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The map label for this gene is holA [H]

Identifier: 148358878

GI number: 148358878

Start: 1552237

End: 1553262

Strand: Reverse

Name: holA [H]

Synonym: LPC_0762

Alternate gene names: 148358878

Gene position: 1553262-1552237 (Counterclockwise)

Preceding gene: 148358879

Following gene: 148358877

Centisome position: 43.43

GC content: 32.07

Gene sequence:

>1026_bases
ATGCAAATAAATCAACAAGCTCTTACTCAGCTTTTACAAAAAAAAATACATCATCTTAATATACTAATTGGACAAGATCA
TTATCTTATTGACGAAGCACTCAATAACATAAAATCAATGCTTAAAAAATCGTCTGAATGTGATGAGAAAATCCTCTCTA
TTCAGTCCCCTGAAGAATGGCATGTCGTTCTGGAAGAAACAAATAATTACTCTCTTTTTTATCAAACAGTTATTTTAACC
ATTTTCTTTGATAAAAAAACGATAGATACAACGGGAAAAAAAATTCTTAGTGAATATCTCAAATCAGCCAACTCTCATAG
TTATATTATTATCAGAGCCCCTAACCTTACCGCCAAGCAACTTCAATGGTTAACACATGATGAACAAGCGCTGATTATCA
TTGCGCAACCATTAAGCTCAGAAGCAATGAAGAGATGGATTAATGAGCAATTAAAATTAAATACTATCTCTTTTGATCCA
TATGTTCCTGAATTAATTTATCAATATACTAAAGGAAATATGCTAGCTACCGCTCAGGTAATTGAAAAAATTACTTTGAG
CAATACACCCGGCACTCTCATTACTCCTTACCTGGCCTTGGAACATTTATCGGATCAATGTGATTTTTCCCTTTTTGAAC
TGATTGATTCATGCCTACTTGGTCATAGCGACAGAGCAATTCATATTTTAAGACAAGCTGCCAATAATAAAACAGAAGTC
ACATTGGTATTATGGATACTTACCCAAGAAATAAGAACGCTATTACAATTATTATTTCTAATGCAACAAAAGATGGATAT
TAAAATGGCATCTAATCAATTAAAAATTTGGACTCAAAGAGTTAATCTTTATCAATCAGCTGTTAAAAGATTAAATACTT
TACTTTTACAACAACTTCATCACTATTGCCAATCTATTGATGATAAAATCAAATCCAACTCAAACAATCAAGCATGGAAT
GCTCTAGAGAACATTTCTCTTTCCTTATGTTTAGGGCAATTACTAGGTGATGCATGCATAGCATAG

Upstream 100 bases:

>100_bases
GACAGGATATTAGGGTCAAATGAAGAACAAGCTCTTTTAGTCAGCGAAATGAGGCGTGATGCCGCTATTCAAATCATTAA
TCGTTTAAACCGACCATAAT

Downstream 100 bases:

>100_bases
CAATATTTGGTGGAACATTTGACCCAGTGCATAATGGCCATATCAAGACCAGCTTGGCAATTCAAGCTAATTTTGGCTTT
GATTCCTATTATTTTTTACC

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MQINQQALTQLLQKKIHHLNILIGQDHYLIDEALNNIKSMLKKSSECDEKILSIQSPEEWHVVLEETNNYSLFYQTVILT
IFFDKKTIDTTGKKILSEYLKSANSHSYIIIRAPNLTAKQLQWLTHDEQALIIIAQPLSSEAMKRWINEQLKLNTISFDP
YVPELIYQYTKGNMLATAQVIEKITLSNTPGTLITPYLALEHLSDQCDFSLFELIDSCLLGHSDRAIHILRQAANNKTEV
TLVLWILTQEIRTLLQLLFLMQQKMDIKMASNQLKIWTQRVNLYQSAVKRLNTLLLQQLHHYCQSIDDKIKSNSNNQAWN
ALENISLSLCLGQLLGDACIA

Sequences:

>Translated_341_residues
MQINQQALTQLLQKKIHHLNILIGQDHYLIDEALNNIKSMLKKSSECDEKILSIQSPEEWHVVLEETNNYSLFYQTVILT
IFFDKKTIDTTGKKILSEYLKSANSHSYIIIRAPNLTAKQLQWLTHDEQALIIIAQPLSSEAMKRWINEQLKLNTISFDP
YVPELIYQYTKGNMLATAQVIEKITLSNTPGTLITPYLALEHLSDQCDFSLFELIDSCLLGHSDRAIHILRQAANNKTEV
TLVLWILTQEIRTLLQLLFLMQQKMDIKMASNQLKIWTQRVNLYQSAVKRLNTLLLQQLHHYCQSIDDKIKSNSNNQAWN
ALENISLSLCLGQLLGDACIA
>Mature_341_residues
MQINQQALTQLLQKKIHHLNILIGQDHYLIDEALNNIKSMLKKSSECDEKILSIQSPEEWHVVLEETNNYSLFYQTVILT
IFFDKKTIDTTGKKILSEYLKSANSHSYIIIRAPNLTAKQLQWLTHDEQALIIIAQPLSSEAMKRWINEQLKLNTISFDP
YVPELIYQYTKGNMLATAQVIEKITLSNTPGTLITPYLALEHLSDQCDFSLFELIDSCLLGHSDRAIHILRQAANNKTEV
TLVLWILTQEIRTLLQLLFLMQQKMDIKMASNQLKIWTQRVNLYQSAVKRLNTLLLQQLHHYCQSIDDKIKSNSNNQAWN
ALENISLSLCLGQLLGDACIA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=284, Percent_Identity=23.5915492957746, Blast_Score=78, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39190; Mature: 39190

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQINQQALTQLLQKKIHHLNILIGQDHYLIDEALNNIKSMLKKSSECDEKILSIQSPEEW
CCCCHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCE
HVVLEETNNYSLFYQTVILTIFFDKKTIDTTGKKILSEYLKSANSHSYIIIRAPNLTAKQ
EEEEEECCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
LQWLTHDEQALIIIAQPLSSEAMKRWINEQLKLNTISFDPYVPELIYQYTKGNMLATAQV
HHHHCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCEEHHHHH
IEKITLSNTPGTLITPYLALEHLSDQCDFSLFELIDSCLLGHSDRAIHILRQAANNKTEV
HHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEE
TLVLWILTQEIRTLLQLLFLMQQKMDIKMASNQLKIWTQRVNLYQSAVKRLNTLLLQQLH
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HYCQSIDDKIKSNSNNQAWNALENISLSLCLGQLLGDACIA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQINQQALTQLLQKKIHHLNILIGQDHYLIDEALNNIKSMLKKSSECDEKILSIQSPEEW
CCCCHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCE
HVVLEETNNYSLFYQTVILTIFFDKKTIDTTGKKILSEYLKSANSHSYIIIRAPNLTAKQ
EEEEEECCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
LQWLTHDEQALIIIAQPLSSEAMKRWINEQLKLNTISFDPYVPELIYQYTKGNMLATAQV
HHHHCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCEEHHHHH
IEKITLSNTPGTLITPYLALEHLSDQCDFSLFELIDSCLLGHSDRAIHILRQAANNKTEV
HHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEE
TLVLWILTQEIRTLLQLLFLMQQKMDIKMASNQLKIWTQRVNLYQSAVKRLNTLLLQQLH
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HYCQSIDDKIKSNSNNQAWNALENISLSLCLGQLLGDACIA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]