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The map label for this gene is envZ [H]

Identifier: 148261168

GI number: 148261168

Start: 2403597

End: 2404961

Strand: Reverse

Name: envZ [H]

Synonym: Acry_2178

Alternate gene names: 148261168

Gene position: 2404961-2403597 (Counterclockwise)

Preceding gene: 148261169

Following gene: 148261167

Centisome position: 70.96

GC content: 71.06

Gene sequence:

>1365_bases
ATGACCCTCGGCCGGATCTGGGCACGGCTGAAATTCTGGCCTTCCAGCCTCGCCTGGCGCACCGGGCTCGTTCTGCTGCT
CGGGTTTTCGCTGATCCAGGCCATCGGCCTCGGCGTTCATGTGCTCAACCAGATCGAGGTGAACGGGATCGTCGCCGAAC
GCGCGATCGCGACGCGGGACGGCGCGCTCTATCGCCGGGTGGTGAGCGCGCCGAAGCCGCTGCGGGCGCAGATCGTGGCG
GAGGCGAACGGCGTCGCCGGCGACCGGGTCAGCCTCGATCCGGTGCCGCCCTATTCCGGCACCTTCACCCTGCCGCTGCC
GACCCGGCAGATCATCCAGGGTTCGCTGCTCGCCTTTCCGATGCCCGATTTCCTGCAGCCGAGGCAGGTGGTGATGCGGG
GCACGACCGCGCCCTCGACCACGATCCTGAGCTTCGAGCTGCCGGATGGCGGCTGGCTGACGGTGCAGAGCCCGTTCCGG
CCGCGCCCGCCCTGGGAACAGCCCGGCTTCGCGAGCGCCTTTCTGGTGATGTTCGCGCTCGGCGCGCTGCTGATCTTCTG
GGGGGTGGTCAGGCTGACCGCGCCGGTCCGCACGCTGGCCGCCGCCGCCGAGCAGCTCGGGCGCGACATCGCCCATGCGC
CGTCGCTGCCGGAGGGCGGGGCGACCGAGATCGCCACCGCGGCCATCGCGTTCAATACGATGGCCGCGCGCATCCGCCGC
TTCGTCGAGGACCGGACCTTCCTGCTCACCGCCATCGGCCACGACCTGCGCACGCCGATCACCCGGCTCCGGCTGCGCGC
CGAATTCCTCGACGACGACGCGCAGCGCGAGAAGATCCTCGCCGATCTCGACGAGCTGGAGGCGATGCTGACCTCGACCA
TCGCCTTCGGGCGCGACGTGGCGCAGACCGAGGCCTCGGTGCCGGTCGACCTCGCGATCCTGCTGCGCACCGTGATCGAC
GAGACGGCCGATATCGCCCCCGCCGCTTCGGCCAGGCTCGCCTATCAGGGGCCCGATCACATCACCATCCGCGGCCGGCC
GCTCTCGCTCAAGCGCGCCTTCGCCAACCTGATCGGCAACGCGGTGAAATACGGCCAGTCGGCGCGGGTCTCGCTGCACC
AGGCGGAGCGGCATACGCTGCGCGTCGATATCGAGGATGACGGGCCGGGCGTGCCGCCGGGCGAGCTGGAGCGGGTGTTC
GAGCCGTTCCGCCGGCTGGAGACCAGCCGCAACCGCGAGACCGGCGGCTCGGGGCTCGGCCTCGCCATCGCCCGCAACGC
GATCCGCGCGCATGGCGGCGACATCACGCTGGCGAACCGGCCGGGCGGCAAGGGGCTGATCGCCAGCGTGTATCTGCCCG
AATGA

Upstream 100 bases:

>100_bases
CGCGGCTGCGGCGCAAGCTCGAGGATGACGGGCGGCACGCGCAGATCATCAAGACGGTGCGCGGCGGCGGCTATGTGCTG
GCGGTGCCGGTCGAGCGTTC

Downstream 100 bases:

>100_bases
ACGCAGGCGCATCGCCGCGAGACCGGATCTGGCGGCGATGCGCCGGTTGAGGAAGATCGAGTAAAATACAGGGATATTTC
CGCGCGTTCGCCGGGAATGA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MTLGRIWARLKFWPSSLAWRTGLVLLLGFSLIQAIGLGVHVLNQIEVNGIVAERAIATRDGALYRRVVSAPKPLRAQIVA
EANGVAGDRVSLDPVPPYSGTFTLPLPTRQIIQGSLLAFPMPDFLQPRQVVMRGTTAPSTTILSFELPDGGWLTVQSPFR
PRPPWEQPGFASAFLVMFALGALLIFWGVVRLTAPVRTLAAAAEQLGRDIAHAPSLPEGGATEIATAAIAFNTMAARIRR
FVEDRTFLLTAIGHDLRTPITRLRLRAEFLDDDAQREKILADLDELEAMLTSTIAFGRDVAQTEASVPVDLAILLRTVID
ETADIAPAASARLAYQGPDHITIRGRPLSLKRAFANLIGNAVKYGQSARVSLHQAERHTLRVDIEDDGPGVPPGELERVF
EPFRRLETSRNRETGGSGLGLAIARNAIRAHGGDITLANRPGGKGLIASVYLPE

Sequences:

>Translated_454_residues
MTLGRIWARLKFWPSSLAWRTGLVLLLGFSLIQAIGLGVHVLNQIEVNGIVAERAIATRDGALYRRVVSAPKPLRAQIVA
EANGVAGDRVSLDPVPPYSGTFTLPLPTRQIIQGSLLAFPMPDFLQPRQVVMRGTTAPSTTILSFELPDGGWLTVQSPFR
PRPPWEQPGFASAFLVMFALGALLIFWGVVRLTAPVRTLAAAAEQLGRDIAHAPSLPEGGATEIATAAIAFNTMAARIRR
FVEDRTFLLTAIGHDLRTPITRLRLRAEFLDDDAQREKILADLDELEAMLTSTIAFGRDVAQTEASVPVDLAILLRTVID
ETADIAPAASARLAYQGPDHITIRGRPLSLKRAFANLIGNAVKYGQSARVSLHQAERHTLRVDIEDDGPGVPPGELERVF
EPFRRLETSRNRETGGSGLGLAIARNAIRAHGGDITLANRPGGKGLIASVYLPE
>Mature_453_residues
TLGRIWARLKFWPSSLAWRTGLVLLLGFSLIQAIGLGVHVLNQIEVNGIVAERAIATRDGALYRRVVSAPKPLRAQIVAE
ANGVAGDRVSLDPVPPYSGTFTLPLPTRQIIQGSLLAFPMPDFLQPRQVVMRGTTAPSTTILSFELPDGGWLTVQSPFRP
RPPWEQPGFASAFLVMFALGALLIFWGVVRLTAPVRTLAAAAEQLGRDIAHAPSLPEGGATEIATAAIAFNTMAARIRRF
VEDRTFLLTAIGHDLRTPITRLRLRAEFLDDDAQREKILADLDELEAMLTSTIAFGRDVAQTEASVPVDLAILLRTVIDE
TADIAPAASARLAYQGPDHITIRGRPLSLKRAFANLIGNAVKYGQSARVSLHQAERHTLRVDIEDDGPGVPPGELERVFE
PFRRLETSRNRETGGSGLGLAIARNAIRAHGGDITLANRPGGKGLIASVYLPE

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=300, Percent_Identity=33, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1790346, Length=266, Percent_Identity=30.8270676691729, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1787894, Length=245, Percent_Identity=34.6938775510204, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=30.9608540925267, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786783, Length=291, Percent_Identity=27.4914089347079, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1786600, Length=222, Percent_Identity=28.3783783783784, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1789149, Length=342, Percent_Identity=24.5614035087719, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=292, Percent_Identity=26.3698630136986, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1786912, Length=224, Percent_Identity=33.0357142857143, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790861, Length=300, Percent_Identity=27, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=25.1101321585903, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790551, Length=286, Percent_Identity=24.8251748251748, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=26.6949152542373, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788713, Length=223, Percent_Identity=27.3542600896861, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=235, Percent_Identity=25.9574468085106, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=24.3119266055046, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789403, Length=286, Percent_Identity=30.4195804195804, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49184; Mature: 49053

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLGRIWARLKFWPSSLAWRTGLVLLLGFSLIQAIGLGVHVLNQIEVNGIVAERAIATRD
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHCC
GALYRRVVSAPKPLRAQIVAEANGVAGDRVSLDPVPPYSGTFTLPLPTRQIIQGSLLAFP
HHHHHHHHCCCCCHHHEEEECCCCCCCCCEECCCCCCCCCEEEECCCHHHHHCCCCEECC
MPDFLQPRQVVMRGTTAPSTTILSFELPDGGWLTVQSPFRPRPPWEQPGFASAFLVMFAL
CCHHCCCHHHHHCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHH
GALLIFWGVVRLTAPVRTLAAAAEQLGRDIAHAPSLPEGGATEIATAAIAFNTMAARIRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FVEDRTFLLTAIGHDLRTPITRLRLRAEFLDDDAQREKILADLDELEAMLTSTIAFGRDV
HHHHHHEEEHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHH
AQTEASVPVDLAILLRTVIDETADIAPAASARLAYQGPDHITIRGRPLSLKRAFANLIGN
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHH
AVKYGQSARVSLHQAERHTLRVDIEDDGPGVPPGELERVFEPFRRLETSRNRETGGSGLG
HHHCCCCHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCH
LAIARNAIRAHGGDITLANRPGGKGLIASVYLPE
HHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCC
>Mature Secondary Structure 
TLGRIWARLKFWPSSLAWRTGLVLLLGFSLIQAIGLGVHVLNQIEVNGIVAERAIATRD
CHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHCC
GALYRRVVSAPKPLRAQIVAEANGVAGDRVSLDPVPPYSGTFTLPLPTRQIIQGSLLAFP
HHHHHHHHCCCCCHHHEEEECCCCCCCCCEECCCCCCCCCEEEECCCHHHHHCCCCEECC
MPDFLQPRQVVMRGTTAPSTTILSFELPDGGWLTVQSPFRPRPPWEQPGFASAFLVMFAL
CCHHCCCHHHHHCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHH
GALLIFWGVVRLTAPVRTLAAAAEQLGRDIAHAPSLPEGGATEIATAAIAFNTMAARIRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FVEDRTFLLTAIGHDLRTPITRLRLRAEFLDDDAQREKILADLDELEAMLTSTIAFGRDV
HHHHHHEEEHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHH
AQTEASVPVDLAILLRTVIDETADIAPAASARLAYQGPDHITIRGRPLSLKRAFANLIGN
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHH
AVKYGQSARVSLHQAERHTLRVDIEDDGPGVPPGELERVFEPFRRLETSRNRETGGSGLG
HHHCCCCHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCH
LAIARNAIRAHGGDITLANRPGGKGLIASVYLPE
HHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]