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The map label for this gene is uvrC [H]

Identifier: 148358620

GI number: 148358620

Start: 3168465

End: 3170321

Strand: Reverse

Name: uvrC [H]

Synonym: LPC_0494

Alternate gene names: 148358620

Gene position: 3170321-3168465 (Counterclockwise)

Preceding gene: 148358619

Following gene: 148358624

Centisome position: 88.64

GC content: 39.47

Gene sequence:

>1857_bases
ATGAATGACTTACAGCTTTCCGCTGAACTCGCTTTATTTTTAACGAAACTCCCAGGTGAACCGGGTATATACCGCATGTT
AGACGAGGAAGGCACCGTTCTATATGTGGGAAAAGCAGCCAATCTAAAAAAAAGAGTCAATAGCTATTTTAGTAAACAAA
ATACAGGAGTTAAGACACGAGCACTGGTAAGCCAAATCAAATCCATAGAAATTTCTGTGACAAGATCGGAGACAGAGGCC
TTATTATTAGAGAGTAATTTAATTAAAGCGTTAAGGCCAAAATATAATGTTTTGTTGCGCGATGACAAATCCTATCCTTA
TATTCATCTATCAAATCATCCAGACTTTCCAAGAATTGAGTTATACCGAAGTAAAAAGAAGCCTCCCTCCGGTAATTTTT
TTGGCCCCTATCCTGGTGTAGCTGCTGTAAGAGAAACGATAGTCACCATTCAAAAAATATTTAAAATTCGCAATTGCAGA
GACAGCTATTTTAAAGCTCGTTCTCGCCCTTGTTTGCAATATCAAATAAAACGTTGTACTGCGCCTTGCGTTCATTATAT
TTCTCCTGAAAACTACAAATTGTCTGTAGAGGATGCCATAAGATTTTTACAGGGGAAGTGCCAAATAATTCTTGATGAAC
TTGCCGAACGAATGAAACAAGCGGTAAGTCAATTAAATTTCGAAGAAGCTGCTGTTTTGCGTGATCAGATAAAAAATTTG
CGCTTAATTCAAGAACAACAAGGAGTTGTCCAGTTACGTGGTGATGCTGATGTGATCGCAATAGAAGTACGTCCTGGTTT
CGCATGTATTCAGTGTGTGACTATTCGTGAAGGACAAGTACTGAATAGTCAAAGCTTTTTCCCTACAGTGCCTTATGCAG
TATTAGATGAAGAATTGGATGCCAATTCACTTTGGCAGCAGACTTTTGAAGCCTTTGTTGGTTTTTATTATTTGGATACA
TCAGAAAGAATTCCGGATTTAATAATTACTAATCAATCGATAACAGAGAGTCGTTCATTAGAATATATTTTGTCCCAGCG
ACGAGGCAAATCCTGTAAAATTCAAGTCAATCCAAGAGGAGTCAAATCGAGGTGGATGGATTTTGCAGTGAACAATTTAC
GAATTTCAGTAGCAGAATATGTCAGCAAACACTCTACGATAAAATCAAGATATCAGGCATTAAAGCAATTGCTTGCGCTT
GATAAAAATATAGAGCGAATGGAGTGTTTTGATATTAGCCATACTCAAGGTGAATCAACTGTCGCATCTTGTGTTGTATT
TGATACAGAAGGCCCTCGCCCCAGTGAATACAGGCGATTTAACATTGAGGGTATTACTCCAGGGGATGATTACGCAGCAA
TGGAACAGGCAGTTACTCGCCGATTTAAAAGACTGATTGATGCTCAATTATTGCCAGATGTTTTGATTATTGATGGAGGT
AAAGGTCAGGTTTCTATTGTAAAACGAGTTATAACCTCTCTGGGTGTGGAAGATATTACTCTATTAGGTGTATCCAAGGG
GCCTTCACGAAAGGCGGGATGGGAGAAATTGATACTGGTTAATGAAAACAGAGAATTTGTTTTGCCAGAGGACTCCAAAG
CGCTTCATCTTTTACAACATATTCGTGATGAAGCGCATCGTTTTGCTATTACTGCCCATCGGAAGAAAAGACAAAAGACA
CGTGTTGAATCCACTCTTGAAAGTATAGAGGGTGTTGGCACGAAACGACGTCAAGCGTTGCTGCAGCGTTTTGGCGGGTT
GCGAGAGTTGGCTAAAGCGCCACTGGAAGAAATTTGTAAAGTCCAGGGAATCAACGAGCAGTTGGCAAAGCGAATTTATG
AACATTTCCACCCTTGA

Upstream 100 bases:

>100_bases
TGGGGATTAAAAATGATGTGGAGCTTACTTATTTGGCTATGAAGCACCGCATTATTGAACACCCCAATGATTTGTCACAA
GATGATTAGATGTTAATTTC

Downstream 100 bases:

>100_bases
TCAAAATTGAAGCTTTGCCATACTTAAAAGGCTCTTACAGCACGTACAGCAGCCGTTTTACTTTTTGCAATGTCTTTAAT
TTCCCCTGTTTTAGAATTAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MNDLQLSAELALFLTKLPGEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTRALVSQIKSIEISVTRSETEA
LLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRIELYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCR
DSYFKARSRPCLQYQIKRCTAPCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKQAVSQLNFEEAAVLRDQIKNL
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELDANSLWQQTFEAFVGFYYLDT
SERIPDLIITNQSITESRSLEYILSQRRGKSCKIQVNPRGVKSRWMDFAVNNLRISVAEYVSKHSTIKSRYQALKQLLAL
DKNIERMECFDISHTQGESTVASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIDAQLLPDVLIIDGG
KGQVSIVKRVITSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQHIRDEAHRFAITAHRKKRQKT
RVESTLESIEGVGTKRRQALLQRFGGLRELAKAPLEEICKVQGINEQLAKRIYEHFHP

Sequences:

>Translated_618_residues
MNDLQLSAELALFLTKLPGEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTRALVSQIKSIEISVTRSETEA
LLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRIELYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCR
DSYFKARSRPCLQYQIKRCTAPCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKQAVSQLNFEEAAVLRDQIKNL
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELDANSLWQQTFEAFVGFYYLDT
SERIPDLIITNQSITESRSLEYILSQRRGKSCKIQVNPRGVKSRWMDFAVNNLRISVAEYVSKHSTIKSRYQALKQLLAL
DKNIERMECFDISHTQGESTVASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIDAQLLPDVLIIDGG
KGQVSIVKRVITSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQHIRDEAHRFAITAHRKKRQKT
RVESTLESIEGVGTKRRQALLQRFGGLRELAKAPLEEICKVQGINEQLAKRIYEHFHP
>Mature_618_residues
MNDLQLSAELALFLTKLPGEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTRALVSQIKSIEISVTRSETEA
LLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRIELYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCR
DSYFKARSRPCLQYQIKRCTAPCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKQAVSQLNFEEAAVLRDQIKNL
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELDANSLWQQTFEAFVGFYYLDT
SERIPDLIITNQSITESRSLEYILSQRRGKSCKIQVNPRGVKSRWMDFAVNNLRISVAEYVSKHSTIKSRYQALKQLLAL
DKNIERMECFDISHTQGESTVASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIDAQLLPDVLIIDGG
KGQVSIVKRVITSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQHIRDEAHRFAITAHRKKRQKT
RVESTLESIEGVGTKRRQALLQRFGGLRELAKAPLEEICKVQGINEQLAKRIYEHFHP

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=608, Percent_Identity=48.5197368421053, Blast_Score=561, Evalue=1e-161,
Organism=Escherichia coli, GI1788037, Length=201, Percent_Identity=28.8557213930348, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 70466; Mature: 70466

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLQLSAELALFLTKLPGEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTR
CCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHH
ALVSQIKSIEISVTRSETEALLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRIE
HHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCCHHH
LYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCRDSYFKARSRPCLQYQIKRCT
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHC
APCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKQAVSQLNFEEAAVLRDQIKNL
HHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELD
HHHHHCCCCEEEECCCCEEEEEECCCCEEEEEEEECCCCEECCCCCCCCCCHHHHHCCCC
ANSLWQQTFEAFVGFYYLDTSERIPDLIITNQSITESRSLEYILSQRRGKSCKIQVNPRG
HHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCC
VKSRWMDFAVNNLRISVAEYVSKHSTIKSRYQALKQLLALDKNIERMECFDISHTQGEST
HHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCCCCCC
VASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIDAQLLPDVLIIDGG
EEEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
KGQVSIVKRVITSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQH
CCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEECCCCCHHHHHHHH
IRDEAHRFAITAHRKKRQKTRVESTLESIEGVGTKRRQALLQRFGGLRELAKAPLEEICK
HHHHHHHEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHCCHHHHHH
VQGINEQLAKRIYEHFHP
HCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNDLQLSAELALFLTKLPGEPGIYRMLDEEGTVLYVGKAANLKKRVNSYFSKQNTGVKTR
CCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHH
ALVSQIKSIEISVTRSETEALLLESNLIKALRPKYNVLLRDDKSYPYIHLSNHPDFPRIE
HHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCCHHH
LYRSKKKPPSGNFFGPYPGVAAVRETIVTIQKIFKIRNCRDSYFKARSRPCLQYQIKRCT
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHC
APCVHYISPENYKLSVEDAIRFLQGKCQIILDELAERMKQAVSQLNFEEAAVLRDQIKNL
HHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RLIQEQQGVVQLRGDADVIAIEVRPGFACIQCVTIREGQVLNSQSFFPTVPYAVLDEELD
HHHHHCCCCEEEECCCCEEEEEECCCCEEEEEEEECCCCEECCCCCCCCCCHHHHHCCCC
ANSLWQQTFEAFVGFYYLDTSERIPDLIITNQSITESRSLEYILSQRRGKSCKIQVNPRG
HHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCC
VKSRWMDFAVNNLRISVAEYVSKHSTIKSRYQALKQLLALDKNIERMECFDISHTQGEST
HHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCCCCCC
VASCVVFDTEGPRPSEYRRFNIEGITPGDDYAAMEQAVTRRFKRLIDAQLLPDVLIIDGG
EEEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
KGQVSIVKRVITSLGVEDITLLGVSKGPSRKAGWEKLILVNENREFVLPEDSKALHLLQH
CCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEECCCCCHHHHHHHH
IRDEAHRFAITAHRKKRQKTRVESTLESIEGVGTKRRQALLQRFGGLRELAKAPLEEICK
HHHHHHHEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHCCHHHHHH
VQGINEQLAKRIYEHFHP
HCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA