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The map label for this gene is gmk [H]

Identifier: 148260448

GI number: 148260448

Start: 1608185

End: 1608766

Strand: Reverse

Name: gmk [H]

Synonym: Acry_1447

Alternate gene names: 148260448

Gene position: 1608766-1608185 (Counterclockwise)

Preceding gene: 148260449

Following gene: 148260447

Centisome position: 47.47

GC content: 64.6

Gene sequence:

>582_bases
TTGAATAGGCGCGGCCTCTGCCTCGTGCTTGCAGCGCCTTCTGGCGCCGGCAAGACGTCGCTCTCTCGGGCGTTGCTTGC
CGGTGATTCACGGCTGTCGCTGTCGATCAGCGCCACCACCCGCGCGCCGCGCGATGGCGAGCAGGAGGGGGTGCATTATT
TCTTCCGCACCCCGGAACAGTTTGCGGGCATGGTCGCGGCAGGCGAATTCCTTGAGTATGCGACGGTGTTCGGCCGGTCC
TACGGCACGCCGCGCGCGCATGTCGGGGAGATGCTGGCGGCGGGCCGGGACATCCTGTTCGATATCGACTGGCAGGGCTT
TCGCCAGCTCAGGGCCGCGCTGCCGCGCGATGTGGTTGGCGTATTCATCCGCACGAGCAGCCTTGAGGAACTTCATCGCC
GCCTTGTGGCGCGTGGCGATGATCCCGCCGCGATCGCGATGCGGATGGAGGAGGCCGAGGACGAACTCGCGCATCAGGGC
GAATTCGATTTCATCATCGAAAACAACGATTTCGATACGGCTCTTGGCGATCTTTCGGCGATCCTGCGGGCGGCGCGGCT
GATGGCGTCTCGTATGGCATGA

Upstream 100 bases:

>100_bases
GCGAACACGCTGTGCAGCAAGTCGGCGTCGCTGCAACTGACCGCCATCGGGCTCGACCTCAAGGCAACGATCGAGCAGCT
GCGCGAACAGGTTCAGAACA

Downstream 100 bases:

>100_bases
ATGCTTGCCTGTCAGAGGCAAGTGCGCCTAAAGAGCGATGACGTTTTTCATAAAAACGAACATCACTTTATGCGGAGAGA
TGTCGTGGCCGAGGAAAATT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MNRRGLCLVLAAPSGAGKTSLSRALLAGDSRLSLSISATTRAPRDGEQEGVHYFFRTPEQFAGMVAAGEFLEYATVFGRS
YGTPRAHVGEMLAAGRDILFDIDWQGFRQLRAALPRDVVGVFIRTSSLEELHRRLVARGDDPAAIAMRMEEAEDELAHQG
EFDFIIENNDFDTALGDLSAILRAARLMASRMA

Sequences:

>Translated_193_residues
MNRRGLCLVLAAPSGAGKTSLSRALLAGDSRLSLSISATTRAPRDGEQEGVHYFFRTPEQFAGMVAAGEFLEYATVFGRS
YGTPRAHVGEMLAAGRDILFDIDWQGFRQLRAALPRDVVGVFIRTSSLEELHRRLVARGDDPAAIAMRMEEAEDELAHQG
EFDFIIENNDFDTALGDLSAILRAARLMASRMA
>Mature_193_residues
MNRRGLCLVLAAPSGAGKTSLSRALLAGDSRLSLSISATTRAPRDGEQEGVHYFFRTPEQFAGMVAAGEFLEYATVFGRS
YGTPRAHVGEMLAAGRDILFDIDWQGFRQLRAALPRDVVGVFIRTSSLEELHRRLVARGDDPAAIAMRMEEAEDELAHQG
EFDFIIENNDFDTALGDLSAILRAARLMASRMA

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=180, Percent_Identity=35, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI226874833, Length=180, Percent_Identity=35, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI4504221, Length=180, Percent_Identity=35, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI21361598, Length=190, Percent_Identity=28.9473684210526, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI38570142, Length=175, Percent_Identity=28, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI111154074, Length=177, Percent_Identity=28.2485875706215, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1790080, Length=191, Percent_Identity=47.1204188481675, Blast_Score=168, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI193203132, Length=189, Percent_Identity=34.9206349206349, Blast_Score=113, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=189, Percent_Identity=34.9206349206349, Blast_Score=112, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71988048, Length=178, Percent_Identity=30.3370786516854, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71988041, Length=178, Percent_Identity=30.3370786516854, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17557440, Length=183, Percent_Identity=28.4153005464481, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=35.3260869565217, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356141, Length=172, Percent_Identity=38.953488372093, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI116007136, Length=181, Percent_Identity=29.2817679558011, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45554481, Length=181, Percent_Identity=29.2817679558011, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI85724806, Length=181, Percent_Identity=29.2817679558011, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640542, Length=181, Percent_Identity=29.2817679558011, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45554489, Length=181, Percent_Identity=29.2817679558011, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161077626, Length=181, Percent_Identity=29.2817679558011, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21148; Mature: 21148

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRGLCLVLAAPSGAGKTSLSRALLAGDSRLSLSISATTRAPRDGEQEGVHYFFRTPEQ
CCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEEECHHH
FAGMVAAGEFLEYATVFGRSYGTPRAHVGEMLAAGRDILFDIDWQGFRQLRAALPRDVVG
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCHHHHH
VFIRTSSLEELHRRLVARGDDPAAIAMRMEEAEDELAHQGEFDFIIENNDFDTALGDLSA
HHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHH
ILRAARLMASRMA
HHHHHHHHHHHCC
>Mature Secondary Structure
MNRRGLCLVLAAPSGAGKTSLSRALLAGDSRLSLSISATTRAPRDGEQEGVHYFFRTPEQ
CCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEEECHHH
FAGMVAAGEFLEYATVFGRSYGTPRAHVGEMLAAGRDILFDIDWQGFRQLRAALPRDVVG
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCHHHHH
VFIRTSSLEELHRRLVARGDDPAAIAMRMEEAEDELAHQGEFDFIIENNDFDTALGDLSA
HHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHH
ILRAARLMASRMA
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA