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The map label for this gene is gabT [H]

Identifier: 148358449

GI number: 148358449

Start: 337132

End: 338454

Strand: Direct

Name: gabT [H]

Synonym: LPC_0315

Alternate gene names: 148358449

Gene position: 337132-338454 (Clockwise)

Preceding gene: 148358448

Following gene: 148358450

Centisome position: 9.43

GC content: 42.93

Gene sequence:

>1323_bases
ATGAAAAAAATTCATATCAAAACGTCAATACCCGGACCCAAATCGCAACAGTTGATGGAATTGCGACGTCAGCATGTTGC
AAGAGGGCCATTTCATGCTACTCCTATCTTTGTGAAGCAGGCCAAAGGTTCTTTTGTGGAGGATGTTGATGGAAATGTAT
TTTTGGACTTTTCATCAGGGTTTGGGGTGGTCAATACAGGGCACTGTCCTGATTCAGTGGTCAACGCCATCAAGCTCCAG
GCCGAAAAATTCATACACACCGGGTTTAACATCATTCCTTATGAAGCCTATATCAAGGTGTGTGAAAAATTAAATTATCA
CACCCCGGGACATTTCGAAAAAAAATCGCTTCTTTTGAATTCCGGTGCGGAAGCAGTTGAAAATGCCATTAAAATTGCTC
GTGCCTATACGGGCAAACAAGCAGTGATTTGTTTTGATCATGCTTTTCATGGACGCACGTACATGGCAATGACACTCACT
TCGAAAAACAAGCCCTATAAGCATGGATTCGGCCCATTTCCTTCCGAAATCCATCGCGCTCCTTTTCCTTATGAGTATCG
TTGGAAGGGAGCAAATTGTGTAGAAGAATGTTTCAATGAGTTTACCGATCTTGCCAATTTCCGTGTCGGTGTTGAAAACA
TTGCTGCAGTCATTATAGAGCCGGTATTGGGTGAAGGTGGATTTATTCAATCCCCTGCCTTATTTTTGCAAAAACTTCGT
GAGTTTTGTACGACAAACGATATCGTTTTTATTGCCGATGAAATCCAATCCGGTTTTGGCCGCACAGGAAATCTGTTTGC
GATGAATACTTTGGGAGTAACCCCCGATCTCACCATATCAGCAAAAGGCCTTGGCGGTGGGGTAGTGCTTGCTGGTGTAA
CAGGTAAGGCTGAAATCATGGATGCGGCTATGGAAGGGGGGTTGGGTGGAACTTTTGGTGGAAATCCCCTTAGTTGTGCT
GCTGCTCTTGAAGTGTTCCATATTTTTGAAGAAGGAAGTCTGCTGCAAAATGTTACCCATCTTGCAAAGATACTGCAGTC
CAGACTTTCTGGATTTAAGGAAAAATACAAGGTAGTTGGTGATGTTCGTGGTTTGGGTGTCATGCAGGCAATCGAATTGG
TAAAGGATAAAAACACGAAAGAACCTAATAAAGAAGCCACAGTACAATTGGCTCAATTTTGTTTAGAACATGGGTTGATC
ATTTTGACCTGTGGAACATATGGGAACGTCATTCGTCTCCACATGCCACTTTCTACTGGCGTAAAAGATTTGGAAATCGG
CCTTTCGATTATTGAGGAAGGGCTTAAGCGACTATCAATATAG

Upstream 100 bases:

>100_bases
GCGGGTCGTGAGTTAGGCTTGTATGGCATTGAGAGTTACCTTGAGGTCAAGCAAGTGAATATTAACCTGGATGAAACACC
AATTGGTTGGTACTAAACTA

Downstream 100 bases:

