Click here to switch to the map view.

The map label for this gene is htrA [H]

Identifier: 148358863

GI number: 148358863

Start: 1536813

End: 1538189

Strand: Reverse

Name: htrA [H]

Synonym: LPC_0747

Alternate gene names: 148358863

Gene position: 1538189-1536813 (Counterclockwise)

Preceding gene: 148358864

Following gene: 148358862

Centisome position: 43.01

GC content: 39.22

Gene sequence:

>1377_bases
ATGATTACACGTATAAAATTATTCATAGCAAGTCTGCTAGTATTTTTCATCCCGGTAGCCGATGCAGCACAAGATCTTAC
AAACATGCCCAGCCTGGCTCCTGTTCTGAAAAATGCTATGCCGGCTATTGTTAACGTGGCTGTTCAAGGCTACTTGCCTA
ATAATATGGCATCCGGAAATGCAGACGATGATGACGGGGAAAACAGTAAACAGCCTTCCAGAATACCTGAAAAAGGCAGA
AAATTTGAAAGTATAGGGTCCGGAGTTATCATTGACCCTAAAAATGGCATTATTATAACGAATGACCATGTTATTCGTAA
CGCCAATTTAATTACTATAACTCTTCAAGATGGCAGGAGATTAAAAGCTCGCCTGATTGGAGGTGATAGTGAAACGGACT
TGGCTGTTTTAAAAATTGATGCTAAAAATTTGAAATCCCTGGTAATTGGTGATTCCGATAAGCTGGAAGTCGGAGATTAT
GTTGTTGCTATTGGAAACCCCTTTGGATTAAACAGCTTTGGAAATAGTCAATCTGCTACGTTTGGAATAGTGAGTGCCTT
AAAACGCAGCGATTTAAATATTGAAGGTGTTGAAAACTTTATTCAAACTGACGCAGCTATCAATCCTGGTAATTCAGGAG
GTGCTTTGGTCAATGCAAAAGGCGAATTAATTGGCATTAATACAGCCATTATTTCACCCTATGGAGGAAATGTAGGTATT
GGTTTTGCGATCCCAATTAATATGGTAAAAGATGTAGCGCAGCAAATCATTAAATTTGGCTCTATTCATCGTGGTTTAAT
GGGTATATTTGTTCAACATTTAACACCAGAGCTTGCCCAATCAATGGGATATGCCGAGGATTTTCAAGGAGCTTTAGTAT
CACAGGTCAATGAAAATTCACCTGCTCAATTGGCTGGTCTAAAATCAGGCGATGTCATTGTACAAATTAATGATACCAAG
ATAACTCAGGCAACACAGGTAAAAACAACTATTAGCCTGTTGCGAGCCGGCTCTACTGCTAAAATTAAAATCTTGCGGGA
TAATAAGCCGCTTACATTAGATGTAGAAGTCACAGATATCAAAAAACATGAACAAAAATTACAATCCAATAATCCATTTC
TCTACGGATTAGCCTTACGTAATTTTGAACAAGAATCACCGCCTCATGGTAATGTTGTTGGAGTTCAGGTTGTAGGTGCT
TCGGAAACCAGTGCGGGCTGGCGAGCTGGCTTAAGACCAGGAGATATAATCATTTCTGCTAATAAAACACCGGTTAAAGA
CATTAAATCTTTACAAGCTGTTGCACACGAGAAAAAGAAACAGCTATTAGTCCAGGTGCTGAGAGGAGCAGGAGCACTCT
ACCTGTTGATTATTTAA

Upstream 100 bases:

>100_bases
TTTGAGTTAAAAAATGAATTCTATTCCTATCGCAGAGAATCACAAACAGGTAGAATAGGTACTTTCATCTGGATTAATGA
GTAAAATCAGGATTAATAAT

Downstream 100 bases:

>100_bases
ATTTTTTATCCAAATAATGAAGTAAAGCATCCTCTTTATTTAAGCCCATCTCTGAGAGATGGGCTTAAATTTTGATAAAT
TATCCTGCTTTTGGTAATGC

Product: periplasmic serine protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MITRIKLFIASLLVFFIPVADAAQDLTNMPSLAPVLKNAMPAIVNVAVQGYLPNNMASGNADDDDGENSKQPSRIPEKGR
KFESIGSGVIIDPKNGIIITNDHVIRNANLITITLQDGRRLKARLIGGDSETDLAVLKIDAKNLKSLVIGDSDKLEVGDY
VVAIGNPFGLNSFGNSQSATFGIVSALKRSDLNIEGVENFIQTDAAINPGNSGGALVNAKGELIGINTAIISPYGGNVGI
GFAIPINMVKDVAQQIIKFGSIHRGLMGIFVQHLTPELAQSMGYAEDFQGALVSQVNENSPAQLAGLKSGDVIVQINDTK
ITQATQVKTTISLLRAGSTAKIKILRDNKPLTLDVEVTDIKKHEQKLQSNNPFLYGLALRNFEQESPPHGNVVGVQVVGA
SETSAGWRAGLRPGDIIISANKTPVKDIKSLQAVAHEKKKQLLVQVLRGAGALYLLII

Sequences:

