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The map label for this gene is bioF [C]

Identifier: 148260862

GI number: 148260862

Start: 2060549

End: 2061694

Strand: Reverse

Name: bioF [C]

Synonym: Acry_1868

Alternate gene names: 148260862

Gene position: 2061694-2060549 (Counterclockwise)

Preceding gene: 148260865

Following gene: 148260861

Centisome position: 60.83

GC content: 72.43

Gene sequence:

>1146_bases
ATGACCACGCTCGACCAGTTCGCGACCGACAAGCTCGCCCGCCTCGAGGCCGGCGCCCTCCGCCGCCGCCTGCGCCCGAC
CGCCCGCGCCCCCGGCGCGGTGCTGGAGCGCGACGGGCAGCGGCTGATCTCGTTCTCCTGCAACGACTATCTCAACCTCT
CCACCCACCCGGCGGTGATCGACGCCGCGATCGACGCCGCCCGCCGCCACGGCGCCGGCGCCGGCGCCTCCCGCCTCGTC
ACCGGCGACCATCCGCTCTATTGCGCGCTCGAGGCGCGCCTCGCCGCGCTGAAACAGACGGAAGACGCCGTGGTGTTCGG
CTCGGGCTTCCTCGCCAATACCGGCATCATCCCGGCGCTGATGGCGCGGGAGGATGCGATCTTCGTCGACGAGCTCGCCC
ATGCCTGCATCTGGGCCGGCGCCCGCCTGTCCGGCGCCGCGCTCCACGTCTTCCGCCACAACGACCTCGCGCATCTCGCC
GAACTCCTCGCCGCCCATCGCCAAGCCGCCCGCCACGCGATGGTGGTGACCGACGGCGTCTTCTCCATGGATGGCGACCT
CGCGCCCGTCGGCGAGATGCTCGCCTTGGCCAAGGCGCATGACGCCTGGCTGATGACGGACGATGCGCACGGCATCGGCG
TCATCAACGAAGGGCGCGGCTCGGCCCACGGCCATGACGTGCCGTTGCAGATGGGCACGCTGTCCAAGGCGGTGGGCAGC
TATGGCGGCTATCTCTGCGCCTCGCACGTGGTGTGCGAGCTGATCCGCAACCGTGCCCGCAGCTTCGTCTACACCACCGG
CCTGCCGCCGGCGGTGGTCGGCGCCTCGATCGCAGCCCTCGACCTGATCGCGACCGACCCCGCAATGTGCGCCGCCCCGC
TCGCCCATGCCCGCCGCTTCTGCGCCGCCCTGGGCCTGCCACCGGCCGAAAGCCCGATCGTGCCGCTCCTGCTCGGCACC
GCCGAGCGCGCCCTCGCGGCGCAGGCCGTGCTGGAGGCGGCGGGCTTTCTGGTCGCCGCCATCCGCCCGCCCACGGTGCC
CGAGGGCACGGCGCGGCTCCGCTTCGCCTTCACCGCCTGCCACGCCCCAGATGACATCGACCGTCTGGCCCAACTCGTCC
ACGACAGAATCCTGGTGACCGCATGA

Upstream 100 bases:

>100_bases
GTGCGATGGACATGGCAAGCTCCGATTTGCCCCAAGGGGTCGAACCGGTGATAAACGCTGCATCCGCGTTCGTGAAGCTT
TTGCGGCAGATTGAGACAGG

Downstream 100 bases:

>100_bases
GCCATTTCTTCATCACCGCATCCGGCACCGAGATCGGCAAGACGCATGTCGCCGCCGGCATGATCCGCCACTGGCGGGCC
GGCGACGTTCCCGCGCGGGC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTTLDQFATDKLARLEAGALRRRLRPTARAPGAVLERDGQRLISFSCNDYLNLSTHPAVIDAAIDAARRHGAGAGASRLV
TGDHPLYCALEARLAALKQTEDAVVFGSGFLANTGIIPALMAREDAIFVDELAHACIWAGARLSGAALHVFRHNDLAHLA
ELLAAHRQAARHAMVVTDGVFSMDGDLAPVGEMLALAKAHDAWLMTDDAHGIGVINEGRGSAHGHDVPLQMGTLSKAVGS
YGGYLCASHVVCELIRNRARSFVYTTGLPPAVVGASIAALDLIATDPAMCAAPLAHARRFCAALGLPPAESPIVPLLLGT
AERALAAQAVLEAAGFLVAAIRPPTVPEGTARLRFAFTACHAPDDIDRLAQLVHDRILVTA

Sequences:

>Translated_381_residues
MTTLDQFATDKLARLEAGALRRRLRPTARAPGAVLERDGQRLISFSCNDYLNLSTHPAVIDAAIDAARRHGAGAGASRLV
TGDHPLYCALEARLAALKQTEDAVVFGSGFLANTGIIPALMAREDAIFVDELAHACIWAGARLSGAALHVFRHNDLAHLA
ELLAAHRQAARHAMVVTDGVFSMDGDLAPVGEMLALAKAHDAWLMTDDAHGIGVINEGRGSAHGHDVPLQMGTLSKAVGS
YGGYLCASHVVCELIRNRARSFVYTTGLPPAVVGASIAALDLIATDPAMCAAPLAHARRFCAALGLPPAESPIVPLLLGT
AERALAAQAVLEAAGFLVAAIRPPTVPEGTARLRFAFTACHAPDDIDRLAQLVHDRILVTA
>Mature_380_residues
TTLDQFATDKLARLEAGALRRRLRPTARAPGAVLERDGQRLISFSCNDYLNLSTHPAVIDAAIDAARRHGAGAGASRLVT
GDHPLYCALEARLAALKQTEDAVVFGSGFLANTGIIPALMAREDAIFVDELAHACIWAGARLSGAALHVFRHNDLAHLAE
LLAAHRQAARHAMVVTDGVFSMDGDLAPVGEMLALAKAHDAWLMTDDAHGIGVINEGRGSAHGHDVPLQMGTLSKAVGSY
GGYLCASHVVCELIRNRARSFVYTTGLPPAVVGASIAALDLIATDPAMCAAPLAHARRFCAALGLPPAESPIVPLLLGTA
ERALAAQAVLEAAGFLVAAIRPPTVPEGTARLRFAFTACHAPDDIDRLAQLVHDRILVTA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=342, Percent_Identity=37.1345029239766, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI284448556, Length=342, Percent_Identity=37.1345029239766, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI83977440, Length=397, Percent_Identity=30.9823677581864, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI83977442, Length=397, Percent_Identity=30.9823677581864, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI83977444, Length=397, Percent_Identity=30.9823677581864, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI4758668, Length=389, Percent_Identity=28.7917737789203, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4502025, Length=357, Percent_Identity=29.6918767507003, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI40316939, Length=357, Percent_Identity=29.6918767507003, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI119220554, Length=389, Percent_Identity=29.0488431876607, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI5454084, Length=269, Percent_Identity=28.2527881040892, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1786993, Length=359, Percent_Identity=42.3398328690808, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1790046, Length=343, Percent_Identity=38.1924198250729, Blast_Score=214, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI71994529, Length=342, Percent_Identity=37.1345029239766, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI32566772, Length=416, Percent_Identity=26.4423076923077, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17560912, Length=318, Percent_Identity=26.7295597484277, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17560914, Length=318, Percent_Identity=26.7295597484277, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71982625, Length=266, Percent_Identity=25.5639097744361, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71982617, Length=266, Percent_Identity=25.5639097744361, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=380, Percent_Identity=31.8421052631579, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320267, Length=396, Percent_Identity=27.2727272727273, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323954, Length=267, Percent_Identity=25.0936329588015, Blast_Score=106, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24662918, Length=365, Percent_Identity=30.6849315068493, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI17137420, Length=388, Percent_Identity=31.1855670103093, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI17136286, Length=341, Percent_Identity=29.6187683284457, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24653280, Length=282, Percent_Identity=24.822695035461, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24653276, Length=282, Percent_Identity=24.822695035461, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24653278, Length=282, Percent_Identity=24.822695035461, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_ACICJ (A5FZN8)

Other databases:

- EMBL:   CP000697
- RefSeq:   YP_001234989.1
- ProteinModelPortal:   A5FZN8
- STRING:   A5FZN8
- GeneID:   5159571
- GenomeReviews:   CP000697_GR
- KEGG:   acr:Acry_1868
- eggNOG:   COG0156
- HOGENOM:   HBG649839
- OMA:   GCENDID
- BioCyc:   ACRY349163:ACRY_1868-MONOMER
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 40007; Mature: 39876

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 22-22 BINDING 134-134 BINDING 182-182 BINDING 345-345

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLDQFATDKLARLEAGALRRRLRPTARAPGAVLERDGQRLISFSCNDYLNLSTHPAVI
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCCCCHHH
DAAIDAARRHGAGAGASRLVTGDHPLYCALEARLAALKQTEDAVVFGSGFLANTGIIPAL
HHHHHHHHHCCCCCCCCCEEECCCCEEEHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHH
MAREDAIFVDELAHACIWAGARLSGAALHVFRHNDLAHLAELLAAHRQAARHAMVVTDGV
HHCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCEEEEECCC
FSMDGDLAPVGEMLALAKAHDAWLMTDDAHGIGVINEGRGSAHGHDVPLQMGTLSKAVGS
EECCCCCCHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCCCCCCCEEHHHHHHHHHH
YGGYLCASHVVCELIRNRARSFVYTTGLPPAVVGASIAALDLIATDPAMCAAPLAHARRF
HCHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
CAALGLPPAESPIVPLLLGTAERALAAQAVLEAAGFLVAAIRPPTVPEGTARLRFAFTAC
HHHHCCCCCCCCCHHHEECCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCEEEEEEEEC
HAPDDIDRLAQLVHDRILVTA
CCCCHHHHHHHHHHHHHEECC
>Mature Secondary Structure 
TTLDQFATDKLARLEAGALRRRLRPTARAPGAVLERDGQRLISFSCNDYLNLSTHPAVI
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCCCCHHH
DAAIDAARRHGAGAGASRLVTGDHPLYCALEARLAALKQTEDAVVFGSGFLANTGIIPAL
HHHHHHHHHCCCCCCCCCEEECCCCEEEHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHH
MAREDAIFVDELAHACIWAGARLSGAALHVFRHNDLAHLAELLAAHRQAARHAMVVTDGV
HHCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCEEEEECCC
FSMDGDLAPVGEMLALAKAHDAWLMTDDAHGIGVINEGRGSAHGHDVPLQMGTLSKAVGS
EECCCCCCHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCCCCCCCEEHHHHHHHHHH
YGGYLCASHVVCELIRNRARSFVYTTGLPPAVVGASIAALDLIATDPAMCAAPLAHARRF
HCHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
CAALGLPPAESPIVPLLLGTAERALAAQAVLEAAGFLVAAIRPPTVPEGTARLRFAFTAC
HHHHCCCCCCCCCHHHEECCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCEEEEEEEEC
HAPDDIDRLAQLVHDRILVTA
CCCCHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA