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The map label for this gene is cysK [H]

Identifier: 148260489

GI number: 148260489

Start: 1652650

End: 1653657

Strand: Reverse

Name: cysK [H]

Synonym: Acry_1489

Alternate gene names: 148260489

Gene position: 1653657-1652650 (Counterclockwise)

Preceding gene: 148260494

Following gene: 148260486

Centisome position: 48.79

GC content: 63.59

Gene sequence:

>1008_bases
GTGACAGTGCAATCAGCGACCTCGATCGCCGGCGGATTCATCGGTGCGATCGGCCATACACCCTTGATCCGCCTGCGTCG
TGCATCCGAGGCGACTGGCTGTGAAATCCTTGGCAAGGCCGAATTCATGAATCCGGGCGGCTCTGTGAAGGATCGTGCGG
CGCTCGCGATTATCGAGGATGCCGAGGCGCGGGGCCTGCTCACGCCGGGCCGGTCAGGCACCATCGTCGAGGGAACGGCG
GGCAACACCGGGATTGGCCTCACGCTGGTGGCCAATGCGCGCGGCTATCGCAGCATTATTGTGATGCCCGAGACGCAGAG
CCAGGAAAAGAAGGATTTTCTCCGCATGATCGGCGCCGATCTGCGCCTCGTGCCGGCAAAACCCTATCGCGATCCCGGCA
ACTACGTTCACGTTTCCCGTCGTATTGCCGAGGAATGCGGCGGCTACTGGGCGAACCAGTTCGACAACCTTGCCAACCGG
GAGGGGCATCGCCGCACGACCGGGCCGGAGATATGGGCGCAGACGGGCGGCAGGATCGATGCCTTCACCTGCGCTTGCGG
AACCGGCGGCACGCTCGCCGGCGTCGCCTTGGCGTTGAAGGAGCGCAATCCGGCCACCCGCATCGTGCTTGCCGACCCCG
AAGGCAGCGCCTTGCATTCGTGGATCAAGACCGGTGAGATAACGTCTTCCGGATCATCGATTTCCGAGGGAATCGGCCAG
GGACGGGTTACGGCCAATCTGGAAGGCGCGCCAATTGATGATGCGGTGCGCATTCCCGATACCGAAATGCTCGGGCAGGT
CTACGACCTGATGATCCACGAGGGCCTCTCGGTCGGTGGTTCCGCGGGAATCAATGTCGCAGCGGCCATTCGCGTCGCAC
ACGAAATGGGGCCGGGCCACACGATCGTGACGATCCTTTGCGATGGCGCGTCGCGTTACCAGTCGAAGCTGTTCAACCCG
GAATTCCTGCGCGGCAAGGGGCTGCCGGTGCCGCCCTGGCTCGGGTAA

Upstream 100 bases:

>100_bases
CAACCATATCATCCTCCGGTTCATCGCCTTCCTGGCATCGAAGCATTGTTGTCCGACGCCAGGTTCTGATGCAAGACGGT
TACACGGGAGAAAGAACAGC

Downstream 100 bases:

>100_bases
GGGGGAATCAGACGCGACGGTAGGTCAGGACCAGAACATCCCGGAAGGCGGGGCGCGCGGGGTCGATCGGGACCACCGGC
GTCACGCCATGAAACACGCG

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTVQSATSIAGGFIGAIGHTPLIRLRRASEATGCEILGKAEFMNPGGSVKDRAALAIIEDAEARGLLTPGRSGTIVEGTA
GNTGIGLTLVANARGYRSIIVMPETQSQEKKDFLRMIGADLRLVPAKPYRDPGNYVHVSRRIAEECGGYWANQFDNLANR
EGHRRTTGPEIWAQTGGRIDAFTCACGTGGTLAGVALALKERNPATRIVLADPEGSALHSWIKTGEITSSGSSISEGIGQ
GRVTANLEGAPIDDAVRIPDTEMLGQVYDLMIHEGLSVGGSAGINVAAAIRVAHEMGPGHTIVTILCDGASRYQSKLFNP
EFLRGKGLPVPPWLG

Sequences:

>Translated_335_residues
MTVQSATSIAGGFIGAIGHTPLIRLRRASEATGCEILGKAEFMNPGGSVKDRAALAIIEDAEARGLLTPGRSGTIVEGTA
GNTGIGLTLVANARGYRSIIVMPETQSQEKKDFLRMIGADLRLVPAKPYRDPGNYVHVSRRIAEECGGYWANQFDNLANR
EGHRRTTGPEIWAQTGGRIDAFTCACGTGGTLAGVALALKERNPATRIVLADPEGSALHSWIKTGEITSSGSSISEGIGQ
GRVTANLEGAPIDDAVRIPDTEMLGQVYDLMIHEGLSVGGSAGINVAAAIRVAHEMGPGHTIVTILCDGASRYQSKLFNP
EFLRGKGLPVPPWLG
>Mature_334_residues
TVQSATSIAGGFIGAIGHTPLIRLRRASEATGCEILGKAEFMNPGGSVKDRAALAIIEDAEARGLLTPGRSGTIVEGTAG
NTGIGLTLVANARGYRSIIVMPETQSQEKKDFLRMIGADLRLVPAKPYRDPGNYVHVSRRIAEECGGYWANQFDNLANRE
GHRRTTGPEIWAQTGGRIDAFTCACGTGGTLAGVALALKERNPATRIVLADPEGSALHSWIKTGEITSSGSSISEGIGQG
RVTANLEGAPIDDAVRIPDTEMLGQVYDLMIHEGLSVGGSAGINVAAAIRVAHEMGPGHTIVTILCDGASRYQSKLFNPE
FLRGKGLPVPPWLG

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=325, Percent_Identity=40, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI295821200, Length=325, Percent_Identity=40, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4557415, Length=325, Percent_Identity=40, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI2367138, Length=315, Percent_Identity=36.8253968253968, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI1788754, Length=317, Percent_Identity=39.1167192429022, Blast_Score=155, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17535051, Length=312, Percent_Identity=35.8974358974359, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=36.7892976588629, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=36.7892976588629, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI115535073, Length=303, Percent_Identity=38.6138613861386, Blast_Score=160, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17534315, Length=332, Percent_Identity=33.433734939759, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17561720, Length=318, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25147552, Length=324, Percent_Identity=33.0246913580247, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=33.6448598130841, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71996324, Length=335, Percent_Identity=26.865671641791, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321449, Length=323, Percent_Identity=41.1764705882353, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321594, Length=327, Percent_Identity=35.474006116208, Blast_Score=178, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24643623, Length=330, Percent_Identity=34.5454545454545, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI20129101, Length=330, Percent_Identity=34.5454545454545, Blast_Score=171, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 35224; Mature: 35092

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVQSATSIAGGFIGAIGHTPLIRLRRASEATGCEILGKAEFMNPGGSVKDRAALAIIED
CCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCEECCCCCCCCCCEEEEEEEC
AEARGLLTPGRSGTIVEGTAGNTGIGLTLVANARGYRSIIVMPETQSQEKKDFLRMIGAD
CCCCCEECCCCCCCEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCC
LRLVPAKPYRDPGNYVHVSRRIAEECGGYWANQFDNLANREGHRRTTGPEIWAQTGGRID
EEEECCCCCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEE
AFTCACGTGGTLAGVALALKERNPATRIVLADPEGSALHSWIKTGEITSSGSSISEGIGQ
EEEEECCCCCHHHHHEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHCCC
GRVTANLEGAPIDDAVRIPDTEMLGQVYDLMIHEGLSVGGSAGINVAAAIRVAHEMGPGH
CEEEEECCCCCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCC
TIVTILCDGASRYQSKLFNPEFLRGKGLPVPPWLG
EEEEEEECCHHHHHHHCCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TVQSATSIAGGFIGAIGHTPLIRLRRASEATGCEILGKAEFMNPGGSVKDRAALAIIED
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCEECCCCCCCCCCEEEEEEEC
AEARGLLTPGRSGTIVEGTAGNTGIGLTLVANARGYRSIIVMPETQSQEKKDFLRMIGAD
CCCCCEECCCCCCCEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCC
LRLVPAKPYRDPGNYVHVSRRIAEECGGYWANQFDNLANREGHRRTTGPEIWAQTGGRID
EEEECCCCCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEE
AFTCACGTGGTLAGVALALKERNPATRIVLADPEGSALHSWIKTGEITSSGSSISEGIGQ
EEEEECCCCCHHHHHEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHCCC
GRVTANLEGAPIDDAVRIPDTEMLGQVYDLMIHEGLSVGGSAGINVAAAIRVAHEMGPGH
CEEEEECCCCCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCC
TIVTILCDGASRYQSKLFNPEFLRGKGLPVPPWLG
EEEEEEECCHHHHHHHCCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA