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The map label for this gene is fabD [H]

Identifier: 148284428

GI number: 148284428

Start: 721745

End: 722683

Strand: Direct

Name: fabD [H]

Synonym: OTBS_0743

Alternate gene names: 148284428

Gene position: 721745-722683 (Clockwise)

Preceding gene: 148284426

Following gene: 148284431

Centisome position: 33.93

GC content: 33.97

Gene sequence:

>939_bases
ATGTATACAGTATTTGTTTTTCCTGGTCAAGGAGTACAATTTGTTGGTATGGGAAAAGACTTATATGATAATTTTCCTGT
AGCTAGAGATGTTTTTCATGAGGTAAACGATATTATTGCAGAAAAATTAACTGATATTATATTTAATGGTCCTATCAGTA
CTCTAACATTAACTAAGAATGCTCAACTAGCAATTATTGCAGTTTCAATGGCAATAATTAGAGTATTGGAGCAACAAGCT
ACTATGGAATGTTATCAAATGGCAGATTATGTAGCTGGCCATTCTTTGGGTGAATACAGCGCACTGTGCGCAGCTGGTGC
TTTATCATTAGATGAAGTTACGAAGATACTTAAGGTTAGAGCTAATGCTATGCATGCTGTAGCATCTAGATGTGATGGTA
GTATGGCGGCTTGTCTTGGTGTTACCATGGAAGAATTAAATCCAATTCTTGACTATTGTTCCACTATAGGAGTCTGCGAA
ATTGCTAATGACAATATATTGGGGCAAGTAGTTATTAGTGGTCATACTACTGCAATTAACTTAGCAATGAATATGTTGCG
CGCTAAAGGCAAGAGAGCTATCAAATTAAACGTAAGTGGTCCTTTTCACTGTTCGCTAATGGCAGATGCTACAAGCATAT
TTAGGCAAGCTATTGATAAAGTAAATATTCAACCTACCAAAATGATTGTTGTAGCTAATTACAGCGCTAATATTGTTACT
ACGCCTATTGATATTAAAAATTGCCTAATAAGACAGATTGAAGGGAAAGTAAGGTGGCGAGAAACTTTAGATTTACTACA
ACAAAAAAATGTTAGTAGACTAATTGAAATAGGTCCTGGCAAAGTTTTAATTAATCTAGCAAAAAAAGGGCAGTATACTT
TTAAATGTAGTAGCATCAATTCAATATTTGAAATTGATGCTTTCTTAAATAATATATAG

Upstream 100 bases:

>100_bases
GAGTACAATAAATAAATATTGATAACAACAGTAAAAAAGATTAACTTAATGATTTTCATATTTAATATCCAACTCTAGAA
TATATAACAAAAGAATATCT

Downstream 100 bases:

>100_bases
CATTTTTTTAATTGAAAATTGAAGCATAAAAAATTATATTGCTATAACTTAAACTTATGCAAAAACAATAAAAAGCGTCT
AGAATCTAAGCTTCAGTTTA

Product: acyl-carrier-protein S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MYTVFVFPGQGVQFVGMGKDLYDNFPVARDVFHEVNDIIAEKLTDIIFNGPISTLTLTKNAQLAIIAVSMAIIRVLEQQA
TMECYQMADYVAGHSLGEYSALCAAGALSLDEVTKILKVRANAMHAVASRCDGSMAACLGVTMEELNPILDYCSTIGVCE
IANDNILGQVVISGHTTAINLAMNMLRAKGKRAIKLNVSGPFHCSLMADATSIFRQAIDKVNIQPTKMIVVANYSANIVT
TPIDIKNCLIRQIEGKVRWRETLDLLQQKNVSRLIEIGPGKVLINLAKKGQYTFKCSSINSIFEIDAFLNNI

Sequences:

>Translated_312_residues
MYTVFVFPGQGVQFVGMGKDLYDNFPVARDVFHEVNDIIAEKLTDIIFNGPISTLTLTKNAQLAIIAVSMAIIRVLEQQA
TMECYQMADYVAGHSLGEYSALCAAGALSLDEVTKILKVRANAMHAVASRCDGSMAACLGVTMEELNPILDYCSTIGVCE
IANDNILGQVVISGHTTAINLAMNMLRAKGKRAIKLNVSGPFHCSLMADATSIFRQAIDKVNIQPTKMIVVANYSANIVT
TPIDIKNCLIRQIEGKVRWRETLDLLQQKNVSRLIEIGPGKVLINLAKKGQYTFKCSSINSIFEIDAFLNNI
>Mature_312_residues
MYTVFVFPGQGVQFVGMGKDLYDNFPVARDVFHEVNDIIAEKLTDIIFNGPISTLTLTKNAQLAIIAVSMAIIRVLEQQA
TMECYQMADYVAGHSLGEYSALCAAGALSLDEVTKILKVRANAMHAVASRCDGSMAACLGVTMEELNPILDYCSTIGVCE
IANDNILGQVVISGHTTAINLAMNMLRAKGKRAIKLNVSGPFHCSLMADATSIFRQAIDKVNIQPTKMIVVANYSANIVT
TPIDIKNCLIRQIEGKVRWRETLDLLQQKNVSRLIEIGPGKVLINLAKKGQYTFKCSSINSIFEIDAFLNNI

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=296, Percent_Identity=31.7567567567568, Blast_Score=138, Evalue=7e-33,
Organism=Escherichia coli, GI1787334, Length=316, Percent_Identity=32.9113924050633, Blast_Score=155, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71984332, Length=296, Percent_Identity=30.7432432432432, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17550940, Length=294, Percent_Identity=24.8299319727891, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24665753, Length=313, Percent_Identity=33.2268370607029, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 34098; Mature: 34098

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTVFVFPGQGVQFVGMGKDLYDNFPVARDVFHEVNDIIAEKLTDIIFNGPISTLTLTKN
CEEEEEECCCCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
AQLAIIAVSMAIIRVLEQQATMECYQMADYVAGHSLGEYSALCAAGALSLDEVTKILKVR
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHH
ANAMHAVASRCDGSMAACLGVTMEELNPILDYCSTIGVCEIANDNILGQVVISGHTTAIN
HHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCHHHH
LAMNMLRAKGKRAIKLNVSGPFHCSLMADATSIFRQAIDKVNIQPTKMIVVANYSANIVT
HHHHHHHHCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEE
TPIDIKNCLIRQIEGKVRWRETLDLLQQKNVSRLIEIGPGKVLINLAKKGQYTFKCSSIN
CCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCEEEEEEECCCCEEEEECCCC
SIFEIDAFLNNI
HHHHHHHHHHCC
>Mature Secondary Structure
MYTVFVFPGQGVQFVGMGKDLYDNFPVARDVFHEVNDIIAEKLTDIIFNGPISTLTLTKN
CEEEEEECCCCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
AQLAIIAVSMAIIRVLEQQATMECYQMADYVAGHSLGEYSALCAAGALSLDEVTKILKVR
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHH
ANAMHAVASRCDGSMAACLGVTMEELNPILDYCSTIGVCEIANDNILGQVVISGHTTAIN
HHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCHHHH
LAMNMLRAKGKRAIKLNVSGPFHCSLMADATSIFRQAIDKVNIQPTKMIVVANYSANIVT
HHHHHHHHCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEE
TPIDIKNCLIRQIEGKVRWRETLDLLQQKNVSRLIEIGPGKVLINLAKKGQYTFKCSSIN
CCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCEEEEEEECCCCEEEEECCCC
SIFEIDAFLNNI
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]