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The map label for this gene is hisA

Identifier: 148269107

GI number: 148269107

Start: 2870705

End: 2871409

Strand: Reverse

Name: hisA

Synonym: SaurJH9_2698

Alternate gene names: 148269107

Gene position: 2871409-2870705 (Counterclockwise)

Preceding gene: 148269108

Following gene: 148269106

Centisome position: 98.79

GC content: 38.87

Gene sequence:

>705_bases
ATGATTGAATTATGGCCAGCGATTGATTTGATTGGGTCAACAAGTGTGAGGTTAACAGAGGGTAAATATGATAGTGAAGA
AAAAATGTCGCGTTCGGCTGAAGAAAGTATTGCTTACTATAGTCAATTTGAATGTGTGAATCGTATTCATATCGTCGACT
TGATAGGTGCTAAGGCACAGTATGCCCGAGAGTTTGATTATATTAAGTCATTGAGGAGATTAACAACCAAAGATATTGAA
GTAGGTGGTGGCATTCGTACGAAGTCACAAATCATGGACTACTTTGCCGCAGGGATTAATTATTGCATAGTTGGAACGAA
AGGCATTCAAGATACTGATTGGCTTAAAGAGATGGCACATACATTTCCAGGTCGTATTTATCTGTCAGTTGATGCTTATG
GAGAAGATATTAAAGTGAACGGATGGGAAGAGGACACAGAGTTAAATTTATTTAGTTTTGTGAGACAGTTATCGGATATA
CCTCTTGGAGGCATTATATATACTGATATTGCTAAAGATGGCAAAATGTCCGGACCTAACTTTGAATTAACTGGTCAATT
AGTAAAGGCAACGACGATTCCTGTCATTGCTTCCGGTGGTATTAGACATCAGCAAGATATTCAACGATTAGCGTCGCTAA
ATGTTCACGCTGCTATTATAGGAAAGGCTGCACATCAAGCATCTTTTTGGGAGGGGCTAGAATGA

Upstream 100 bases:

>100_bases
GTTCAATTTAACAATTATATTGGTATTCAATTCCATCCTGAAAAAAGCGGTACATATGGGTTACAAATTTTGCGTCAGGC
AATACAAGGGGGATTTATAA

Downstream 100 bases:

>100_bases
TTAAAAAACGTATCATTCCATGTTTAGATGTCAAAGATGGTCGTGTCGTTAAAGGGATTCAATTTAAAGGATTAAGGGAT
ATAGGGAATCCTGTTGATTT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MIELWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQYAREFDYIKSLRRLTTKDIE
VGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAHTFPGRIYLSVDAYGEDIKVNGWEEDTELNLFSFVRQLSDI
PLGGIIYTDIAKDGKMSGPNFELTGQLVKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASFWEGLE

Sequences:

>Translated_234_residues
MIELWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQYAREFDYIKSLRRLTTKDIE
VGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAHTFPGRIYLSVDAYGEDIKVNGWEEDTELNLFSFVRQLSDI
PLGGIIYTDIAKDGKMSGPNFELTGQLVKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASFWEGLE
>Mature_234_residues
MIELWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQYAREFDYIKSLRRLTTKDIE
VGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAHTFPGRIYLSVDAYGEDIKVNGWEEDTELNLFSFVRQLSDI
PLGGIIYTDIAKDGKMSGPNFELTGQLVKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASFWEGLE

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=231, Percent_Identity=27.2727272727273, Blast_Score=98, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_STAA1 (A7X764)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001443248.1
- ProteinModelPortal:   A7X764
- SMR:   A7X764
- STRING:   A7X764
- EnsemblBacteria:   EBSTAT00000005394
- GeneID:   5560324
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_2658
- eggNOG:   COG0106
- GeneTree:   EBGT00050000024239
- HOGENOM:   HBG541613
- OMA:   LLAINGW
- ProtClustDB:   PRK13587
- BioCyc:   SAUR418127:SAHV_2658-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26090; Mature: 26090

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: ACT_SITE 9-9 ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQ
CCCCCCHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHCCHHH
YAREFDYIKSLRRLTTKDIEVGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAH
HHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH
TFPGRIYLSVDAYGEDIKVNGWEEDTELNLFSFVRQLSDIPLGGIIYTDIAKDGKMSGPN
HCCCEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCC
FELTGQLVKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASFWEGLE
EEEEEEEEEHEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIELWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQ
CCCCCCHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHCCHHH
YAREFDYIKSLRRLTTKDIEVGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAH
HHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH
TFPGRIYLSVDAYGEDIKVNGWEEDTELNLFSFVRQLSDIPLGGIIYTDIAKDGKMSGPN
HCCCEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCC
FELTGQLVKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASFWEGLE
EEEEEEEEEHEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA