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The map label for this gene is hslU [H]

Identifier: 148260411

GI number: 148260411

Start: 1565168

End: 1566487

Strand: Reverse

Name: hslU [H]

Synonym: Acry_1409

Alternate gene names: 148260411

Gene position: 1566487-1565168 (Counterclockwise)

Preceding gene: 148260412

Following gene: 148260406

Centisome position: 46.22

GC content: 68.56

Gene sequence:

>1320_bases
GTGATCGACAGCCCGACCTACACGCCCCGCGAAATCGTCTCCGAGCTCGACCGCTTCATCGTCGGCCAGCAGGACGCGAA
GCGCGCCGTCGCCATCGCGCTGCGCAACCGATGGCGCCGCCAGCAGCTCCCCGAGGGGCTGCGCGAGGAGGTGGTGCCGA
AGAACATCCTGATGATCGGGCCGACCGGCTGCGGCAAGACCGAGATCGCCCGCCGCCTCGCCAAGCTCGCCCAGGCGCCG
TTCATCAAGGTCGAGGCGACGAAATTCACCGAGGTGGGCTATGTTGGCCGCGATGTGGAAAGCATCGTGCGCGACCTCGT
CGAGGTGTCCATCACGATGCTGCGCGACATGAGCCGCAAGGGCGTGCAGGCCCGCGCCGAACTCGCCGCCGAGGATCGGC
TGCTGACCGCGCTGGTGGGCGAGGGGGCCTCGTCGGAGACGCGCAACCGCTTCCGCCGGATGCTGCGCGACGGCGAGATG
GAAGAAAAGGAAATCGACGTCGACGTGAGCGAGGCGCCGCCCAACGTGATCGGCCAGATGGACATGCCGGGCATGCCGCC
GGGCGGCGCGATCAATCTCGGCGACATGATGAAGTCGATGTTCGGCCGCCAGCATGGCCGCAAGCGGATGACCGTCGCCG
CCGCCCGCGCCGCGCTGGAGCGCGAGGAGGCCGACCGCCTGCTCGACAACGAGCAGCTGACCGCCGATGCCCGCCTGCAC
GCCGAGACGCACGGCATCGTCTTTCTCGACGAGATCGACAAGATCTGCGCGCGCACCGAAAGCGGCTTCCGCGGTGGCGA
CGTCTCGCGCGAGGGCGTGCAGCGCGACCTGCTGCCGCTGATCGAGGGCACGACGGTCTCGACCAAATACGGTCCGGTGA
AGACCGATCACATTCTCTTCATCGCCTCGGGCGCGTTCCACGTCGCCAAGCCGTCGGACCTGCTGCCGGAACTGCAGGGG
CGGCTGCCGATCCGCGTCGAGCTCGCCTCGCTCTCGCGCGAGGATTTCCGCCGCATCCTGACCGAGCCGGAACATTCCCT
GCTCAAGCAGTATGTCGCGCTGATGAAGACCGAGAATGTCGACCTGCACTTCACCGACGACGCGGTCGATGCCGTGGCGG
CGCTGGCGGCCGACATCAACGACCGGGTCGAGAATATCGGCGCGCGTCGGCTGGCCACGGTGCTGGAGCGGCTGCTCGAG
GAGATCAGCTTCGCCGCGACCGACCGCGCCGGCGAGACCGTGACGGTCGACGCCGCCCTGGTCAACGACAAGGTCGCCCC
GCTCGCCGCGCGCGGCGATCTCGGCCGCTTCATCCTGTAA

Upstream 100 bases:

>100_bases
CGGTGGACGGCATGACCGCCGAGGACATCGCCCGCCGGGCGATGAAGATCGCCGGCGACATCTGCGTCTACACCAACCAT
CACGTGACGGTGGAAATCCT

Downstream 100 bases:

>100_bases
CGGCGCGGGTCTCCGGCGACGCCAGGGGGATCAATCCCCCAGCGTGCGCCGCCGGGACTCGAACTCGGCAGCGTCGATCT
CGCCGCGCGCGAAGCGCTCC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MIDSPTYTPREIVSELDRFIVGQQDAKRAVAIALRNRWRRQQLPEGLREEVVPKNILMIGPTGCGKTEIARRLAKLAQAP
FIKVEATKFTEVGYVGRDVESIVRDLVEVSITMLRDMSRKGVQARAELAAEDRLLTALVGEGASSETRNRFRRMLRDGEM
EEKEIDVDVSEAPPNVIGQMDMPGMPPGGAINLGDMMKSMFGRQHGRKRMTVAAARAALEREEADRLLDNEQLTADARLH
AETHGIVFLDEIDKICARTESGFRGGDVSREGVQRDLLPLIEGTTVSTKYGPVKTDHILFIASGAFHVAKPSDLLPELQG
RLPIRVELASLSREDFRRILTEPEHSLLKQYVALMKTENVDLHFTDDAVDAVAALAADINDRVENIGARRLATVLERLLE
EISFAATDRAGETVTVDAALVNDKVAPLAARGDLGRFIL

Sequences:

>Translated_439_residues
MIDSPTYTPREIVSELDRFIVGQQDAKRAVAIALRNRWRRQQLPEGLREEVVPKNILMIGPTGCGKTEIARRLAKLAQAP
FIKVEATKFTEVGYVGRDVESIVRDLVEVSITMLRDMSRKGVQARAELAAEDRLLTALVGEGASSETRNRFRRMLRDGEM
EEKEIDVDVSEAPPNVIGQMDMPGMPPGGAINLGDMMKSMFGRQHGRKRMTVAAARAALEREEADRLLDNEQLTADARLH
AETHGIVFLDEIDKICARTESGFRGGDVSREGVQRDLLPLIEGTTVSTKYGPVKTDHILFIASGAFHVAKPSDLLPELQG
RLPIRVELASLSREDFRRILTEPEHSLLKQYVALMKTENVDLHFTDDAVDAVAALAADINDRVENIGARRLATVLERLLE
EISFAATDRAGETVTVDAALVNDKVAPLAARGDLGRFIL
>Mature_439_residues
MIDSPTYTPREIVSELDRFIVGQQDAKRAVAIALRNRWRRQQLPEGLREEVVPKNILMIGPTGCGKTEIARRLAKLAQAP
FIKVEATKFTEVGYVGRDVESIVRDLVEVSITMLRDMSRKGVQARAELAAEDRLLTALVGEGASSETRNRFRRMLRDGEM
EEKEIDVDVSEAPPNVIGQMDMPGMPPGGAINLGDMMKSMFGRQHGRKRMTVAAARAALEREEADRLLDNEQLTADARLH
AETHGIVFLDEIDKICARTESGFRGGDVSREGVQRDLLPLIEGTTVSTKYGPVKTDHILFIASGAFHVAKPSDLLPELQG
RLPIRVELASLSREDFRRILTEPEHSLLKQYVALMKTENVDLHFTDDAVDAVAALAADINDRVENIGARRLATVLERLLE
EISFAATDRAGETVTVDAALVNDKVAPLAARGDLGRFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=114, Percent_Identity=36.8421052631579, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790366, Length=447, Percent_Identity=56.3758389261745, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI1786642, Length=264, Percent_Identity=31.0606060606061, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71982908, Length=245, Percent_Identity=33.0612244897959, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71982905, Length=236, Percent_Identity=33.8983050847458, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648291, Length=255, Percent_Identity=31.7647058823529, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648289, Length=255, Percent_Identity=31.7647058823529, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 48535; Mature: 48535

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDSPTYTPREIVSELDRFIVGQQDAKRAVAIALRNRWRRQQLPEGLREEVVPKNILMIG
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
PTGCGKTEIARRLAKLAQAPFIKVEATKFTEVGYVGRDVESIVRDLVEVSITMLRDMSRK
CCCCCHHHHHHHHHHHHHCCCEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GVQARAELAAEDRLLTALVGEGASSETRNRFRRMLRDGEMEEKEIDVDVSEAPPNVIGQM
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCC
DMPGMPPGGAINLGDMMKSMFGRQHGRKRMTVAAARAALEREEADRLLDNEQLTADARLH
CCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEE
AETHGIVFLDEIDKICARTESGFRGGDVSREGVQRDLLPLIEGTTVSTKYGPVKTDHILF
ECCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCEEEE
IASGAFHVAKPSDLLPELQGRLPIRVELASLSREDFRRILTEPEHSLLKQYVALMKTENV
EECCCEECCCCHHHHHHHHCCCCEEEEHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCC
DLHFTDDAVDAVAALAADINDRVENIGARRLATVLERLLEEISFAATDRAGETVTVDAAL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHH
VNDKVAPLAARGDLGRFIL
HCCCCCCEECCCCCCCCCC
>Mature Secondary Structure
MIDSPTYTPREIVSELDRFIVGQQDAKRAVAIALRNRWRRQQLPEGLREEVVPKNILMIG
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
PTGCGKTEIARRLAKLAQAPFIKVEATKFTEVGYVGRDVESIVRDLVEVSITMLRDMSRK
CCCCCHHHHHHHHHHHHHCCCEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GVQARAELAAEDRLLTALVGEGASSETRNRFRRMLRDGEMEEKEIDVDVSEAPPNVIGQM
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCC
DMPGMPPGGAINLGDMMKSMFGRQHGRKRMTVAAARAALEREEADRLLDNEQLTADARLH
CCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEE
AETHGIVFLDEIDKICARTESGFRGGDVSREGVQRDLLPLIEGTTVSTKYGPVKTDHILF
ECCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCEEEE
IASGAFHVAKPSDLLPELQGRLPIRVELASLSREDFRRILTEPEHSLLKQYVALMKTENV
EECCCEECCCCHHHHHHHHCCCCEEEEHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCC
DLHFTDDAVDAVAALAADINDRVENIGARRLATVLERLLEEISFAATDRAGETVTVDAAL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHH
VNDKVAPLAARGDLGRFIL
HCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA