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The map label for this gene is upp [H]

Identifier: 148260885

GI number: 148260885

Start: 2085877

End: 2086518

Strand: Reverse

Name: upp [H]

Synonym: Acry_1892

Alternate gene names: 148260885

Gene position: 2086518-2085877 (Counterclockwise)

Preceding gene: 148260886

Following gene: 148260878

Centisome position: 61.56

GC content: 69.0

Gene sequence:

>642_bases
ATGCAGGCAATGCCGGACAACGTCATGGTGGTCGATCACCCGCTGGTCGCGCACAAGCTCACCCTGCTGCGCGCCGCGGC
GACGCCGACGGGCGATTTCCGCCGCCTCGTCCGCGAGATCAGCCTGCTGATGGGCTACGAGGTGCTGCGCGACCTGCCGA
CCGAGCCGGTCCATATCGAAACCCCGCTGGAGCCGATGACGGCCCGCCAGGTCTCCGGCAAGAAACTCTGCTTCATCTCG
ATCCTGCGCGCCGGCAACGGCATTCTCGACGGCATGGTCGACCTCGTGCCCTCGGCGCGCATCGGTCATGTCGGCCTCTA
CCGCGACCCGCTCTCGCACGAGCCGATCGAATACTACTTCAAGGTCCCGGACGACATGGACCAGCGCCTGACCGTGGTGG
TCGACCCGATGCTCGCCACCGGCCATTCGGCGGCGGCGGCGGTCACCAGGCTGAAGCGGGCAGGGGCGGGGGCGATCAAG
TTCGTCTGCCTCATCGCCGCCCCGGAAGGCATCGCCGCCCTGCACGCCGCCCATCCGGACGTGCCGGTCTACACCGCGGC
GATCGACCGGCAGCTCGACGAGCACGCCTATATCCGCCCCGGCCTCGGCGACGCCGGCGACCGTCTCTTCGGCACCAAGT
GA

Upstream 100 bases:

>100_bases
AGCTTCCCCGGCGAAGCCCGCCGCCGTAAGGAAGGCGGCGGCCGCGAAACCCCGGGCGGCCGCGCGCCGGCGCTGAACCT
CGGGGCGACAGGAGATCGGG

Downstream 100 bases:

>100_bases
TTTCGCGCCTCCCCCGCCGCGCGGGCGGGTGGAGGCGCAAAATCACTCCATGACCGCCATTTCCGGCTTCTCCGCCTTCG
CGGCCATGGCGGCCTGCGGC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MQAMPDNVMVVDHPLVAHKLTLLRAAATPTGDFRRLVREISLLMGYEVLRDLPTEPVHIETPLEPMTARQVSGKKLCFIS
ILRAGNGILDGMVDLVPSARIGHVGLYRDPLSHEPIEYYFKVPDDMDQRLTVVVDPMLATGHSAAAAVTRLKRAGAGAIK
FVCLIAAPEGIAALHAAHPDVPVYTAAIDRQLDEHAYIRPGLGDAGDRLFGTK

Sequences:

>Translated_213_residues
MQAMPDNVMVVDHPLVAHKLTLLRAAATPTGDFRRLVREISLLMGYEVLRDLPTEPVHIETPLEPMTARQVSGKKLCFIS
ILRAGNGILDGMVDLVPSARIGHVGLYRDPLSHEPIEYYFKVPDDMDQRLTVVVDPMLATGHSAAAAVTRLKRAGAGAIK
FVCLIAAPEGIAALHAAHPDVPVYTAAIDRQLDEHAYIRPGLGDAGDRLFGTK
>Mature_213_residues
MQAMPDNVMVVDHPLVAHKLTLLRAAATPTGDFRRLVREISLLMGYEVLRDLPTEPVHIETPLEPMTARQVSGKKLCFIS
ILRAGNGILDGMVDLVPSARIGHVGLYRDPLSHEPIEYYFKVPDDMDQRLTVVVDPMLATGHSAAAAVTRLKRAGAGAIK
FVCLIAAPEGIAALHAAHPDVPVYTAAIDRQLDEHAYIRPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=27.7227722772277, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=27.7227722772277, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI21450816, Length=174, Percent_Identity=27.0114942528736, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=51.6908212560386, Blast_Score=218, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17539892, Length=213, Percent_Identity=24.4131455399061, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=213, Percent_Identity=24.4131455399061, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=38.5416666666667, Blast_Score=123, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45550449, Length=200, Percent_Identity=29.5, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28573516, Length=200, Percent_Identity=29.5, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28573514, Length=200, Percent_Identity=29.5, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28573512, Length=200, Percent_Identity=29.5, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21358379, Length=175, Percent_Identity=28, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23114; Mature: 23114

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAMPDNVMVVDHPLVAHKLTLLRAAATPTGDFRRLVREISLLMGYEVLRDLPTEPVHIE
CCCCCCCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
TPLEPMTARQVSGKKLCFISILRAGNGILDGMVDLVPSARIGHVGLYRDPLSHEPIEYYF
CCCCCHHHHHCCCCEEHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCEEEEE
KVPDDMDQRLTVVVDPMLATGHSAAAAVTRLKRAGAGAIKFVCLIAAPEGIAALHAAHPD
ECCCCCCCCEEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCC
VPVYTAAIDRQLDEHAYIRPGLGDAGDRLFGTK
CCEEHHHHHHHHHCCCEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MQAMPDNVMVVDHPLVAHKLTLLRAAATPTGDFRRLVREISLLMGYEVLRDLPTEPVHIE
CCCCCCCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
TPLEPMTARQVSGKKLCFISILRAGNGILDGMVDLVPSARIGHVGLYRDPLSHEPIEYYF
CCCCCHHHHHCCCCEEHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCEEEEE
KVPDDMDQRLTVVVDPMLATGHSAAAAVTRLKRAGAGAIKFVCLIAAPEGIAALHAAHPD
ECCCCCCCCEEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCC
VPVYTAAIDRQLDEHAYIRPGLGDAGDRLFGTK
CCEEHHHHHHHHHCCCEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA