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The map label for this gene is glnS [H]

Identifier: 148358848

GI number: 148358848

Start: 1513925

End: 1515580

Strand: Direct

Name: glnS [H]

Synonym: LPC_0731

Alternate gene names: 148358848

Gene position: 1513925-1515580 (Clockwise)

Preceding gene: 148358847

Following gene: 148358849

Centisome position: 42.33

GC content: 39.07

Gene sequence:

>1656_bases
ATGACAGAACAAACTGAAAAAAGAGCTCATTTTATTAGACAACTCATTATAGATGATTTGGCAAATGGAAAACATCAGGG
AATCGTTACTCGTTTTCCTCCTGAACCAAATGGATATCTCCATGTTGGACATGCCAAATCTATTTGTCTTAATTTTGGTT
TGGCAGAAGAGTTTAAGGGAAAATGCTTTTTACGTTTTGATGACACCAATCCAATTAAAGAAGAAGAAGAATATGTAAAC
GCGATCATTGATGATGTTCGTTGGTTGGGATTTGAATGGTGTGCCATGACGCATTCCTCCGATTACTATCATGAGCTGTA
TGAATTAGCCATTTATCTTATTAAGAAAGATATGGCTTATGTCGATAGCCTGAGTATGGAAGAAATTCGTGCCTTTCGCG
GTACTCTACAAGAACCAGGGCGCGAAAGCCCTTATAGAAACAGAACAATCGAAGAGAATCTGGATTTATTCGCTCGGATG
AAAGCTGGTGAGTTTCCTGATGGAACTCATGTTTTGAGAGCAAAAATAGATATGAAATCAGGTAATTTAAATATGCGTGA
TCCGGTTTTATATCGTATACGTCATGCCCGACATCAGCGTACAGGAGATGAATGGTGTATTTATCCCATGTATGATTATG
CTCATCCTATTTCTGATGCCCTGGAAAAAATAACACATTCTTTATGTACGTTGGAATTCCAGGATCATAGACCTTTGTAT
GATTGGCTGGTTGATAATTTACCTTTGCCTGCCAAACCAGTACAAACCGAATTTGCCAGATTAAATTTATCCCATACTGT
TACGAGCAAGAGAAAATTACGTGAATTGGTTGAAAAAAAAATCGTTACAGGATGGGATGACCCACGATTGCCTACATTAC
GTGGTATGCGCAAAAGGGGATACCCACCTGCTGCAATTCGGCAATTCTGTGAAATAATTGGCATATCAAGAAGTGATTCA
GTGATTGATATGAGTTTACTTGAGGAATGTGTACGCGCTGAATTTAATAAAACTGCAAAACGGGCTCTCTGTGTTATGGA
TCCCTTAAAAGTTGTTATTGTAAATTATCCGGAAAATAAAGTAGAACAGCTTCAAGCAGCTTTCTACCCTCAAAATCCTG
AGTCAGAGAGTAGGAATTTACCCTTTTCCCGTGAAATTTATATTGAAAAGTCTGATTTTATGGAAAATCCGCCCAATAAA
TATTTCCGGTTATCTCCTGGAGCTGAAGTACGCTTACGTCATGCCTATGTTATAAAGTGTCAGCAAGTTATCCGTAATGA
CCAAGGCGAAATAACAGAATTGCATTGCACTTATGATGAAAATACTCTCGGTAAAAATCCGGAGGATCGCAAAGTGAAGG
GCGTCATTCATTGGGTGTCTTCATCACATGCCTATCCTGTCACTATTTATCAATATGATAGGTTATTTACAGATCCTAAT
CCTGCACGGGAAGAGGATTATTTTCAGTTTCTGAACCATAACTCTTTACAAACCCTCCAGGGATTTTGTGAACCGGCAAT
GGCTGAACAGGCAGAAGGAGATGTGTTTCAATTTGAGCGTTTAGGTTATTATTGCGTCAATTCAGTGGCTGAGGGCTGTG
TTCAAGCCTTTCATCGGGTAGTGGATTTGAAGGACACTTGGGGTAAAGTGAGTTGA

Upstream 100 bases:

>100_bases
AAATCATTGAAGCCTATGAGGCCAAGAAAGATCCGCTGCAAGCAAGCGGGGCTCTATTGAGTTCCATGAGGCAAGCTATC
GATAATATTGGAAGTATGGT

Downstream 100 bases:

>100_bases
GAGGCAGACATGTTACATTTATATAATTCTTTGACCAGAAAAAAAGAACCATTTGTTTCCTTAAGGCCCGGAAAGATAGG
TATGTATGTTTGCGGAATTA

Product: glutaminyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamine--tRNA ligase; GlnRS [H]

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MTEQTEKRAHFIRQLIIDDLANGKHQGIVTRFPPEPNGYLHVGHAKSICLNFGLAEEFKGKCFLRFDDTNPIKEEEEYVN
AIIDDVRWLGFEWCAMTHSSDYYHELYELAIYLIKKDMAYVDSLSMEEIRAFRGTLQEPGRESPYRNRTIEENLDLFARM
KAGEFPDGTHVLRAKIDMKSGNLNMRDPVLYRIRHARHQRTGDEWCIYPMYDYAHPISDALEKITHSLCTLEFQDHRPLY
DWLVDNLPLPAKPVQTEFARLNLSHTVTSKRKLRELVEKKIVTGWDDPRLPTLRGMRKRGYPPAAIRQFCEIIGISRSDS
VIDMSLLEECVRAEFNKTAKRALCVMDPLKVVIVNYPENKVEQLQAAFYPQNPESESRNLPFSREIYIEKSDFMENPPNK
YFRLSPGAEVRLRHAYVIKCQQVIRNDQGEITELHCTYDENTLGKNPEDRKVKGVIHWVSSSHAYPVTIYQYDRLFTDPN
PAREEDYFQFLNHNSLQTLQGFCEPAMAEQAEGDVFQFERLGYYCVNSVAEGCVQAFHRVVDLKDTWGKVS

Sequences:

>Translated_551_residues
MTEQTEKRAHFIRQLIIDDLANGKHQGIVTRFPPEPNGYLHVGHAKSICLNFGLAEEFKGKCFLRFDDTNPIKEEEEYVN
AIIDDVRWLGFEWCAMTHSSDYYHELYELAIYLIKKDMAYVDSLSMEEIRAFRGTLQEPGRESPYRNRTIEENLDLFARM
KAGEFPDGTHVLRAKIDMKSGNLNMRDPVLYRIRHARHQRTGDEWCIYPMYDYAHPISDALEKITHSLCTLEFQDHRPLY
DWLVDNLPLPAKPVQTEFARLNLSHTVTSKRKLRELVEKKIVTGWDDPRLPTLRGMRKRGYPPAAIRQFCEIIGISRSDS
VIDMSLLEECVRAEFNKTAKRALCVMDPLKVVIVNYPENKVEQLQAAFYPQNPESESRNLPFSREIYIEKSDFMENPPNK
YFRLSPGAEVRLRHAYVIKCQQVIRNDQGEITELHCTYDENTLGKNPEDRKVKGVIHWVSSSHAYPVTIYQYDRLFTDPN
PAREEDYFQFLNHNSLQTLQGFCEPAMAEQAEGDVFQFERLGYYCVNSVAEGCVQAFHRVVDLKDTWGKVS
>Mature_550_residues
TEQTEKRAHFIRQLIIDDLANGKHQGIVTRFPPEPNGYLHVGHAKSICLNFGLAEEFKGKCFLRFDDTNPIKEEEEYVNA
IIDDVRWLGFEWCAMTHSSDYYHELYELAIYLIKKDMAYVDSLSMEEIRAFRGTLQEPGRESPYRNRTIEENLDLFARMK
AGEFPDGTHVLRAKIDMKSGNLNMRDPVLYRIRHARHQRTGDEWCIYPMYDYAHPISDALEKITHSLCTLEFQDHRPLYD
WLVDNLPLPAKPVQTEFARLNLSHTVTSKRKLRELVEKKIVTGWDDPRLPTLRGMRKRGYPPAAIRQFCEIIGISRSDSV
IDMSLLEECVRAEFNKTAKRALCVMDPLKVVIVNYPENKVEQLQAAFYPQNPESESRNLPFSREIYIEKSDFMENPPNKY
FRLSPGAEVRLRHAYVIKCQQVIRNDQGEITELHCTYDENTLGKNPEDRKVKGVIHWVSSSHAYPVTIYQYDRLFTDPNP
AREEDYFQFLNHNSLQTLQGFCEPAMAEQAEGDVFQFERLGYYCVNSVAEGCVQAFHRVVDLKDTWGKVS

Specific function: Unknown

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI4826960, Length=531, Percent_Identity=42.9378531073446, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI62241042, Length=505, Percent_Identity=35.2475247524752, Blast_Score=298, Evalue=1e-80,
Organism=Escherichia coli, GI1786895, Length=556, Percent_Identity=56.1151079136691, Blast_Score=653, Evalue=0.0,
Organism=Escherichia coli, GI1788743, Length=122, Percent_Identity=31.1475409836066, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17543332, Length=529, Percent_Identity=42.1550094517958, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17511007, Length=514, Percent_Identity=34.4357976653696, Blast_Score=267, Evalue=9e-72,
Organism=Saccharomyces cerevisiae, GI6324742, Length=564, Percent_Identity=38.2978723404255, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6321192, Length=520, Percent_Identity=34.4230769230769, Blast_Score=294, Evalue=3e-80,
Organism=Drosophila melanogaster, GI17864488, Length=557, Percent_Identity=40.5745062836625, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24649466, Length=525, Percent_Identity=34.0952380952381, Blast_Score=282, Evalue=4e-76,

Paralogues:

None

Copy number: 520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR004514
- InterPro:   IPR022861
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR020059
- InterPro:   IPR020056
- InterPro:   IPR011035
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c; PF03950 tRNA-synt_1c_C [H]

EC number: =6.1.1.18 [H]

Molecular weight: Translated: 64158; Mature: 64026

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQTEKRAHFIRQLIIDDLANGKHQGIVTRFPPEPNGYLHVGHAKSICLNFGLAEEFKG
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEECCHHHHHHCCCCHHHCCC
KCFLRFDDTNPIKEEEEYVNAIIDDVRWLGFEWCAMTHSSDYYHELYELAIYLIKKDMAY
CEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHEEECCCCHHHHHHHHHHHHHHHHHHHH
VDSLSMEEIRAFRGTLQEPGRESPYRNRTIEENLDLFARMKAGEFPDGTHVLRAKIDMKS
HHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEECC
GNLNMRDPVLYRIRHARHQRTGDEWCIYPMYDYAHPISDALEKITHSLCTLEFQDHRPLY
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHCCHHHHHHHHHHHHHHEEEECCCCCHH
DWLVDNLPLPAKPVQTEFARLNLSHTVTSKRKLRELVEKKIVTGWDDPRLPTLRGMRKRG
HHHHCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCC
YPPAAIRQFCEIIGISRSDSVIDMSLLEECVRAEFNKTAKRALCVMDPLKVVIVNYPENK
CCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHH
VEQLQAAFYPQNPESESRNLPFSREIYIEKSDFMENPPNKYFRLSPGAEVRLRHAYVIKC
HHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHCCCCCCCEEEECCCCCEEEHHHHHHHH
QQVIRNDQGEITELHCTYDENTLGKNPEDRKVKGVIHWVSSSHAYPVTIYQYDRLFTDPN
HHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHEEEEECCCCCCEEEEEEECHHCCCCC
PAREEDYFQFLNHNSLQTLQGFCEPAMAEQAEGDVFQFERLGYYCVNSVAEGCVQAFHRV
CCCHHHHHHHHCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VDLKDTWGKVS
HCCHHCCCCCC
>Mature Secondary Structure 
TEQTEKRAHFIRQLIIDDLANGKHQGIVTRFPPEPNGYLHVGHAKSICLNFGLAEEFKG
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEECCHHHHHHCCCCHHHCCC
KCFLRFDDTNPIKEEEEYVNAIIDDVRWLGFEWCAMTHSSDYYHELYELAIYLIKKDMAY
CEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHEEECCCCHHHHHHHHHHHHHHHHHHHH
VDSLSMEEIRAFRGTLQEPGRESPYRNRTIEENLDLFARMKAGEFPDGTHVLRAKIDMKS
HHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEECC
GNLNMRDPVLYRIRHARHQRTGDEWCIYPMYDYAHPISDALEKITHSLCTLEFQDHRPLY
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHCCHHHHHHHHHHHHHHEEEECCCCCHH
DWLVDNLPLPAKPVQTEFARLNLSHTVTSKRKLRELVEKKIVTGWDDPRLPTLRGMRKRG
HHHHCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCC
YPPAAIRQFCEIIGISRSDSVIDMSLLEECVRAEFNKTAKRALCVMDPLKVVIVNYPENK
CCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHH
VEQLQAAFYPQNPESESRNLPFSREIYIEKSDFMENPPNKYFRLSPGAEVRLRHAYVIKC
HHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHCCCCCCCEEEECCCCCEEEHHHHHHHH
QQVIRNDQGEITELHCTYDENTLGKNPEDRKVKGVIHWVSSSHAYPVTIYQYDRLFTDPN
HHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHEEEEECCCCCCEEEEEEECHHCCCCC
PAREEDYFQFLNHNSLQTLQGFCEPAMAEQAEGDVFQFERLGYYCVNSVAEGCVQAFHRV
CCCHHHHHHHHCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VDLKDTWGKVS
HCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]