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The map label for this gene is mdtN [H]

Identifier: 148358155

GI number: 148358155

Start: 19639

End: 20712

Strand: Direct

Name: mdtN [H]

Synonym: LPC_0016

Alternate gene names: 148358155

Gene position: 19639-20712 (Clockwise)

Preceding gene: 148358154

Following gene: 148358156

Centisome position: 0.55

GC content: 35.85

Gene sequence:

>1074_bases
GTGAAAGAGAAGTTTGCCACATGGTATAAAATAGCAACTAAACATATCCGGTTTTTCTTTAGTTATTCTATCCCTATGTT
TTTTAAAAAGGCCAAAAATTACATTAATCTTCCCATTATTGTCGTTGGCTTGGCTCTTATTATTGGTCTTTTTCATTTAT
TTTCCTATTTGATCCCTTTCACTGACAATGCGTTTGTTGTTACTAATGTGACCCCTGTAGCTGCTGATGTATCTGGTTTT
ATTACTGAAATCTATGTAAAGAATGGCCAAAAAGTAAAGAAGAACGATCCTATATTTAGCGTTTACAGGGTTCCTTATGA
GTTGGCTTATCAGCAAGCAATGGCTGATTACAAGGAAGGATTAAAAAAAATAGACGTATTTCAAAAGCAGATTGAAAGAA
CGGTTGCTTTGATTAAAGCAACGGACTCTGAGCTTGAAAAAGCTCAATTTGCTCTTGGCCTTAAAAAAAATAAGAACGTG
GCAGAAGCAGTATCTGTTCTTGAATTAAAAAATCTTGGTTATGATGTTTCTACTTTAAGTAATAAAAGAAATGCTCTGCA
ACAGGAAGTGGCGGTTTTGCAAGCCAAGATTGAACAACAAAGACATACTGTCGCCAGCCTTAAGGCAAAAATGGATAATG
CCAAGGTTAATCTTGATTTAACCATTGTCAGAGCTCCTGGTGATGGAGTGATAGATAATATGTATGTCTCTCCAAATACC
CCTATCGAGATCCATAAACCGGTGTTTTCTTTTATAGATACCGCAAATTATTATATCCAGGCTAATTTTAATGAAACGGA
CTTACGCAATGTACGTCAAGGTGATAAAGCGTATATTATTTTACGCATGTATTATTTTGACAAAATATTTCATGGGGTTG
TTGTCAACTCGTTATGGGCTGCTGAACGACAAAGCACTGCTCCAAAGAGTCAAATTCAGGTTGTTACAAATCAAAATGAA
TGGCTGTTGCTTCCTCAGCGATTTCCATTACAAATCAAGATATTGGATCCCGATCCTGACTATCCTTTAAATCCTGGCGC
CAGTGCTTATGTTTATATCTCAACTAAAAGATAA

Upstream 100 bases:

>100_bases
TTTAATGCTGAAATAGGGGAGGGCCTTGTCGTGGGGTTTCTCTCTTTGAGAGATAAACTGATGTTGTATCATAGAGTCAT
CATCAAAGAGGCGCTGCATT

Downstream 100 bases:

>100_bases
GCTTGCATCCTACGATAGGTATAAAGAGCATCGTATTAACGGATTAAAAGCAGTGTTTGTTTTGGAACTGATGATTTTAT
TTTACTTTTTTTCCTCCATT

Product: multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKEKFATWYKIATKHIRFFFSYSIPMFFKKAKNYINLPIIVVGLALIIGLFHLFSYLIPFTDNAFVVTNVTPVAADVSGF
ITEIYVKNGQKVKKNDPIFSVYRVPYELAYQQAMADYKEGLKKIDVFQKQIERTVALIKATDSELEKAQFALGLKKNKNV
AEAVSVLELKNLGYDVSTLSNKRNALQQEVAVLQAKIEQQRHTVASLKAKMDNAKVNLDLTIVRAPGDGVIDNMYVSPNT
PIEIHKPVFSFIDTANYYIQANFNETDLRNVRQGDKAYIILRMYYFDKIFHGVVVNSLWAAERQSTAPKSQIQVVTNQNE
WLLLPQRFPLQIKILDPDPDYPLNPGASAYVYISTKR

Sequences:

>Translated_357_residues
MKEKFATWYKIATKHIRFFFSYSIPMFFKKAKNYINLPIIVVGLALIIGLFHLFSYLIPFTDNAFVVTNVTPVAADVSGF
ITEIYVKNGQKVKKNDPIFSVYRVPYELAYQQAMADYKEGLKKIDVFQKQIERTVALIKATDSELEKAQFALGLKKNKNV
AEAVSVLELKNLGYDVSTLSNKRNALQQEVAVLQAKIEQQRHTVASLKAKMDNAKVNLDLTIVRAPGDGVIDNMYVSPNT
PIEIHKPVFSFIDTANYYIQANFNETDLRNVRQGDKAYIILRMYYFDKIFHGVVVNSLWAAERQSTAPKSQIQVVTNQNE
WLLLPQRFPLQIKILDPDPDYPLNPGASAYVYISTKR
>Mature_357_residues
MKEKFATWYKIATKHIRFFFSYSIPMFFKKAKNYINLPIIVVGLALIIGLFHLFSYLIPFTDNAFVVTNVTPVAADVSGF
ITEIYVKNGQKVKKNDPIFSVYRVPYELAYQQAMADYKEGLKKIDVFQKQIERTVALIKATDSELEKAQFALGLKKNKNV
AEAVSVLELKNLGYDVSTLSNKRNALQQEVAVLQAKIEQQRHTVASLKAKMDNAKVNLDLTIVRAPGDGVIDNMYVSPNT
PIEIHKPVFSFIDTANYYIQANFNETDLRNVRQGDKAYIILRMYYFDKIFHGVVVNSLWAAERQSTAPKSQIQVVTNQNE
WLLLPQRFPLQIKILDPDPDYPLNPGASAYVYISTKR

Specific function: Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790519, Length=312, Percent_Identity=28.2051282051282, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789637, Length=327, Percent_Identity=26.9113149847095, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790024, Length=268, Percent_Identity=25.7462686567164, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790012, Length=292, Percent_Identity=26.7123287671233, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081951, Length=324, Percent_Identity=22.5308641975309, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789041, Length=323, Percent_Identity=24.4582043343653, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788711, Length=311, Percent_Identity=24.4372990353698, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40724; Mature: 40724

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKFATWYKIATKHIRFFFSYSIPMFFKKAKNYINLPIIVVGLALIIGLFHLFSYLIPF
CCCHHHHHHHHHHHHHHEEHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
TDNAFVVTNVTPVAADVSGFITEIYVKNGQKVKKNDPIFSVYRVPYELAYQQAMADYKEG
CCCEEEEEECCHHHHHHHHHHHEEEECCCCEECCCCCEEEEECCCHHHHHHHHHHHHHHH
LKKIDVFQKQIERTVALIKATDSELEKAQFALGLKKNKNVAEAVSVLELKNLGYDVSTLS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHH
NKRNALQQEVAVLQAKIEQQRHTVASLKAKMDNAKVNLDLTIVRAPGDGVIDNMYVSPNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCEEECCCC
PIEIHKPVFSFIDTANYYIQANFNETDLRNVRQGDKAYIILRMYYFDKIFHGVVVNSLWA
CEEEHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHH
AERQSTAPKSQIQVVTNQNEWLLLPQRFPLQIKILDPDPDYPLNPGASAYVYISTKR
HHHHCCCCCCCEEEEECCCCEEEECCCCCEEEEEECCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MKEKFATWYKIATKHIRFFFSYSIPMFFKKAKNYINLPIIVVGLALIIGLFHLFSYLIPF
CCCHHHHHHHHHHHHHHEEHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
TDNAFVVTNVTPVAADVSGFITEIYVKNGQKVKKNDPIFSVYRVPYELAYQQAMADYKEG
CCCEEEEEECCHHHHHHHHHHHEEEECCCCEECCCCCEEEEECCCHHHHHHHHHHHHHHH
LKKIDVFQKQIERTVALIKATDSELEKAQFALGLKKNKNVAEAVSVLELKNLGYDVSTLS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHH
NKRNALQQEVAVLQAKIEQQRHTVASLKAKMDNAKVNLDLTIVRAPGDGVIDNMYVSPNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCEEECCCC
PIEIHKPVFSFIDTANYYIQANFNETDLRNVRQGDKAYIILRMYYFDKIFHGVVVNSLWA
CEEEHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHH
AERQSTAPKSQIQVVTNQNEWLLLPQRFPLQIKILDPDPDYPLNPGASAYVYISTKR
HHHHCCCCCCCEEEEECCCCEEEECCCCCEEEEEECCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]