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The map label for this gene is moaA [H]

Identifier: 148260603

GI number: 148260603

Start: 1772570

End: 1773565

Strand: Reverse

Name: moaA [H]

Synonym: Acry_1605

Alternate gene names: 148260603

Gene position: 1773565-1772570 (Counterclockwise)

Preceding gene: 148260605

Following gene: 148260602

Centisome position: 52.33

GC content: 69.48

Gene sequence:

>996_bases
ATGACAGACATGATCGATCCGTTCGGCCGCGCCATCACCTATCTCCGCATCTCGGTCACCGACCGGTGCGATTTCCGCTG
CGTCTACTGCATGGCGGAGGACATGACCTTCCTGCCGAAGGCGGACCTGCTCTCGCTCGAGGAGCTGGAGCGGCTGGCGG
GCGCCTTCGTCGATCTCGGCGTGCGCAAGCTGCGGCTGACCGGCGGCGAGCCGCTGGTCCGGCGCGGGGTGATGGCGCTG
ATCAACCGGCTGGGCCAGCGGATCGGCCAGGGGCTCGACGAGCTGACCCTGACCACCAATGGCAGCCAGCTCGGCCGCTT
CGCCGACGAGCTGGTCGCGGCCGGGGTGAAGCGGGTGAACGTCTCGATCGACACGCTGGACGAGGAGAAATTCCGCACGA
TCACCCGCTGGGGCCGGCTGCCGCAGGTGATCGACGGCGTGATGGCGGCGAAGGCGGCGGGGCTGCGGGTGAAGGTCAAC
GCCGTGGCGCTGAAGGGCGTGAACGAGGACGAGTTCGACGCCATGCTGGACTGGTGCGGCCGGCACGGCTTCGATTTCTG
CCTGATCGAGACGATGCCGCTCGGCGAGGTGGACCAGGACCGGACCGACCAGTACCTGCCGCTCTCCACCGTGCGCCAGC
GCCTCGCCGCGCGCTGGACGCTGACGCCGACCGACTACGTGACCGGCGGGCCGGCGCGGTATTTCGACGTCGCCGAGACC
GGCACGAGGCTCGGCTTCATCACCCCGCTCACGCATAATTTCTGCGAGGGCTGCAACCGGGTGCGGCTGACCTGCACCGG
CACGCTCTACATGTGCCTCGGCCAGGACGACGCGGCGGACCTGCGCGCCGTGCTGCGCGGCTCGGACGATGACGCGGTGC
TGCGCCAGGCGATCCTCGATGCGATCGCGCGCAAGCCGAAAGGGCATGATTTCGTGATCGACCGCGCCGGGCAGGCGCCG
GCGGTGGCCCGGCACATGAGCGTGACCGGCGGATAG

Upstream 100 bases:

>100_bases
CAGAGATATTGCCCGGGTCAAGCCACGGGCGGAGAAATGCCGCATTGCGCCCCGGTGCCGGCCGGAAACGGGACTTGCGT
TTGCGGGCGCGAGAGTAAAG

Downstream 100 bases:

>100_bases
GCCGGGGGCCTTCGCCGGGCGCGGTGGGACGGTTTCATCCTGTTCTTGAGTCACGAGAAATAAATTTGACAATCGATATG
ATCGTGGATAGAGATCTTCG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTDMIDPFGRAITYLRISVTDRCDFRCVYCMAEDMTFLPKADLLSLEELERLAGAFVDLGVRKLRLTGGEPLVRRGVMAL
INRLGQRIGQGLDELTLTTNGSQLGRFADELVAAGVKRVNVSIDTLDEEKFRTITRWGRLPQVIDGVMAAKAAGLRVKVN
AVALKGVNEDEFDAMLDWCGRHGFDFCLIETMPLGEVDQDRTDQYLPLSTVRQRLAARWTLTPTDYVTGGPARYFDVAET
GTRLGFITPLTHNFCEGCNRVRLTCTGTLYMCLGQDDAADLRAVLRGSDDDAVLRQAILDAIARKPKGHDFVIDRAGQAP
AVARHMSVTGG

Sequences:

>Translated_331_residues
MTDMIDPFGRAITYLRISVTDRCDFRCVYCMAEDMTFLPKADLLSLEELERLAGAFVDLGVRKLRLTGGEPLVRRGVMAL
INRLGQRIGQGLDELTLTTNGSQLGRFADELVAAGVKRVNVSIDTLDEEKFRTITRWGRLPQVIDGVMAAKAAGLRVKVN
AVALKGVNEDEFDAMLDWCGRHGFDFCLIETMPLGEVDQDRTDQYLPLSTVRQRLAARWTLTPTDYVTGGPARYFDVAET
GTRLGFITPLTHNFCEGCNRVRLTCTGTLYMCLGQDDAADLRAVLRGSDDDAVLRQAILDAIARKPKGHDFVIDRAGQAP
AVARHMSVTGG
>Mature_330_residues
TDMIDPFGRAITYLRISVTDRCDFRCVYCMAEDMTFLPKADLLSLEELERLAGAFVDLGVRKLRLTGGEPLVRRGVMALI
NRLGQRIGQGLDELTLTTNGSQLGRFADELVAAGVKRVNVSIDTLDEEKFRTITRWGRLPQVIDGVMAAKAAGLRVKVNA
VALKGVNEDEFDAMLDWCGRHGFDFCLIETMPLGEVDQDRTDQYLPLSTVRQRLAARWTLTPTDYVTGGPARYFDVAETG
TRLGFITPLTHNFCEGCNRVRLTCTGTLYMCLGQDDAADLRAVLRGSDDDAVLRQAILDAIARKPKGHDFVIDRAGQAPA
VARHMSVTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=326, Percent_Identity=36.1963190184049, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI22027536, Length=326, Percent_Identity=36.1963190184049, Blast_Score=182, Evalue=5e-46,
Organism=Escherichia coli, GI1786999, Length=333, Percent_Identity=31.5315315315315, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI32566331, Length=335, Percent_Identity=33.134328358209, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17561210, Length=309, Percent_Identity=34.3042071197411, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32566329, Length=314, Percent_Identity=34.0764331210191, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI28574490, Length=335, Percent_Identity=36.4179104477612, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28574488, Length=318, Percent_Identity=37.1069182389937, Blast_Score=183, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36506; Mature: 36375

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDMIDPFGRAITYLRISVTDRCDFRCVYCMAEDMTFLPKADLLSLEELERLAGAFVDLG
CCCCCCHHHHEEEEEEEEECCCCCCEEEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHHC
VRKLRLTGGEPLVRRGVMALINRLGQRIGQGLDELTLTTNGSQLGRFADELVAAGVKRVN
CEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCHHHHHHHHHHHHCCHHEEE
VSIDTLDEEKFRTITRWGRLPQVIDGVMAAKAAGLRVKVNAVALKGVNEDEFDAMLDWCG
EEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHHHH
RHGFDFCLIETMPLGEVDQDRTDQYLPLSTVRQRLAARWTLTPTDYVTGGPARYFDVAET
CCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCHHEEEHHHC
GTRLGFITPLTHNFCEGCNRVRLTCTGTLYMCLGQDDAADLRAVLRGSDDDAVLRQAILD
CCCEEEECCHHHHHHCCCCEEEEEEEEEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHH
AIARKPKGHDFVIDRAGQAPAVARHMSVTGG
HHHCCCCCCEEEEECCCCCCHHHHHCCCCCC
>Mature Secondary Structure 
TDMIDPFGRAITYLRISVTDRCDFRCVYCMAEDMTFLPKADLLSLEELERLAGAFVDLG
CCCCCHHHHEEEEEEEEECCCCCCEEEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHHC
VRKLRLTGGEPLVRRGVMALINRLGQRIGQGLDELTLTTNGSQLGRFADELVAAGVKRVN
CEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCHHHHHHHHHHHHCCHHEEE
VSIDTLDEEKFRTITRWGRLPQVIDGVMAAKAAGLRVKVNAVALKGVNEDEFDAMLDWCG
EEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHHHH
RHGFDFCLIETMPLGEVDQDRTDQYLPLSTVRQRLAARWTLTPTDYVTGGPARYFDVAET
CCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCHHEEEHHHC
GTRLGFITPLTHNFCEGCNRVRLTCTGTLYMCLGQDDAADLRAVLRGSDDDAVLRQAILD
CCCEEEECCHHHHHHCCCCEEEEEEEEEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHH
AIARKPKGHDFVIDRAGQAPAVARHMSVTGG
HHHCCCCCCEEEEECCCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA