAATTAGGAAGTCAAGCTACAATATGTGCAGGAGGTAGATATGATATGCTGGTAGAGT
TCCTTGGCGGAGCACCCACACCTGCAGTTGGGTTTGCTTTAGGGTTGGAAAGAATATTTCTTTTAATGGAAACTTTAAAC
TTGTTGAATGAAAGTAACAACAAGCAATCAATATTTATCATTGCTACTAATGAAGAGGCCATATTGAAAGCGCTTGTCAT
GGCAGAGTCAATTCGAAATGCTCATCCATCTCTTGATGTCATTACCAATACGGCAGGCGGTGGTTTTAAAAGCCAATTTA
AAAAGGCCGATAAAAGTGGGGCTCGCTTGGCTTTGATTCTTGGGGAAGACGAAATAGCCAGGGAATATGTAAGCATTAAA
GATTTAAGAACTGAAATAGAACAAATATCAATACCGATGACCAAAATAAATGAATTTTTGCAAGATTATCTAGCTTAA

Upstream 100 bases:

>100_bases
ATCAGTGAAACCAGTTCGGAAATTAAATTGACTGATTTATCAAAAATGGAATCGTTATTAACGCCCAATAATGCACAAAT
GACGCCTTTGGAGAAAAATG

Downstream 100 bases:

>100_bases
GGGCAGGAGAATATTATATGTCTGTTTACATGACGGAAGAAGAACAATTAGAGATTATAAAAAAATGGTGGAAGCGATAT
GGCAATATGATAACTATTTT

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MVDKIQAIRGMNDVLPDSTSVWRFIEQTFINCLVRYGYKEIRFPIVENTQLFKRTIGEITDIVEKEMYTFNDLNGDSITL
RPEGTAGCVRACIEHGLLHNQQQKLWYLGPMFRHERPQKGRYRQFNQFGVEALGITGTAIELELISICRRLWADLGFSQS
VQLQVNSLGEINERQKYRSILVEYLRDHFHILDEDSKRRLDKNPLRVLDSKNPDLQQLIQNAPKLIDVLGDDSKEHFQSF
CNGLETLGIPYSINPVLVRGLDYYGQTVFEWVTDQLGSQATICAGGRYDMLVEFLGGAPTPAVGFALGLERIFLLMETLN
LLNESNNKQSIFIIATNEEAILKALVMAESIRNAHPSLDVITNTAGGGFKSQFKKADKSGARLALILGEDEIAREYVSIK
DLRTEIEQISIPMTKINEFLQDYLA

Sequences:

>Translated_425_residues
MVDKIQAIRGMNDVLPDSTSVWRFIEQTFINCLVRYGYKEIRFPIVENTQLFKRTIGEITDIVEKEMYTFNDLNGDSITL
RPEGTAGCVRACIEHGLLHNQQQKLWYLGPMFRHERPQKGRYRQFNQFGVEALGITGTAIELELISICRRLWADLGFSQS
VQLQVNSLGEINERQKYRSILVEYLRDHFHILDEDSKRRLDKNPLRVLDSKNPDLQQLIQNAPKLIDVLGDDSKEHFQSF
CNGLETLGIPYSINPVLVRGLDYYGQTVFEWVTDQLGSQATICAGGRYDMLVEFLGGAPTPAVGFALGLERIFLLMETLN
LLNESNNKQSIFIIATNEEAILKALVMAESIRNAHPSLDVITNTAGGGFKSQFKKADKSGARLALILGEDEIAREYVSIK
DLRTEIEQISIPMTKINEFLQDYLA
>Mature_425_residues
MVDKIQAIRGMNDVLPDSTSVWRFIEQTFINCLVRYGYKEIRFPIVENTQLFKRTIGEITDIVEKEMYTFNDLNGDSITL
RPEGTAGCVRACIEHGLLHNQQQKLWYLGPMFRHERPQKGRYRQFNQFGVEALGITGTAIELELISICRRLWADLGFSQS
VQLQVNSLGEINERQKYRSILVEYLRDHFHILDEDSKRRLDKNPLRVLDSKNPDLQQLIQNAPKLIDVLGDDSKEHFQSF
CNGLETLGIPYSINPVLVRGLDYYGQTVFEWVTDQLGSQATICAGGRYDMLVEFLGGAPTPAVGFALGLERIFLLMETLN
LLNESNNKQSIFIIATNEEAILKALVMAESIRNAHPSLDVITNTAGGGFKSQFKKADKSGARLALILGEDEIAREYVSIK
DLRTEIEQISIPMTKINEFLQDYLA

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788861, Length=425, Percent_Identity=56, Blast_Score=501, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI71993686, Length=466, Percent_Identity=22.9613733905579, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71993693, Length=466, Percent_Identity=22.9613733905579, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 48275; Mature: 48275

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDKIQAIRGMNDVLPDSTSVWRFIEQTFINCLVRYGYKEIRFPIVENTQLFKRTIGEIT
CCCHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHHHH
DIVEKEMYTFNDLNGDSITLRPEGTAGCVRACIEHGLLHNQQQKLWYLGPMFRHERPQKG
HHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCHHHEEECCHHHCCCCCCC
RYRQFNQFGVEALGITGTAIELELISICRRLWADLGFSQSVQLQVNSLGEINERQKYRSI
HHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHH
LVEYLRDHFHILDEDSKRRLDKNPLRVLDSKNPDLQQLIQNAPKLIDVLGDDSKEHFQSF
HHHHHHHHHHCCCCCHHHCCCCCCHHHHCCCCCCHHHHHHCCHHHHHHHCCCCHHHHHHH
CNGLETLGIPYSINPVLVRGLDYYGQTVFEWVTDQLGSQATICAGGRYDMLVEFLGGAPT
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCC
PAVGFALGLERIFLLMETLNLLNESNNKQSIFIIATNEEAILKALVMAESIRNAHPSLDV
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCEE
ITNTAGGGFKSQFKKADKSGARLALILGEDEIAREYVSIKDLRTEIEQISIPMTKINEFL
EECCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QDYLA
HHHCC
>Mature Secondary Structure
MVDKIQAIRGMNDVLPDSTSVWRFIEQTFINCLVRYGYKEIRFPIVENTQLFKRTIGEIT
CCCHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHHHH
DIVEKEMYTFNDLNGDSITLRPEGTAGCVRACIEHGLLHNQQQKLWYLGPMFRHERPQKG
HHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCHHHEEECCHHHCCCCCCC
RYRQFNQFGVEALGITGTAIELELISICRRLWADLGFSQSVQLQVNSLGEINERQKYRSI
HHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHH
LVEYLRDHFHILDEDSKRRLDKNPLRVLDSKNPDLQQLIQNAPKLIDVLGDDSKEHFQSF
HHHHHHHHHHCCCCCHHHCCCCCCHHHHCCCCCCHHHHHHCCHHHHHHHCCCCHHHHHHH
CNGLETLGIPYSINPVLVRGLDYYGQTVFEWVTDQLGSQATICAGGRYDMLVEFLGGAPT
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCC
PAVGFALGLERIFLLMETLNLLNESNNKQSIFIIATNEEAILKALVMAESIRNAHPSLDV
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCEE
ITNTAGGGFKSQFKKADKSGARLALILGEDEIAREYVSIKDLRTEIEQISIPMTKINEFL
EECCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QDYLA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA