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The map label for this gene is msrA [H]

Identifier: 148358261

GI number: 148358261

Start: 127823

End: 128413

Strand: Reverse

Name: msrA [H]

Synonym: LPC_0123

Alternate gene names: 148358261

Gene position: 128413-127823 (Counterclockwise)

Preceding gene: 148358262

Following gene: 148358260

Centisome position: 3.59

GC content: 36.21

Gene sequence:

>591_bases
ATGTTGCGTATCCTTTTGTATTTTCTCTTACTCATTAACACAACATTTTGTCTGGCAAAGACTGAAAAAGCCATTTTTGC
AGGTGGATGTTTTTGGTGCATGGAAGCAGACTTTGACCATCTTCCTGGAGTCCTGTCAACCACATCAGGATTTGATGGGG
ACACTCTTAAAAATCCAACTTATGAACAAGTTTCTGCCGGTAATACCCATTACGCCGAATCGGTAATGGTAGAGTTTGAT
CCCAATAAATTAAGTTACAAAAAACTGGTTGAGTATTTCTTTATGCATATTGATCCTACCGTCAAAAATGCGCAATTTTG
TGATCAGGGCCGCCAATATCGCAGTGCAATTTTTTACATGAATGATCAACAAAAGAAAATTGCCATGGAATACAAAAAAG
AGTTAGAGCAAAAATTCCCCACAATTTATACAGAAATTGTCCCATCAACTTCTTTTTATCCGGCAGAAGAATATCATCAA
AATTATTACAAAAAAAATCCTATACGTTATAAGTATTATCGATATCGTTGTGGCCGGGATGCCCGAGTTCAAGAGGTTTG
GGGTAATAAAAAACAAGAGAATAATTCTTAA

Upstream 100 bases:

>100_bases
ATAAATTTTCCGAAGCCTGATTTAAAACTTTCTCTGATTTTATGCTGACTCCAATACAAAATCTTGTATAATTTATAGCA
ATTCATAAAAGAGGCTTACA

Downstream 100 bases:

>100_bases
TCATGATCCATAGTTTTATCACTTATCAAAAAAGAATAAGCAAATCATGAGAAAACGCGCTAATCTAATAAATAATAATT
TTTCAATTTTTTACTAATAC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MLRILLYFLLLINTTFCLAKTEKAIFAGGCFWCMEADFDHLPGVLSTTSGFDGDTLKNPTYEQVSAGNTHYAESVMVEFD
PNKLSYKKLVEYFFMHIDPTVKNAQFCDQGRQYRSAIFYMNDQQKKIAMEYKKELEQKFPTIYTEIVPSTSFYPAEEYHQ
NYYKKNPIRYKYYRYRCGRDARVQEVWGNKKQENNS

Sequences:

>Translated_196_residues
MLRILLYFLLLINTTFCLAKTEKAIFAGGCFWCMEADFDHLPGVLSTTSGFDGDTLKNPTYEQVSAGNTHYAESVMVEFD
PNKLSYKKLVEYFFMHIDPTVKNAQFCDQGRQYRSAIFYMNDQQKKIAMEYKKELEQKFPTIYTEIVPSTSFYPAEEYHQ
NYYKKNPIRYKYYRYRCGRDARVQEVWGNKKQENNS
>Mature_196_residues
MLRILLYFLLLINTTFCLAKTEKAIFAGGCFWCMEADFDHLPGVLSTTSGFDGDTLKNPTYEQVSAGNTHYAESVMVEFD
PNKLSYKKLVEYFFMHIDPTVKNAQFCDQGRQYRSAIFYMNDQQKKIAMEYKKELEQKFPTIYTEIVPSTSFYPAEEYHQ
NYYKKNPIRYKYYRYRCGRDARVQEVWGNKKQENNS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=155, Percent_Identity=41.9354838709677, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI208609995, Length=155, Percent_Identity=41.9354838709677, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=40.1869158878505, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=41.4473684210526, Blast_Score=115, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=37.6712328767123, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=161, Percent_Identity=34.1614906832298, Blast_Score=89, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=35.1724137931034, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=35.2941176470588, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24664631, Length=145, Percent_Identity=34.4827586206897, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23189; Mature: 23189

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRILLYFLLLINTTFCLAKTEKAIFAGGCFWCMEADFDHLPGVLSTTSGFDGDTLKNPT
CHHHHHHHHHHHCCHHHHHHCCCCEEECCEEEEECCCHHHCCCCCCCCCCCCCCCCCCCC
YEQVSAGNTHYAESVMVEFDPNKLSYKKLVEYFFMHIDPTVKNAQFCDQGRQYRSAIFYM
HHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEE
NDQQKKIAMEYKKELEQKFPTIYTEIVPSTSFYPAEEYHQNYYKKNPIRYKYYRYRCGRD
CCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCC
ARVQEVWGNKKQENNS
CHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLRILLYFLLLINTTFCLAKTEKAIFAGGCFWCMEADFDHLPGVLSTTSGFDGDTLKNPT
CHHHHHHHHHHHCCHHHHHHCCCCEEECCEEEEECCCHHHCCCCCCCCCCCCCCCCCCCC
YEQVSAGNTHYAESVMVEFDPNKLSYKKLVEYFFMHIDPTVKNAQFCDQGRQYRSAIFYM
HHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEE
NDQQKKIAMEYKKELEQKFPTIYTEIVPSTSFYPAEEYHQNYYKKNPIRYKYYRYRCGRD
CCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCC
ARVQEVWGNKKQENNS
CHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA