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The map label for this gene is cpnA [H]

Identifier: 148358727

GI number: 148358727

Start: 1380333

End: 1381217

Strand: Reverse

Name: cpnA [H]

Synonym: LPC_0606

Alternate gene names: 148358727

Gene position: 1381217-1380333 (Counterclockwise)

Preceding gene: 148358728

Following gene: 148358726

Centisome position: 38.62

GC content: 37.18

Gene sequence:

>885_bases
ATGACAAAGACGGATAAAAAAATAGTGGTGGTCACAGGTTGTTCAAAAACATCCGGCGTGGGATATAATCTTGTATGTGA
AATGCTAAAACGCGGGCATCAAGTCATTGCAACGGTGAGAAATCTTGAAACAAGCCAAATTAACAAAGCAAACCTCCCAA
ACTCCAGCAATTTGGATGTAAAAATATTGGATCTTTGCGATGAAAATTCAATTGACCGCTTTATTAAAGAAGTCTTAAGT
CAATATCAATACATTGACGCATTGGTTAACAATGCTGCTAATGTGGCTATTGGCCCTGTTGAAAGCACAACCACTCAAGA
TGTATTAACAACCTTTCAAACCAAAGTATTTGGCCCATTGTCTTTAATCAGGGGATTCATCCCTGTAATGAGAGAAAGGA
AAAAAGGTTTATTAACAACAACATCCACGATTTTTACCTCTGTTCCCGTTAGTATTCCAGGTGTCGCAATCTATTTTTCA
GCACTTGCAGCATTTGAACGATTACAAGAATCCTTGGCGATTGAGCTGGCCCCATGGAATATCAAAGTAATTAATTTCCA
ACCTGGACCAATTGCGACAGAATTGACCCGATTTGAAGGCTCTCGCTCTGATATTGTTGAGAAATACTATAAAAACTTTA
CTGAACAAGCTTATCAATGGTTCCATCAGAATACTGTTTTTCAAAATGCAGTGGAAGTAGCCAAAGTATTTGCTGAAGTC
ATTGATATGGAGAATCCCGATTTATATTACCAAAGCAATCTTTTTGGAAAGCAGTTTGTTGCAAAAAACAAAAAAGATAC
AACAGGGCGTGAGGGAATGAATGAACTACTGGAACATTTCAAAAACTTATCTCACGACAATCCTGATGATTGGAAAATTC
AATAA

Upstream 100 bases:

>100_bases
AACCTTTTTTTAACAAAGAGATTGGGGGTTTTCGTAAGTTCTGAATAAATAAAAGGGCTATACTCAGTTTATTACTCTAA
AAGATCATTAGGATAGGGAC

Downstream 100 bases:

>100_bases
ATCATTTACTGGATAAAGTCATACTATCCGCCGCGAAATCTCTGTGCATAAGCAAAAAATCGGTCATGCCCGCATAGGCG
CTGAGTGATTTTTTTGCTCA

Product: short chain type dehydrogenase/reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTKTDKKIVVVTGCSKTSGVGYNLVCEMLKRGHQVIATVRNLETSQINKANLPNSSNLDVKILDLCDENSIDRFIKEVLS
QYQYIDALVNNAANVAIGPVESTTTQDVLTTFQTKVFGPLSLIRGFIPVMRERKKGLLTTTSTIFTSVPVSIPGVAIYFS
ALAAFERLQESLAIELAPWNIKVINFQPGPIATELTRFEGSRSDIVEKYYKNFTEQAYQWFHQNTVFQNAVEVAKVFAEV
IDMENPDLYYQSNLFGKQFVAKNKKDTTGREGMNELLEHFKNLSHDNPDDWKIQ

Sequences:

>Translated_294_residues
MTKTDKKIVVVTGCSKTSGVGYNLVCEMLKRGHQVIATVRNLETSQINKANLPNSSNLDVKILDLCDENSIDRFIKEVLS
QYQYIDALVNNAANVAIGPVESTTTQDVLTTFQTKVFGPLSLIRGFIPVMRERKKGLLTTTSTIFTSVPVSIPGVAIYFS
ALAAFERLQESLAIELAPWNIKVINFQPGPIATELTRFEGSRSDIVEKYYKNFTEQAYQWFHQNTVFQNAVEVAKVFAEV
IDMENPDLYYQSNLFGKQFVAKNKKDTTGREGMNELLEHFKNLSHDNPDDWKIQ
>Mature_293_residues
TKTDKKIVVVTGCSKTSGVGYNLVCEMLKRGHQVIATVRNLETSQINKANLPNSSNLDVKILDLCDENSIDRFIKEVLSQ
YQYIDALVNNAANVAIGPVESTTTQDVLTTFQTKVFGPLSLIRGFIPVMRERKKGLLTTTSTIFTSVPVSIPGVAIYFSA
LAAFERLQESLAIELAPWNIKVINFQPGPIATELTRFEGSRSDIVEKYYKNFTEQAYQWFHQNTVFQNAVEVAKVFAEVI
DMENPDLYYQSNLFGKQFVAKNKKDTTGREGMNELLEHFKNLSHDNPDDWKIQ

Specific function: Reduces cyclopentanol to cyclopentanone. The enzyme also shows considerable activity toward cyclohexanol [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7657478, Length=281, Percent_Identity=26.3345195729537, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI223718074, Length=258, Percent_Identity=27.5193798449612, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI7706318, Length=249, Percent_Identity=28.9156626506024, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI119392083, Length=232, Percent_Identity=25.4310344827586, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI20149619, Length=211, Percent_Identity=27.4881516587678, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786701, Length=195, Percent_Identity=28.7179487179487, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787820, Length=210, Percent_Identity=30, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786812, Length=210, Percent_Identity=23.8095238095238, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=236, Percent_Identity=26.6949152542373, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193210355, Length=259, Percent_Identity=26.6409266409266, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=223, Percent_Identity=27.8026905829596, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322067, Length=194, Percent_Identity=30.4123711340206, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323882, Length=220, Percent_Identity=28.1818181818182, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21358495, Length=198, Percent_Identity=30.8080808080808, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357041, Length=216, Percent_Identity=28.7037037037037, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28571526, Length=219, Percent_Identity=25.5707762557078, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24643142, Length=194, Percent_Identity=29.8969072164948, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.163 [H]

Molecular weight: Translated: 33146; Mature: 33015

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTDKKIVVVTGCSKTSGVGYNLVCEMLKRGHQVIATVRNLETSQINKANLPNSSNLDV
CCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCE
KILDLCDENSIDRFIKEVLSQYQYIDALVNNAANVAIGPVESTTTQDVLTTFQTKVFGPL
EEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHCCHH
SLIRGFIPVMRERKKGLLTTTSTIFTSVPVSIPGVAIYFSALAAFERLQESLAIELAPWN
HHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCE
IKVINFQPGPIATELTRFEGSRSDIVEKYYKNFTEQAYQWFHQNTVFQNAVEVAKVFAEV
EEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDMENPDLYYQSNLFGKQFVAKNKKDTTGREGMNELLEHFKNLSHDNPDDWKIQ
HCCCCCCEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TKTDKKIVVVTGCSKTSGVGYNLVCEMLKRGHQVIATVRNLETSQINKANLPNSSNLDV
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCE
KILDLCDENSIDRFIKEVLSQYQYIDALVNNAANVAIGPVESTTTQDVLTTFQTKVFGPL
EEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHCCHH
SLIRGFIPVMRERKKGLLTTTSTIFTSVPVSIPGVAIYFSALAAFERLQESLAIELAPWN
HHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCE
IKVINFQPGPIATELTRFEGSRSDIVEKYYKNFTEQAYQWFHQNTVFQNAVEVAKVFAEV
EEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDMENPDLYYQSNLFGKQFVAKNKKDTTGREGMNELLEHFKNLSHDNPDDWKIQ
HCCCCCCEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12406764 [H]