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The map label for this gene is hbpA [H]

Identifier: 148261070

GI number: 148261070

Start: 2287867

End: 2289519

Strand: Reverse

Name: hbpA [H]

Synonym: Acry_2078

Alternate gene names: 148261070

Gene position: 2289519-2287867 (Counterclockwise)

Preceding gene: 148261077

Following gene: 148261069

Centisome position: 67.55

GC content: 65.7

Gene sequence:

>1653_bases
ATGAAGTTCAGACTGCCGAACCAGCAGGCGCGTTCAGGGCTCGACGAGCTGCAAAATCACGTGATCGACGAGTTCCTGGC
CGGGCGGATCGACCGCCGGGGGCTGCTGCGGCATGGCAGCGCCTACGGGATTTCCGCCGCCCTGCTCGGCGGCATGATCG
GCGAGGCGCCGGGGCGGGCGCTGGCCGCGGGCGGGGAGGGTGCGACCATCCGCGTCTCGATCACCGCGCCGTCGACCGCG
ATCAACCCCGTCGTCGCCGGGGATACCGGCAGCCTGTGCATGTTGCAGCAGGCGGGCGAATTCCTGCTGTTCGACAATCC
GAAGACGCTGCGGCTGGAGCCGATGCTGGCGACGTCGTGGAAGTCGAGCCGGGATGGCAGGGTGTGGACCTTCACGCTGC
GCAAGGGGGTGAAATTCCACAGCGGCGGCACGATGACGGCGGATGACGTGGTCTATTCGCTCGCCCGCCTCGCCGACCCG
AAGAACGGCTCCAACGCGCTTTCCACCTTCAAGGGCGTGCTGAAGCCGGAGGGGGTGGTGAAGGTCGACGATCATACCGT
CGCGTTCCATCTCGAAGCGCCGAACGGGAATTTCGCCTATCTCGTCTCCTCGGACAATTACAACGCGATCATCCTGCCGA
AGGGATCGGTCGCCGCGGATTACGAGAAGACCTTCGATGGCACCGGGCCGTTCCGGCTCGACGCCTACACGCCGGGGCGC
GGCGCGAGCTTCGTGCGCAACCCCGCCTGGTGGGGCGGCAAGGTGATGCCGGCGCGGACCGAGTTCGGCTTCTACAGCAA
CCAGCAATCGCAGGTGCTGGCGCTGCAGGGCGGGCAGGTCGACGTGATCCAGCAGATCGTGGTGCAGGGCGCGCAGGGGC
TGCTGCACGACCCTTCGGTGAAGATCCTCAACATCCGCTCCTCGAACCATCGCGAGGTGCACATGCGCTGCGACAAGCCG
CCCTTCACCGACAAGCGGGTGCGCCAGGCGGTGGCGCTGACGCTGAACCGGCCGGGCATCGTGCACGCGCTGTTCGGCGG
GCTTTCCGACCTCGGCAATGACAGCCCGTTCGCGCCGATCTATCCCTCGACCAACACGAGCGTGCCGCAGCGGCACCGGC
AGATCGCGCGGGCGAAGCACCTGATGGCGGAGGCCGGGCTCGCGCATGGCGCCGAGGTGACGCTGACCACCGAGCAGGTG
CAGGAAATCCCCGACTATGCCGTGCTGATCCAGAACGCCGCGGCGGAGATCGGGCTGAAGATCAACCTCAAGATCGAGAC
AAGCGCCGCCTATTACGGAAAGGCAACGTTCGGCAATTCGGACTGGCTCGATTCCACCATGGGAATCACCGATTACGGCC
ATCGCGGCGTGCCCAACGTGTTTCTCACCGCGCCGCTGGAATCGGGCGGTTCGTGGAACGCCGCGCATTTCAACAACAAG
ACCTACGACAAGCTGGTGGCCGATTACATCGCCACCGTCGACCTCACGCGCCAGCGCGAATATTCCGGGCGGATCGAGCG
GCTGCTGCTCGACGAGACGCCGATCATCTTCGCGTATTTCTACAACTACCTCGCGGCCACGAAAAAGACCGTCAGCGGGG
TGGTGGTGACCGGGATGTCGCAGGTGTTCCTGCAGCACGCCACGGTGGCATAG

Upstream 100 bases:

>100_bases
CAATGACAGGGAGATTTGAAAAAAACAAAGGCGCGGGCAGGGTTTTTCGCGCCTCGCGCGGCGGCGCGCCGCGCGGGATA
ACGGAACGGAGAACGGGGAC

Downstream 100 bases:

>100_bases
GGCATGGCGCGGCGGCTGCTCGGCCTGCTCGCGGGGCGGCTGATGCTCGGCCTCGTGACGCTGCTGCTGCTGAGCATGGT
CGTCTTCGCCGGGGCGCAGC

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MKFRLPNQQARSGLDELQNHVIDEFLAGRIDRRGLLRHGSAYGISAALLGGMIGEAPGRALAAGGEGATIRVSITAPSTA
INPVVAGDTGSLCMLQQAGEFLLFDNPKTLRLEPMLATSWKSSRDGRVWTFTLRKGVKFHSGGTMTADDVVYSLARLADP
KNGSNALSTFKGVLKPEGVVKVDDHTVAFHLEAPNGNFAYLVSSDNYNAIILPKGSVAADYEKTFDGTGPFRLDAYTPGR
GASFVRNPAWWGGKVMPARTEFGFYSNQQSQVLALQGGQVDVIQQIVVQGAQGLLHDPSVKILNIRSSNHREVHMRCDKP
PFTDKRVRQAVALTLNRPGIVHALFGGLSDLGNDSPFAPIYPSTNTSVPQRHRQIARAKHLMAEAGLAHGAEVTLTTEQV
QEIPDYAVLIQNAAAEIGLKINLKIETSAAYYGKATFGNSDWLDSTMGITDYGHRGVPNVFLTAPLESGGSWNAAHFNNK
TYDKLVADYIATVDLTRQREYSGRIERLLLDETPIIFAYFYNYLAATKKTVSGVVVTGMSQVFLQHATVA

Sequences:

>Translated_550_residues
MKFRLPNQQARSGLDELQNHVIDEFLAGRIDRRGLLRHGSAYGISAALLGGMIGEAPGRALAAGGEGATIRVSITAPSTA
INPVVAGDTGSLCMLQQAGEFLLFDNPKTLRLEPMLATSWKSSRDGRVWTFTLRKGVKFHSGGTMTADDVVYSLARLADP
KNGSNALSTFKGVLKPEGVVKVDDHTVAFHLEAPNGNFAYLVSSDNYNAIILPKGSVAADYEKTFDGTGPFRLDAYTPGR
GASFVRNPAWWGGKVMPARTEFGFYSNQQSQVLALQGGQVDVIQQIVVQGAQGLLHDPSVKILNIRSSNHREVHMRCDKP
PFTDKRVRQAVALTLNRPGIVHALFGGLSDLGNDSPFAPIYPSTNTSVPQRHRQIARAKHLMAEAGLAHGAEVTLTTEQV
QEIPDYAVLIQNAAAEIGLKINLKIETSAAYYGKATFGNSDWLDSTMGITDYGHRGVPNVFLTAPLESGGSWNAAHFNNK
TYDKLVADYIATVDLTRQREYSGRIERLLLDETPIIFAYFYNYLAATKKTVSGVVVTGMSQVFLQHATVA
>Mature_550_residues
MKFRLPNQQARSGLDELQNHVIDEFLAGRIDRRGLLRHGSAYGISAALLGGMIGEAPGRALAAGGEGATIRVSITAPSTA
INPVVAGDTGSLCMLQQAGEFLLFDNPKTLRLEPMLATSWKSSRDGRVWTFTLRKGVKFHSGGTMTADDVVYSLARLADP
KNGSNALSTFKGVLKPEGVVKVDDHTVAFHLEAPNGNFAYLVSSDNYNAIILPKGSVAADYEKTFDGTGPFRLDAYTPGR
GASFVRNPAWWGGKVMPARTEFGFYSNQQSQVLALQGGQVDVIQQIVVQGAQGLLHDPSVKILNIRSSNHREVHMRCDKP
PFTDKRVRQAVALTLNRPGIVHALFGGLSDLGNDSPFAPIYPSTNTSVPQRHRQIARAKHLMAEAGLAHGAEVTLTTEQV
QEIPDYAVLIQNAAAEIGLKINLKIETSAAYYGKATFGNSDWLDSTMGITDYGHRGVPNVFLTAPLESGGSWNAAHFNNK
TYDKLVADYIATVDLTRQREYSGRIERLLLDETPIIFAYFYNYLAATKKTVSGVVVTGMSQVFLQHATVA

Specific function: Important role in heme acquisition or metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=492, Percent_Identity=24.390243902439, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1787762, Length=444, Percent_Identity=26.3513513513513, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI87081878, Length=527, Percent_Identity=25.8064516129032, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1787052, Length=544, Percent_Identity=23.8970588235294, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1787551, Length=335, Percent_Identity=25.3731343283582, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787495, Length=443, Percent_Identity=24.1534988713318, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1789887, Length=434, Percent_Identity=23.5023041474654, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1789397, Length=455, Percent_Identity=21.0989010989011, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 59664; Mature: 59664

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFRLPNQQARSGLDELQNHVIDEFLAGRIDRRGLLRHGSAYGISAALLGGMIGEAPGRA
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCE
LAAGGEGATIRVSITAPSTAINPVVAGDTGSLCMLQQAGEFLLFDNPKTLRLEPMLATSW
EECCCCCCEEEEEEECCCCCCCCEEECCCCCEEEEECCCCEEEECCCCEEEECCEEEECC
KSSRDGRVWTFTLRKGVKFHSGGTMTADDVVYSLARLADPKNGSNALSTFKGVLKPEGVV
CCCCCCEEEEEEECCCCEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEE
KVDDHTVAFHLEAPNGNFAYLVSSDNYNAIILPKGSVAADYEKTFDGTGPFRLDAYTPGR
EECCCEEEEEEECCCCCEEEEEECCCCCEEEEECCCCCCCHHHHCCCCCCEEEEEECCCC
GASFVRNPAWWGGKVMPARTEFGFYSNQQSQVLALQGGQVDVIQQIVVQGAQGLLHDPSV
CCCHHCCCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCE
KILNIRSSNHREVHMRCDKPPFTDKRVRQAVALTLNRPGIVHALFGGLSDLGNDSPFAPI
EEEEEECCCCEEEEEEECCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHCCCCCCCCCC
YPSTNTSVPQRHRQIARAKHLMAEAGLAHGAEVTLTTEQVQEIPDYAVLIQNAAAEIGLK
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCCEEEHHHHHHHEEEE
INLKIETSAAYYGKATFGNSDWLDSTMGITDYGHRGVPNVFLTAPLESGGSWNAAHFNNK
EEEEEEECCEEEECEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEECCCCC
TYDKLVADYIATVDLTRQREYSGRIERLLLDETPIIFAYFYNYLAATKKTVSGVVVTGMS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCEEEHHHH
QVFLQHATVA
HHHHHHHCCC
>Mature Secondary Structure
MKFRLPNQQARSGLDELQNHVIDEFLAGRIDRRGLLRHGSAYGISAALLGGMIGEAPGRA
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCE
LAAGGEGATIRVSITAPSTAINPVVAGDTGSLCMLQQAGEFLLFDNPKTLRLEPMLATSW
EECCCCCCEEEEEEECCCCCCCCEEECCCCCEEEEECCCCEEEECCCCEEEECCEEEECC
KSSRDGRVWTFTLRKGVKFHSGGTMTADDVVYSLARLADPKNGSNALSTFKGVLKPEGVV
CCCCCCEEEEEEECCCCEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEE
KVDDHTVAFHLEAPNGNFAYLVSSDNYNAIILPKGSVAADYEKTFDGTGPFRLDAYTPGR
EECCCEEEEEEECCCCCEEEEEECCCCCEEEEECCCCCCCHHHHCCCCCCEEEEEECCCC
GASFVRNPAWWGGKVMPARTEFGFYSNQQSQVLALQGGQVDVIQQIVVQGAQGLLHDPSV
CCCHHCCCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCE
KILNIRSSNHREVHMRCDKPPFTDKRVRQAVALTLNRPGIVHALFGGLSDLGNDSPFAPI
EEEEEECCCCEEEEEEECCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHCCCCCCCCCC
YPSTNTSVPQRHRQIARAKHLMAEAGLAHGAEVTLTTEQVQEIPDYAVLIQNAAAEIGLK
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCCEEEHHHHHHHEEEE
INLKIETSAAYYGKATFGNSDWLDSTMGITDYGHRGVPNVFLTAPLESGGSWNAAHFNNK
EEEEEEECCEEEECEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEECCCCC
TYDKLVADYIATVDLTRQREYSGRIERLLLDETPIIFAYFYNYLAATKKTVSGVVVTGMS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCEEEHHHH
QVFLQHATVA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]