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The map label for this gene is gcsA [H]

Identifier: 148358274

GI number: 148358274

Start: 142324

End: 143694

Strand: Reverse

Name: gcsA [H]

Synonym: LPC_0136

Alternate gene names: 148358274

Gene position: 143694-142324 (Counterclockwise)

Preceding gene: 148358275

Following gene: 148358273

Centisome position: 4.02

GC content: 44.49

Gene sequence:

>1371_bases
ATGCCTTATATTCCACACACGCCCAATGATACCAAAGAGATGCTAGAGGCAATTGGTGCTCAAGACATTCAGGATTTATT
TGATGAAATACCAGCTTCTTTGCAATATGCAGGATTTCAAAATATCCCTGCCGGCATTAACGAAATGGAAATGTTGAAAG
AAGCCCAGAATCAAGCCCAAAAGAATCGCAACGGCATATGCTTTATTGGTGCTGGATGTTATGAGCATCATATTCCAGCA
GCCGTGTGGGATATTGCATCTCGCGGTGAATTTTTAACTGCCTACACACCCTATCAAGCTGAGGCCAGCCAGGGAACTTT
GCAATTATTGTATGAATATCAAACCATGATCTGTGAGTTGACCGGCATGGAAGTATCCAATGCGTCAATGTATGACGGAG
CAACTGCATTAGCTGAAGCAGTACTAATGGCAGTCCGCCTTAATAAACACAGCAAAACCAACAGGGTACTGATTGCAGGC
ACAGTTCATCCTTTTTATCGCGAAACCATTGAAACGATAGTACGTAATCAGCATATTGAAGTCATCACCCTCCCTTTTGA
TGAACAGCAAGGAATCACTGATCTTGGCTCTCTCAATCAATACACCGGAGAAGATATTACAGCTTTGGTCATAGCCCAAC
CGAATTTCTTTGGTTGCCTCGAACAAGTCGATAAAATGACTTCCTGGGCACATCATAACAAAACAATCAGTGTAGCTTGT
GTTAACCCGACTTCATTGGCTTTATTAAAACCACCCGGCTCATGGGGAGAACATGGGGTAGACATCGTATGCGGTGAAGG
ACAACCTTTAGGCTCACCTATGGCATCAGGAGGCCCTTATTTTGGTTTTCTGAGCACCCGTATGGCCCATGTCAGACAAA
TGCCCGGAAGAATAATTGGCCGCACAGTAGACAAGGATGGAAAAACCGGTTTTAGTTTAACTCTCCAGGCAAGAGAGCAG
CATATTCGGCGTGCTAAAGCCACTTCAAACATATGCACCAACCAAGGTTTACTTGTAACAGCGGCAACTATCTATATGAG
TCTTTTAGGGCCGGAAGGTCTAAGCCAAGTGGCAACTCAATGCCATCAAAACACTCATGAATTGATTACTGCCTTAACAC
AAATCGAGGGGGTAGAACTGGCATTCAAAGCCCCGTTTTTCCATGAAGCCTTGATTAAACTAAACCAACCAGTTCAGTAC
GTATTGCAACAACTGGCTGATGCTGGAATTGCTGGAGGTTATGCACCGGAACAACACTACCCTCAGCTAGCCAATACGCT
GTTAGTTTGTGCGACAGAGGTGCGCACTGCGGAGGATATCGCGAAATATGCAAAAACATTAAAAACCATAATGTCCAAGC
GAGGTGCCTGA

Upstream 100 bases:

>100_bases
AAGGTTGGCTCGTGAAGCTAAAGCCCAGCCATCCTGATGAAATAAAAAGCCTGTTGAGTGATGAGCAATATCAAAATGAG
ATAGCTGAGGAAAATTAATT

Downstream 100 bases:

>100_bases
TGTTTATTGTTCAATTAACCTATTTAGTTCCCATCAATGAAGTAAACAAATATCTGCAGGCACACAGGGAGTTTCTAGAT
TACCACTACAAACAAGGGCT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MPYIPHTPNDTKEMLEAIGAQDIQDLFDEIPASLQYAGFQNIPAGINEMEMLKEAQNQAQKNRNGICFIGAGCYEHHIPA
AVWDIASRGEFLTAYTPYQAEASQGTLQLLYEYQTMICELTGMEVSNASMYDGATALAEAVLMAVRLNKHSKTNRVLIAG
TVHPFYRETIETIVRNQHIEVITLPFDEQQGITDLGSLNQYTGEDITALVIAQPNFFGCLEQVDKMTSWAHHNKTISVAC
VNPTSLALLKPPGSWGEHGVDIVCGEGQPLGSPMASGGPYFGFLSTRMAHVRQMPGRIIGRTVDKDGKTGFSLTLQAREQ
HIRRAKATSNICTNQGLLVTAATIYMSLLGPEGLSQVATQCHQNTHELITALTQIEGVELAFKAPFFHEALIKLNQPVQY
VLQQLADAGIAGGYAPEQHYPQLANTLLVCATEVRTAEDIAKYAKTLKTIMSKRGA

Sequences:

>Translated_456_residues
MPYIPHTPNDTKEMLEAIGAQDIQDLFDEIPASLQYAGFQNIPAGINEMEMLKEAQNQAQKNRNGICFIGAGCYEHHIPA
AVWDIASRGEFLTAYTPYQAEASQGTLQLLYEYQTMICELTGMEVSNASMYDGATALAEAVLMAVRLNKHSKTNRVLIAG
TVHPFYRETIETIVRNQHIEVITLPFDEQQGITDLGSLNQYTGEDITALVIAQPNFFGCLEQVDKMTSWAHHNKTISVAC
VNPTSLALLKPPGSWGEHGVDIVCGEGQPLGSPMASGGPYFGFLSTRMAHVRQMPGRIIGRTVDKDGKTGFSLTLQAREQ
HIRRAKATSNICTNQGLLVTAATIYMSLLGPEGLSQVATQCHQNTHELITALTQIEGVELAFKAPFFHEALIKLNQPVQY
VLQQLADAGIAGGYAPEQHYPQLANTLLVCATEVRTAEDIAKYAKTLKTIMSKRGA
>Mature_455_residues
PYIPHTPNDTKEMLEAIGAQDIQDLFDEIPASLQYAGFQNIPAGINEMEMLKEAQNQAQKNRNGICFIGAGCYEHHIPAA
VWDIASRGEFLTAYTPYQAEASQGTLQLLYEYQTMICELTGMEVSNASMYDGATALAEAVLMAVRLNKHSKTNRVLIAGT
VHPFYRETIETIVRNQHIEVITLPFDEQQGITDLGSLNQYTGEDITALVIAQPNFFGCLEQVDKMTSWAHHNKTISVACV
NPTSLALLKPPGSWGEHGVDIVCGEGQPLGSPMASGGPYFGFLSTRMAHVRQMPGRIIGRTVDKDGKTGFSLTLQAREQH
IRRAKATSNICTNQGLLVTAATIYMSLLGPEGLSQVATQCHQNTHELITALTQIEGVELAFKAPFFHEALIKLNQPVQYV
LQQLADAGIAGGYAPEQHYPQLANTLLVCATEVRTAEDIAKYAKTLKTIMSKRGA

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=408, Percent_Identity=33.578431372549, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1789269, Length=371, Percent_Identity=35.3099730458221, Blast_Score=194, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17535605, Length=396, Percent_Identity=36.3636363636364, Blast_Score=210, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6323843, Length=413, Percent_Identity=32.4455205811138, Blast_Score=201, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24645648, Length=365, Percent_Identity=35.0684931506849, Blast_Score=226, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49898; Mature: 49766

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYIPHTPNDTKEMLEAIGAQDIQDLFDEIPASLQYAGFQNIPAGINEMEMLKEAQNQAQ
CCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHH
KNRNGICFIGAGCYEHHIPAAVWDIASRGEFLTAYTPYQAEASQGTLQLLYEYQTMICEL
HCCCCEEEEECCHHHHCCCHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
TGMEVSNASMYDGATALAEAVLMAVRLNKHSKTNRVLIAGTVHPFYRETIETIVRNQHIE
CCCEECCCCHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEE
VITLPFDEQQGITDLGSLNQYTGEDITALVIAQPNFFGCLEQVDKMTSWAHHNKTISVAC
EEEECCCCCCCCCHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEE
VNPTSLALLKPPGSWGEHGVDIVCGEGQPLGSPMASGGPYFGFLSTRMAHVRQMPGRIIG
ECCCEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHC
RTVDKDGKTGFSLTLQAREQHIRRAKATSNICTNQGLLVTAATIYMSLLGPEGLSQVATQ
CCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
CHQNTHELITALTQIEGVELAFKAPFFHEALIKLNQPVQYVLQQLADAGIAGGYAPEQHY
HHCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHH
PQLANTLLVCATEVRTAEDIAKYAKTLKTIMSKRGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PYIPHTPNDTKEMLEAIGAQDIQDLFDEIPASLQYAGFQNIPAGINEMEMLKEAQNQAQ
CCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHH
KNRNGICFIGAGCYEHHIPAAVWDIASRGEFLTAYTPYQAEASQGTLQLLYEYQTMICEL
HCCCCEEEEECCHHHHCCCHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
TGMEVSNASMYDGATALAEAVLMAVRLNKHSKTNRVLIAGTVHPFYRETIETIVRNQHIE
CCCEECCCCHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEE
VITLPFDEQQGITDLGSLNQYTGEDITALVIAQPNFFGCLEQVDKMTSWAHHNKTISVAC
EEEECCCCCCCCCHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEE
VNPTSLALLKPPGSWGEHGVDIVCGEGQPLGSPMASGGPYFGFLSTRMAHVRQMPGRIIG
ECCCEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHC
RTVDKDGKTGFSLTLQAREQHIRRAKATSNICTNQGLLVTAATIYMSLLGPEGLSQVATQ
CCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
CHQNTHELITALTQIEGVELAFKAPFFHEALIKLNQPVQYVLQQLADAGIAGGYAPEQHY
HHCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHH
PQLANTLLVCATEVRTAEDIAKYAKTLKTIMSKRGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA