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The map label for this gene is groEL [H]

Identifier: 148260379

GI number: 148260379

Start: 1532301

End: 1533935

Strand: Reverse

Name: groEL [H]

Synonym: Acry_1376

Alternate gene names: 148260379

Gene position: 1533935-1532301 (Counterclockwise)

Preceding gene: 148260380

Following gene: 148260376

Centisome position: 45.26

GC content: 69.97

Gene sequence:

>1635_bases
ATGGCTAAGCTGCTTCTGCATAATTCCGAAGCCCGGCGTGCGCTGGCCCGCGGTGTGGGCCGGCTCGCGGCGGCCGTCGA
GCCCACGCTCGGGCCTAAAGGCATGAACGCGATGATCGACCGGCCGATCGGCACGCCGATGGTCACGCGCGATGGCGTCA
GCATCGCGGTGGAGATCGAGCTGCCGAACCGGTTCGAGAACATGGGCGCGCAGGTCGTCCGCGAGGTCTCGATGCAGACC
AACGAACTCGCGGGCGACGGCACCACCACCGCGATCGTGCTCGCCAACGCGCTCGTCCAGGCCGGCGTCGAGGCCAGCGA
GCGCGGCGCCCGCGCGGTCGATCTCATTCGCGGGATCGATCTCGCGGTCGAGCGCGTGGCATCGTCCCTCAAGGAAGCGG
CCCGGCCGGCTTCCGGCAACGGCATGCTCGCCGCGGTGGCCAACATCGCCGCAACCGAGCCGCATCTCGGCGCGCTGGTC
GCCGAGGCCTTCGCGCGCGTCGGCGCCGAGGGCGTGATCACTACCGACTTCAGCGTGACCACCGCAACGACGCTCGAGGT
CGTCGAAGGCATGTCCTTCGATCGCGGCTATATCTCGCATCACATGGTGACCGATCAGGAGAAGATGGAAGCCGTGCTCG
AACGGCCGCTGATCCTGATGACGGATCTCAAGATCCGCGATCCCCATGCGCTCGATGCGGCGCGCGCGCTCGCCGCCGAC
GCCCACCGCCCGCTTCTCGTGATCGCCGAGGAGGTGGCGCCGGAGGTCGTCGTCAGCCTGCTCGGGCGCGACGGGCCGGG
CCGCTACCTCGTCGTGCATCCGCCCGAATATGGCAACTGGCGCAAGGCGATGATGGAGGATATCGCCATCATCACCGGCG
GCCGCGTCATCGCCCGCGATCTTGGCGGCCGGGTCGAGGACGTCACGGCGGCCGATCTCGGCGCCGCCGAGCGGGTGCGC
ACCAGTGCGACGCACACCGCGATCATCGGCGGCGCCGGCGATCCGGCGGCGATCGCCGCGCGCCGGGCGCAGGTGCAGCG
GATGCACGATATCGCCCCGCCCAATATCGAGCAGGACAAGCTGCGCGAGCGCCTCGCGAAGCTTTCCGGCGGTACCGCCA
TACTTTATGCCGGCGGAGCGACGCCGGTCGAGCAGAAGCGCACCATCCAGCTGATCGAGGATTCGCTCGCCGCCGTGCGC
GCCGCGAGCGAGGAGGGGGTGGTTGCCGGCGGCGGCACCGCACTGGCGCAGATCGGCCCGGTGCTCGACGAGGTTCTGGC
CGGCGTCGGCGGCGATGTCGCGGAAGGGGTGAAGCTCGTCCGCTCCATCCTCACCCGCCCGCTCTGGCGCATCGTGACCA
ATGCCGGCGGCGACCCCGACCACGTGGTCGCTCAGGTCTCGGCGGTGAATGGCGGTTTCGGCTACAATGCCGCCATCGGC
ACGTTCCAGAACATGTACGATGCCGGCATCATCGATCCCGTCCGCGTCACCTGCACGGCGCTGCGCAACGCCGCCTCGGT
CGCCAAGCTGATCCTGACCACGGAAACGCTGGTGGGCGATCTGGGTGAGGACGAGGAAGACCCGACCGCGTCTCCCGCCC
GCGGCGGCGGCGCCGAGCGTCTCGGCCGCGCATGA

Upstream 100 bases:

>100_bases
TCGCGGCGAAGAAGGCGGCGCTTGCGGCCTCGCCGCTCGCGGTCGCCGCCGAATAGGCCGGTCCACGCAGCACGCCGGCC
ATCGGCCGAAGGGAGACAAA

Downstream 100 bases:

>100_bases
TCTCCGGCGTCAAGGGCGGCTGGATTCCGGCCGCCCTTGCCGTTCAGACGAAGCCGCGCCTGATTCCGAACTGGTCGAGC
TTCCGGTAGAGCGTCGGCCG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 4; Protein Cpn60 4 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAKLLLHNSEARRALARGVGRLAAAVEPTLGPKGMNAMIDRPIGTPMVTRDGVSIAVEIELPNRFENMGAQVVREVSMQT
NELAGDGTTTAIVLANALVQAGVEASERGARAVDLIRGIDLAVERVASSLKEAARPASGNGMLAAVANIAATEPHLGALV
AEAFARVGAEGVITTDFSVTTATTLEVVEGMSFDRGYISHHMVTDQEKMEAVLERPLILMTDLKIRDPHALDAARALAAD
AHRPLLVIAEEVAPEVVVSLLGRDGPGRYLVVHPPEYGNWRKAMMEDIAIITGGRVIARDLGGRVEDVTAADLGAAERVR
TSATHTAIIGGAGDPAAIAARRAQVQRMHDIAPPNIEQDKLRERLAKLSGGTAILYAGGATPVEQKRTIQLIEDSLAAVR
AASEEGVVAGGGTALAQIGPVLDEVLAGVGGDVAEGVKLVRSILTRPLWRIVTNAGGDPDHVVAQVSAVNGGFGYNAAIG
TFQNMYDAGIIDPVRVTCTALRNAASVAKLILTTETLVGDLGEDEEDPTASPARGGGAERLGRA

Sequences:

>Translated_544_residues
MAKLLLHNSEARRALARGVGRLAAAVEPTLGPKGMNAMIDRPIGTPMVTRDGVSIAVEIELPNRFENMGAQVVREVSMQT
NELAGDGTTTAIVLANALVQAGVEASERGARAVDLIRGIDLAVERVASSLKEAARPASGNGMLAAVANIAATEPHLGALV
AEAFARVGAEGVITTDFSVTTATTLEVVEGMSFDRGYISHHMVTDQEKMEAVLERPLILMTDLKIRDPHALDAARALAAD
AHRPLLVIAEEVAPEVVVSLLGRDGPGRYLVVHPPEYGNWRKAMMEDIAIITGGRVIARDLGGRVEDVTAADLGAAERVR
TSATHTAIIGGAGDPAAIAARRAQVQRMHDIAPPNIEQDKLRERLAKLSGGTAILYAGGATPVEQKRTIQLIEDSLAAVR
AASEEGVVAGGGTALAQIGPVLDEVLAGVGGDVAEGVKLVRSILTRPLWRIVTNAGGDPDHVVAQVSAVNGGFGYNAAIG
TFQNMYDAGIIDPVRVTCTALRNAASVAKLILTTETLVGDLGEDEEDPTASPARGGGAERLGRA
>Mature_543_residues
AKLLLHNSEARRALARGVGRLAAAVEPTLGPKGMNAMIDRPIGTPMVTRDGVSIAVEIELPNRFENMGAQVVREVSMQTN
ELAGDGTTTAIVLANALVQAGVEASERGARAVDLIRGIDLAVERVASSLKEAARPASGNGMLAAVANIAATEPHLGALVA
EAFARVGAEGVITTDFSVTTATTLEVVEGMSFDRGYISHHMVTDQEKMEAVLERPLILMTDLKIRDPHALDAARALAADA
HRPLLVIAEEVAPEVVVSLLGRDGPGRYLVVHPPEYGNWRKAMMEDIAIITGGRVIARDLGGRVEDVTAADLGAAERVRT
SATHTAIIGGAGDPAAIAARRAQVQRMHDIAPPNIEQDKLRERLAKLSGGTAILYAGGATPVEQKRTIQLIEDSLAAVRA
ASEEGVVAGGGTALAQIGPVLDEVLAGVGGDVAEGVKLVRSILTRPLWRIVTNAGGDPDHVVAQVSAVNGGFGYNAAIGT
FQNMYDAGIIDPVRVTCTALRNAASVAKLILTTETLVGDLGEDEEDPTASPARGGGAERLGRA

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=37.8531073446328, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=37.8531073446328, Blast_Score=331, Evalue=1e-90,
Organism=Escherichia coli, GI1790586, Length=527, Percent_Identity=44.022770398482, Blast_Score=394, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=38.3742911153119, Blast_Score=337, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI193210679, Length=230, Percent_Identity=37.8260869565217, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=39.4285714285714, Blast_Score=343, Evalue=5e-95,
Organism=Saccharomyces cerevisiae, GI6322524, Length=353, Percent_Identity=23.2294617563739, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=38.6363636363636, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=38.6363636363636, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=38.3587786259542, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=38.3587786259542, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=38.3587786259542, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI17864606, Length=542, Percent_Identity=34.1328413284133, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24584129, Length=515, Percent_Identity=33.0097087378641, Blast_Score=234, Evalue=8e-62,
Organism=Drosophila melanogaster, GI19921262, Length=515, Percent_Identity=33.0097087378641, Blast_Score=234, Evalue=8e-62,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56667; Mature: 56536

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLLLHNSEARRALARGVGRLAAAVEPTLGPKGMNAMIDRPIGTPMVTRDGVSIAVEIE
CCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCEEECCCEEEEEEE
LPNRFENMGAQVVREVSMQTNELAGDGTTTAIVLANALVQAGVEASERGARAVDLIRGID
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHH
LAVERVASSLKEAARPASGNGMLAAVANIAATEPHLGALVAEAFARVGAEGVITTDFSVT
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCH
TATTLEVVEGMSFDRGYISHHMVTDQEKMEAVLERPLILMTDLKIRDPHALDAARALAAD
HHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHCCEEEEECCEECCCHHHHHHHHHHHC
AHRPLLVIAEEVAPEVVVSLLGRDGPGRYLVVHPPEYGNWRKAMMEDIAIITGGRVIARD
CCCCEEEEHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHEECCCHHHHH
LGGRVEDVTAADLGAAERVRTSATHTAIIGGAGDPAAIAARRAQVQRMHDIAPPNIEQDK
HCCCCCHHHHHHCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHH
LRERLAKLSGGTAILYAGGATPVEQKRTIQLIEDSLAAVRAASEEGVVAGGGTALAQIGP
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHH
VLDEVLAGVGGDVAEGVKLVRSILTRPLWRIVTNAGGDPDHVVAQVSAVNGGFGYNAAIG
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEEECCCCCCCCHHHH
TFQNMYDAGIIDPVRVTCTALRNAASVAKLILTTETLVGDLGEDEEDPTASPARGGGAER
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
LGRA
CCCC
>Mature Secondary Structure 
AKLLLHNSEARRALARGVGRLAAAVEPTLGPKGMNAMIDRPIGTPMVTRDGVSIAVEIE
CCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCEEECCCEEEEEEE
LPNRFENMGAQVVREVSMQTNELAGDGTTTAIVLANALVQAGVEASERGARAVDLIRGID
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHH
LAVERVASSLKEAARPASGNGMLAAVANIAATEPHLGALVAEAFARVGAEGVITTDFSVT
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCH
TATTLEVVEGMSFDRGYISHHMVTDQEKMEAVLERPLILMTDLKIRDPHALDAARALAAD
HHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHCCEEEEECCEECCCHHHHHHHHHHHC
AHRPLLVIAEEVAPEVVVSLLGRDGPGRYLVVHPPEYGNWRKAMMEDIAIITGGRVIARD
CCCCEEEEHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHEECCCHHHHH
LGGRVEDVTAADLGAAERVRTSATHTAIIGGAGDPAAIAARRAQVQRMHDIAPPNIEQDK
HCCCCCHHHHHHCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHH
LRERLAKLSGGTAILYAGGATPVEQKRTIQLIEDSLAAVRAASEEGVVAGGGTALAQIGP
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHH
VLDEVLAGVGGDVAEGVKLVRSILTRPLWRIVTNAGGDPDHVVAQVSAVNGGFGYNAAIG
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEEECCCCCCCCHHHH
TFQNMYDAGIIDPVRVTCTALRNAASVAKLILTTETLVGDLGEDEEDPTASPARGGGAER
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
LGRA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]