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The map label for this gene is yfhQ [H]

Identifier: 148260502

GI number: 148260502

Start: 1663732

End: 1664775

Strand: Reverse

Name: yfhQ [H]

Synonym: Acry_1502

Alternate gene names: 148260502

Gene position: 1664775-1663732 (Counterclockwise)

Preceding gene: 148260503

Following gene: 148260500

Centisome position: 49.12

GC content: 67.72

Gene sequence:

>1044_bases
GTGAGTCGGTCCCTGCCATCCGCCGAAAATCTGCTCCGCTGGTATCATGTTCACCGGCGCATCCTGCCTTGGCGCGCCGG
CCCGGGTACCCTGCCCGATCCCTATCATGTCTGGCTGAGCGAAATCATGCTGCAGCAGACAGTCGTAGCGACTGTCATAC
CTTATTTCCATCGCTTCATCGAGCGTTTCCCCACGATCAGCGACCTCGCGGTCGCGGTGGATGATGAGATTCTGGGCCTG
TGGGCGGGGCTTGGCTATTACGCGCGGGCACGCAACCTGATCCGCTGCGCGAGGGCCGTCGCCGAGGCGGGCGGGTTTCC
CGTCACGCTCGACGGGCTACGTGCGCTGCCCGGCATCGGCCCTTATACGGCTGCGGCGATCGGCGCGATCGCCTTCGATA
TTCCGGTGGTTCCGGTGGACGGCAATGTCGAGCGGGTTACCGCCAGGATGTTCGCGATCGAGGAGGCGTTGCCCGCGGCG
AAGGACGCGATTGCGGTCGCCGCTGCCCGCCTTGGCGCGCAGGCGGCAGCGCAATCCAGCCCAGGTGACTTTGCGCAGGC
ATTGTTCGATCTCGGAGCCACCGTCTGCACGCCGCGCAGTCCATCATGCATGGTCTGCCCGTGGCGCGACGGATGCGCGG
CACATGCCCGGGGGCTGTCCGCCGACCTGCCGCGCAAGGCGAAGCGCGCGGCGCGGCCCGTGCGGCGCGGCACCGTGTTC
GTGATGCAGGATCGATCCGGCATGATTGGCCTGCGCCGGCGGCCACCACGCGGATTGCTCGGAGGGATGCTGGAGGTGCC
GGGCACGGATTGGGAGGCGACAGCTCCGCCCCCGGTGCCGCCATGCGCCGCGCATTGGCTTGATGCCGGCACGATCATTC
ACGTTTTCACCCATTTCGAGTTGCGCCTCACCGTGAAGGCGGGCCGCGTCGCGGCGCTACCCGGCGGGATCGTCGCCGCG
CCGCCCGATACGCCTCTGCCGACCGTGATGCGCAAGGCGCTGGAGGCCGGGCTTGCTGTTCTCGATGAGCGGTCGCCGAA
ATAA

Upstream 100 bases:

>100_bases
GCCGGCCGCAGCACGGGGGCAAGCAGGGCTGCGATGCCGCGCGGCGCGTTGTGCCGCGGCGCTTCCGGTGCCGGCATCCT
GGGTCTCGTCGGCGTTTTTC

Downstream 100 bases:

>100_bases
AAAGCTGCCCCGGACATGAAGTCCGGGGCGAGTTGACAGGACGGGTGCCGGCCCGATGCCGGCACCGCGGGGGAACTCGA
AGGGATCAGCGATCCGGTGC

Product: HhH-GPD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSRSLPSAENLLRWYHVHRRILPWRAGPGTLPDPYHVWLSEIMLQQTVVATVIPYFHRFIERFPTISDLAVAVDDEILGL
WAGLGYYARARNLIRCARAVAEAGGFPVTLDGLRALPGIGPYTAAAIGAIAFDIPVVPVDGNVERVTARMFAIEEALPAA
KDAIAVAAARLGAQAAAQSSPGDFAQALFDLGATVCTPRSPSCMVCPWRDGCAAHARGLSADLPRKAKRAARPVRRGTVF
VMQDRSGMIGLRRRPPRGLLGGMLEVPGTDWEATAPPPVPPCAAHWLDAGTIIHVFTHFELRLTVKAGRVAALPGGIVAA
PPDTPLPTVMRKALEAGLAVLDERSPK

Sequences:

>Translated_347_residues
MSRSLPSAENLLRWYHVHRRILPWRAGPGTLPDPYHVWLSEIMLQQTVVATVIPYFHRFIERFPTISDLAVAVDDEILGL
WAGLGYYARARNLIRCARAVAEAGGFPVTLDGLRALPGIGPYTAAAIGAIAFDIPVVPVDGNVERVTARMFAIEEALPAA
KDAIAVAAARLGAQAAAQSSPGDFAQALFDLGATVCTPRSPSCMVCPWRDGCAAHARGLSADLPRKAKRAARPVRRGTVF
VMQDRSGMIGLRRRPPRGLLGGMLEVPGTDWEATAPPPVPPCAAHWLDAGTIIHVFTHFELRLTVKAGRVAALPGGIVAA
PPDTPLPTVMRKALEAGLAVLDERSPK
>Mature_346_residues
SRSLPSAENLLRWYHVHRRILPWRAGPGTLPDPYHVWLSEIMLQQTVVATVIPYFHRFIERFPTISDLAVAVDDEILGLW
AGLGYYARARNLIRCARAVAEAGGFPVTLDGLRALPGIGPYTAAAIGAIAFDIPVVPVDGNVERVTARMFAIEEALPAAK
DAIAVAAARLGAQAAAQSSPGDFAQALFDLGATVCTPRSPSCMVCPWRDGCAAHARGLSADLPRKAKRAARPVRRGTVFV
MQDRSGMIGLRRRPPRGLLGGMLEVPGTDWEATAPPPVPPCAAHWLDAGTIIHVFTHFELRLTVKAGRVAALPGGIVAAP
PDTPLPTVMRKALEAGLAVLDERSPK

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=362, Percent_Identity=35.3591160220994, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI115298654, Length=362, Percent_Identity=35.3591160220994, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI115298652, Length=362, Percent_Identity=35.3591160220994, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI115298650, Length=362, Percent_Identity=35.3591160220994, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI190358497, Length=362, Percent_Identity=35.3591160220994, Blast_Score=177, Evalue=9e-45,
Organism=Homo sapiens, GI6912520, Length=362, Percent_Identity=35.3591160220994, Blast_Score=177, Evalue=9e-45,
Organism=Escherichia coli, GI1789331, Length=309, Percent_Identity=41.747572815534, Blast_Score=201, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 37165; Mature: 37033

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSLPSAENLLRWYHVHRRILPWRAGPGTLPDPYHVWLSEIMLQQTVVATVIPYFHRFI
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERFPTISDLAVAVDDEILGLWAGLGYYARARNLIRCARAVAEAGGFPVTLDGLRALPGIG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHCCCCC
PYTAAAIGAIAFDIPVVPVDGNVERVTARMFAIEEALPAAKDAIAVAAARLGAQAAAQSS
CHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
PGDFAQALFDLGATVCTPRSPSCMVCPWRDGCAAHARGLSADLPRKAKRAARPVRRGTVF
CHHHHHHHHHCCCCEECCCCCCEEEECCCCCHHHHHCCCCCCCCHHHHHHHCHHHCCEEE
VMQDRSGMIGLRRRPPRGLLGGMLEVPGTDWEATAPPPVPPCAAHWLDAGTIIHVFTHFE
EEECCCCCCCCCCCCCHHHHCCCEECCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEEEEE
LRLTVKAGRVAALPGGIVAAPPDTPLPTVMRKALEAGLAVLDERSPK
EEEEEECCEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRSLPSAENLLRWYHVHRRILPWRAGPGTLPDPYHVWLSEIMLQQTVVATVIPYFHRFI
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERFPTISDLAVAVDDEILGLWAGLGYYARARNLIRCARAVAEAGGFPVTLDGLRALPGIG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHCCCCC
PYTAAAIGAIAFDIPVVPVDGNVERVTARMFAIEEALPAAKDAIAVAAARLGAQAAAQSS
CHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
PGDFAQALFDLGATVCTPRSPSCMVCPWRDGCAAHARGLSADLPRKAKRAARPVRRGTVF
CHHHHHHHHHCCCCEECCCCCCEEEECCCCCHHHHHCCCCCCCCHHHHHHHCHHHCCEEE
VMQDRSGMIGLRRRPPRGLLGGMLEVPGTDWEATAPPPVPPCAAHWLDAGTIIHVFTHFE
EEECCCCCCCCCCCCCHHHHCCCEECCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEEEEE
LRLTVKAGRVAALPGGIVAAPPDTPLPTVMRKALEAGLAVLDERSPK
EEEEEECCEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]