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The map label for this gene is murC

Identifier: 148358651

GI number: 148358651

Start: 3126536

End: 3127945

Strand: Reverse

Name: murC

Synonym: LPC_0527

Alternate gene names: 148358651

Gene position: 3127945-3126536 (Counterclockwise)

Preceding gene: 148358650

Following gene: 148358652

Centisome position: 87.46

GC content: 42.27

Gene sequence:

>1410_bases
TTGAATAACTCAGAGCAATTTTTATCTCCGCGCATGGGGCGTGTAGAGCAAATTCATTTTGTTGGCATTGGTGGTGCTGG
TATGTGTGGTATTGCCGAAGTATTGCATAACCAGGGCTACCGTATTACTGGTTCGGATCTCGGAGAAAGTGGCACGGTAC
AACGCTTAAGGTCATTAGGTATTCAAGTCTATATCGGTCACAGGCTGGAAAACATTAAAGGCGCTGATGTTGTAGTAAGG
TCTTCGGCCGTTGATTTTAATAATCCCGAAATTGTGGCTGCTCGTGAGTTAATGATTCCAGTTATTCCCAGAGCAGCTAT
GCTTGCTGAGCTAATGCGATTTAGGCATGGTATAGCAATTGCCGGTACTCATGGCAAAACGACAACAACGAGCTTGGTCA
GTAGTTTGCTTGCCGAAGGAGGTTTGGATCCCAGTTTTGTTATTGGCGGAAAGCTGAATAGTTGTGGTGCGAACGCTCAG
CTTGGAAAGTCAGCTTATTTTGTTGTAGAGGCTGATGAGAGCGACGCCTCGTTTTTGTTTTTGAAGCCTATGATGGCGGT
AGTGACTAATATTGATGCTGATCACATGGATACTTATGAAGGTGATTTTGAAAAATTAAGAACAACATTTTTGGAATTTT
TGCATCATTTGCCTTTTTATGGATTAGCAGTAGTTTGTTTGGAAGATGAAGAAATTTGCCGTATCCTCCCGGCTATTCAA
AGACCAACCTTAACTTATGGGTTTAAAGAAGAAGCTCATTATCGGGCAATTAATTGGACTCAAAAGGGCATGCTGAGTGA
GTTTGTAGTCGTTCGACCTGCACCACATAAACAACTGACTATACAATTCCAATATCCAGGCCGTCACAATGTATTAAATG
CATTAGCTTCTATAGCAATTGCCACCGAGTTGGGAGTTGATGACGATTCCATTGTTCGTGGCTTACAAAAATTCCAAGGG
GTAGGACGCCGCTTTCAAATGCTTGGTGAAAAACAGTTTGAAAAAGGCGCGGCGATTATTGTGGATGATTATGGACATCA
TCCACAGGAAATTTTATCCACAATTGATGCTTTTAGACGTGTTTGGCCCGAGAGACGTTTGGTTCATGTCTTTCAACCCC
ATCGTTATACCAGAACACAGTCCTTGCATAGACAATTTGTCGATGTTTTAAGTTTATCGGATGAGTTGTTATTGATGGAT
ATCTATGCAGCGGGAGAAACAGCTATTCCAGGCGTTACCAGTGAAAATCTGGCCAATGAAATACGATCCAGGGATAAACG
AGTGACCATAGTGAGCGAGCAATCGTTGAAAGCCACTTTAGATGAATTTATTAAAGATGGTGACGTAATTTTGATGCAGG
GAGCTGGAAGTATCGGCCAAATGGCAGTGAACCTGATGAAAAACATGTGA

Upstream 100 bases:

>100_bases
GGTAATTAATTGTATCGTTATTGCACTATTATTGCGCATAGATCATGAAAATCGTTGGCAGTCTCTTGGGTTGAAACCGC
TAACGGCTTAAGGGGGAATA

Downstream 100 bases:

>100_bases
GAATGAACATGAGCATAACGGGAATGGACAGCAGTCATGTAACAGAGTCTCAGGGCGCTTTGCTTTTCAATGAGCCTTTG
GCCGAGTATACTACCTGGCG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLGIQVYIGHRLENIKGADVVVR
SSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAIAGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQ
LGKSAYFVVEADESDASFLFLKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAIATELGVDDDSIVRGLQKFQG
VGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRRVWPERRLVHVFQPHRYTRTQSLHRQFVDVLSLSDELLLMD
IYAAGETAIPGVTSENLANEIRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQMAVNLMKNM

Sequences:

>Translated_469_residues
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLGIQVYIGHRLENIKGADVVVR
SSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAIAGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQ
LGKSAYFVVEADESDASFLFLKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAIATELGVDDDSIVRGLQKFQG
VGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRRVWPERRLVHVFQPHRYTRTQSLHRQFVDVLSLSDELLLMD
IYAAGETAIPGVTSENLANEIRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQMAVNLMKNM
>Mature_469_residues
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLGIQVYIGHRLENIKGADVVVR
SSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAIAGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQ
LGKSAYFVVEADESDASFLFLKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAIATELGVDDDSIVRGLQKFQG
VGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRRVWPERRLVHVFQPHRYTRTQSLHRQFVDVLSLSDELLLMD
IYAAGETAIPGVTSENLANEIRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQMAVNLMKNM

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=463, Percent_Identity=53.9956803455724, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1790680, Length=395, Percent_Identity=28.6075949367089, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_LEGPA (Q5X1S6)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_124972.1
- ProteinModelPortal:   Q5X1S6
- SMR:   Q5X1S6
- STRING:   Q5X1S6
- GeneID:   3118110
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp2667
- LegioList:   lpp2667
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   LPNE297246:LPP2667-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51983; Mature: 51983

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLG
CCCCHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCC
IQVYIGHRLENIKGADVVVRSSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAI
EEEEECCHHCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHCCCHHHHHHHHHHHHCCEEE
AGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQLGKSAYFVVEADESDASFLF
EECCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCEEH
LKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
HHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHC
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAI
CCCEEECCCCCCCEEEECCHHHCCHHCEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHH
ATELGVDDDSIVRGLQKFQGVGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
VWPERRLVHVFQPHRYTRTQSLHRQFVDVLSLSDELLLMDIYAAGETAIPGVTSENLANE
HCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHH
IRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQMAVNLMKNM
HHCCCCEEEEEECHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLG
CCCCHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCC
IQVYIGHRLENIKGADVVVRSSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAI
EEEEECCHHCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHCCCHHHHHHHHHHHHCCEEE
AGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQLGKSAYFVVEADESDASFLF
EECCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCEEH
LKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
HHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHC
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAI
CCCEEECCCCCCCEEEECCHHHCCHHCEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHH
ATELGVDDDSIVRGLQKFQGVGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
VWPERRLVHVFQPHRYTRTQSLHRQFVDVLSLSDELLLMDIYAAGETAIPGVTSENLANE
HCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHH
IRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQMAVNLMKNM
HHCCCCEEEEEECHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA