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The map label for this gene is prlC [H]

Identifier: 148358300

GI number: 148358300

Start: 179183

End: 181198

Strand: Direct

Name: prlC [H]

Synonym: LPC_0162

Alternate gene names: 148358300

Gene position: 179183-181198 (Clockwise)

Preceding gene: 148358299

Following gene: 148358301

Centisome position: 5.01

GC content: 44.25

Gene sequence:

>2016_bases
ATGTCGACCACAGTTGGATTGCCACAATTTAGCCATATAAAAATTGAACATTTCAAATCTCATCTTGATGCTTTATTAAA
AAACCATCTTGAGGAAATTGACAGGCTGCTTAAGGAAAATCACCACTATACCTGGGATAATTTAATTTATCCTTTAGATA
GCCTCGCCGATGAACTGGAGCGTTTTTGGTCTCCTTTTGCACATATGCATGCAGTGATGGATTCTGAGGCAATACGTGAA
TCCTATGAAGCGTGTTTGCCATTGCTGTCTGCCTATGATGCTGCGATTGGGCATAATCAAGACTTGTATGAGGCGATTAA
ATCGATAGATCAGCATTCCCTTAACCCTGCCCAGAAAAAAATCATTGCAGACAGCATACAGGATTTTGAGCTATCGGGAG
TTGCTTTATCCAAGGCGAATAAAAAGCGCTTTGAAGCCATTCAATCAAGACTGGCCGAATTATCCAGCAAATTCGAAAAC
AATGTGCTGGACGCAACCCATGCCTACACTATCCATATTACCGAAGCAGAACGTGTGGCAGGATTACCTGAGCATGCATT
AAATACGGCAAAAGAGTTGGCGCATGAGAAAGGGCTCGATGGTTTTGTTTTAACCCTCGAATACCCATGTTTTCAGGCTG
TTATTACTCATGCTGAAGACAGGGCTTTACGTGAAGAAATGTATCGAGCTTACATCACCAGAGCTTCAGATCAAGGCCCT
AATGCAGGAACTTTTGATAATACTCCGCTGATTGATGAAATTCTGTCCCTGCGCCATGAAAAAGCCGAGCTTTTGGGGTT
TAATAATTTTGCCGAGTTATCCCTGGCTACCAAGATGGCTGCCTCGACCAATCAAGTCACTGAATTTATCTATGATTTGA
TCAGCAGAACTCGTGACAAGGGTAAAACTGAATTTAGGCAACTTGAAGTGTTTGCACAGGATAAATGGAATCTGAGCCCG
GTAAACCCATGGGACGTTGCTTATCTTTCTGAAAAAAGAAGACAGGATTTGTATTCCTTATCTCAAGAGGAATTACGGCC
TTATTTTCCACAGCCTAAAGTGATGCAAGGCTTGTTCGCGATTGTTAAAAAGCTCTTTGGTATGAGTATCGAGGAGATTG
AGGGCGTGGATGTTTGGCATAAGGATGTTCAATGCTATTGCATAGTCGATGAATCCAATCAAACGCGCGGGTACATTTAC
ACGGATTTGTTTGCCAGACCGCACAAGCGGAATGGTGCCTGGATGGACTCCATGCAAAGCCGCAGAAAACTCGAGGATGG
CACAGTTCAATTACCCATTGCGACCTTGACTTGCAATTTTGCCAAGCCTTCTGCAAACAGACCGGCCATGTTATCGCACG
ATGAAGTGGTGACTTTGTTTCATGAGTTTGGTCATTGTCTGCATCACGTTTTGACTCAAGTCGATTACCTTGGCGGCTCA
GGGATTAATGGCGTGGAATGGGATGCGGTGGAATTACCCAGCCAATTTTTCGAAAACTGGTGCTGGGATGAGCACGCATT
GTCTTTACTGACTTCGCACGTGGATACAGGGGAAACCTTGCCTTCCGCATTGTACGAGCGCTTGATTGCCGCTAAAAATT
TTCAATCCGCCATGGCCATGTTAAGACAAATGGAATTCGCCTTGTTTGATTTTCGCATTCACCAGGAATATCAAACCGGC
AAAGCGTCCTATGTCGCAAATATTCTGGCGGATGTACGTTCTAAAACCACTGTTGTACCCATTGTTCCTTATAATCGCTT
TCAACATAGTTTCTCGCATATTTTTGGGGGTGGCTACGCCGCGGGTTATTACAGTTACATGTGGGCAGAAGTACTATCCA
GCGATGCCTTTGCGCGCTTTGAGGAGGAAGGTATTTTCAACCCCAAAACCGGACATGACTTTTTGAAATCCATTTTGGAG
GCAGGCGGCTCAAGAAAAGCAGCCGATGCTTTTCTTGAATTCCGAGGAAGACCCGCGACGATTGATGCTTTGCTGCGTCA
TAACGGGATTTTATAA

Upstream 100 bases:

>100_bases
ATTCATTACTGTACTTTGCCATTTCAGCGCCGGCAAAGTATAGAGACTAATTCAATTGAATGTTATGCTTTCAAAAAATT
ACATGATGGAAAGGTATAAC

Downstream 100 bases:

>100_bases
AAACAGGACTTGCGCCCCCCCAGCGCTCTCGGTAAAACATTTTTTGCCTTGACCTTGGGGGTTTTCCGTAAGTTCTGAAA
ATATATTCGGTATGCTGGCG

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 671; Mature: 670

Protein sequence:

>671_residues
MSTTVGLPQFSHIKIEHFKSHLDALLKNHLEEIDRLLKENHHYTWDNLIYPLDSLADELERFWSPFAHMHAVMDSEAIRE
SYEACLPLLSAYDAAIGHNQDLYEAIKSIDQHSLNPAQKKIIADSIQDFELSGVALSKANKKRFEAIQSRLAELSSKFEN
NVLDATHAYTIHITEAERVAGLPEHALNTAKELAHEKGLDGFVLTLEYPCFQAVITHAEDRALREEMYRAYITRASDQGP
NAGTFDNTPLIDEILSLRHEKAELLGFNNFAELSLATKMAASTNQVTEFIYDLISRTRDKGKTEFRQLEVFAQDKWNLSP
VNPWDVAYLSEKRRQDLYSLSQEELRPYFPQPKVMQGLFAIVKKLFGMSIEEIEGVDVWHKDVQCYCIVDESNQTRGYIY
TDLFARPHKRNGAWMDSMQSRRKLEDGTVQLPIATLTCNFAKPSANRPAMLSHDEVVTLFHEFGHCLHHVLTQVDYLGGS
GINGVEWDAVELPSQFFENWCWDEHALSLLTSHVDTGETLPSALYERLIAAKNFQSAMAMLRQMEFALFDFRIHQEYQTG
KASYVANILADVRSKTTVVPIVPYNRFQHSFSHIFGGGYAAGYYSYMWAEVLSSDAFARFEEEGIFNPKTGHDFLKSILE
AGGSRKAADAFLEFRGRPATIDALLRHNGIL

Sequences:

>Translated_671_residues
MSTTVGLPQFSHIKIEHFKSHLDALLKNHLEEIDRLLKENHHYTWDNLIYPLDSLADELERFWSPFAHMHAVMDSEAIRE
SYEACLPLLSAYDAAIGHNQDLYEAIKSIDQHSLNPAQKKIIADSIQDFELSGVALSKANKKRFEAIQSRLAELSSKFEN
NVLDATHAYTIHITEAERVAGLPEHALNTAKELAHEKGLDGFVLTLEYPCFQAVITHAEDRALREEMYRAYITRASDQGP
NAGTFDNTPLIDEILSLRHEKAELLGFNNFAELSLATKMAASTNQVTEFIYDLISRTRDKGKTEFRQLEVFAQDKWNLSP
VNPWDVAYLSEKRRQDLYSLSQEELRPYFPQPKVMQGLFAIVKKLFGMSIEEIEGVDVWHKDVQCYCIVDESNQTRGYIY
TDLFARPHKRNGAWMDSMQSRRKLEDGTVQLPIATLTCNFAKPSANRPAMLSHDEVVTLFHEFGHCLHHVLTQVDYLGGS
GINGVEWDAVELPSQFFENWCWDEHALSLLTSHVDTGETLPSALYERLIAAKNFQSAMAMLRQMEFALFDFRIHQEYQTG
KASYVANILADVRSKTTVVPIVPYNRFQHSFSHIFGGGYAAGYYSYMWAEVLSSDAFARFEEEGIFNPKTGHDFLKSILE
AGGSRKAADAFLEFRGRPATIDALLRHNGIL
>Mature_670_residues
STTVGLPQFSHIKIEHFKSHLDALLKNHLEEIDRLLKENHHYTWDNLIYPLDSLADELERFWSPFAHMHAVMDSEAIRES
YEACLPLLSAYDAAIGHNQDLYEAIKSIDQHSLNPAQKKIIADSIQDFELSGVALSKANKKRFEAIQSRLAELSSKFENN
VLDATHAYTIHITEAERVAGLPEHALNTAKELAHEKGLDGFVLTLEYPCFQAVITHAEDRALREEMYRAYITRASDQGPN
AGTFDNTPLIDEILSLRHEKAELLGFNNFAELSLATKMAASTNQVTEFIYDLISRTRDKGKTEFRQLEVFAQDKWNLSPV
NPWDVAYLSEKRRQDLYSLSQEELRPYFPQPKVMQGLFAIVKKLFGMSIEEIEGVDVWHKDVQCYCIVDESNQTRGYIYT
DLFARPHKRNGAWMDSMQSRRKLEDGTVQLPIATLTCNFAKPSANRPAMLSHDEVVTLFHEFGHCLHHVLTQVDYLGGSG
INGVEWDAVELPSQFFENWCWDEHALSLLTSHVDTGETLPSALYERLIAAKNFQSAMAMLRQMEFALFDFRIHQEYQTGK
ASYVANILADVRSKTTVVPIVPYNRFQHSFSHIFGGGYAAGYYSYMWAEVLSSDAFARFEEEGIFNPKTGHDFLKSILEA
GGSRKAADAFLEFRGRPATIDALLRHNGIL

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=611, Percent_Identity=30.114566284779, Blast_Score=288, Evalue=1e-77,
Organism=Homo sapiens, GI14149738, Length=613, Percent_Identity=30.5057096247961, Blast_Score=265, Evalue=8e-71,
Organism=Homo sapiens, GI156105687, Length=608, Percent_Identity=27.1381578947368, Blast_Score=206, Evalue=8e-53,
Organism=Escherichia coli, GI1789913, Length=672, Percent_Identity=49.8511904761905, Blast_Score=706, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=670, Percent_Identity=28.3582089552239, Blast_Score=270, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI32565901, Length=563, Percent_Identity=23.6234458259325, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71999758, Length=591, Percent_Identity=23.5194585448393, Blast_Score=113, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319793, Length=588, Percent_Identity=28.4013605442177, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6322715, Length=703, Percent_Identity=23.7553342816501, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI21356111, Length=674, Percent_Identity=25.6676557863501, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI20129717, Length=598, Percent_Identity=24.247491638796, Blast_Score=174, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76350; Mature: 76219

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTVGLPQFSHIKIEHFKSHLDALLKNHLEEIDRLLKENHHYTWDNLIYPLDSLADELE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHH
RFWSPFAHMHAVMDSEAIRESYEACLPLLSAYDAAIGHNQDLYEAIKSIDQHSLNPAQKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHH
IIADSIQDFELSGVALSKANKKRFEAIQSRLAELSSKFENNVLDATHAYTIHITEAERVA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHC
GLPEHALNTAKELAHEKGLDGFVLTLEYPCFQAVITHAEDRALREEMYRAYITRASDQGP
CCCHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NAGTFDNTPLIDEILSLRHEKAELLGFNNFAELSLATKMAASTNQVTEFIYDLISRTRDK
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GKTEFRQLEVFAQDKWNLSPVNPWDVAYLSEKRRQDLYSLSQEELRPYFPQPKVMQGLFA
CHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHH
IVKKLFGMSIEEIEGVDVWHKDVQCYCIVDESNQTRGYIYTDLFARPHKRNGAWMDSMQS
HHHHHHCCCHHHHCCCHHCCCCCEEEEEEECCCCCCCEEEEHHHCCCCCCCCCHHHHHHH
RRKLEDGTVQLPIATLTCNFAKPSANRPAMLSHDEVVTLFHEFGHCLHHVLTQVDYLGGS
HHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
GINGVEWDAVELPSQFFENWCWDEHALSLLTSHVDTGETLPSALYERLIAAKNFQSAMAM
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRQMEFALFDFRIHQEYQTGKASYVANILADVRSKTTVVPIVPYNRFQHSFSHIFGGGYA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCHH
AGYYSYMWAEVLSSDAFARFEEEGIFNPKTGHDFLKSILEAGGSRKAADAFLEFRGRPAT
HHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHH
IDALLRHNGIL
HHHHHHHCCCC
>Mature Secondary Structure 
STTVGLPQFSHIKIEHFKSHLDALLKNHLEEIDRLLKENHHYTWDNLIYPLDSLADELE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHH
RFWSPFAHMHAVMDSEAIRESYEACLPLLSAYDAAIGHNQDLYEAIKSIDQHSLNPAQKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHH
IIADSIQDFELSGVALSKANKKRFEAIQSRLAELSSKFENNVLDATHAYTIHITEAERVA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHC
GLPEHALNTAKELAHEKGLDGFVLTLEYPCFQAVITHAEDRALREEMYRAYITRASDQGP
CCCHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NAGTFDNTPLIDEILSLRHEKAELLGFNNFAELSLATKMAASTNQVTEFIYDLISRTRDK
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GKTEFRQLEVFAQDKWNLSPVNPWDVAYLSEKRRQDLYSLSQEELRPYFPQPKVMQGLFA
CHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHH
IVKKLFGMSIEEIEGVDVWHKDVQCYCIVDESNQTRGYIYTDLFARPHKRNGAWMDSMQS
HHHHHHCCCHHHHCCCHHCCCCCEEEEEEECCCCCCCEEEEHHHCCCCCCCCCHHHHHHH
RRKLEDGTVQLPIATLTCNFAKPSANRPAMLSHDEVVTLFHEFGHCLHHVLTQVDYLGGS
HHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
GINGVEWDAVELPSQFFENWCWDEHALSLLTSHVDTGETLPSALYERLIAAKNFQSAMAM
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRQMEFALFDFRIHQEYQTGKASYVANILADVRSKTTVVPIVPYNRFQHSFSHIFGGGYA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCHH
AGYYSYMWAEVLSSDAFARFEEEGIFNPKTGHDFLKSILEAGGSRKAADAFLEFRGRPAT
HHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHH
IDALLRHNGIL
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]