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The map label for this gene is nhaA [H]

Identifier: 148260959

GI number: 148260959

Start: 2156548

End: 2157345

Strand: Reverse

Name: nhaA [H]

Synonym: Acry_1966

Alternate gene names: 148260959

Gene position: 2157345-2156548 (Counterclockwise)

Preceding gene: 148260960

Following gene: 148260956

Centisome position: 63.65

GC content: 69.05

Gene sequence:

>798_bases
ATGACGCTCCGCCTGCCGTGGTCGCGCCCGTGCGTGCCGGTGATCCGGCTTGCCGGGCTGATCTCGCCGCGCGAGGGGGC
GGTCAATCTCGAACGCTTTGCTCCGGCCATCGACCGCGGTTTCGACCTCGCCAAGGGCGGGACGAAGCTGCTGATCCTCG
CGATCGAGAGCCCCGGCGGCTCGCCGGTGCAATCCGACCTGATCGGCCGCCACATCCGCCGCAAGGCCGAGGAGACGGGC
GTGCGCGTTCTCGCCGTGATCGGCGATGTCGGCGCTTCCGGCGGCTACTGGATCGCCTGCGCCGGCGACGAGATCTTCGC
CAATCCGATGTCGATCGTCGGCTCGATCGGGGTGGTCGGCGGCGGTTTCGGCCTGCATGACCTGATCCGCCGCTTCGGGA
TCGAGCGCCGCATCGTCACCGCCGGCGCCAACAAGCTGCGCAACGATCCGTTCTCACCCGAACGGCCGGGGGACGCCGCA
TTCAACCAGGCGCTGCTCGACGACATTCACGATGCCTTCAAGGCGTGGGTGCGCGAGCGCCGCGGCGCCGCCCTGAAAGG
CGACGACACGGTGTTCGACGGCTCCTACATGCTGGGTAGCGCGGCGAAGGCACGCGGTCTGATCGACGGATTCGGCGATG
TGCGCGGCCTGATCACCGGGCGCTGCGGCCCGCGCGCGAAGCCGGTCTTTCTTGGCCCGAAGCGGAAATTCTCGCTGCTG
CGGCTGTTCGGCCGCTCCAGCCTGATCGAACTCGCCAATGCGATGGAGGCCGAGGCGCTCACGCCGAAACTCGGCTGA

Upstream 100 bases:

>100_bases
ACGACGCGCCGGCCGACCTGCCGGAAGGCGGCCGCACTTCCGGCATCGAGGACCTGCCGCCGGCGCTGCGGCGCGACCTG
CGCGCCCTGGCGCTGCTGCC

Downstream 100 bases:

>100_bases
GCGCCCCGGTCGCTTCGGCGTCCTACGACGCCTGGGTCACGAACTTGGTGGCGAGATAGGCCTCGATCGCCTCGGCGCCG
CCTTCCCAGCCATAGCCGCT

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MTLRLPWSRPCVPVIRLAGLISPREGAVNLERFAPAIDRGFDLAKGGTKLLILAIESPGGSPVQSDLIGRHIRRKAEETG
VRVLAVIGDVGASGGYWIACAGDEIFANPMSIVGSIGVVGGGFGLHDLIRRFGIERRIVTAGANKLRNDPFSPERPGDAA
FNQALLDDIHDAFKAWVRERRGAALKGDDTVFDGSYMLGSAAKARGLIDGFGDVRGLITGRCGPRAKPVFLGPKRKFSLL
RLFGRSSLIELANAMEAEALTPKLG

Sequences:

>Translated_265_residues
MTLRLPWSRPCVPVIRLAGLISPREGAVNLERFAPAIDRGFDLAKGGTKLLILAIESPGGSPVQSDLIGRHIRRKAEETG
VRVLAVIGDVGASGGYWIACAGDEIFANPMSIVGSIGVVGGGFGLHDLIRRFGIERRIVTAGANKLRNDPFSPERPGDAA
FNQALLDDIHDAFKAWVRERRGAALKGDDTVFDGSYMLGSAAKARGLIDGFGDVRGLITGRCGPRAKPVFLGPKRKFSLL
RLFGRSSLIELANAMEAEALTPKLG
>Mature_264_residues
TLRLPWSRPCVPVIRLAGLISPREGAVNLERFAPAIDRGFDLAKGGTKLLILAIESPGGSPVQSDLIGRHIRRKAEETGV
RVLAVIGDVGASGGYWIACAGDEIFANPMSIVGSIGVVGGGFGLHDLIRRFGIERRIVTAGANKLRNDPFSPERPGDAAF
NQALLDDIHDAFKAWVRERRGAALKGDDTVFDGSYMLGSAAKARGLIDGFGDVRGLITGRCGPRAKPVFLGPKRKFSLLR
LFGRSSLIELANAMEAEALTPKLG

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=166, Percent_Identity=29.5180722891566, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787527, Length=161, Percent_Identity=30.4347826086957, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 28268; Mature: 28137

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRLPWSRPCVPVIRLAGLISPREGAVNLERFAPAIDRGFDLAKGGTKLLILAIESPGG
CEEECCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEECCCC
SPVQSDLIGRHIRRKAEETGVRVLAVIGDVGASGGYWIACAGDEIFANPMSIVGSIGVVG
CCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCCHHHHCHHHHHHHHHHCC
GGFGLHDLIRRFGIERRIVTAGANKLRNDPFSPERPGDAAFNQALLDDIHDAFKAWVRER
CCCCHHHHHHHHCCCCEEEHHCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RGAALKGDDTVFDGSYMLGSAAKARGLIDGFGDVRGLITGRCGPRAKPVFLGPKRKFSLL
CCCCCCCCCEEECCCHHHCCHHHHHHHHHCHHHHHHHHCCCCCCCCCCEEECCHHHHHHH
RLFGRSSLIELANAMEAEALTPKLG
HHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TLRLPWSRPCVPVIRLAGLISPREGAVNLERFAPAIDRGFDLAKGGTKLLILAIESPGG
EEECCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEECCCC
SPVQSDLIGRHIRRKAEETGVRVLAVIGDVGASGGYWIACAGDEIFANPMSIVGSIGVVG
CCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCCHHHHCHHHHHHHHHHCC
GGFGLHDLIRRFGIERRIVTAGANKLRNDPFSPERPGDAAFNQALLDDIHDAFKAWVRER
CCCCHHHHHHHHCCCCEEEHHCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RGAALKGDDTVFDGSYMLGSAAKARGLIDGFGDVRGLITGRCGPRAKPVFLGPKRKFSLL
CCCCCCCCCEEECCCHHHCCHHHHHHHHHCHHHHHHHHCCCCCCCCCCEEECCHHHHHHH
RLFGRSSLIELANAMEAEALTPKLG
HHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA