Click here to switch to the map view.

The map label for this gene is murB

Identifier: 148358652

GI number: 148358652

Start: 3125601

End: 3126527

Strand: Reverse

Name: murB

Synonym: LPC_0528

Alternate gene names: 148358652

Gene position: 3126527-3125601 (Counterclockwise)

Preceding gene: 148358651

Following gene: 148358653

Centisome position: 87.42

GC content: 44.44

Gene sequence:

>927_bases
ATGAGCATAACGGGAATGGACAGCAGTCATGTAACAGAGTCTCAGGGCGCTTTGCTTTTCAATGAGCCTTTGGCCGAGTA
TACTACCTGGCGAGTTGGTGGCCCTGCAGCGAGGCTCTATAAACCAGCAAATATAGATGATTTGGCTTTGTTTTTAAGTC
GATTGCCTTTTGATGAGCCATTATTATGGTTAGGTTTAGGCTCTAATTCTCTAATTCGCGATGGCGGTTTTTCCGGTACC
GTGATTCTCACTCAGGGCTGTTTAAAAGAAATGACCCTATTGAGCGATAACTGTATTCGGGTTGAGGCAGGGGTATCCTG
TGCCAGTATGGCTCGTTTTTCTGCGCGTAATAATCTGTCAGGAGGAGAGTTTTGGGCTGGTATCCCCGGTACCATGGGTG
GTGCTCTGCGAATGAATGCCGGTTGTCATGGAGGTGAAACCTGGCAGTCGGTTATTGAAGTACAAACGATAAATCGTCGA
GGTGAAATCAGAACCCGTAAACCGGAAGAATTTGAAGTAGCTTATCGACATGTTGCTGGCTTGGGAGATGAATGGTTTAT
TTCCGCCAAGCTTCAGCTATCACCGGGTAATAAAGAGACATCCTTGCAATTAATTAAGGATTTATTGGCTCATAGAGCCA
AGACCCAACCAACTAATGAATATAATTGTGGGTCGGTATTTAGAAACCCTCCTGGAGATTTTGCAGCGCGACTTATTGAA
TCTTGTGGCCTCAAGGGGGTAAGCATTGGTGGGGCAGTTGTTTCTGAAAAACATGCCAATTTTATTATCAATCATCAAGG
TACTGCCACGGCAGCTAATATTGAAGCCTTGATTCATTTGGTGCAAACTAAAGTTCGAGAGCAAACATCTATAGAGTTGA
TACGCGAAGTACATATCATTGGAGACGCTAATGTCCAAACCCGTTAA

Upstream 100 bases:

>100_bases
TAGATGAATTTATTAAAGATGGTGACGTAATTTTGATGCAGGGAGCTGGAAGTATCGGCCAAATGGCAGTGAACCTGATG
AAAAACATGTGAGAATGAAC

Downstream 100 bases:

>100_bases
TTTGGTTTTACTTTATGGTGGAAAATCAGGCGAGCATGAAGTGTCACTGGTTTCTGCCGCATCGGTTCTAAAACACCTGG
ATTCCGAGAAATATCATATT

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSITGMDSSHVTESQGALLFNEPLAEYTTWRVGGPAARLYKPANIDDLALFLSRLPFDEPLLWLGLGSNSLIRDGGFSGT
VILTQGCLKEMTLLSDNCIRVEAGVSCASMARFSARNNLSGGEFWAGIPGTMGGALRMNAGCHGGETWQSVIEVQTINRR
GEIRTRKPEEFEVAYRHVAGLGDEWFISAKLQLSPGNKETSLQLIKDLLAHRAKTQPTNEYNCGSVFRNPPGDFAARLIE
SCGLKGVSIGGAVVSEKHANFIINHQGTATAANIEALIHLVQTKVREQTSIELIREVHIIGDANVQTR

Sequences:

>Translated_308_residues
MSITGMDSSHVTESQGALLFNEPLAEYTTWRVGGPAARLYKPANIDDLALFLSRLPFDEPLLWLGLGSNSLIRDGGFSGT
VILTQGCLKEMTLLSDNCIRVEAGVSCASMARFSARNNLSGGEFWAGIPGTMGGALRMNAGCHGGETWQSVIEVQTINRR
GEIRTRKPEEFEVAYRHVAGLGDEWFISAKLQLSPGNKETSLQLIKDLLAHRAKTQPTNEYNCGSVFRNPPGDFAARLIE
SCGLKGVSIGGAVVSEKHANFIINHQGTATAANIEALIHLVQTKVREQTSIELIREVHIIGDANVQTR
>Mature_307_residues
SITGMDSSHVTESQGALLFNEPLAEYTTWRVGGPAARLYKPANIDDLALFLSRLPFDEPLLWLGLGSNSLIRDGGFSGTV
ILTQGCLKEMTLLSDNCIRVEAGVSCASMARFSARNNLSGGEFWAGIPGTMGGALRMNAGCHGGETWQSVIEVQTINRRG
EIRTRKPEEFEVAYRHVAGLGDEWFISAKLQLSPGNKETSLQLIKDLLAHRAKTQPTNEYNCGSVFRNPPGDFAARLIES
CGLKGVSIGGAVVSEKHANFIINHQGTATAANIEALIHLVQTKVREQTSIELIREVHIIGDANVQTR

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_LEGPC (A5IAW3)

Other databases:

- EMBL:   CP000675
- RefSeq:   YP_001249859.1
- ProteinModelPortal:   A5IAW3
- SMR:   A5IAW3
- STRING:   A5IAW3
- GeneID:   5182323
- GenomeReviews:   CP000675_GR
- KEGG:   lpc:LPC_0528
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- BioCyc:   LPNE400673:LPC_0528-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 33419; Mature: 33288

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 176-176 ACT_SITE 225-225 ACT_SITE 296-296

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITGMDSSHVTESQGALLFNEPLAEYTTWRVGGPAARLYKPANIDDLALFLSRLPFDEP
CCCCCCCCCCCCCCCCCEEECCCHHHHHEEECCCCHHHHCCCCCHHHHHHHHHHCCCCCC
LLWLGLGSNSLIRDGGFSGTVILTQGCLKEMTLLSDNCIRVEAGVSCASMARFSARNNLS
EEEEECCCCCEEECCCCCCEEEEEHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCC
GGEFWAGIPGTMGGALRMNAGCHGGETWQSVIEVQTINRRGEIRTRKPEEFEVAYRHVAG
CCCEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHC
LGDEWFISAKLQLSPGNKETSLQLIKDLLAHRAKTQPTNEYNCGSVFRNPPGDFAARLIE
CCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
SCGLKGVSIGGAVVSEKHANFIINHQGTATAANIEALIHLVQTKVREQTSIELIREVHII
HCCCCCEECCCHHEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
GDANVQTR
ECCCCCCC
>Mature Secondary Structure 
SITGMDSSHVTESQGALLFNEPLAEYTTWRVGGPAARLYKPANIDDLALFLSRLPFDEP
CCCCCCCCCCCCCCCCEEECCCHHHHHEEECCCCHHHHCCCCCHHHHHHHHHHCCCCCC
LLWLGLGSNSLIRDGGFSGTVILTQGCLKEMTLLSDNCIRVEAGVSCASMARFSARNNLS
EEEEECCCCCEEECCCCCCEEEEEHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCC
GGEFWAGIPGTMGGALRMNAGCHGGETWQSVIEVQTINRRGEIRTRKPEEFEVAYRHVAG
CCCEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHC
LGDEWFISAKLQLSPGNKETSLQLIKDLLAHRAKTQPTNEYNCGSVFRNPPGDFAARLIE
CCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
SCGLKGVSIGGAVVSEKHANFIINHQGTATAANIEALIHLVQTKVREQTSIELIREVHII
HCCCCCEECCCHHEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
GDANVQTR
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA