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The map label for this gene is pdc [H]

Identifier: 148358739

GI number: 148358739

Start: 1395395

End: 1397074

Strand: Direct

Name: pdc [H]

Synonym: LPC_0618

Alternate gene names: 148358739

Gene position: 1395395-1397074 (Clockwise)

Preceding gene: 148358738

Following gene: 148358741

Centisome position: 39.02

GC content: 40.06

Gene sequence:

>1680_bases
ATGTGCTCAATTGGAGAGTATTTGGCAAAGCGGCTGGAGGAATTAAATATTTCTGAATATTTTGCTATACCGGGTGATTA
CAATCTTATTTTACTCGATGAAGTCCTGAAAAACGAAAAATTAAAAATGATAAATTGCTGTAATGAGTTGAATGCAGGAT
ACGCTGCGGATGGCTATGCCCGGGTAAAAGGGGTCTCCGCTTTATTCGTTACTTATAGTGTGGGTGGACTTAGTACTGTT
AATGCAGTTGCAGGAGCGTATGCCGAAAATCTCCCCATTTTGGTTATATCGGGTGGCCCAAATACTAATTCCATACAGGA
TGCTGAAATTCTCCATCATACGCTGGCGACTGAAGATAATTTGTATGTAAGGGACATTTTTTCTCGAATTACTGCCCATG
TCGTTTGTATTCGAAAGCCAGAGCAGGCTGCCATGCAGATAGACGAGGCTATAGCAATCGCAATCGCTAAAAAAAAGCCG
GTCTATATTGAAATAGCGTGTAATATTGCTAACTATCCTATCTCCAAGCCTACTCAACGCGCATTCAACACCTATAAAAT
TAGCGACAGTTCGTCTCTGGCTGCAGCAGTAGAGCATGCTGCTGAAAAATTAAACTCCGCTCTAAAGCCCAGCTTGATTG
TAGGTAGTAAGGTTAGGCATTGTAATGCAATCAATTCTGTCAGCGAGTTGGCAAAGTGTACTGGATATGCTATGGCGGCT
ATGCCCGATGCGAAAGGATTTATCTCAGAACAGCATCCCAACTTTATAGGTATCTATTGGGGACCAGTCAGCTCTTCTGG
ATGCGCCGAAATTATCGATTCCAGTGATGCCTATCTGCTTATTGGGCCTAATGAGAATGACTATACTACAGTTGGGTATG
TATGGGGAATCAACCCCCACAAATCAATAAAGACCACCAAGGGAGGGGTTATTATTGGTGAAACAGTTTATACCAATATC
TTCATGAATGATTTTCTCAGAGAATTAAGTAAAAAATTAAAATTTAATGATGCTTCATACAAAGCTTATAAACGAATTGC
TGAAGAAACTGTCGTTTATCCAGAGTTAGATCAACCAGACGCTCCATTAAGCAGTCGTTATTTGTTTGGCCAAATTCAGA
AAATGCTTTCTGACAAAAAAGCTTTGTTGGCTGAAACAGGGGACTCCTGGTTTAATTGTATGCGCCTGTCTTTGCCTGAA
GGTTGTCCTTTCGAAATTCAAATGCAGTATGGTTCTATTGGTTGGTCAGTAGGTGCTTTGCTAGGCATGCAAGCTGCTTT
GCATAATCAAAAAAGAGTGATTGCCTGCATAGGAGATGGCTCATTTCAAATGACTGCCCAGGAAATATCAACCATGATAC
GTTACGGGTATAAACCAATTATTTTTTTAATGAATAATGCTTGTTACACTATTGAAGTACAAATTCATGATGGTCCTTAT
AATGTCATTAATAATTGGCGTTACGCTGAACTGGTTAATGTATTCCGCGGGGAACAGAGTAATGCAAAATCTTTTGTAGT
TAAAACCAACAAGGAACTACTCACTGCAATTAAACAGGCAGAAAAAACAGACGCGCTTTGTTTTATTGAAGTGTTCCTGG
ACAAGGATGATTGCAATAAAAACTTGTTGGAATGGGGCTCAAGAGTGGCAAATTATAATAGCCGTCCTCCTCGTAGATAG

Upstream 100 bases:

>100_bases
ATACTTTGTGAACTCTATTTTCTAGCAGGTATTCACTTGCCACCTACTGATTTTTGGCTGTGCTATAATTTAAAAAGTTC
TTATTTAATAAGGGATTAAC

Downstream 100 bases:

>100_bases
ATCTTGGGTAGGAATTATAAGAATCGCCTACCCTGATATTAATGATTTGACGTGTTTTTATTTGGAGCCCAGCTCTATTG
AGAAGGCAATGGCCAGCTTT

Product: pyruvate decarboxylase

Products: NA

Alternate protein names: PDC [H]

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MCSIGEYLAKRLEELNISEYFAIPGDYNLILLDEVLKNEKLKMINCCNELNAGYAADGYARVKGVSALFVTYSVGGLSTV
NAVAGAYAENLPILVISGGPNTNSIQDAEILHHTLATEDNLYVRDIFSRITAHVVCIRKPEQAAMQIDEAIAIAIAKKKP
VYIEIACNIANYPISKPTQRAFNTYKISDSSSLAAAVEHAAEKLNSALKPSLIVGSKVRHCNAINSVSELAKCTGYAMAA
MPDAKGFISEQHPNFIGIYWGPVSSSGCAEIIDSSDAYLLIGPNENDYTTVGYVWGINPHKSIKTTKGGVIIGETVYTNI
FMNDFLRELSKKLKFNDASYKAYKRIAEETVVYPELDQPDAPLSSRYLFGQIQKMLSDKKALLAETGDSWFNCMRLSLPE
GCPFEIQMQYGSIGWSVGALLGMQAALHNQKRVIACIGDGSFQMTAQEISTMIRYGYKPIIFLMNNACYTIEVQIHDGPY
NVINNWRYAELVNVFRGEQSNAKSFVVKTNKELLTAIKQAEKTDALCFIEVFLDKDDCNKNLLEWGSRVANYNSRPPRR

Sequences:

>Translated_559_residues
MCSIGEYLAKRLEELNISEYFAIPGDYNLILLDEVLKNEKLKMINCCNELNAGYAADGYARVKGVSALFVTYSVGGLSTV
NAVAGAYAENLPILVISGGPNTNSIQDAEILHHTLATEDNLYVRDIFSRITAHVVCIRKPEQAAMQIDEAIAIAIAKKKP
VYIEIACNIANYPISKPTQRAFNTYKISDSSSLAAAVEHAAEKLNSALKPSLIVGSKVRHCNAINSVSELAKCTGYAMAA
MPDAKGFISEQHPNFIGIYWGPVSSSGCAEIIDSSDAYLLIGPNENDYTTVGYVWGINPHKSIKTTKGGVIIGETVYTNI
FMNDFLRELSKKLKFNDASYKAYKRIAEETVVYPELDQPDAPLSSRYLFGQIQKMLSDKKALLAETGDSWFNCMRLSLPE
GCPFEIQMQYGSIGWSVGALLGMQAALHNQKRVIACIGDGSFQMTAQEISTMIRYGYKPIIFLMNNACYTIEVQIHDGPY
NVINNWRYAELVNVFRGEQSNAKSFVVKTNKELLTAIKQAEKTDALCFIEVFLDKDDCNKNLLEWGSRVANYNSRPPRR
>Mature_559_residues
MCSIGEYLAKRLEELNISEYFAIPGDYNLILLDEVLKNEKLKMINCCNELNAGYAADGYARVKGVSALFVTYSVGGLSTV
NAVAGAYAENLPILVISGGPNTNSIQDAEILHHTLATEDNLYVRDIFSRITAHVVCIRKPEQAAMQIDEAIAIAIAKKKP
VYIEIACNIANYPISKPTQRAFNTYKISDSSSLAAAVEHAAEKLNSALKPSLIVGSKVRHCNAINSVSELAKCTGYAMAA
MPDAKGFISEQHPNFIGIYWGPVSSSGCAEIIDSSDAYLLIGPNENDYTTVGYVWGINPHKSIKTTKGGVIIGETVYTNI
FMNDFLRELSKKLKFNDASYKAYKRIAEETVVYPELDQPDAPLSSRYLFGQIQKMLSDKKALLAETGDSWFNCMRLSLPE
GCPFEIQMQYGSIGWSVGALLGMQAALHNQKRVIACIGDGSFQMTAQEISTMIRYGYKPIIFLMNNACYTIEVQIHDGPY
NVINNWRYAELVNVFRGEQSNAKSFVVKTNKELLTAIKQAEKTDALCFIEVFLDKDDCNKNLLEWGSRVANYNSRPPRR

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1790104, Length=478, Percent_Identity=24.4769874476987, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323163, Length=562, Percent_Identity=31.4946619217082, Blast_Score=267, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6323073, Length=562, Percent_Identity=30.7829181494662, Blast_Score=262, Evalue=9e-71,
Organism=Saccharomyces cerevisiae, GI6321524, Length=566, Percent_Identity=30.0353356890459, Blast_Score=259, Evalue=9e-70,
Organism=Saccharomyces cerevisiae, GI6320123, Length=558, Percent_Identity=27.9569892473118, Blast_Score=236, Evalue=8e-63,
Organism=Saccharomyces cerevisiae, GI6320588, Length=602, Percent_Identity=25.2491694352159, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323755, Length=577, Percent_Identity=21.6637781629116, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.1 [H]

Molecular weight: Translated: 61874; Mature: 61874

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCSIGEYLAKRLEELNISEYFAIPGDYNLILLDEVLKNEKLKMINCCNELNAGYAADGYA
CCCHHHHHHHHHHHCCCHHEEECCCCCCEEEEHHHHCCCCCHHHHHHHHCCCCCCCCCHH
RVKGVSALFVTYSVGGLSTVNAVAGAYAENLPILVISGGPNTNSIQDAEILHHTLATEDN
HHCCCEEEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCC
LYVRDIFSRITAHVVCIRKPEQAAMQIDEAIAIAIAKKKPVYIEIACNIANYPISKPTQR
CHHHHHHHHHHHEEEEEECCHHHHHHHHHHEEEEEECCCCEEEEEEEEECCCCCCCCHHH
AFNTYKISDSSSLAAAVEHAAEKLNSALKPSLIVGSKVRHCNAINSVSELAKCTGYAMAA
CCCEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCEEEC
MPDAKGFISEQHPNFIGIYWGPVSSSGCAEIIDSSDAYLLIGPNENDYTTVGYVWGINPH
CCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCEEEECCCCCCEEEEEEEEECCCC
KSIKTTKGGVIIGETVYTNIFMNDFLRELSKKLKFNDASYKAYKRIAEETVVYPELDQPD
CCCEECCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEECCCCCCCC
APLSSRYLFGQIQKMLSDKKALLAETGDSWFNCMRLSLPEGCPFEIQMQYGSIGWSVGAL
CCCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHEEEECCCCCCCEEEEEECCCCCHHHHHH
LGMQAALHNQKRVIACIGDGSFQMTAQEISTMIRYGYKPIIFLMNNACYTIEVQIHDGPY
HHHHHHHCCCCEEEEEEECCCCEEEHHHHHHHHHCCCCEEEEEECCCEEEEEEEEECCCH
NVINNWRYAELVNVFRGEQSNAKSFVVKTNKELLTAIKQAEKTDALCFIEVFLDKDDCNK
HHHCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEEEECCCCCCH
NLLEWGSRVANYNSRPPRR
HHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MCSIGEYLAKRLEELNISEYFAIPGDYNLILLDEVLKNEKLKMINCCNELNAGYAADGYA
CCCHHHHHHHHHHHCCCHHEEECCCCCCEEEEHHHHCCCCCHHHHHHHHCCCCCCCCCHH
RVKGVSALFVTYSVGGLSTVNAVAGAYAENLPILVISGGPNTNSIQDAEILHHTLATEDN
HHCCCEEEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCC
LYVRDIFSRITAHVVCIRKPEQAAMQIDEAIAIAIAKKKPVYIEIACNIANYPISKPTQR
CHHHHHHHHHHHEEEEEECCHHHHHHHHHHEEEEEECCCCEEEEEEEEECCCCCCCCHHH
AFNTYKISDSSSLAAAVEHAAEKLNSALKPSLIVGSKVRHCNAINSVSELAKCTGYAMAA
CCCEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCEEEC
MPDAKGFISEQHPNFIGIYWGPVSSSGCAEIIDSSDAYLLIGPNENDYTTVGYVWGINPH
CCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCEEEECCCCCCEEEEEEEEECCCC
KSIKTTKGGVIIGETVYTNIFMNDFLRELSKKLKFNDASYKAYKRIAEETVVYPELDQPD
CCCEECCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEECCCCCCCC
APLSSRYLFGQIQKMLSDKKALLAETGDSWFNCMRLSLPEGCPFEIQMQYGSIGWSVGAL
CCCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHEEEECCCCCCCEEEEEECCCCCHHHHHH
LGMQAALHNQKRVIACIGDGSFQMTAQEISTMIRYGYKPIIFLMNNACYTIEVQIHDGPY
HHHHHHHCCCCEEEEEEECCCCEEEHHHHHHHHHCCCCEEEEEECCCEEEEEEEEECCCH
NVINNWRYAELVNVFRGEQSNAKSFVVKTNKELLTAIKQAEKTDALCFIEVFLDKDDCNK
HHHCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEEEECCCCCCH
NLLEWGSRVANYNSRPPRR
HHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3546263; 3029726; 3029037; 2838467; 8645153; 9655927; 9685367 [H]