>100_bases
ATAAACAGTCTGAAATGAGATAGATCTCTTAACGTTCACTTAATTAGTTTTTGATATCATTTGTTCCAATTAATTACAGG
TGAATAATATGTGGTATCAA

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKKIHIKTSIPGPKSQQLMELRRQHVARGPFHATPIFVKQAKGSFVEDVDGNVFLDFSSGFGVVNTGHCPDSVVNAIKLQ
AEKFIHTGFNIIPYEAYIKVCEKLNYHTPGHFEKKSLLLNSGAEAVENAIKIARAYTGKQAVICFDHAFHGRTYMAMTLT
SKNKPYKHGFGPFPSEIHRAPFPYEYRWKGANCVEECFNEFTDLANFRVGVENIAAVIIEPVLGEGGFIQSPALFLQKLR
EFCTTNDIVFIADEIQSGFGRTGNLFAMNTLGVTPDLTISAKGLGGGVVLAGVTGKAEIMDAAMEGGLGGTFGGNPLSCA
AALEVFHIFEEGSLLQNVTHLAKILQSRLSGFKEKYKVVGDVRGLGVMQAIELVKDKNTKEPNKEATVQLAQFCLEHGLI
ILTCGTYGNVIRLHMPLSTGVKDLEIGLSIIEEGLKRLSI

Sequences:

>Translated_440_residues
MKKIHIKTSIPGPKSQQLMELRRQHVARGPFHATPIFVKQAKGSFVEDVDGNVFLDFSSGFGVVNTGHCPDSVVNAIKLQ
AEKFIHTGFNIIPYEAYIKVCEKLNYHTPGHFEKKSLLLNSGAEAVENAIKIARAYTGKQAVICFDHAFHGRTYMAMTLT
SKNKPYKHGFGPFPSEIHRAPFPYEYRWKGANCVEECFNEFTDLANFRVGVENIAAVIIEPVLGEGGFIQSPALFLQKLR
EFCTTNDIVFIADEIQSGFGRTGNLFAMNTLGVTPDLTISAKGLGGGVVLAGVTGKAEIMDAAMEGGLGGTFGGNPLSCA
AALEVFHIFEEGSLLQNVTHLAKILQSRLSGFKEKYKVVGDVRGLGVMQAIELVKDKNTKEPNKEATVQLAQFCLEHGLI
ILTCGTYGNVIRLHMPLSTGVKDLEIGLSIIEEGLKRLSI
>Mature_440_residues
MKKIHIKTSIPGPKSQQLMELRRQHVARGPFHATPIFVKQAKGSFVEDVDGNVFLDFSSGFGVVNTGHCPDSVVNAIKLQ
AEKFIHTGFNIIPYEAYIKVCEKLNYHTPGHFEKKSLLLNSGAEAVENAIKIARAYTGKQAVICFDHAFHGRTYMAMTLT
SKNKPYKHGFGPFPSEIHRAPFPYEYRWKGANCVEECFNEFTDLANFRVGVENIAAVIIEPVLGEGGFIQSPALFLQKLR
EFCTTNDIVFIADEIQSGFGRTGNLFAMNTLGVTPDLTISAKGLGGGVVLAGVTGKAEIMDAAMEGGLGGTFGGNPLSCA
AALEVFHIFEEGSLLQNVTHLAKILQSRLSGFKEKYKVVGDVRGLGVMQAIELVKDKNTKEPNKEATVQLAQFCLEHGLI
ILTCGTYGNVIRLHMPLSTGVKDLEIGLSIIEEGLKRLSI

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=451, Percent_Identity=31.9290465631929, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI37574042, Length=447, Percent_Identity=30.8724832214765, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI13994255, Length=455, Percent_Identity=28.1318681318681, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI226442705, Length=447, Percent_Identity=30.4250559284116, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI24119277, Length=425, Percent_Identity=30.1176470588235, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=31.3131313131313, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI284507298, Length=329, Percent_Identity=32.8267477203647, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI188536080, Length=413, Percent_Identity=25.4237288135593, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI38679950, Length=413, Percent_Identity=25.4237288135593, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI38679946, Length=413, Percent_Identity=25.4237288135593, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1789016, Length=425, Percent_Identity=44.7058823529412, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=42.75, Blast_Score=331, Evalue=5e-92,
Organism=Escherichia coli, GI1789759, Length=417, Percent_Identity=33.0935251798561, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1788044, Length=408, Percent_Identity=32.1078431372549, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI145693181, Length=438, Percent_Identity=31.2785388127854, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1786991, Length=395, Percent_Identity=30.6329113924051, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786349, Length=360, Percent_Identity=27.7777777777778, Blast_Score=126, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32564660, Length=444, Percent_Identity=29.954954954955, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71992977, Length=410, Percent_Identity=29.2682926829268, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI25144271, Length=431, Percent_Identity=28.3062645011601, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI25144274, Length=294, Percent_Identity=28.9115646258503, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17541228, Length=477, Percent_Identity=24.1090146750524, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71981843, Length=181, Percent_Identity=27.0718232044199, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=439, Percent_Identity=30.2961275626424, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6324432, Length=401, Percent_Identity=30.4239401496259, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6324386, Length=416, Percent_Identity=26.2019230769231, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=408, Percent_Identity=26.7156862745098, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI161085790, Length=462, Percent_Identity=28.3549783549784, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI28574759, Length=457, Percent_Identity=27.5711159737418, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI21357415, Length=440, Percent_Identity=29.7727272727273, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI21356575, Length=422, Percent_Identity=30.0947867298578, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI281366494, Length=426, Percent_Identity=25.8215962441315, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24667139, Length=426, Percent_Identity=25.8215962441315, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24667143, Length=426, Percent_Identity=25.8215962441315, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 48022; Mature: 48022

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIHIKTSIPGPKSQQLMELRRQHVARGPFHATPIFVKQAKGSFVEDVDGNVFLDFSSG
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCCCEEEEECCC
FGVVNTGHCPDSVVNAIKLQAEKFIHTGFNIIPYEAYIKVCEKLNYHTPGHFEKKSLLLN
CCEEECCCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHCCCCCCCCCCHHHHHHC
SGAEAVENAIKIARAYTGKQAVICFDHAFHGRTYMAMTLTSKNKPYKHGFGPFPSEIHRA
CCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCHHHCCC
PFPYEYRWKGANCVEECFNEFTDLANFRVGVENIAAVIIEPVLGEGGFIQSPALFLQKLR
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
EFCTTNDIVFIADEIQSGFGRTGNLFAMNTLGVTPDLTISAKGLGGGVVLAGVTGKAEIM
HHHCCCCEEEEEEHHHHCCCCCCCEEEEEECCCCCCCEEEECCCCCCEEEEECCCHHHHH
DAAMEGGLGGTFGGNPLSCAAALEVFHIFEEGSLLQNVTHLAKILQSRLSGFKEKYKVVG
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVRGLGVMQAIELVKDKNTKEPNKEATVQLAQFCLEHGLIILTCGTYGNVIRLHMPLSTG
HHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEECHHCC
VKDLEIGLSIIEEGLKRLSI
CHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKIHIKTSIPGPKSQQLMELRRQHVARGPFHATPIFVKQAKGSFVEDVDGNVFLDFSSG
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCCCEEEEECCC
FGVVNTGHCPDSVVNAIKLQAEKFIHTGFNIIPYEAYIKVCEKLNYHTPGHFEKKSLLLN
CCEEECCCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHCCCCCCCCCCHHHHHHC
SGAEAVENAIKIARAYTGKQAVICFDHAFHGRTYMAMTLTSKNKPYKHGFGPFPSEIHRA
CCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCHHHCCC
PFPYEYRWKGANCVEECFNEFTDLANFRVGVENIAAVIIEPVLGEGGFIQSPALFLQKLR
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
EFCTTNDIVFIADEIQSGFGRTGNLFAMNTLGVTPDLTISAKGLGGGVVLAGVTGKAEIM
HHHCCCCEEEEEEHHHHCCCCCCCEEEEEECCCCCCCEEEECCCCCCEEEEECCCHHHHH
DAAMEGGLGGTFGGNPLSCAAALEVFHIFEEGSLLQNVTHLAKILQSRLSGFKEKYKVVG
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVRGLGVMQAIELVKDKNTKEPNKEATVQLAQFCLEHGLIILTCGTYGNVIRLHMPLSTG
HHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEECHHCC
VKDLEIGLSIIEEGLKRLSI
CHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]