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The map label for this gene is uvrB [H]

Identifier: 148358232

GI number: 148358232

Start: 89806

End: 91797

Strand: Direct

Name: uvrB [H]

Synonym: LPC_0094

Alternate gene names: 148358232

Gene position: 89806-91797 (Clockwise)

Preceding gene: 148358227

Following gene: 148358233

Centisome position: 2.51

GC content: 42.97

Gene sequence:

>1992_bases
ATGAAAGACTTATTTAAAATTTACTCAAATTACCAACCTGCCGGCGATCAACCTACAGCCATAGCCTCTTTGATTGATGG
TCTTGAATCAGGTTTAGCCAAACAAACATTATTAGGCGTTACCGGTTCTGGTAAAACATTTACTATAGCTCATGTTATTC
AAGCCATGAAAAGACCCACTTTGATCATGGCGCCGAACAAAACGCTTGCGGCTCAACTTTATGGAGAGTTTAAAGCCTTC
TTTCCTGATAATGCCGTAGAATATTTCGTTTCCTACTACGATTATTATCAGCCCGAAGCGTATGTGCCTGCTTCAGATAC
TTTTATAGAAAAGGATGCCTCCATTAATGAACACATAGAGCAGATGCGCTTGTCGGCAACCAAAGCGTTGATTGAACGCA
AAGATGCCATCATTGTAGCGACGGTTTCTGCCATTTATGGATTGGGCGACCCGGATTCCTATCTGCGTATGTTATTACAT
CTCTCCCGTGGAGAACAATCCGATCAGCGTAAAATTTTAAAGCGTCTTGCAGAAATGCAGTACACACGAACCAATCTCAG
CCTTGAGCGCGGTCAATTCCGGGTACATGGTGATGTCATTGATATTTTCCCGGCTGATTCCGAGAAAGAAGCGATAAGAA
TTGAGCTTTTTGACGATGAGGTTGATAATATTGCCCGCTTTGATCCTTTAACAGGAGAAATTTTACAGCGACTGCCCCGT
GTCACTATTTTTCCTAAAACTCATTATGTCACTCCCAGAGAACGTATTTTAGAAACAGTAGAAAAAGTAAAAGCAGAACT
ACAAGAAAGACTGGCTGAGTTGAATGCTCAAAATAAGTTGGTAGAAGCTCAGCGTTTGGAACAAAGAACTTGTTTTGATA
TTGAAATGATGTTGGAGCTGGGTTATTGCTCTGGCATTGAAAATTACTCGCGTTATTTATCCAACCGCGAAGCCGGGGAA
GCACCGCCTACTCTTTTTGATTATCTCCCACCCGATGCCTTGTTAATTATCGACGAATCGCATGTTACTGTTCCTCAAAT
AGGTGGAATGTATCGCGGAGACAGGGCGCGCAAGGAAACCTTGGTTAATTATGGATTTCGCCTGCCTTCTGCCTTGGATA
ATAGGCCTTTGCGTTTTGAAGAATTTGAAGAGCGTTCGCCGCAGACTATTTATATTTCAGCAACTCCAGGGCCTTATGAA
CAGGAACATTCGGATAATGTGGCTGAGCAAGTGGTAAGACCGACCGGATTGATTGATCCTGAGGTGGAAATCAGGCCGGT
AAAAACTCAGGTGGATGATCTTATGTCTGAAATCAGACAGGTGATCGCTCAGGGCAGCCGTATTCTTGTCACGACATTAA
CCAAACGCATGGCAGAGGATTTGACAGAGTATCTGAGTGAGCACGGGATCAAGGTGCGCTATTTGCATTCCGACGTCGAT
ACGGTTGAGCGCATGGAAATTATTCGTGATTTGCGTTTGGGTGAGTTTGATGTTCTGGTAGGGATTAATTTATTGCGTGA
AGGTCTTGATATGCCTGAGGTTGCTCTTGTTGCGATTTTGGACGCTGACAAGGAGGGTTTTTTGCGATCGGAGCGTTCTT
TAATTCAAACGATTGGCCGTGCAGCACGTAATGTGAAGGGGCGAGCTATTTTGTATGCCGATACCATGACCGGTTCGATG
CAAAGAGCATTGATGGAAACAGAGAGACGACGTGAAAAACAAAAGGCATTCAATTTGAAACATGGCATTACTCCCAAGGG
TATTAATAAATCAGTTGAGGATATTTTGGAGGGTGCCTATATCGGTAAACGAAAAACAATGGTTGCTGAACAAGCTCCCC
GATATACCCATTGGTCTCCTCAGGAATTGGCAAAACAGATTAATGCACTGGAAAAACAAATGTATGCTCATGCTCAAAAT
ATGGAATTTGAATTGGCAGCTAAAATTCGGGATGAATACCTGCTATTAAAAGAGCAGCTCATGAAGATATAA

Upstream 100 bases:

>100_bases
AAGGGTAGGTGAAGGTTTTACTTTTTGTACACGCTTTGCCAATGCGATATCCATCTGTTGCTCCTGTGAATTATAGGGGT
ACTAGCATATAATATAAAAT

Downstream 100 bases:

>100_bases
CCCGATGGGTACCGGATTTTGAACCCTTAGGTTCAAGTGGGCAGCGAATGCATCGGTTCAGGCTTCCCACTCTATTGGTG
GGCTTGCTCAACGCCGATAA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MKDLFKIYSNYQPAGDQPTAIASLIDGLESGLAKQTLLGVTGSGKTFTIAHVIQAMKRPTLIMAPNKTLAAQLYGEFKAF
FPDNAVEYFVSYYDYYQPEAYVPASDTFIEKDASINEHIEQMRLSATKALIERKDAIIVATVSAIYGLGDPDSYLRMLLH
LSRGEQSDQRKILKRLAEMQYTRTNLSLERGQFRVHGDVIDIFPADSEKEAIRIELFDDEVDNIARFDPLTGEILQRLPR
VTIFPKTHYVTPRERILETVEKVKAELQERLAELNAQNKLVEAQRLEQRTCFDIEMMLELGYCSGIENYSRYLSNREAGE
APPTLFDYLPPDALLIIDESHVTVPQIGGMYRGDRARKETLVNYGFRLPSALDNRPLRFEEFEERSPQTIYISATPGPYE
QEHSDNVAEQVVRPTGLIDPEVEIRPVKTQVDDLMSEIRQVIAQGSRILVTTLTKRMAEDLTEYLSEHGIKVRYLHSDVD
TVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVALVAILDADKEGFLRSERSLIQTIGRAARNVKGRAILYADTMTGSM
QRALMETERRREKQKAFNLKHGITPKGINKSVEDILEGAYIGKRKTMVAEQAPRYTHWSPQELAKQINALEKQMYAHAQN
MEFELAAKIRDEYLLLKEQLMKI

Sequences:

>Translated_663_residues
MKDLFKIYSNYQPAGDQPTAIASLIDGLESGLAKQTLLGVTGSGKTFTIAHVIQAMKRPTLIMAPNKTLAAQLYGEFKAF
FPDNAVEYFVSYYDYYQPEAYVPASDTFIEKDASINEHIEQMRLSATKALIERKDAIIVATVSAIYGLGDPDSYLRMLLH
LSRGEQSDQRKILKRLAEMQYTRTNLSLERGQFRVHGDVIDIFPADSEKEAIRIELFDDEVDNIARFDPLTGEILQRLPR
VTIFPKTHYVTPRERILETVEKVKAELQERLAELNAQNKLVEAQRLEQRTCFDIEMMLELGYCSGIENYSRYLSNREAGE
APPTLFDYLPPDALLIIDESHVTVPQIGGMYRGDRARKETLVNYGFRLPSALDNRPLRFEEFEERSPQTIYISATPGPYE
QEHSDNVAEQVVRPTGLIDPEVEIRPVKTQVDDLMSEIRQVIAQGSRILVTTLTKRMAEDLTEYLSEHGIKVRYLHSDVD
TVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVALVAILDADKEGFLRSERSLIQTIGRAARNVKGRAILYADTMTGSM
QRALMETERRREKQKAFNLKHGITPKGINKSVEDILEGAYIGKRKTMVAEQAPRYTHWSPQELAKQINALEKQMYAHAQN
MEFELAAKIRDEYLLLKEQLMKI
>Mature_663_residues
MKDLFKIYSNYQPAGDQPTAIASLIDGLESGLAKQTLLGVTGSGKTFTIAHVIQAMKRPTLIMAPNKTLAAQLYGEFKAF
FPDNAVEYFVSYYDYYQPEAYVPASDTFIEKDASINEHIEQMRLSATKALIERKDAIIVATVSAIYGLGDPDSYLRMLLH
LSRGEQSDQRKILKRLAEMQYTRTNLSLERGQFRVHGDVIDIFPADSEKEAIRIELFDDEVDNIARFDPLTGEILQRLPR
VTIFPKTHYVTPRERILETVEKVKAELQERLAELNAQNKLVEAQRLEQRTCFDIEMMLELGYCSGIENYSRYLSNREAGE
APPTLFDYLPPDALLIIDESHVTVPQIGGMYRGDRARKETLVNYGFRLPSALDNRPLRFEEFEERSPQTIYISATPGPYE
QEHSDNVAEQVVRPTGLIDPEVEIRPVKTQVDDLMSEIRQVIAQGSRILVTTLTKRMAEDLTEYLSEHGIKVRYLHSDVD
TVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVALVAILDADKEGFLRSERSLIQTIGRAARNVKGRAILYADTMTGSM
QRALMETERRREKQKAFNLKHGITPKGINKSVEDILEGAYIGKRKTMVAEQAPRYTHWSPQELAKQINALEKQMYAHAQN
MEFELAAKIRDEYLLLKEQLMKI

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=667, Percent_Identity=69.8650674662669, Blast_Score=930, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=317, Percent_Identity=21.4511041009464, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75638; Mature: 75638

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDLFKIYSNYQPAGDQPTAIASLIDGLESGLAKQTLLGVTGSGKTFTIAHVIQAMKRPT
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEHHHHHHHHCCCE
LIMAPNKTLAAQLYGEFKAFFPDNAVEYFVSYYDYYQPEAYVPASDTFIEKDASINEHIE
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCHHCCCCCHHHHHH
QMRLSATKALIERKDAIIVATVSAIYGLGDPDSYLRMLLHLSRGEQSDQRKILKRLAEMQ
HHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
YTRTNLSLERGQFRVHGDVIDIFPADSEKEAIRIELFDDEVDNIARFDPLTGEILQRLPR
HHHHCCEEECCCEEEECCEEEEECCCCCCCEEEEEEECCCHHHHHHCCCCHHHHHHHCCC
VTIFPKTHYVTPRERILETVEKVKAELQERLAELNAQNKLVEAQRLEQRTCFDIEMMLEL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
GYCSGIENYSRYLSNREAGEAPPTLFDYLPPDALLIIDESHVTVPQIGGMYRGDRARKET
HHHCCHHHHHHHHCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHH
LVNYGFRLPSALDNRPLRFEEFEERSPQTIYISATPGPYEQEHSDNVAEQVVRPTGLIDP
HHHHCCCCCHHHCCCCCCCHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCC
EVEIRPVKTQVDDLMSEIRQVIAQGSRILVTTLTKRMAEDLTEYLSEHGIKVRYLHSDVD
CCEEEEHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
TVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVALVAILDADKEGFLRSERSLIQTIGR
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
AARNVKGRAILYADTMTGSMQRALMETERRREKQKAFNLKHGITPKGINKSVEDILEGAY
HHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
IGKRKTMVAEQAPRYTHWSPQELAKQINALEKQMYAHAQNMEFELAAKIRDEYLLLKEQL
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
MKI
HCC
>Mature Secondary Structure
MKDLFKIYSNYQPAGDQPTAIASLIDGLESGLAKQTLLGVTGSGKTFTIAHVIQAMKRPT
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEHHHHHHHHCCCE
LIMAPNKTLAAQLYGEFKAFFPDNAVEYFVSYYDYYQPEAYVPASDTFIEKDASINEHIE
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCHHCCCCCHHHHHH
QMRLSATKALIERKDAIIVATVSAIYGLGDPDSYLRMLLHLSRGEQSDQRKILKRLAEMQ
HHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
YTRTNLSLERGQFRVHGDVIDIFPADSEKEAIRIELFDDEVDNIARFDPLTGEILQRLPR
HHHHCCEEECCCEEEECCEEEEECCCCCCCEEEEEEECCCHHHHHHCCCCHHHHHHHCCC
VTIFPKTHYVTPRERILETVEKVKAELQERLAELNAQNKLVEAQRLEQRTCFDIEMMLEL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
GYCSGIENYSRYLSNREAGEAPPTLFDYLPPDALLIIDESHVTVPQIGGMYRGDRARKET
HHHCCHHHHHHHHCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHH
LVNYGFRLPSALDNRPLRFEEFEERSPQTIYISATPGPYEQEHSDNVAEQVVRPTGLIDP
HHHHCCCCCHHHCCCCCCCHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCC
EVEIRPVKTQVDDLMSEIRQVIAQGSRILVTTLTKRMAEDLTEYLSEHGIKVRYLHSDVD
CCEEEEHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
TVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVALVAILDADKEGFLRSERSLIQTIGR
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
AARNVKGRAILYADTMTGSMQRALMETERRREKQKAFNLKHGITPKGINKSVEDILEGAY
HHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
IGKRKTMVAEQAPRYTHWSPQELAKQINALEKQMYAHAQNMEFELAAKIRDEYLLLKEQL
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
MKI
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA