Click here to switch to the map view.

The map label for this gene is serA [C]

Identifier: 148358494

GI number: 148358494

Start: 390854

End: 392065

Strand: Direct

Name: serA [C]

Synonym: LPC_0360

Alternate gene names: 148358494

Gene position: 390854-392065 (Clockwise)

Preceding gene: 148358487

Following gene: 148358496

Centisome position: 10.93

GC content: 44.39

Gene sequence:

>1212_bases
ATGTTCAGCCAGAGTCAGCAAAAAATTGTTTGTGTGCTTTATGATGATCCTAAGGGGGGATTTCCTCCAAACTATGCAAG
AGAATCCATTCCAGAATTGAAACAATATCCTGATGGTCAATGTTTACCTACTCCTGATTCGATTGATTTTATTCCAGGTG
AAATGCTAGGTTCTGTGAGTGGTGAATTGGGACTAAGACAGTTTCTTGAAAGCAATGGGCATCAATTGGTAGTAACCTCT
GATAAGGATGGCTCTGATTCAGTATTTGCCAGGGAGTTAAAAGACGCTGCTGTCGTCATTTCCCAACCTTTTTGGCCAGC
TTATTTAACTCGTGATCGTATTGAAAGTGCACCTAAGCTTAAGCTCGCTATCACCGCAGGTATCGGCTCGGATCATGTCG
ATTTGCAAGCGGCCATGGAACATAATATCACCGTTTGTGAGGTCACTTATTGTAACAGCATCAGTGTTGCTGAGCATACC
GTGATGATGATTTTAGCCTTGGTGCGGGATTTTATACCACAATACAACACGGTAATTGATGGCGGGTGGAATATTGCGGA
TTGCGTCAGTCGCTCTTATGATTTGGAAGGCATGCAGGTAGGATGTGTTGCTGCAGGCCGAATTGGATTGGCTGTTTTAA
GACGTTTAAAGCCATTTGCTGTAAAACTGCATTACACAGACCGACATAGACTACCACTACACATGGAACAGGAACTGAAT
TTGACCTATCACCCATCTGTCGAATCCATGGTGAAAGTTTGTGATGTCGTATCGATTCATTGTCCATTGCATCCGGAAAC
AGAATATCTTTTTGATGATCGATTAATAAAACAGATGAAACGAGGCTCTTATTTAATTAATACCGCCCGTGGAAAAATAT
GCGATCAGCATGCTGTAGCGGATGCTCTGGAATCTGGGCATTTGGCTGGTTATGCCGGAGACGTTTGGTTTCCACAACCC
CCAGCCAAAAACCATCCTTGGCGATCGATGCCAAATCACGCCATGACACCACATACATCAGGAACTACCCTGTCCGCGCA
AGCGCGATATGCGGCGGGAGTCAGAGAAATATTAGAGTGTTGGTTAGGGAACAAACCAATAAGGGAGGAATATCTGATCG
TGTCTCAAGGCCGCTTAGCCGGGGTTGGTTCTCATTCTTATAGTGCGGGTAATACTACTACGGGAACTGAGCAAGCAGTA
GAATTGGTTTGA

Upstream 100 bases:

>100_bases
GAATAGTATTTTTATTGAGATGAATGAATTAAATCAAGTATAGTGAGCGTTGTAAAAAAATCAGGATGTTTTTACTTCAA
ACTATGAAAAGGAGTCAGGT

Downstream 100 bases:

