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The map label for this gene is tdcB [H]

Identifier: 148260895

GI number: 148260895

Start: 2100000

End: 2100983

Strand: Reverse

Name: tdcB [H]

Synonym: Acry_1902

Alternate gene names: 148260895

Gene position: 2100983-2100000 (Counterclockwise)

Preceding gene: 148260896

Following gene: 148260894

Centisome position: 61.99

GC content: 75.91

Gene sequence:

>984_bases
ATGACCCGCCTGCCCACCGCCGAGGATGTTCTCGCCGCCCACGCCCTGATCGCCCCGCACATCGTCCGCACCCCGGCGCT
GCGCTCTCCCGCGCTCGACGAGCGGACCGGCGCGGAGGTGTTCATCAAGGCCGAGCCGCTGCAGCGCACCGGCAGCTTCA
AGCTGCGCGGCGCGACCAACGCGATCCTGCGGCTCGCCCCCGCGGCGCGCGCGGCCGGCGTCGTCGCCTATTCCTCGGGC
AATCACGGCCAGGCGGTGGCCTGCGCCGCCGCCGCCCTCGGGATTCCCGCCACCATCGTGATGCCGCGCGACGCCCCCGC
CATCAAGCGCGACTCGACCGCCGCCTGGGGGGCCGACATCGTGCAGTACGACCGCCGCACCGAGGACCGCGAGGCGATCG
GCGCCGCCATCGCCGCCCGCACCGGCGCCGCCCTGATCCCCCCCTACGACCATCCGGACGTGATCGCCGGGCAGGGCACC
CTCGCCCTCGAACTGGTGGAGGATGCGCGGGCGGCGGGCGCCGAACTCGATCTCGTCTTCGTCTGCACCGGCGGCGGCGG
CCTGACCGCCGGCTGCGCCCTCGCCCTCGAACACGCCTCGCCCGCGACCCGGCTGATCGCCGTCGAGCCCGAGGGCTGGG
ACGATACCGGCCGCTCGCTGGCCGCCGGCACCCGCCTCGCCAACGACGGCGCGGGCTCCGCGCTCTGCGACGCGCTGATG
GCGATGACGCCCGGCGAACTCACCTTCGCGCTCAACGCGCCCCGCCTCGCCGGCGCCGTCGCCGTCGGCGAGTCGCAGGT
GCTCGCCGCGATGGGCTTCGCGCTGCGCCATCTCAAGCTCGCGGTCGAGCCCGGCGGCGCGGTGGCGCTGGCGGCGGTGC
TGGCCGAGGCGCTGCCGCTCGACGGCCTGGCGGTGGGAGTCGTTCTCTCCGGCGGCAATGCCGATCCCGGAACGCTGGCC
CGCGCCCTCGAAGTCACCTGCTGA

Upstream 100 bases:

>100_bases
GCCATGCCGCCCGCCGCCGCGCCGGCGTCGCGATCGAATCCTACGCCCTGTCCGCCGCCCGTCTCGCCGCCGCCCCCGCC
GCACTCATGAGGCCCAAGCA

Downstream 100 bases:

>100_bases
CGGTCTCCGATTCAGCCTTTTTTAACCCCCACCCCCGATACTCCGCCCCGAAAGGTGACAAGGGGTTCATGGCGCAGCGC
AAGAAGAAGGGCGGCAAGGG

Product: pyridoxal-5'-phosphate-dependent enzyme subunit beta

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTRLPTAEDVLAAHALIAPHIVRTPALRSPALDERTGAEVFIKAEPLQRTGSFKLRGATNAILRLAPAARAAGVVAYSSG
NHGQAVACAAAALGIPATIVMPRDAPAIKRDSTAAWGADIVQYDRRTEDREAIGAAIAARTGAALIPPYDHPDVIAGQGT
LALELVEDARAAGAELDLVFVCTGGGGLTAGCALALEHASPATRLIAVEPEGWDDTGRSLAAGTRLANDGAGSALCDALM
AMTPGELTFALNAPRLAGAVAVGESQVLAAMGFALRHLKLAVEPGGAVALAAVLAEALPLDGLAVGVVLSGGNADPGTLA
RALEVTC

Sequences:

>Translated_327_residues
MTRLPTAEDVLAAHALIAPHIVRTPALRSPALDERTGAEVFIKAEPLQRTGSFKLRGATNAILRLAPAARAAGVVAYSSG
NHGQAVACAAAALGIPATIVMPRDAPAIKRDSTAAWGADIVQYDRRTEDREAIGAAIAARTGAALIPPYDHPDVIAGQGT
LALELVEDARAAGAELDLVFVCTGGGGLTAGCALALEHASPATRLIAVEPEGWDDTGRSLAAGTRLANDGAGSALCDALM
AMTPGELTFALNAPRLAGAVAVGESQVLAAMGFALRHLKLAVEPGGAVALAAVLAEALPLDGLAVGVVLSGGNADPGTLA
RALEVTC
>Mature_326_residues
TRLPTAEDVLAAHALIAPHIVRTPALRSPALDERTGAEVFIKAEPLQRTGSFKLRGATNAILRLAPAARAAGVVAYSSGN
HGQAVACAAAALGIPATIVMPRDAPAIKRDSTAAWGADIVQYDRRTEDREAIGAAIAARTGAALIPPYDHPDVIAGQGTL
ALELVEDARAAGAELDLVFVCTGGGGLTAGCALALEHASPATRLIAVEPEGWDDTGRSLAAGTRLANDGAGSALCDALMA
MTPGELTFALNAPRLAGAVAVGESQVLAAMGFALRHLKLAVEPGGAVALAAVLAEALPLDGLAVGVVLSGGNADPGTLAR
ALEVTC

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=313, Percent_Identity=36.1022364217252, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI19923959, Length=155, Percent_Identity=36.1290322580645, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1789505, Length=326, Percent_Identity=36.8098159509202, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI1790207, Length=295, Percent_Identity=34.5762711864407, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17508781, Length=330, Percent_Identity=31.5151515151515, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71991565, Length=317, Percent_Identity=32.807570977918, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17537387, Length=318, Percent_Identity=34.5911949685535, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322631, Length=312, Percent_Identity=44.5512820512821, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6320930, Length=271, Percent_Identity=37.2693726937269, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319788, Length=284, Percent_Identity=27.4647887323944, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355833, Length=326, Percent_Identity=35.5828220858896, Blast_Score=125, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 32868; Mature: 32737

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00435 PEROXIDASE_1 ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLPTAEDVLAAHALIAPHIVRTPALRSPALDERTGAEVFIKAEPLQRTGSFKLRGATN
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCC
AILRLAPAARAAGVVAYSSGNHGQAVACAAAALGIPATIVMPRDAPAIKRDSTAAWGADI
EEEEECCCHHHCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHH
VQYDRRTEDREAIGAAIAARTGAALIPPYDHPDVIAGQGTLALELVEDARAAGAELDLVF
HHHHCCCCHHHHHHHHHHHCCCCEECCCCCCCCEEECCCCEEEEEHHHHHHCCCCEEEEE
VCTGGGGLTAGCALALEHASPATRLIAVEPEGWDDTGRSLAAGTRLANDGAGSALCDALM
EEECCCCCHHHHHEEECCCCCCEEEEEECCCCCCCCCCHHHHCCEECCCCCCHHHHHHHH
AMTPGELTFALNAPRLAGAVAVGESQVLAAMGFALRHLKLAVEPGGAVALAAVLAEALPL
HCCCCCEEEEECCCCHHCEEEECCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCC
DGLAVGVVLSGGNADPGTLARALEVTC
CCEEEEEEEECCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
TRLPTAEDVLAAHALIAPHIVRTPALRSPALDERTGAEVFIKAEPLQRTGSFKLRGATN
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCC
AILRLAPAARAAGVVAYSSGNHGQAVACAAAALGIPATIVMPRDAPAIKRDSTAAWGADI
EEEEECCCHHHCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHH
VQYDRRTEDREAIGAAIAARTGAALIPPYDHPDVIAGQGTLALELVEDARAAGAELDLVF
HHHHCCCCHHHHHHHHHHHCCCCEECCCCCCCCEEECCCCEEEEEHHHHHHCCCCEEEEE
VCTGGGGLTAGCALALEHASPATRLIAVEPEGWDDTGRSLAAGTRLANDGAGSALCDALM
EEECCCCCHHHHHEEECCCCCCEEEEEECCCCCCCCCCHHHHCCEECCCCCCHHHHHHHH
AMTPGELTFALNAPRLAGAVAVGESQVLAAMGFALRHLKLAVEPGGAVALAAVLAEALPL
HCCCCCEEEEECCCCHHCEEEECCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCC
DGLAVGVVLSGGNADPGTLARALEVTC
CCEEEEEEEECCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]