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The map label for this gene is bioD

Identifier: 148260861

GI number: 148260861

Start: 2059881

End: 2060552

Strand: Reverse

Name: bioD

Synonym: Acry_1867

Alternate gene names: 148260861

Gene position: 2060552-2059881 (Counterclockwise)

Preceding gene: 148260862

Following gene: 148260860

Centisome position: 60.8

GC content: 72.02

Gene sequence:

>672_bases
ATGAGCCATTTCTTCATCACCGCATCCGGCACCGAGATCGGCAAGACGCATGTCGCCGCCGGCATGATCCGCCACTGGCG
GGCCGGCGACGTTCCCGCGCGGGCGCTCAAGCCGGTCGCCAGCGGCTACCAGCCCGCGCTCTCCGCGTCGAGCGATGCCG
GTATCCTGCTGCGGGCGATGGGCAGTTCGATGGTGAACGACGAGGCGGTCGCCACCATCTGCCCCTGGCGGTTTCCCGAC
CCGATCTCGCCGGACATGGCGGCGGCGCGCAGCGGGCGGCGCATTCCGTTCGACGACCTCGTCGCCTTCTGCCAGGCCGA
GATCGTCGGCGCGGCCGGCCCCATGCTGGTCGAGGGCGTCGGCGGCGCGATGGTGCCGCTGGATGAAACGCACACCGTGC
GCGACTGGATCGCCGCCCTCGGCATCGAGGTCGTGCTGGTCGCCGGCGGCTATCTCGGCACGATCAGCCACACGCTCTGC
GCCGTCGAGGCGCTGCGCGCGCGCGGGATCGCGATTGCCGCGGTCGTGATCAACCCGATGGAGCCGCTGCCGGTGCCGGT
CGAGCGCACGCGGGAGTCGCTGCTGCGGCATCTCGGCGCCACCCCGCCGCCGGTCTTCATCGACGATACGCCGGACTGGC
ACGCCTGGCTCGACGAGGCCGCCCGCCGCTGA

Upstream 100 bases:

>100_bases
AGGGCACGGCGCGGCTCCGCTTCGCCTTCACCGCCTGCCACGCCCCAGATGACATCGACCGTCTGGCCCAACTCGTCCAC
GACAGAATCCTGGTGACCGC

Downstream 100 bases:

>100_bases
GTCGCCGGATGATACGAACGGCGTGTTGACACCCCCCGAAATCCTATATACCGGTTATTGAAAATCTGCATGGGGAGACC
GACGGATGCGCGCTCTTGTG

Product: dethiobiotin synthase

Products: NA

Alternate protein names: DTB synthetase; DTBS; Dethiobiotin synthase

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MSHFFITASGTEIGKTHVAAGMIRHWRAGDVPARALKPVASGYQPALSASSDAGILLRAMGSSMVNDEAVATICPWRFPD
PISPDMAAARSGRRIPFDDLVAFCQAEIVGAAGPMLVEGVGGAMVPLDETHTVRDWIAALGIEVVLVAGGYLGTISHTLC
AVEALRARGIAIAAVVINPMEPLPVPVERTRESLLRHLGATPPPVFIDDTPDWHAWLDEAARR

Sequences:

>Translated_223_residues
MSHFFITASGTEIGKTHVAAGMIRHWRAGDVPARALKPVASGYQPALSASSDAGILLRAMGSSMVNDEAVATICPWRFPD
PISPDMAAARSGRRIPFDDLVAFCQAEIVGAAGPMLVEGVGGAMVPLDETHTVRDWIAALGIEVVLVAGGYLGTISHTLC
AVEALRARGIAIAAVVINPMEPLPVPVERTRESLLRHLGATPPPVFIDDTPDWHAWLDEAARR
>Mature_222_residues
SHFFITASGTEIGKTHVAAGMIRHWRAGDVPARALKPVASGYQPALSASSDAGILLRAMGSSMVNDEAVATICPWRFPDP
ISPDMAAARSGRRIPFDDLVAFCQAEIVGAAGPMLVEGVGGAMVPLDETHTVRDWIAALGIEVVLVAGGYLGTISHTLCA
VEALRARGIAIAAVVINPMEPLPVPVERTRESLLRHLGATPPPVFIDDTPDWHAWLDEAARR

Specific function: Bioconversion of pimelate into dethiobiotin. [C]

COG id: COG0132

COG function: function code H; Dethiobiotin synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dethiobiotin synthetase family

Homologues:

Organism=Escherichia coli, GI1786995, Length=208, Percent_Identity=32.2115384615385, Blast_Score=91, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOD_ACICJ (A5FZN7)

Other databases:

- EMBL:   CP000697
- RefSeq:   YP_001234988.1
- ProteinModelPortal:   A5FZN7
- SMR:   A5FZN7
- STRING:   A5FZN7
- GeneID:   5159734
- GenomeReviews:   CP000697_GR
- KEGG:   acr:Acry_1867
- eggNOG:   COG0132
- HOGENOM:   HBG650065
- OMA:   ANCVDPN
- ProtClustDB:   CLSK971271
- BioCyc:   ACRY349163:ACRY_1867-MONOMER
- HAMAP:   MF_00336
- InterPro:   IPR004472
- PIRSF:   PIRSF006755
- TIGRFAMs:   TIGR00347

Pfam domain/function: NA

EC number: =6.3.3.3

Molecular weight: Translated: 23644; Mature: 23512

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHFFITASGTEIGKTHVAAGMIRHWRAGDVPARALKPVASGYQPALSASSDAGILLRAM
CCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHH
GSSMVNDEAVATICPWRFPDPISPDMAAARSGRRIPFDDLVAFCQAEIVGAAGPMLVEGV
CCHHCCCCHHEEECCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEECC
GGAMVPLDETHTVRDWIAALGIEVVLVAGGYLGTISHTLCAVEALRARGIAIAAVVINPM
CCCCCCCCCCHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHCCEEEEEEEECCC
EPLPVPVERTRESLLRHLGATPPPVFIDDTPDWHAWLDEAARR
CCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SHFFITASGTEIGKTHVAAGMIRHWRAGDVPARALKPVASGYQPALSASSDAGILLRAM
CEEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHH
GSSMVNDEAVATICPWRFPDPISPDMAAARSGRRIPFDDLVAFCQAEIVGAAGPMLVEGV
CCHHCCCCHHEEECCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEECC
GGAMVPLDETHTVRDWIAALGIEVVLVAGGYLGTISHTLCAVEALRARGIAIAAVVINPM
CCCCCCCCCCHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHCCEEEEEEEECCC
EPLPVPVERTRESLLRHLGATPPPVFIDDTPDWHAWLDEAARR
CCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA