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The map label for this gene is ppx [H]

Identifier: 148261004

GI number: 148261004

Start: 2206370

End: 2207464

Strand: Reverse

Name: ppx [H]

Synonym: Acry_2012

Alternate gene names: 148261004

Gene position: 2207464-2206370 (Counterclockwise)

Preceding gene: 148261006

Following gene: 148261003

Centisome position: 65.13

GC content: 67.95

Gene sequence:

>1095_bases
ATGGCAACCAACGTCGCCGTTCCGCGCTTGTCCGACTCAACGCCCGCCGGTGCAGAACGGCGCGGTGAAGGGCGTGGCGC
GCCCGATCGCCGGGCGCGGCCGCCGGCTTTCGCGGCGATTGATCTCGGCACCAATAACTGCCGGATGCTCATCGGCGTGC
CGAGCGGCGGCGGTTTCCACGTTCTGGACAGTTTCAGCCGGGTCGTTCGTCTGGGCGAGGGCTTGTATCGCACCGGCATG
CTCTCGGATGCGGCGATGGACCGCGCTATCGAGGCCCTCTCCATCTGTGCGGACCGGCAGCGCCGCTGGCAGGTGAGCGC
CACCAGGGCGATCGCCACCGAGGCGTGTCGTCAGGCCGAGAATGGCCATGCCTTCATCGCCCGGGCGCGTACCGAAACCG
GCCTGCCGATCGAGACGATCTCTCCGCGTGAAGAAATCTGCCTTGCCATGGAGAGCTGCGCCTCGCTCATCACCCAGGCG
GAACGGAGGGCTCTCCTGTTCGATATCGGCGGCGGATCCACCGAGATCGCATGGGTCCGCGTGCCCGCCGCGCATGGTGG
GTCCGACCGCGTAACGCCTCAATTGATCGGGTACCACACAATTCCCGTCGGAGTCGTCACGCTCTCGGAGCGCTGCGCTG
GCTGGTGCGAGACGGAAGCCGGATTCGCCGGCGTGGTGGACGAAGTCAAGGCGCTGCTCCGCCCGTTCGAGGAAACCCAC
CGCATCAGCCAGGAAATCCGCATGGGCGGTGTCCGTCTGGTCGGCACCAGCGGCACCGTGACCACTATCGCGGGAATTGC
CCTCAATCTCGACCGATATCGCCGTGGCGCGATCGACGGCACGGTGCTGCCGCACGATGTCGTCGCCGCCGGTCTCGAGT
CGATCCGCGCAATGGGCCGGGCCCGCCTGACCGAGCATCCCTGCATCGGCGCCGACCGGGTGGATTTCGTCCTTCCCGGT
TGCGCGATCTTCGCGGCGATCGAGGAGATGTGGCCGGCCGCCGATCTCGCTGTGGCCGACCGCGGCCTGCGCGAGGGGAT
GCTGATGCGCCTCATCCGCAACGCGCGTTCACGTCCGCGCCGCTGCCAGGCATGA

Upstream 100 bases:

>100_bases
CGATATGAGGCAATCACCGACTGGCCGCGTTGTCGGTCCCCGAGGTGCGTGCAAATCTGTCTTGCTCTCAGCCCATGGGT
CTGCCCATTATATCAATGTC

Downstream 100 bases:

>100_bases
CCGAGGAAACCATCGGCTCGCGCCGCCGCGCCGCCGTGCGGCTCAAGGCCGCGCGCAAGCACAAGCCCTCGTCGCAGAAA
TGGCTGCTCCGCCAGTTGAA

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MATNVAVPRLSDSTPAGAERRGEGRGAPDRRARPPAFAAIDLGTNNCRMLIGVPSGGGFHVLDSFSRVVRLGEGLYRTGM
LSDAAMDRAIEALSICADRQRRWQVSATRAIATEACRQAENGHAFIARARTETGLPIETISPREEICLAMESCASLITQA
ERRALLFDIGGGSTEIAWVRVPAAHGGSDRVTPQLIGYHTIPVGVVTLSERCAGWCETEAGFAGVVDEVKALLRPFEETH
RISQEIRMGGVRLVGTSGTVTTIAGIALNLDRYRRGAIDGTVLPHDVVAAGLESIRAMGRARLTEHPCIGADRVDFVLPG
CAIFAAIEEMWPAADLAVADRGLREGMLMRLIRNARSRPRRCQA

Sequences:

>Translated_364_residues
MATNVAVPRLSDSTPAGAERRGEGRGAPDRRARPPAFAAIDLGTNNCRMLIGVPSGGGFHVLDSFSRVVRLGEGLYRTGM
LSDAAMDRAIEALSICADRQRRWQVSATRAIATEACRQAENGHAFIARARTETGLPIETISPREEICLAMESCASLITQA
ERRALLFDIGGGSTEIAWVRVPAAHGGSDRVTPQLIGYHTIPVGVVTLSERCAGWCETEAGFAGVVDEVKALLRPFEETH
RISQEIRMGGVRLVGTSGTVTTIAGIALNLDRYRRGAIDGTVLPHDVVAAGLESIRAMGRARLTEHPCIGADRVDFVLPG
CAIFAAIEEMWPAADLAVADRGLREGMLMRLIRNARSRPRRCQA
>Mature_363_residues
ATNVAVPRLSDSTPAGAERRGEGRGAPDRRARPPAFAAIDLGTNNCRMLIGVPSGGGFHVLDSFSRVVRLGEGLYRTGML
SDAAMDRAIEALSICADRQRRWQVSATRAIATEACRQAENGHAFIARARTETGLPIETISPREEICLAMESCASLITQAE
RRALLFDIGGGSTEIAWVRVPAAHGGSDRVTPQLIGYHTIPVGVVTLSERCAGWCETEAGFAGVVDEVKALLRPFEETHR
ISQEIRMGGVRLVGTSGTVTTIAGIALNLDRYRRGAIDGTVLPHDVVAAGLESIRAMGRARLTEHPCIGADRVDFVLPGC
AIFAAIEEMWPAADLAVADRGLREGMLMRLIRNARSRPRRCQA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=328, Percent_Identity=27.7439024390244, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI48994966, Length=234, Percent_Identity=32.9059829059829, Blast_Score=90, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 39117; Mature: 38986

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATNVAVPRLSDSTPAGAERRGEGRGAPDRRARPPAFAAIDLGTNNCRMLIGVPSGGGFH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCHH
VLDSFSRVVRLGEGLYRTGMLSDAAMDRAIEALSICADRQRRWQVSATRAIATEACRQAE
HHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NGHAFIARARTETGLPIETISPREEICLAMESCASLITQAERRALLFDIGGGSTEIAWVR
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEE
VPAAHGGSDRVTPQLIGYHTIPVGVVTLSERCAGWCETEAGFAGVVDEVKALLRPFEETH
EECCCCCCCCCCHHHHCEEECCHHEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RISQEIRMGGVRLVGTSGTVTTIAGIALNLDRYRRGAIDGTVLPHDVVAAGLESIRAMGR
HHHHHHHHCCEEEEECCCCHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
ARLTEHPCIGADRVDFVLPGCAIFAAIEEMWPAADLAVADRGLREGMLMRLIRNARSRPR
HHCCCCCCCCCCCHHHHCCHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHCCCC
RCQA
CCCC
>Mature Secondary Structure 
ATNVAVPRLSDSTPAGAERRGEGRGAPDRRARPPAFAAIDLGTNNCRMLIGVPSGGGFH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCHH
VLDSFSRVVRLGEGLYRTGMLSDAAMDRAIEALSICADRQRRWQVSATRAIATEACRQAE
HHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NGHAFIARARTETGLPIETISPREEICLAMESCASLITQAERRALLFDIGGGSTEIAWVR
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEE
VPAAHGGSDRVTPQLIGYHTIPVGVVTLSERCAGWCETEAGFAGVVDEVKALLRPFEETH
EECCCCCCCCCCHHHHCEEECCHHEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RISQEIRMGGVRLVGTSGTVTTIAGIALNLDRYRRGAIDGTVLPHDVVAAGLESIRAMGR
HHHHHHHHCCEEEEECCCCHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
ARLTEHPCIGADRVDFVLPGCAIFAAIEEMWPAADLAVADRGLREGMLMRLIRNARSRPR
HHCCCCCCCCCCCHHHHCCHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHCCCC
RCQA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]