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The map label for this gene is hutC [H]

Identifier: 148260746

GI number: 148260746

Start: 1931858

End: 1932622

Strand: Reverse

Name: hutC [H]

Synonym: Acry_1750

Alternate gene names: 148260746

Gene position: 1932622-1931858 (Counterclockwise)

Preceding gene: 148260747

Following gene: 148260741

Centisome position: 57.02

GC content: 73.99

Gene sequence:

>765_bases
ATGGCGCCTCCCGATCGCGAACCCGCCGCGCGGGTGCCGCTCTACGCCCGGGTGAAGGAGGCGATCGTCGAGCGCATCGC
CAGCGGCCAGATCGGCCCCGGCGGCCGCCTGCCCTCCGAGCACGAGCTGATGGCCGAATTCGGCGTCTCGCGGATGACGG
CGCATCGCGCCCTGCGCGAACTCTCCGCCGCCGGCCTCGTCGCTCGCGTGCAGGGCAGGGGCAGCTTCGCCGCGCCGCCG
CGCCCGCGCCTCGAATGGCTCGAAATCCGCGACATCTCCGATGAGATCGTCGCCTCCGGCCACCGCCACCGCGTCCGCGT
CCTCGCCCAGGAAGCCACCCGCGCCCGCGCCGACCAGGCGCTCGCCTTCGGCCTGCGCCCCGGCGCGCGCATCTTCCACG
CCACCCTGCTGCATTACGAGGACGACGTGCCGGTGCAGATCGAGGACCGGCTGGTCTCGCCCCGCTTCGCCCCGGATTTC
CTCGAACAGGATTTCACGAAGGAGACCGTCGCCGCCTATCTCCTCCGCCTCGGCCCGGCGACCGAGACCGAGCACGTCGT
CTACGCGACCACGCCCTCGCCCGAGATCCGCGCGCTGCTCGAGATCGGGCGCGACGAGGAGCAGGCCTGCCTCGTCGTCC
TCCGCCGCACCTGGAGCGGCGGGCTTCCCGCCACCCAGACCGAGTTCATCCACCCCGGCGCCCGCTACGCGCTCGGCACC
CGCTCCTCGATGGGCGACCGGCCGGACGGCCCGGCCGCCCCCTGA

Upstream 100 bases:

>100_bases
AGGCGACGATGCTCCGCCTGCCCGGCTTCGCCGCGCTGCAGGCGAGCCTCACCCGCATCCTCGCGCGGGTCGCCGCCGCC
GTGCCGGCGCTGGTCTGACC

Downstream 100 bases:

>100_bases
AGCTCAGCCGGTGATCCCCGGCAGGTTCAGCCCGTTCTCCCGCGCGCAGTCGATGGCGATGTCGTAGCCGGCATCGGCAT
GGCGCATCACCCCGGTCGCC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MAPPDREPAARVPLYARVKEAIVERIASGQIGPGGRLPSEHELMAEFGVSRMTAHRALRELSAAGLVARVQGRGSFAAPP
RPRLEWLEIRDISDEIVASGHRHRVRVLAQEATRARADQALAFGLRPGARIFHATLLHYEDDVPVQIEDRLVSPRFAPDF
LEQDFTKETVAAYLLRLGPATETEHVVYATTPSPEIRALLEIGRDEEQACLVVLRRTWSGGLPATQTEFIHPGARYALGT
RSSMGDRPDGPAAP

Sequences:

>Translated_254_residues
MAPPDREPAARVPLYARVKEAIVERIASGQIGPGGRLPSEHELMAEFGVSRMTAHRALRELSAAGLVARVQGRGSFAAPP
RPRLEWLEIRDISDEIVASGHRHRVRVLAQEATRARADQALAFGLRPGARIFHATLLHYEDDVPVQIEDRLVSPRFAPDF
LEQDFTKETVAAYLLRLGPATETEHVVYATTPSPEIRALLEIGRDEEQACLVVLRRTWSGGLPATQTEFIHPGARYALGT
RSSMGDRPDGPAAP
>Mature_253_residues
APPDREPAARVPLYARVKEAIVERIASGQIGPGGRLPSEHELMAEFGVSRMTAHRALRELSAAGLVARVQGRGSFAAPPR
PRLEWLEIRDISDEIVASGHRHRVRVLAQEATRARADQALAFGLRPGARIFHATLLHYEDDVPVQIEDRLVSPRFAPDFL
EQDFTKETVAAYLLRLGPATETEHVVYATTPSPEIRALLEIGRDEEQACLVVLRRTWSGGLPATQTEFIHPGARYALGTR
SSMGDRPDGPAAP

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=149, Percent_Identity=29.5302013422819, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786950, Length=199, Percent_Identity=25.6281407035176, Blast_Score=71, Evalue=6e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27914; Mature: 27783

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPPDREPAARVPLYARVKEAIVERIASGQIGPGGRLPSEHELMAEFGVSRMTAHRALRE
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHH
LSAAGLVARVQGRGSFAAPPRPRLEWLEIRDISDEIVASGHRHRVRVLAQEATRARADQA
HHHHCCEEEEECCCCCCCCCCCCCEEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHH
LAFGLRPGARIFHATLLHYEDDVPVQIEDRLVSPRFAPDFLEQDFTKETVAAYLLRLGPA
HHHCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TETEHVVYATTPSPEIRALLEIGRDEEQACLVVLRRTWSGGLPATQTEFIHPGARYALGT
CCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCHHCCCC
RSSMGDRPDGPAAP
CCCCCCCCCCCCCC
>Mature Secondary Structure 
APPDREPAARVPLYARVKEAIVERIASGQIGPGGRLPSEHELMAEFGVSRMTAHRALRE
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHH
LSAAGLVARVQGRGSFAAPPRPRLEWLEIRDISDEIVASGHRHRVRVLAQEATRARADQA
HHHHCCEEEEECCCCCCCCCCCCCEEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHH
LAFGLRPGARIFHATLLHYEDDVPVQIEDRLVSPRFAPDFLEQDFTKETVAAYLLRLGPA
HHHCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TETEHVVYATTPSPEIRALLEIGRDEEQACLVVLRRTWSGGLPATQTEFIHPGARYALGT
CCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCHHCCCC
RSSMGDRPDGPAAP
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]