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The map label for this gene is mvaA [H]

Identifier: 148268978

GI number: 148268978

Start: 2716003

End: 2717280

Strand: Reverse

Name: mvaA [H]

Synonym: SaurJH9_2568

Alternate gene names: 148268978

Gene position: 2717280-2716003 (Counterclockwise)

Preceding gene: 148268980

Following gene: 148268975

Centisome position: 93.48

GC content: 39.28

Gene sequence:

>1278_bases
ATGCAAAGTTTAGATAAGAATTTCCGACATTTATCTCGTCAACAAAAGTTACAACAATTGGTAGATAAGCAATGGTTATC
AGAAGATCAATTCGACATTTTATTGAATCATCCATTAATTGATGAGGAAGTAGCAAATAGTTTAATTGAAAATGTCATCG
CGCAAGGTGCATTACCCGTTGGATTATTACCGAATATCATTGTGGACGATAAGGCATATGTTGTACCTATGATGGTGGAA
GAGCCTTCAGTTGTCGCTGCAGCTAGTTATGGTGCAAAGCTAGTGAATCAGACTGGCGGATTTAAAACGGTATCTTCTGA
ACGTATTATGATAGGTCAAATCGTCTTTGATGGCGTTGACGATACTGAAAAATTATCAGCAGACATTAAAGCTTTAGAAA
AGCAAATTCATAAAATTGCGGATGAGGCATATCCTTCTATTAAAGCGCGTGGTGGTGGTTACCAACGTATAGCTATTGAT
ACATTTCCTGAGCAACAGTTACTATCTTTAAAAGTATTTGTTGATACGAAAGATGCTATGGGCGCTAATATGCTTAATAC
GATTTTAGAGGCCATAACTGCATTTTTAAAAAATGAATCTCCACAAAGCGACATTTTAATGAGTATTTTATCCAATCATG
CAACAGCGTCCGTTGTTAAAGTTCAAGGCGAAATTGACGTTAAAGATTTAGCAAGGGGCGAGAGAACTGGAGAAGAGGTT
GCCAAACGAATGGAACGTGCTTCTGTATTGGCACAAGTTGATATTCATCGTGCTGCAACACATAATAAAGGTGTTATGAA
TGGCATACATGCCGTTGTTTTAGCAACAGGAAATGATACGCGTGGTGCAGAAGCAAGTGCGCATGCATACGCGAGTCGTG
ACGGACAGTATCGTGGTATTGCAACATGGAGATACGATCAAAAACGTCAACGTTTAATTGGTACAATAGAAGTGCCTATG
ACATTGGCAATCGTTGGCGGTGGTACAAAAGTATTACCAATTGCTAAAGCTTCTTTAGAATTGCTAAATGTAGATTCAGC
ACAAGAATTAGGTCATGTAGTTGCTGCCGTTGGTTTAGCACAGAACTTTGCAGCATGTCGCGCGCTCGTTTCCGAAGGTA
TCCAGCAAGGCCATATGAGCTTGCAATATAAATCTTTAGCTATTGTTGTAGGTGCAAAAGGTGATGAAATTGCGCAAGTA
GCTGAAGCATTGAAGCAAGAACCCCGTGCGAATACACAAGTAGCTGAACGCATTTTACAAGAAATTAGACAACAATAG

Upstream 100 bases:

>100_bases
AATTATTCAATTGAATTTTAAGACGAATAACGTTATTTTATGGTAAAAATAGTAGTGATTGAAATGTTAAAAAATTATGT
GAAGTAAAAGGAGTATGTCC

Downstream 100 bases:

>100_bases
TAAATGGCGAATAGCGATTTTAAAGAAAAGTTTAAGTCAGTCCATCGTAGCGCTTAGATAAATTAATATGAACAAAAAAT
AAAAACTTCTATCACACGCA

Product: hydroxymethylglutaryl-CoA reductase, degradative

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MQSLDKNFRHLSRQQKLQQLVDKQWLSEDQFDILLNHPLIDEEVANSLIENVIAQGALPVGLLPNIIVDDKAYVVPMMVE
EPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVDDTEKLSADIKALEKQIHKIADEAYPSIKARGGGYQRIAID
TFPEQQLLSLKVFVDTKDAMGANMLNTILEAITAFLKNESPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASRDGQYRGIATWRYDQKRQRLIGTIEVPM
TLAIVGGGTKVLPIAKASLELLNVDSAQELGHVVAAVGLAQNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAQV
AEALKQEPRANTQVAERILQEIRQQ

Sequences:

>Translated_425_residues
MQSLDKNFRHLSRQQKLQQLVDKQWLSEDQFDILLNHPLIDEEVANSLIENVIAQGALPVGLLPNIIVDDKAYVVPMMVE
EPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVDDTEKLSADIKALEKQIHKIADEAYPSIKARGGGYQRIAID
TFPEQQLLSLKVFVDTKDAMGANMLNTILEAITAFLKNESPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASRDGQYRGIATWRYDQKRQRLIGTIEVPM
TLAIVGGGTKVLPIAKASLELLNVDSAQELGHVVAAVGLAQNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAQV
AEALKQEPRANTQVAERILQEIRQQ
>Mature_425_residues
MQSLDKNFRHLSRQQKLQQLVDKQWLSEDQFDILLNHPLIDEEVANSLIENVIAQGALPVGLLPNIIVDDKAYVVPMMVE
EPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVDDTEKLSADIKALEKQIHKIADEAYPSIKARGGGYQRIAID
TFPEQQLLSLKVFVDTKDAMGANMLNTILEAITAFLKNESPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASRDGQYRGIATWRYDQKRQRLIGTIEVPM
TLAIVGGGTKVLPIAKASLELLNVDSAQELGHVVAAVGLAQNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAQV
AEALKQEPRANTQVAERILQEIRQQ

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323483, Length=392, Percent_Identity=25.765306122449, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323565, Length=374, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 46181; Mature: 46181

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSLDKNFRHLSRQQKLQQLVDKQWLSEDQFDILLNHPLIDEEVANSLIENVIAQGALPV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCC
GLLPNIIVDDKAYVVPMMVEEPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVD
CCCCCEEECCCCEEEEEEECCCCEEEEHHHHHHHHHCCCCCEEECCCCEEEEEEEECCCC
DTEKLSADIKALEKQIHKIADEAYPSIKARGGGYQRIAIDTFPEQQLLSLKVFVDTKDAM
CHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEECCCCHHHEEEEEEEECCHHC
GANMLNTILEAITAFLKNESPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHCCCCCHHHH
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASRDGQYRGI
HHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEEEEEECCCCCCCCCHHHHHHCCCCCCCCE
ATWRYDQKRQRLIGTIEVPMTLAIVGGGTKVLPIAKASLELLNVDSAQELGHVVAAVGLA
EEEECHHHHHHHHEEEECCEEEEEECCCCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHH
QNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAQVAEALKQEPRANTQVAERILQ
HHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHH
EIRQQ
HHHCC
>Mature Secondary Structure
MQSLDKNFRHLSRQQKLQQLVDKQWLSEDQFDILLNHPLIDEEVANSLIENVIAQGALPV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCC
GLLPNIIVDDKAYVVPMMVEEPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVD
CCCCCEEECCCCEEEEEEECCCCEEEEHHHHHHHHHCCCCCEEECCCCEEEEEEEECCCC
DTEKLSADIKALEKQIHKIADEAYPSIKARGGGYQRIAIDTFPEQQLLSLKVFVDTKDAM
CHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEECCCCHHHEEEEEEEECCHHC
GANMLNTILEAITAFLKNESPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHCCCCCHHHH
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASRDGQYRGI
HHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEEEEEECCCCCCCCCHHHHHHCCCCCCCCE
ATWRYDQKRQRLIGTIEVPMTLAIVGGGTKVLPIAKASLELLNVDSAQELGHVVAAVGLA
EEEECHHHHHHHHEEEECCEEEEEECCCCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHH
QNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAQVAEALKQEPRANTQVAERILQ
HHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHH
EIRQQ
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]