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The map label for this gene is pgl [H]

Identifier: 148260276

GI number: 148260276

Start: 1421159

End: 1421896

Strand: Reverse

Name: pgl [H]

Synonym: Acry_1273

Alternate gene names: 148260276

Gene position: 1421896-1421159 (Counterclockwise)

Preceding gene: 148260277

Following gene: 148260275

Centisome position: 41.95

GC content: 67.21

Gene sequence:

>738_bases
ATGAAACCTGTGCGTGGCGAACTCGTCGTCGTGCCCGATGCGAAAGCCTTCGCCGAATACGGAGCGCGCCTCTTTGCGGA
AGAGGCCGCCGCCGCGCGCGGCCGGTTCGTGGCCGGCCTCGCCGGCGGATCGACGCCGCGCGCATTGTACGAACGGCTGG
CTGCTGCGCCCTGGCGCGACAGCATCGACTGGACACGCATCGATCTCGTTCTCGGCGATGAGCGGTTCGTCGCGCCGGAT
GACGACAAGAGCAATGTCCGGATGATCCGCGACGCCCTGACCGCGCATCTGCCGGCGGCGCCCCGCCTGCATCAGGTGCC
GTTCGACGGGATGACGGTCGATCAGGCCGCCGCGGCATATCAGCAGGATCTGGCCGAGGTCCATGGCGCAGCGACTCTCG
ATCCTTCGAGGCCATTCTTTGATCTTTGCCTGCTTGGCATGGGCGATGACGGTCATACCGCGTCACTTCTGCCCGGTCAG
GACGATCTGCTCGGTGAACGGCAACGCTGGGTGATTCCGGTGACCAAGGGACGCCCGGAAGCACGCGTCACGCTGACCTA
CCCGATCCTCGAAAGCGCGCGGGTCGTGGTGTTTCTCGTCTCCGGCGCGGGCAAGCGCGACATGCTCGATCGCGTCCTGA
GCGGTTCGGATCGTGACGTGCCCGCCGCCCGCCTCAGGCCGGTCGGACGCCTGATCTGGCTCGCGGATCGCGATGCCGCC
GGACGATGGGCGGACTGA

Upstream 100 bases:

>100_bases
ATGACAGTGTCAAGCGGAAGGCGGATCATGCCACACGCGGCAATGAGGAAGATGGCTTTGCCGAAGCGATGATGCGCTTC
GTGCTCGAGGGGAGACGCTG

Downstream 100 bases:

>100_bases
AGGGGGCACATCGCATGGGAACCGATTTCGAAAATGGCAAGCGTGCGGCCGCGCGGCTGGCCGTCGGTCTCGTCGAATCC
GGAATGCGCGTGGGCCTCGG

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MKPVRGELVVVPDAKAFAEYGARLFAEEAAAARGRFVAGLAGGSTPRALYERLAAAPWRDSIDWTRIDLVLGDERFVAPD
DDKSNVRMIRDALTAHLPAAPRLHQVPFDGMTVDQAAAAYQQDLAEVHGAATLDPSRPFFDLCLLGMGDDGHTASLLPGQ
DDLLGERQRWVIPVTKGRPEARVTLTYPILESARVVVFLVSGAGKRDMLDRVLSGSDRDVPAARLRPVGRLIWLADRDAA
GRWAD

Sequences:

>Translated_245_residues
MKPVRGELVVVPDAKAFAEYGARLFAEEAAAARGRFVAGLAGGSTPRALYERLAAAPWRDSIDWTRIDLVLGDERFVAPD
DDKSNVRMIRDALTAHLPAAPRLHQVPFDGMTVDQAAAAYQQDLAEVHGAATLDPSRPFFDLCLLGMGDDGHTASLLPGQ
DDLLGERQRWVIPVTKGRPEARVTLTYPILESARVVVFLVSGAGKRDMLDRVLSGSDRDVPAARLRPVGRLIWLADRDAA
GRWAD
>Mature_245_residues
MKPVRGELVVVPDAKAFAEYGARLFAEEAAAARGRFVAGLAGGSTPRALYERLAAAPWRDSIDWTRIDLVLGDERFVAPD
DDKSNVRMIRDALTAHLPAAPRLHQVPFDGMTVDQAAAAYQQDLAEVHGAATLDPSRPFFDLCLLGMGDDGHTASLLPGQ
DDLLGERQRWVIPVTKGRPEARVTLTYPILESARVVVFLVSGAGKRDMLDRVLSGSDRDVPAARLRPVGRLIWLADRDAA
GRWAD

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912586, Length=248, Percent_Identity=35.0806451612903, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI52145310, Length=227, Percent_Identity=32.5991189427313, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI115533058, Length=216, Percent_Identity=30.5555555555556, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI115533060, Length=216, Percent_Identity=30.5555555555556, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324362, Length=213, Percent_Identity=30.9859154929577, Blast_Score=99, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6319918, Length=217, Percent_Identity=31.7972350230415, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321957, Length=236, Percent_Identity=26.6949152542373, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6321687, Length=243, Percent_Identity=27.5720164609054, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24641119, Length=246, Percent_Identity=32.9268292682927, Blast_Score=101, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26675; Mature: 26675

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVRGELVVVPDAKAFAEYGARLFAEEAAAARGRFVAGLAGGSTPRALYERLAAAPWRD
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCC
SIDWTRIDLVLGDERFVAPDDDKSNVRMIRDALTAHLPAAPRLHQVPFDGMTVDQAAAAY
CCCEEEEEEEECCCEEECCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHH
QQDLAEVHGAATLDPSRPFFDLCLLGMGDDGHTASLLPGQDDLLGERQRWVIPVTKGRPE
HHHHHHHCCCCCCCCCCCHHHEEEEECCCCCCEEEECCCCHHHCCCCCEEEEEECCCCCC
ARVTLTYPILESARVVVFLVSGAGKRDMLDRVLSGSDRDVPAARLRPVGRLIWLADRDAA
EEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCHHHHCCCCEEEEEECCCCC
GRWAD
CCCCC
>Mature Secondary Structure
MKPVRGELVVVPDAKAFAEYGARLFAEEAAAARGRFVAGLAGGSTPRALYERLAAAPWRD
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCC
SIDWTRIDLVLGDERFVAPDDDKSNVRMIRDALTAHLPAAPRLHQVPFDGMTVDQAAAAY
CCCEEEEEEEECCCEEECCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHH
QQDLAEVHGAATLDPSRPFFDLCLLGMGDDGHTASLLPGQDDLLGERQRWVIPVTKGRPE
HHHHHHHCCCCCCCCCCCHHHEEEEECCCCCCEEEECCCCHHHCCCCCEEEEEECCCCCC
ARVTLTYPILESARVVVFLVSGAGKRDMLDRVLSGSDRDVPAARLRPVGRLIWLADRDAA
EEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCHHHHCCCCEEEEEECCCCC
GRWAD
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]