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The map label for this gene is pcaR [H]

Identifier: 148261189

GI number: 148261189

Start: 2429554

End: 2430375

Strand: Reverse

Name: pcaR [H]

Synonym: Acry_2199

Alternate gene names: 148261189

Gene position: 2430375-2429554 (Counterclockwise)

Preceding gene: 148261190

Following gene: 148261183

Centisome position: 71.71

GC content: 72.51

Gene sequence:

>822_bases
ATGTCGTCCCTGTCCGCCGATTCCATCCAGCCCGCCCCGCCGGCCGCCGCGCCGGCCAATCCGCGCGACCATGTCGAGAG
TTTCGCCCGCGGCCTTGCCATCCTCTGCGCCTTCGGGCCGGACCGGCCGAAAATGACCCTGTCGGACGCCGCCCGCGTCA
CCGGGTTGCAGCGCTCGGCGGCGCGGCGGTTCCTGCTCACCCTGTGCGATCTCGGCTACGCCGTGCAGACCGACCGGTGG
TTCGCGCTCACCCCGCGCGTGCTGGAACTCGGTTACGCCTATCTCGGCAGCCTGCGCTTTCCCGAACTCATCGAACCCTA
TCTGACCGGGCTGACCCGCGAGCTCGGCGAATCGAGCTCGGCGGCGGTGCTGGACGGGACCGACATCGTGTACGTCGCGC
GCTCGGCGGCGCCGCAGCGGCTGATGGCGCTGTCGCTCGGGGTCGGCACCAGGCTGCCGGCGCATGCGACCTCGATGGGC
CAGGCGCTGCTCGCCACCCTGAGCGATGACGAGGTGCGCGCCCGGTACGGGCGGGCGCCGTTGCAGGGGTTCACGCCCGC
GACCATCACCGATGTCGGCCGGCTGCTCGAACGGCTGGCGACGGTGCGGCGGGACGGGTTCGCGCTGAACGACCAGGAAC
TCGAATTCGGCCTGCGCTCGGTCGCGGTGGCGGTGCCGGGCAAGGGGCAGCGGCAGGCGGTGGCGCTGAATGTCGCCACC
AACGCGGCGCGGGTGTCGCATGAGGAGGTGATGCGCCGCATCCTGCCCGCGATTCGCGAGGCGGCGGCGCAATGCGCGCG
GGCGGTCGCCCTGCTCGGCTGA

Upstream 100 bases:

>100_bases
AAACCGCAAGGACGCTTTCCGCAAGACGCATGTTTGCGATTCCCCGGCGCGCCGGTCCGCCATCTTGCAAGCGCGGGGCA
GATGGGCGCAGAACGCACGA

Downstream 100 bases:

>100_bases
GCGGGCGCGCCTGACGGGATCATCATCGGGACCGGACGAGCGGCGGGGCGCGGTTGCGCCGGCGCGGCGGCGCGCAGGCG
GCGGGCGGGCGGAACCGGCG

Product: beta-ketoadipate pathway transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MSSLSADSIQPAPPAAAPANPRDHVESFARGLAILCAFGPDRPKMTLSDAARVTGLQRSAARRFLLTLCDLGYAVQTDRW
FALTPRVLELGYAYLGSLRFPELIEPYLTGLTRELGESSSAAVLDGTDIVYVARSAAPQRLMALSLGVGTRLPAHATSMG
QALLATLSDDEVRARYGRAPLQGFTPATITDVGRLLERLATVRRDGFALNDQELEFGLRSVAVAVPGKGQRQAVALNVAT
NAARVSHEEVMRRILPAIREAAAQCARAVALLG

Sequences:

>Translated_273_residues
MSSLSADSIQPAPPAAAPANPRDHVESFARGLAILCAFGPDRPKMTLSDAARVTGLQRSAARRFLLTLCDLGYAVQTDRW
FALTPRVLELGYAYLGSLRFPELIEPYLTGLTRELGESSSAAVLDGTDIVYVARSAAPQRLMALSLGVGTRLPAHATSMG
QALLATLSDDEVRARYGRAPLQGFTPATITDVGRLLERLATVRRDGFALNDQELEFGLRSVAVAVPGKGQRQAVALNVAT
NAARVSHEEVMRRILPAIREAAAQCARAVALLG
>Mature_272_residues
SSLSADSIQPAPPAAAPANPRDHVESFARGLAILCAFGPDRPKMTLSDAARVTGLQRSAARRFLLTLCDLGYAVQTDRWF
ALTPRVLELGYAYLGSLRFPELIEPYLTGLTRELGESSSAAVLDGTDIVYVARSAAPQRLMALSLGVGTRLPAHATSMGQ
ALLATLSDDEVRARYGRAPLQGFTPATITDVGRLLERLATVRRDGFALNDQELEFGLRSVAVAVPGKGQRQAVALNVATN
AARVSHEEVMRRILPAIREAAAQCARAVALLG

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786468, Length=248, Percent_Identity=31.4516129032258, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI87082359, Length=240, Percent_Identity=29.1666666666667, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788131, Length=247, Percent_Identity=28.7449392712551, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786715, Length=237, Percent_Identity=24.8945147679325, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789999, Length=241, Percent_Identity=22.4066390041494, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29134; Mature: 29003

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLSADSIQPAPPAAAPANPRDHVESFARGLAILCAFGPDRPKMTLSDAARVTGLQRSA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEEECCCCCCCEEHHHHHHHHHHHHHH
ARRFLLTLCDLGYAVQTDRWFALTPRVLELGYAYLGSLRFPELIEPYLTGLTRELGESSS
HHHHHHHHHHCCCEECCCCEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
AAVLDGTDIVYVARSAAPQRLMALSLGVGTRLPAHATSMGQALLATLSDDEVRARYGRAP
CEEECCCCEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCC
LQGFTPATITDVGRLLERLATVRRDGFALNDQELEFGLRSVAVAVPGKGQRQAVALNVAT
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEECCCCCCCEEEEEEEEH
NAARVSHEEVMRRILPAIREAAAQCARAVALLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSLSADSIQPAPPAAAPANPRDHVESFARGLAILCAFGPDRPKMTLSDAARVTGLQRSA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEEECCCCCCCEEHHHHHHHHHHHHHH
ARRFLLTLCDLGYAVQTDRWFALTPRVLELGYAYLGSLRFPELIEPYLTGLTRELGESSS
HHHHHHHHHHCCCEECCCCEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
AAVLDGTDIVYVARSAAPQRLMALSLGVGTRLPAHATSMGQALLATLSDDEVRARYGRAP
CEEECCCCEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCC
LQGFTPATITDVGRLLERLATVRRDGFALNDQELEFGLRSVAVAVPGKGQRQAVALNVAT
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEECCCCCCCEEEEEEEEH
NAARVSHEEVMRRILPAIREAAAQCARAVALLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]