>Translated_458_residues
MITRIKLFIASLLVFFIPVADAAQDLTNMPSLAPVLKNAMPAIVNVAVQGYLPNNMASGNADDDDGENSKQPSRIPEKGR
KFESIGSGVIIDPKNGIIITNDHVIRNANLITITLQDGRRLKARLIGGDSETDLAVLKIDAKNLKSLVIGDSDKLEVGDY
VVAIGNPFGLNSFGNSQSATFGIVSALKRSDLNIEGVENFIQTDAAINPGNSGGALVNAKGELIGINTAIISPYGGNVGI
GFAIPINMVKDVAQQIIKFGSIHRGLMGIFVQHLTPELAQSMGYAEDFQGALVSQVNENSPAQLAGLKSGDVIVQINDTK
ITQATQVKTTISLLRAGSTAKIKILRDNKPLTLDVEVTDIKKHEQKLQSNNPFLYGLALRNFEQESPPHGNVVGVQVVGA
SETSAGWRAGLRPGDIIISANKTPVKDIKSLQAVAHEKKKQLLVQVLRGAGALYLLII
>Mature_458_residues
MITRIKLFIASLLVFFIPVADAAQDLTNMPSLAPVLKNAMPAIVNVAVQGYLPNNMASGNADDDDGENSKQPSRIPEKGR
KFESIGSGVIIDPKNGIIITNDHVIRNANLITITLQDGRRLKARLIGGDSETDLAVLKIDAKNLKSLVIGDSDKLEVGDY
VVAIGNPFGLNSFGNSQSATFGIVSALKRSDLNIEGVENFIQTDAAINPGNSGGALVNAKGELIGINTAIISPYGGNVGI
GFAIPINMVKDVAQQIIKFGSIHRGLMGIFVQHLTPELAQSMGYAEDFQGALVSQVNENSPAQLAGLKSGDVIVQINDTK
ITQATQVKTTISLLRAGSTAKIKILRDNKPLTLDVEVTDIKKHEQKLQSNNPFLYGLALRNFEQESPPHGNVVGVQVVGA
SETSAGWRAGLRPGDIIISANKTPVKDIKSLQAVAHEKKKQLLVQVLRGAGALYLLII

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=256, Percent_Identity=37.5, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4506141, Length=285, Percent_Identity=34.3859649122807, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI22129776, Length=276, Percent_Identity=34.4202898550725, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI7019477, Length=304, Percent_Identity=34.8684210526316, Blast_Score=123, Evalue=4e-28,
Organism=Escherichia coli, GI1786356, Length=451, Percent_Identity=41.019955654102, Blast_Score=308, Evalue=5e-85,
Organism=Escherichia coli, GI1789629, Length=448, Percent_Identity=40.625, Blast_Score=305, Evalue=5e-84,
Organism=Escherichia coli, GI1789630, Length=283, Percent_Identity=42.0494699646643, Blast_Score=191, Evalue=9e-50,
Organism=Drosophila melanogaster, GI24646839, Length=296, Percent_Identity=35.8108108108108, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 48770; Mature: 48770

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITRIKLFIASLLVFFIPVADAAQDLTNMPSLAPVLKNAMPAIVNVAVQGYLPNNMASGN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCC
ADDDDGENSKQPSRIPEKGRKFESIGSGVIIDPKNGIIITNDHVIRNANLITITLQDGRR
CCCCCCCCCCCCCCCCHHCCHHHHCCCCEEECCCCCEEEECCEEEECCCEEEEEECCCCE
LKARLIGGDSETDLAVLKIDAKNLKSLVIGDSDKLEVGDYVVAIGNPFGLNSFGNSQSAT
EEEEEECCCCCCCEEEEEECHHCCCEEEECCCCCEEECCEEEEECCCCCCCCCCCCCCHH
FGIVSALKRSDLNIEGVENFIQTDAAINPGNSGGALVNAKGELIGINTAIISPYGGNVGI
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEECCCCCCEEE
GFAIPINMVKDVAQQIIKFGSIHRGLMGIFVQHLTPELAQSMGYAEDFQGALVSQVNENS
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHCCHHHHHCCCCC
PAQLAGLKSGDVIVQINDTKITQATQVKTTISLLRAGSTAKIKILRDNKPLTLDVEVTDI
CCEEECCCCCCEEEEECCCEECCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEHHH
KKHEQKLQSNNPFLYGLALRNFEQESPPHGNVVGVQVVGASETSAGWRAGLRPGDIIISA
HHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEC
NKTPVKDIKSLQAVAHEKKKQLLVQVLRGAGALYLLII
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
>Mature Secondary Structure
MITRIKLFIASLLVFFIPVADAAQDLTNMPSLAPVLKNAMPAIVNVAVQGYLPNNMASGN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCC
ADDDDGENSKQPSRIPEKGRKFESIGSGVIIDPKNGIIITNDHVIRNANLITITLQDGRR
CCCCCCCCCCCCCCCCHHCCHHHHCCCCEEECCCCCEEEECCEEEECCCEEEEEECCCCE
LKARLIGGDSETDLAVLKIDAKNLKSLVIGDSDKLEVGDYVVAIGNPFGLNSFGNSQSAT
EEEEEECCCCCCCEEEEEECHHCCCEEEECCCCCEEECCEEEEECCCCCCCCCCCCCCHH
FGIVSALKRSDLNIEGVENFIQTDAAINPGNSGGALVNAKGELIGINTAIISPYGGNVGI
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEECCCCCCEEE
GFAIPINMVKDVAQQIIKFGSIHRGLMGIFVQHLTPELAQSMGYAEDFQGALVSQVNENS
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHCCHHHHHCCCCC
PAQLAGLKSGDVIVQINDTKITQATQVKTTISLLRAGSTAKIKILRDNKPLTLDVEVTDI
CCEEECCCCCCEEEEECCCEECCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEHHH
KKHEQKLQSNNPFLYGLALRNFEQESPPHGNVVGVQVVGASETSAGWRAGLRPGDIIISA
HHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEC
NKTPVKDIKSLQAVAHEKKKQLLVQVLRGAGALYLLII
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]