>100_bases
TTCCTCGTCGCTTATGCTGTCTTATGTCTTTCTGTTTTCATTCAAAGTAGCCGCTGCCTTTAAAGACAGCGGCAGTTCAG
GGAAAAGGGGCAAACAGTGG

Product: formate dehydrogenase

Products: NA

Alternate protein names: NAD-dependent formate dehydrogenase; FDH [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MFSQSQQKIVCVLYDDPKGGFPPNYARESIPELKQYPDGQCLPTPDSIDFIPGEMLGSVSGELGLRQFLESNGHQLVVTS
DKDGSDSVFARELKDAAVVISQPFWPAYLTRDRIESAPKLKLAITAGIGSDHVDLQAAMEHNITVCEVTYCNSISVAEHT
VMMILALVRDFIPQYNTVIDGGWNIADCVSRSYDLEGMQVGCVAAGRIGLAVLRRLKPFAVKLHYTDRHRLPLHMEQELN
LTYHPSVESMVKVCDVVSIHCPLHPETEYLFDDRLIKQMKRGSYLINTARGKICDQHAVADALESGHLAGYAGDVWFPQP
PAKNHPWRSMPNHAMTPHTSGTTLSAQARYAAGVREILECWLGNKPIREEYLIVSQGRLAGVGSHSYSAGNTTTGTEQAV
ELV

Sequences:

>Translated_403_residues
MFSQSQQKIVCVLYDDPKGGFPPNYARESIPELKQYPDGQCLPTPDSIDFIPGEMLGSVSGELGLRQFLESNGHQLVVTS
DKDGSDSVFARELKDAAVVISQPFWPAYLTRDRIESAPKLKLAITAGIGSDHVDLQAAMEHNITVCEVTYCNSISVAEHT
VMMILALVRDFIPQYNTVIDGGWNIADCVSRSYDLEGMQVGCVAAGRIGLAVLRRLKPFAVKLHYTDRHRLPLHMEQELN
LTYHPSVESMVKVCDVVSIHCPLHPETEYLFDDRLIKQMKRGSYLINTARGKICDQHAVADALESGHLAGYAGDVWFPQP
PAKNHPWRSMPNHAMTPHTSGTTLSAQARYAAGVREILECWLGNKPIREEYLIVSQGRLAGVGSHSYSAGNTTTGTEQAV
ELV
>Mature_403_residues
MFSQSQQKIVCVLYDDPKGGFPPNYARESIPELKQYPDGQCLPTPDSIDFIPGEMLGSVSGELGLRQFLESNGHQLVVTS
DKDGSDSVFARELKDAAVVISQPFWPAYLTRDRIESAPKLKLAITAGIGSDHVDLQAAMEHNITVCEVTYCNSISVAEHT
VMMILALVRDFIPQYNTVIDGGWNIADCVSRSYDLEGMQVGCVAAGRIGLAVLRRLKPFAVKLHYTDRHRLPLHMEQELN
LTYHPSVESMVKVCDVVSIHCPLHPETEYLFDDRLIKQMKRGSYLINTARGKICDQHAVADALESGHLAGYAGDVWFPQP
PAKNHPWRSMPNHAMTPHTSGTTLSAQARYAAGVREILECWLGNKPIREEYLIVSQGRLAGVGSHSYSAGNTTTGTEQAV
ELV

Specific function: Serine biosynthesis; first step. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=285, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI145580578, Length=281, Percent_Identity=30.6049822064057, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI4557499, Length=281, Percent_Identity=30.6049822064057, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI145580575, Length=281, Percent_Identity=30.6049822064057, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI61743967, Length=266, Percent_Identity=30.0751879699248, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI4557497, Length=266, Percent_Identity=30.0751879699248, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI6912396, Length=229, Percent_Identity=31.0043668122271, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1789279, Length=247, Percent_Identity=34.8178137651822, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787645, Length=188, Percent_Identity=31.3829787234043, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87082289, Length=233, Percent_Identity=27.4678111587983, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788660, Length=251, Percent_Identity=26.6932270916335, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=293, Percent_Identity=30.3754266211604, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25147481, Length=244, Percent_Identity=27.0491803278689, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=347, Percent_Identity=47.8386167146974, Blast_Score=310, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6324980, Length=211, Percent_Identity=45.0236966824645, Blast_Score=166, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6324979, Length=119, Percent_Identity=55.4621848739496, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324055, Length=295, Percent_Identity=30.5084745762712, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=270, Percent_Identity=28.8888888888889, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6322116, Length=250, Percent_Identity=29.6, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19921140, Length=256, Percent_Identity=32.03125, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646446, Length=278, Percent_Identity=30.2158273381295, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646448, Length=278, Percent_Identity=30.2158273381295, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646452, Length=278, Percent_Identity=30.2158273381295, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646450, Length=278, Percent_Identity=30.2158273381295, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI62472511, Length=278, Percent_Identity=30.2158273381295, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28571528, Length=260, Percent_Identity=28.8461538461538, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574286, Length=231, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28574284, Length=235, Percent_Identity=27.2340425531915, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24585514, Length=235, Percent_Identity=27.2340425531915, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28574282, Length=235, Percent_Identity=27.2340425531915, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45552429, Length=235, Percent_Identity=27.2340425531915, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45551003, Length=235, Percent_Identity=27.2340425531915, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24585516, Length=257, Percent_Identity=25.2918287937743, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 44476; Mature: 44476

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSQSQQKIVCVLYDDPKGGFPPNYARESIPELKQYPDGQCLPTPDSIDFIPGEMLGSVS
CCCCCCCCEEEEEEECCCCCCCCCHHHHHCHHHHHCCCCCCCCCCCCCCCCCHHHHHHCC
GELGLRQFLESNGHQLVVTSDKDGSDSVFARELKDAAVVISQPFWPAYLTRDRIESAPKL
HHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCE
KLAITAGIGSDHVDLQAAMEHNITVCEVTYCNSISVAEHTVMMILALVRDFIPQYNTVID
EEEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEC
GGWNIADCVSRSYDLEGMQVGCVAAGRIGLAVLRRLKPFAVKLHYTDRHRLPLHMEQELN
CCCCHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHCCCEEEEEEECCCCCCCEEECCCCC
LTYHPSVESMVKVCDVVSIHCPLHPETEYLFDDRLIKQMKRGSYLINTARGKICDQHAVA
EEECCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHH
DALESGHLAGYAGDVWFPQPPAKNHPWRSMPNHAMTPHTSGTTLSAQARYAAGVREILEC
HHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
WLGNKPIREEYLIVSQGRLAGVGSHSYSAGNTTTGTEQAVELV
HCCCCCCCCCEEEEECCCEEECCCCCCCCCCCCCCCHHHHCCC
>Mature Secondary Structure
MFSQSQQKIVCVLYDDPKGGFPPNYARESIPELKQYPDGQCLPTPDSIDFIPGEMLGSVS
CCCCCCCCEEEEEEECCCCCCCCCHHHHHCHHHHHCCCCCCCCCCCCCCCCCHHHHHHCC
GELGLRQFLESNGHQLVVTSDKDGSDSVFARELKDAAVVISQPFWPAYLTRDRIESAPKL
HHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCE
KLAITAGIGSDHVDLQAAMEHNITVCEVTYCNSISVAEHTVMMILALVRDFIPQYNTVID
EEEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEC
GGWNIADCVSRSYDLEGMQVGCVAAGRIGLAVLRRLKPFAVKLHYTDRHRLPLHMEQELN
CCCCHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHCCCEEEEEEECCCCCCCEEECCCCC
LTYHPSVESMVKVCDVVSIHCPLHPETEYLFDDRLIKQMKRGSYLINTARGKICDQHAVA
EEECCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHH
DALESGHLAGYAGDVWFPQPPAKNHPWRSMPNHAMTPHTSGTTLSAQARYAAGVREILEC
HHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
WLGNKPIREEYLIVSQGRLAGVGSHSYSAGNTTTGTEQAVELV
HCCCCCCCCCEEEEECCCEEECCCCCCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1954846; 2357236; 1597184; 8484798 [H]