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The map label for this gene is idnD [H]

Identifier: 148260588

GI number: 148260588

Start: 1756712

End: 1757740

Strand: Reverse

Name: idnD [H]

Synonym: Acry_1590

Alternate gene names: 148260588

Gene position: 1757740-1756712 (Counterclockwise)

Preceding gene: 148260594

Following gene: 148260587

Centisome position: 51.86

GC content: 75.8

Gene sequence:

>1029_bases
ATGACAGCGATCGTGATCCACGCCGCGGGCGATCTCAGGATCGAGGACCGGCCGGCGCCGCCGCCCGGGCCGGACGAGGT
GCGCGTACGGGTGCGGCGGGGCGGGATCTGCGGCTCCGACCTGCATTACATGCGCCATGGCGGGTTCGGCCCGGTGCGGC
TGGCCGAGCCGATGGTGCTCGGCCACGAGGTGGCGGGCGAGGTGGAGGATGCTGGGGCGGAGACGGGCTTCGCGCCCGGC
GAGGCGGTGGCGATCGACCCGTCGCTGCCCTGCGGCGCCTGCCGGTTCTGCGCCGCCGGGGCGACGCAGCATTGCACCGA
CATGCGGTTCTTCGGCAGCGCGATGCGCCGGCCGCATGTCCACGGCGCGTTCCGCTCCGCGATCACGGTGCCGGCGCGCC
AGCTGGTGCGGCTGCCGGCGGGGCTGGCGGTCGAGCGCGCCGCCTTCGCCGAGCCGCTGGCGGTGGGGCTACACGCCGCG
ACACGGGCCGGGATCGGGCCGGGGATGCGGGTGATCATCGCCGGGATGGGGCCGATCGGCCTGCTCGCCCTGCTCGCCGC
ATGGCATCGCGGGGCCGCCGAGATCGTCGCCTGCGACGTGCTCGGCGCGCCGCTCGCCCTCGCGGCAAGGCTGGGGGCGA
CGGAGACGGTCGATCTCGGCCGGGAGCCGGACGGGTTGGCCCGCTTCGCCGGGGGCAAGGGCTGGTTCGATGCGGGGATC
GAGGCGTCGGGGGCCGCTTCCTCGCTCGCCGGGCTGATCGGGGTGGTGCGGCCGCAGGGGCGGATCGCCCAGCTCGGCCT
CGGCGGCGACATGAGCCTGCCGCTGATGGCGCTGGTGAGCAAGGAGATCGAGCTGGCCGGCGCCTTCCGCTTCGGCCCCG
AATTCGCCGAGGCGGTGGCGCTGCTCGCCTCTGGCGCGATCGACCCCGACCCGTTGCTCAGCGCGGTGCTGCCGGCGGAG
CGGGCGGCGGAGGCCTTCGCGCTCGCGGCGGACAAGGCGCGGGCGGTGAAGGTCCAGCTCGCCTTCTAG

Upstream 100 bases:

>100_bases
GGCGCCGGATGGTTGCCGAAGTGCGGGAACCGGCGCATGTTAGCGGTAACACAGGATGGCGTAACACGAAGTCGGGCCAC
CGCTCAAGGAGGAAATCACC

Downstream 100 bases:

>100_bases
GCGGTTCCGCGATGGCCTCCCCGCCCGACCGCGCGCCGACGATGGACGATGTGGCCGCCGCCGCCGGCGTGTCGAAGATG
ACGGTCTCGCGGGCGCTGCG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MTAIVIHAAGDLRIEDRPAPPPGPDEVRVRVRRGGICGSDLHYMRHGGFGPVRLAEPMVLGHEVAGEVEDAGAETGFAPG
EAVAIDPSLPCGACRFCAAGATQHCTDMRFFGSAMRRPHVHGAFRSAITVPARQLVRLPAGLAVERAAFAEPLAVGLHAA
TRAGIGPGMRVIIAGMGPIGLLALLAAWHRGAAEIVACDVLGAPLALAARLGATETVDLGREPDGLARFAGGKGWFDAGI
EASGAASSLAGLIGVVRPQGRIAQLGLGGDMSLPLMALVSKEIELAGAFRFGPEFAEAVALLASGAIDPDPLLSAVLPAE
RAAEAFALAADKARAVKVQLAF

Sequences:

>Translated_342_residues
MTAIVIHAAGDLRIEDRPAPPPGPDEVRVRVRRGGICGSDLHYMRHGGFGPVRLAEPMVLGHEVAGEVEDAGAETGFAPG
EAVAIDPSLPCGACRFCAAGATQHCTDMRFFGSAMRRPHVHGAFRSAITVPARQLVRLPAGLAVERAAFAEPLAVGLHAA
TRAGIGPGMRVIIAGMGPIGLLALLAAWHRGAAEIVACDVLGAPLALAARLGATETVDLGREPDGLARFAGGKGWFDAGI
EASGAASSLAGLIGVVRPQGRIAQLGLGGDMSLPLMALVSKEIELAGAFRFGPEFAEAVALLASGAIDPDPLLSAVLPAE
RAAEAFALAADKARAVKVQLAF
>Mature_341_residues
TAIVIHAAGDLRIEDRPAPPPGPDEVRVRVRRGGICGSDLHYMRHGGFGPVRLAEPMVLGHEVAGEVEDAGAETGFAPGE
AVAIDPSLPCGACRFCAAGATQHCTDMRFFGSAMRRPHVHGAFRSAITVPARQLVRLPAGLAVERAAFAEPLAVGLHAAT
RAGIGPGMRVIIAGMGPIGLLALLAAWHRGAAEIVACDVLGAPLALAARLGATETVDLGREPDGLARFAGGKGWFDAGIE
ASGAASSLAGLIGVVRPQGRIAQLGLGGDMSLPLMALVSKEIELAGAFRFGPEFAEAVALLASGAIDPDPLLSAVLPAER
AAEAFALAADKARAVKVQLAF

Specific function: Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=329, Percent_Identity=35.5623100303951, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI4501929, Length=362, Percent_Identity=26.5193370165746, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI4501933, Length=359, Percent_Identity=25.6267409470752, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=25.5434782608696, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1790718, Length=315, Percent_Identity=46.984126984127, Blast_Score=267, Evalue=6e-73,
Organism=Escherichia coli, GI1788073, Length=338, Percent_Identity=31.9526627218935, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1790045, Length=321, Percent_Identity=29.9065420560748, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1788407, Length=353, Percent_Identity=30.8781869688385, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI226510992, Length=330, Percent_Identity=30.3030303030303, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1787863, Length=349, Percent_Identity=28.9398280802292, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788075, Length=357, Percent_Identity=29.4117647058824, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87082125, Length=344, Percent_Identity=25.8720930232558, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786825, Length=378, Percent_Identity=25.3968253968254, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=340, Percent_Identity=36.7647058823529, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17562878, Length=328, Percent_Identity=36.280487804878, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319955, Length=336, Percent_Identity=33.9285714285714, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322619, Length=336, Percent_Identity=33.9285714285714, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323099, Length=333, Percent_Identity=30.9309309309309, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6319258, Length=384, Percent_Identity=25, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=346, Percent_Identity=25.1445086705202, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=273, Percent_Identity=29.3040293040293, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=294, Percent_Identity=26.530612244898, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=296, Percent_Identity=27.3648648648649, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=294, Percent_Identity=25.8503401360544, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319949, Length=163, Percent_Identity=31.2883435582822, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17737897, Length=328, Percent_Identity=37.5, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17137530, Length=330, Percent_Identity=35.1515151515151, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI45551930, Length=337, Percent_Identity=24.9258160237389, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45550770, Length=337, Percent_Identity=24.9258160237389, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI221457811, Length=337, Percent_Identity=24.9258160237389, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17737895, Length=358, Percent_Identity=25.9776536312849, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.264 [H]

Molecular weight: Translated: 34947; Mature: 34816

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAIVIHAAGDLRIEDRPAPPPGPDEVRVRVRRGGICGSDLHYMRHGGFGPVRLAEPMVL
CCEEEEECCCCEEECCCCCCCCCCHHEEEEEECCCCCCCCHHHHHCCCCCCHHHCCCHHC
GHEVAGEVEDAGAETGFAPGEAVAIDPSLPCGACRFCAAGATQHCTDMRFFGSAMRRPHV
CHHHHCCHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCH
HGAFRSAITVPARQLVRLPAGLAVERAAFAEPLAVGLHAATRAGIGPGMRVIIAGMGPIG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHH
LLALLAAWHRGAAEIVACDVLGAPLALAARLGATETVDLGREPDGLARFAGGKGWFDAGI
HHHHHHHHCCCCHHEEEEHHHCCHHHHHHHCCCCCEECCCCCCCHHHHHCCCCCCCCCCC
EASGAASSLAGLIGVVRPQGRIAQLGLGGDMSLPLMALVSKEIELAGAFRFGPEFAEAVA
CCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHEEECCCHHHHHHHH
LLASGAIDPDPLLSAVLPAERAAEAFALAADKARAVKVQLAF
HHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEEEC
>Mature Secondary Structure 
TAIVIHAAGDLRIEDRPAPPPGPDEVRVRVRRGGICGSDLHYMRHGGFGPVRLAEPMVL
CEEEEECCCCEEECCCCCCCCCCHHEEEEEECCCCCCCCHHHHHCCCCCCHHHCCCHHC
GHEVAGEVEDAGAETGFAPGEAVAIDPSLPCGACRFCAAGATQHCTDMRFFGSAMRRPHV
CHHHHCCHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCH
HGAFRSAITVPARQLVRLPAGLAVERAAFAEPLAVGLHAATRAGIGPGMRVIIAGMGPIG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHH
LLALLAAWHRGAAEIVACDVLGAPLALAARLGATETVDLGREPDGLARFAGGKGWFDAGI
HHHHHHHHCCCCHHEEEEHHHCCHHHHHHHCCCCCEECCCCCCCHHHHHCCCCCCCCCCC
EASGAASSLAGLIGVVRPQGRIAQLGLGGDMSLPLMALVSKEIELAGAFRFGPEFAEAVA
CCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHEEECCCHHHHHHHH
LLASGAIDPDPLLSAVLPAERAAEAFALAADKARAVKVQLAF
HHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 9658018 [H]