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The map label for this gene is licA [H]

Identifier: 148358939

GI number: 148358939

Start: 1619476

End: 1620618

Strand: Direct

Name: licA [H]

Synonym: LPC_0824

Alternate gene names: 148358939

Gene position: 1619476-1620618 (Clockwise)

Preceding gene: 148358937

Following gene: 148358941

Centisome position: 45.28

GC content: 37.1

Gene sequence:

>1143_bases
ATGAAATTATATTTTTTTGGTGATGATAATAATAAACCCAAATTAAGCGAACATTTAATCATTTACATACTCAGTTTGCT
AGATCCCAAGTCTCAGTCTGTTGCTTCTTTAGTGAATAAAGACTGGTCTCGGCTGGTTCAATTAACACGGCAATACCTGT
CTATGTTACCGGTGATTCATCGAATACCTTTATTTGCGAATTTGGGTCTTGACGTTTTGAAATTAAAATTAATGACAGGT
GGTATGACGAATTCCACATTTAGGCTAAGAATCAAAAATGCGCCTGAGAAATGGGTTATGCGGATTCCTGGAATAGGCTC
TTCAGCATTTATAACCAGAAGAGATGAAGCTCACAATGCTAAACAAGCCGAAAAACTTGGACTGAATGTTCCAATAGCTT
TCTTTGATCCAGAAGATGGGCTGCAGGTAACGCGCTTTATAGAAGGAGTGCATTCTCTGGATGATAAAGCCTTGGCCCGG
AAGGAAATTCTGCATGAGGTAGCGTCTATGATGAGAAGACTTCATAAATCTCCTCCCTTTGATAATAACACGCTTTTTTT
TGAGCGAAATGAAGAGTTATTGGATTTATTAAAACGAAAATCCTTTAATTTCCCAGGGGAAATAGAATTTATTGAGCAAC
AAATGAAAAATCTAAAGGAGATTTTTTCTTCTTATAATATTCAGCAATTTCCTTGCCACAATGATACAACGCCACTTAAT
TTTATCTTGTCAGAAAATCCAGAAATCAAGGGTTCTGAAAAGATTCATCAGATTGATTGGGAATATTCAAGTAATAATGA
TTTTATTTGGGATTTGGTTTATTTTATGGTTGAGGCCAAGCTAAACCGCGAACAACAGCTTATTCTGTTGAAAGCTTACT
TTAATACAGAAGAGCTGAGTGGCTCTCTGTTGGCATGGATAGAGGTTTATAAACCCATCATTGAGTGGTGGATAACCATT
TGGTCATGGACACAATTGGCAAATGGAGCTAATGCAGTTGATTTGAGTTCTTATGAGCAACTAGGGTTTGAACGGTATCA
TAACACCTTAAGTCACTTGAAAAGTGAGGACTATGTCAAAGCCCTGGCACTGATTGAAGCAGATAGTCATAGCATTATTT
TTACGGGGCAGAGACCTTTTTAG

Upstream 100 bases:

>100_bases
ATTCAGTATTCCCTGGAAAGTAATGATGAATTGTATGTTATTTTATTATCAGTTTTTATATAATGCATTCAGTTTTATCA
TTAATTAATAAATGACGTTT

Downstream 100 bases:

>100_bases
CTGCCGCCATTATCTAGAGAGGACAACTCGTTTACAGTGACGATTAAGATCTTCAGAGCATTTTTTTGAGAAATTCCTGT
AAATGCATCTTGTCTTTCTC

Product: choline kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKLYFFGDDNNKPKLSEHLIIYILSLLDPKSQSVASLVNKDWSRLVQLTRQYLSMLPVIHRIPLFANLGLDVLKLKLMTG
GMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEAHNAKQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHSLDDKALAR
KEILHEVASMMRRLHKSPPFDNNTLFFERNEELLDLLKRKSFNFPGEIEFIEQQMKNLKEIFSSYNIQQFPCHNDTTPLN
FILSENPEIKGSEKIHQIDWEYSSNNDFIWDLVYFMVEAKLNREQQLILLKAYFNTEELSGSLLAWIEVYKPIIEWWITI
WSWTQLANGANAVDLSSYEQLGFERYHNTLSHLKSEDYVKALALIEADSHSIIFTGQRPF

Sequences:

>Translated_380_residues
MKLYFFGDDNNKPKLSEHLIIYILSLLDPKSQSVASLVNKDWSRLVQLTRQYLSMLPVIHRIPLFANLGLDVLKLKLMTG
GMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEAHNAKQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHSLDDKALAR
KEILHEVASMMRRLHKSPPFDNNTLFFERNEELLDLLKRKSFNFPGEIEFIEQQMKNLKEIFSSYNIQQFPCHNDTTPLN
FILSENPEIKGSEKIHQIDWEYSSNNDFIWDLVYFMVEAKLNREQQLILLKAYFNTEELSGSLLAWIEVYKPIIEWWITI
WSWTQLANGANAVDLSSYEQLGFERYHNTLSHLKSEDYVKALALIEADSHSIIFTGQRPF
>Mature_380_residues
MKLYFFGDDNNKPKLSEHLIIYILSLLDPKSQSVASLVNKDWSRLVQLTRQYLSMLPVIHRIPLFANLGLDVLKLKLMTG
GMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEAHNAKQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHSLDDKALAR
KEILHEVASMMRRLHKSPPFDNNTLFFERNEELLDLLKRKSFNFPGEIEFIEQQMKNLKEIFSSYNIQQFPCHNDTTPLN
FILSENPEIKGSEKIHQIDWEYSSNNDFIWDLVYFMVEAKLNREQQLILLKAYFNTEELSGSLLAWIEVYKPIIEWWITI
WSWTQLANGANAVDLSSYEQLGFERYHNTLSHLKSEDYVKALALIEADSHSIIFTGQRPF

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 44203; Mature: 44203

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYFFGDDNNKPKLSEHLIIYILSLLDPKSQSVASLVNKDWSRLVQLTRQYLSMLPVIH
CEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIPLFANLGLDVLKLKLMTGGMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEAHNA
HCCHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHEEECCCCCCCCEEEECCHHCCH
KQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHSLDDKALARKEILHEVASMMRRLHKSPPF
HHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
DNNTLFFERNEELLDLLKRKSFNFPGEIEFIEQQMKNLKEIFSSYNIQQFPCHNDTTPLN
CCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEE
FILSENPEIKGSEKIHQIDWEYSSNNDFIWDLVYFMVEAKLNREQQLILLKAYFNTEELS
EEECCCCCCCCCCCEEEEECEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHC
GSLLAWIEVYKPIIEWWITIWSWTQLANGANAVDLSSYEQLGFERYHNTLSHLKSEDYVK
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
ALALIEADSHSIIFTGQRPF
HHHHEECCCCEEEEECCCCC
>Mature Secondary Structure
MKLYFFGDDNNKPKLSEHLIIYILSLLDPKSQSVASLVNKDWSRLVQLTRQYLSMLPVIH
CEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIPLFANLGLDVLKLKLMTGGMTNSTFRLRIKNAPEKWVMRIPGIGSSAFITRRDEAHNA
HCCHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHEEECCCCCCCCEEEECCHHCCH
KQAEKLGLNVPIAFFDPEDGLQVTRFIEGVHSLDDKALARKEILHEVASMMRRLHKSPPF
HHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
DNNTLFFERNEELLDLLKRKSFNFPGEIEFIEQQMKNLKEIFSSYNIQQFPCHNDTTPLN
CCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEE
FILSENPEIKGSEKIHQIDWEYSSNNDFIWDLVYFMVEAKLNREQQLILLKAYFNTEELS
EEECCCCCCCCCCCEEEEECEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHC
GSLLAWIEVYKPIIEWWITIWSWTQLANGANAVDLSSYEQLGFERYHNTLSHLKSEDYVK
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
ALALIEADSHSIIFTGQRPF
HHHHEECCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]